Ultralow frequency vaso-oscillations in human cerebral arteries are independent from Mayer waves biorxiv.org 2026-06-11 This study tests the hypothesis that vasomotion, an ~ 0.1 Hz oscillation in arteriole diameter, is generated by intrinsic oscillations within the arte
Addressing the Elephant in the Room: A Quantitative Approach to Understanding 'Wild' biorxiv.org 2026-06-11 When applied to non-human animals,'wild' is a poorly defined concept despite its central role in conservation, wildlife management, and environmental
Reliability-weighted target-position estimation in a musculoskeletal arm model: adaptive priors and learned source weighting under violations of fixed-precision assumptions biorxiv.org 2026-06-11 Reliability-weighted integration is a normative account of cue combination, but its scope in musculoskeletal models and conditions requiring adaptive
A common connectome-based neural reference space across affective, autonomic, and wakefulness arousal biorxiv.org 2026-06-11 Arousal is often invoked to explain state-dependent variability in attention, emotion, memory, and decision-making.
Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibition biorxiv.org 2026-06-11 Immune checkpoint inhibitor (ICI) combinations that block cytotoxic T lymphocyte associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD
Pathogen-driven reactivation of metabolite prodrugs defines nitroxoline's iron-deprivation antibiotic activity biorxiv.org 2026-06-11 The rise of antimicrobial resistance warrants renewed attention to established but overlooked antibiotics such as nitroxoline (NTX).
Disentangling the sucrose metabolism of the corn smut Ustilago maydis reveals unexpected complexity biorxiv.org 2026-06-11 The race for carbohydrates shapes organismic interactions.
Full-assembly screening reveals mobile antibiotic-resistance cargo missed by chromosome-only genomes biorxiv.org 2026-06-11 Background.
Engineering a Hyper-Adherent E. coli Nissle Probiotic Strain that Reduces Intestinal Carriage of SalmonellaPathogens in Poultry biorxiv.org 2026-06-11 Salmonellosis continues to be one of the most important causes of food-borne illness in the U.S.
First Usutu virus detections in wild birds in Scotland, 2025 biorxiv.org 2026-06-11 In summer 2025, several Eurasian Blackbird (Turdus merula) deaths were reported on the Isle of Arran in Scotland.
Gene duplication and retrotransposition diversify the antiviral repertoire of macaque IFITM proteins biorxiv.org 2026-06-11 Interferon-induced transmembrane (IFITM) proteins are broad-spectrum antiviral restriction factors that inhibit viral entry of diverse enveloped virus
A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile biorxiv.org 2026-06-11 Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial second messenger that coordinates lifestyle transitions, virulence, and developm
Multifaceted regulations of HSV-1 ICP0 on the Anti-Viral Restrictions Imposed by the Host Hippo Kinases Reprogramming biorxiv.org 2026-06-11 The Hippo pathway is conserved across eukaryotes and controls key biological processes, including cell growth and organ development.
Disparate introduction histories but similar climatic distribution patterns among congeneric invasive anurans biorxiv.org 2026-06-11 Commonly shared patterns of introduction and spread into new environmental conditions are often poorly understood, even though a better understanding
Forging together: Parallel adaptation to minewater pollution in brown trout (Salmo trutta L.). biorxiv.org 2026-06-11 Mining pollution is an important stressor of freshwater communities worldwide.
Improving splice site usage prediction with SPLAIRE biorxiv.org 2026-06-11 Alternative splicing, the mechanism by which intronic sequences are excised from pre-mRNAs to produce mature mRNA, affects >95% of human protein-co
Apollo 3: Multi-Species Genome Curation biorxiv.org 2026-06-11 We present Apollo 3, a new manual genome annotation tool that integrates with the JBrowse 2 genome browser.
