The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy biorxiv.org 2026-06-13 The hierarchical organization of sensory cortices and the rich molecular taxonomy of their cell types are defining features of the mammalian cortex.
Extracranial lymphatic-venous anastomosis remodels the choroid plexus-vascular axis in Alzheimer's disease biorxiv.org 2026-06-13 Coordination of brain fluid transport, proteostasis, and vascular function is essential for neural homeostasis, yet whether extracranial lymphatic out
Lesion-Gradient Mapping in Semantic Aphasia: Comparisons of Observed and Simulated Effects of Stroke on Connectivity Gradients biorxiv.org 2026-06-13 Post-stroke semantic aphasia is characterised by multimodal semantic deficits and reflects disruption of a distributed brain network spanning frontal
Dual Developmental Origins and Activity-dependent Specification of Mammalian Subplate Neurons biorxiv.org 2026-06-13 Subplate neurons (SpNs) are among the earliest-generated cortical neurons and are essential for neocortical circuit assembly.
Wavelet analysis of human recombination rates demonstrates divergence on fine scales biorxiv.org 2026-06-13 Background: Recombination rates can be estimated across the genome, underpinning genetic analyses such as identification of regions under selection.
Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in Cryptococcus neoformans biorxiv.org 2026-06-13 Cryptococcus neoformans is the leading cause of fungal meningitis in immunocompromised patients.
Endosomal mRNA transport coordinates local mitochondrial bioenergetics during polar fungal growth biorxiv.org 2026-06-12 Mitochondrial function relies on the precise spatial coordination of protein synthesis and import.
A metabolic checkpoint coordinates bacterial cell envelope biosynthesis and c-di-GMP signaling biorxiv.org 2026-06-12 The bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) drives the transition from motile to biofilm lifestyles, yet the mech
Molecular and ecological determinants of effective reassortment in orthohantaviruses biorxiv.org 2026-06-12 A central unsolved problem in RNA virus evolution is understanding why some viral reassortants establish and persist while others do not.
Unraveling candidate genomic regions responsible for delayed post-harvest deterioration in Cassava (Manihot esculenta Crantz) biorxiv.org 2026-06-12 Post-harvest physiological deterioration (PPD) represents a significant challenge of cassava production and commercialization.
Unlocking viral evasion: Luminal charge interactions in BoHV-1 UL49.5 allosterically control TAP degradation biorxiv.org 2026-06-12 The UL49.5 protein of bovine alphaherpesvirus 1 (BoHV-1) is known to inhibit the transporter associated with antigen processing (TAP) and interfere wi
Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity biorxiv.org 2026-06-12 The anatomical complexity and distinctive tissue environment of the human oral cavity pose major challenges to modeling oral infection and host-microb
Computational Design of Optimal Sequences for Targeted Hypermutagenesis Using Recombination-Coupled Diversity-Generating Retroelements biorxiv.org 2026-06-12 Diversity-generating retroelements (DGRs) are natural systems that accelerate evolution via targeted hypermutation at adenines.
ProMiSE: Protein Multi-State Evaluation Benchmark in Biological Contexts biorxiv.org 2026-06-12 Proteins are inherently dynamic, with biological functions often emerging from transitions between multiple conformational states.
The role of the neutrophil receptor Mrgpra2 in the formation of itch in atopic dermatitis biorxiv.org 2026-06-12 Atopic dermatitis (AD), or eczema, is estimated to affect more than 30 million people in the United States, with over 6 million have moderate or sever
XL-MS-Guided Structure Prediction of Disordered Encephalitozoon hellem Proteins biorxiv.org 2026-06-12 Microsporidia such as Encephalitozoon hellem are obligate intracellular human parasites that remain genetically intractable, limiting functional chara
Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression biorxiv.org 2026-06-12 Perturbation to the early-life microbiota has long-term detrimental effects on health and development, leading to increased risk for metabolic dysfunc
Postpartum Systemic Inflammation is Reflected in Early Distinct Fecal Microbiome Differences in Dairy Cows biorxiv.org 2026-06-12 A tightly regulated inflammatory response occurs during and following parturition; however, excessive or prolonged inflammation negatively affects her
Pathogenesis and host response to a novel Tacaribe virus isolate in experimentally-infected Jamaican fruit bats biorxiv.org 2026-06-12 Tacaribe virus (TCRV) was the first arenavirus discovered in the New World and was isolated from Artibeus bats in Trinidad and Tobago in the 1950s.
Antimicrobial and Cytotoxic Lysolipins I-M Isolated from Streptomyces sp. P8-2B18 biorxiv.org 2026-06-12 Lysolipin I (1) is a highly bioactive xanthone with strong antibacterial and cytotoxic properties.
Primary and secondary antiviral RNAi responses throughout Varroa destructor life stages reveal the vertical transmission of viruses biorxiv.org 2026-06-12 One of the most devastating threats to global honey bee health is the ectoparasitic mite and viral vector Varroa destructor, yet the transmission dyna
CORe Designer: a CRISPR design tool for proteome engineering biorxiv.org 2026-06-12 Precision proteome engineering requires tools that leverage CRISPR technologies, yet most current design platforms remain gene-centric.
BacPROTACs outperform inhibitors in Mycobacterium tuberculosis biorxiv.org 2026-06-12 Antibiotic discovery has long relied on occupancy-driven inhibition, leaving a vast number of potential bacterial targets undrugged.
The efficiency of different transmission routes of Xanthomonas citri pv. fuscans and other seed-borne bacteria to bean seeds. biorxiv.org 2026-06-12 Seed transmission is a critical pathway for the dispersal of phytopathogenic bacteria.
Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins biorxiv.org 2026-06-12 Rust fungi are significant threats to global food security, causing substantial damage to crops through their ability to adapt and evolve new strains
Reward network state dynamics track ASD symptom severity but not diagnosis biorxiv.org 2026-06-12 Autism spectrum disorder (ASD) is a heterogeneous developmental condition characterized by repetitive behaviors and social communication difficulties.
Time, but not reward, shapes replay-based episodic prioritization biorxiv.org 2026-06-12 Why are some experiences remembered better than others?
The dynamic relationship between pupil dilation and neural surprise in natural language comprehension biorxiv.org 2026-06-12 Predictive processing accounts hold that the brain continuously generates predictions and updates internal models from error signals, but it remains u
Developmental emergence of spatiotemporal coordination in cerebellar Purkinje cell populations biorxiv.org 2026-06-12 Coordinated neuronal population activity is essential for brain function, yet how such network-level organization emerges during development remains i
Interplay of sleep neural oscillations enhances coordinated memory reactivation between cortex and hippocampus biorxiv.org 2026-06-12 Memory consolidation during sleep requires coordinated reactivation of specific experiences across hippocampus and cortex.
Movement planning predictions shape somatosensory sensitivity biorxiv.org 2026-06-12 Tactile sensitivity is reduced during limb movement, a phenomenon known as somatosensory gating.
Dorsomedial Striatum Calcium Permeable AMPA Receptors in the Development of Aversion-Resistant Alcohol Drinking biorxiv.org 2026-06-12 Rationale: Alcohol use disorder is defined by drinking alcohol despite knowledge of negative consequences, often referred to as aversion-resistant dri
Intact learning and memory in mice incapable of de novo myelination biorxiv.org 2026-06-12 Motor skill learning stimulates and requires generation of oligodendrocytes (OLs) from their precursors (OLPs) in the adult mouse brain, but the funct
Developmental coordination disorder affects the pre-ordering of sequential movements biorxiv.org 2026-06-12 Research suggests that motor difficulties in Developmental Coordination Disorder (DCD) are related to altered motor sequence planning, but it is uncle
Macroevolutionary shifts in post-hatching ontogeny and the origin of craniofacial disparity in fowl (Aves: Galloanserae) biorxiv.org 2026-06-12 Anseriformes (waterfowl) and Galliformes (landfowl) are among the world most recognisable groups of birds, together comprising the clade Galloanserae.