A stimuli-responsive ex vivo model of osteoarthritis demonstrates TLR4-mediated cartilage degradation and a Rapamycin-induced fast matrix recovery biorxiv.org 2026-06-11 Abstract Background: In osteoarthritis (OA) TLR4 signaling leads to downstream activation of the phosphoinositide 3-kinases/ protein kinase B/ mammali
SPARK: A Systems-level Computational Framework for Reconstructing Transcriptomic State Organisation in Lung Adenocarcinoma biorxiv.org 2026-06-11 Lung adenocarcinoma (LUAD) exhibits substantial molecular heterogeneity, which complicates tumour stratification and limits the ability of mutation-ce
GeroEngine: Generative single-cell aging trajectories reveal a bidirectionally traversable identity core and direction-specific inflammatory remodeling biorxiv.org 2026-06-11 Single-cell RNA sequencing (scRNA-seq) maps aging tissues at high resolution but is destructive, preventing longitudinal tracking; dropout and zero-in
Hyper3D-lite: count-preserving representation auditing for long-read multi-contact genome data biorxiv.org 2026-06-11 Long-read and single-molecule sequencing technologies are rapidly increasing molecule-level data, with platforms such as Oxford Nanopore, PacBio HiFi,
Spatial Transcriptomics Reveals Region-Specific Remodeling in Vein Grafts After Peripheral Arterial Bypass biorxiv.org 2026-06-11 Background: Vein graft failure due to intimal hyperplasia and maladaptive remodeling remains a major limitation of peripheral bypass surgery.
Music facilitates sleep initiation in adults with sleep-onset insomnia: The role of neural synchronization biorxiv.org 2026-06-11 Sleep-onset insomnia is widespread in modern society, and many individuals turn to music to improve their sleep.
Immunological responses to hydrogel-aided induced pluripotent stem cell-derived dopaminergic progenitor transplants in immunodeficient versus cyclosporine immunosuppressed rats. biorxiv.org 2026-06-11 The success of stem cell-derived brain repair for Parkinson's is limited by the variable survival and poor maturation of dopaminergic progenitors afte
The electro-MICA toolbox for integrating electrophysiology within multimodal imaging and connectomics workflows biorxiv.org 2026-06-11 The integration of electrophysiological recordings with multimodal neuroimaging data holds great promise for advancing our understanding of brain func
DigiMus: a connectome-informed spiking framework for multi-region mouse neural-behavior modeling biorxiv.org 2026-06-11 Computational models are increasingly used to relate mouse brain structure, neural activity and behavior, but most models still learn from task data w
Single-camera, calibration-free gaze estimation using corneal reflections biorxiv.org 2026-06-11 Background.
Lifelong self-renewal and competition shape the virtual memory CD8 T-cell compartment during aging biorxiv.org 2026-06-11 Primary CD8 T-cell responses decline with age, increasing susceptibility to novel infections.
Is there a need to implement standardisation into in vitro antimicrobial evaluation systems? A European collaboration perspective biorxiv.org 2026-06-11 Background: Time kill curve (TKC) assessments are an essential step in the study of an antimicrobials pharmacodynamic characteristics.
Murepavadin is a broad-spectrum outer membrane permeabiliser biorxiv.org 2026-06-11 Murepavadin is a Pseudomonas-specific antibiotic that targets LPS transport protein LptD.
No-known-vector flaviviruses exhibit diverse replication and virulence phenotypes in mice biorxiv.org 2026-06-11 The Orthoflavivirus genus (flaviviruses) includes globally significant arboviruses, which cycle between arthropod vectors (mosquitoes and ticks) and v
Insights into the genetic architecture of resistance to viral haemorrhagic septicaemia virus in rainbow trout from a genome-wide association study to in vitro CRISPR-Cas9 functional evaluation biorxiv.org 2026-06-11 Viral haemorrhagic septicaemia (VHS) is a severe disease affecting rainbow trout (Oncorhynchus mykiss) and a wide range of wild freshwater and marine
Liquidity of gene co-expression trajectories across the lifespan highlights delayed maturation and the perinatal GABA switch in schizophrenia risk biorxiv.org 2026-06-11 Schizophrenia genetic and environmental risk factors play out largely in early life, biasing development toward a pathogenic trajectory that becomes c
Social or non-social? An exploratory approach to study inequity aversion in primates biorxiv.org 2026-06-11 Inequity aversion, the sensitivity to inequitable outcomes or processes, has been widely studied in nonhuman primates since 2003.