Enhancer pioneering activity of Wnt/β-catenin signaling biorxiv.org 2026-06-12 Wnt/{beta}-catenin signaling is widely understood as a molecular switch that activates preprogrammed regula-tory states.
Co-Expressed MicroRNAs Identify Potential Mechanisms Underlying Risk for Multimorbid Depression and Type 2 Diabetes in Midlife Women biorxiv.org 2026-06-12 Background Women are disproportionately affected by multimorbid depression and type 2 diabetes (T2D), with prevalence peaking during midlife (40-64 ye
Effects of Left Atrial Wall Thickness on Myocardial Mechanics and Blood Dynamics using Multiscale Modeling biorxiv.org 2026-06-12 Purpose: Patient-specific models of left atrial (LA) mechanics often assume uniform left atrial wall thickness (LAWT), but the effect of LAWT on the m
Receive-Only Coupled Wireless Radiofrequency Probe for Endocavity MR Imaging Using a pTx System biorxiv.org 2026-06-12 Purpose: To enhance the SNR in MRI within a localized region of interest using a novel interventional wireless RF resonator probe combined with a dual
A Graph-based QSAR Modeling Pipeline for Predicting In vitro PubChem Assays and In vivo Human Hepatotoxicity: Mechanistic Analysis of Caspase-3/7 Activation biorxiv.org 2026-06-12 Background: Caspase-3 and -7 are key effector caspases in the apoptotic pathway, a form of programmed cell death, and their activities serve as a well
Inhibition of NSD1 by 5-O-Sulfamoyl Adenosine improved 5-FU sensitivity by suppressing cancer cell proliferation and xenograft tumor growth biorxiv.org 2026-06-12 Epigenetics regulate cell-cycle kinetics, differentiation, apoptosis, and migration.
Systematic Profiling and Functional Characterization of Alternative Splicing in C. elegans Olfactory Learning biorxiv.org 2026-06-12 Alternative splicing (AS) is prevalent in neuronal gene expression. However, its function in learning has not been systematically characterized.
Video-based eye movements are linked to cortical and pupil-based arousal in human sleep biorxiv.org 2026-06-12 Study Objectives To quantify high-resolution video-based eye kinematics across sleep macro- and microstructure and determine their coupling with pupil
A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonates biorxiv.org 2026-06-12 Type 2 conventional dendritic cells (cDC2) orchestrate T cell immunity, yet the signals that regulate their tissue-specific functions across developme
Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulation biorxiv.org 2026-06-12 C3- and C5-nephritic factors are potent but poorly understood autoantibodies that dysregulate complement convertases.
Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males biorxiv.org 2026-06-12 Tuberculosis (TB), the worlds deadliest infection, shows higher prevalence and mortality in males than in females (M/F ratio >1.7).
Increased Expression and Altered Functional Activities of Immune Receptors TREM1, PD-L1, and Others on Hematopoietic Progenitor Cells in a Mouse Model of Rheumatoid Arthritis biorxiv.org 2026-06-12 Hematopoietic stem and progenitor cells (HSPCs) sustain the production of hundreds of billions of new cells per day to maintain our blood and immune s
Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages biorxiv.org 2026-06-12 Lung repair in response to viral infection requires integrated communication between epithelial and immune compartments, yet the impact of antiviral m
An investigation of the IL-23/Th17 axis and transcriptomic profiles of T helper subsets in endometriosis biorxiv.org 2026-06-12 Endometriosis (EMS) is a chronic inflammatory disease characterized by ectopic endometrial-like tissue growth and immune dysregulation.
Deficiency of IL-36 receptor antagonist (DITRA) is associated with decreased homoeostatic CCL27 expression leading to heightened dermal inflammation. biorxiv.org 2026-06-12 Deficiency of the Interleukin-36 Receptor antagonist (DITRA) is a rare autoinflammatory condition which commonly manifests as severe, recurrent episod