Multiplex engineering of rhesus macaque NK cells enhances homing to sites of HIV replication in B cell follicles. biorxiv.org 2026-06-11 One barrier to developing an HIV-1 cure is viral reservoirs persisting within B cell follicles of lymphatic tissues, partly due to failure of HIV-spec
HoloCell: A Generative Foundation Model for Holistic Cellular Modeling biorxiv.org 2026-06-11 Single-cell multi-omics technologies have recently advanced to enable the profiling of epigenomic, transcriptomic, and proteomic layers within individ
Combinatorial docking and molecular generation to navigate over 100-billion molecules for prospective ligand discovery biorxiv.org 2026-06-11 Commercially available make-on-demand libraries now exceed 100 billion compounds, requiring over 50 years to screen on 2,000 CPU cores using conventio
Mechanistic Insights into MLKL Activation via Allosteric Pathways Identified Through Molecular Models biorxiv.org 2026-06-11 The mixed lineage kinase domain-like protein (MLKL) is responsible for plasma membrane (PM) permeabilization during the last stage of necroptosis, a p
Glioblastoma-derived extracellular vesicles released after radiation promote cognitive impairment through NFκB-mediated microglial activation biorxiv.org 2026-06-11 Glioblastoma (GBM) is the most aggressive primary brain tumor in adults.
Galectin-8 Modulates Membrane CD44v Localization and Tempers STAT3 Signaling in Gastric Metaplasia biorxiv.org 2026-06-11 Galectin-8 is lectin that binds N-acetyllactosamine moieties with preference towards those with acidic, terminal modifications (3'-O-sialyated, 3'-O-s
An effector protein that protects a fungal pathogen from the plant microbiota during host colonisation biorxiv.org 2026-06-11 Zymoseptoria tritici is the causal agent of Septoria tritici blotch, one of the most economically important wheat diseases worldwide.
Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Anti-Tumor Immunity In Vivo and in Patient-Derived Cells biorxiv.org 2026-06-11 Small molecule targeting of suppressive myeloid immune checkpoints remains a major challenge in cancer immunotherapy, particularly for non-enzymatic r
The Iberian white-oak syngameon as a legacy of introgression in southern Europe biorxiv.org 2026-06-11 Oaks (Quercus L.) are among the most ecologically important tree genera in the northern hemisphere, with an intricate evolutionary history reflected i
The toll-like receptor signalling pathway is altered in iPSC-derived cortical networks from people with bipolar disorder. biorxiv.org 2026-06-11 Background: Induced pluripotent stem cell (iPSC)-derived brain cells are widely utilized as in vitro models for several neuropsychiatric disorders, as
Dengue virus infection in Aedes aegypti mosquito brains elicits minimal transcriptional response biorxiv.org 2026-06-11 Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes
Scalable microvascular networks-on-chip enable 8-week unidirectional perfusion for long-term vascular toxicity screening biorxiv.org 2026-06-11 Cardiovascular toxicity is a leading cause of late-stage drug attrition, yet current in vitro vascular models lack the longevity and scalability neede
Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells biorxiv.org 2026-06-11 Chemoproteomic mapping of covalent fragment libraries is expanding the ligandable human proteome with direct evidence of cellular target engagement.
A membrane homeostatic response to lipid overload coordinates fatty acid metabolism biorxiv.org 2026-06-11 Excess fatty acids can disrupt membrane and organelle function.
Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis biorxiv.org 2026-06-11 Spermatogonial stem cells (SSCs) maintain male fertility, but how their clonal dynamics change with age remains poorly understood.
A combinatorial DNA origami platform for biologically replicable, thermostable data storage and molecular authentication biorxiv.org 2026-06-11 DNA origami is becoming an attractive platform for data storage, yet current approaches rely on the limited stability of DNA hybridization, preventing