Antifungal tolerance and resistance dynamics depend on infection load, drug treatment, and host innate immunity biorxiv.org 2026-06-09 Fungi contribute substantially to the global antimicrobial resistance crisis.
Purinergic signaling disrupts emergent patterns of multicellular coordination in basal Xenobots. biorxiv.org 2026-06-09 The ability of self-organizing systems to display emergent, adaptive capabilities is a fundamental feature of biological life.
Spatiotemporal unfolding of prefrontal neural response divergence in adolescent depression during naturalistic experience biorxiv.org 2026-06-09 Depression alters how emotional experience is interpreted and regulated, yet how depression-related neural divergence unfolds during ongoing experienc
LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in C. elegans biorxiv.org 2026-06-09 During development, many neurons prune their neurites.
Beyond the Forest and the Trees: Overlooking the Overlooked Terrain of Neural State Dynamics biorxiv.org 2026-06-09 State-transition approaches, including EEG microstate analysis and related fMRI methods such as hidden Markov models (HMMs) and co-activation pattern
Blood-brain barrier model architecture shapes peripheral immune cell trafficking in Parkinson's disease biorxiv.org 2026-06-09 Parkinson's disease (PD) is a neurodegenerative disorder traditionally characterized by dopaminergic neuron loss in the substantial nigra pars compact
Quantitative determination of longitudinal CNS cholesterol loss during myelin damage and repair biorxiv.org 2026-06-09 Cholesterol in the central nervous system (CNS) is largely unesterified (>99%) and is predominantly present in the myelin sheath (~70% of total CNS
Evidence for strong interplay between the nucleotide and base excision repair pathways in D. radiodurans biorxiv.org 2026-06-09 Deinococcus radiodurans harbors a largely classical bacterial DNA repair machinery yet displays exceptional resistance to ultra-violet and ionizing ra
Human Osteochondral Granular Extracellular Matrix (gECM) Hydrogels Drive Tissue-Specific Composition and Mechanics biorxiv.org 2026-06-09 Osteochondral defects remain a major clinical challenge due to the limited regenerative capacity of cartilage and the complexity of the osteochondral
PRIME: scalable, robust inference of mechanistic cell states from multimodal single-cell counts via probability generating functions biorxiv.org 2026-06-09 Single-cell multiomic technologies can now quantify complementary RNA species within the same cell, creating an opportunity to move beyond descriptive
Untargeted cord blood metabolomics reveals altered lipid metabolism in neonates with gastroschisis biorxiv.org 2026-06-09 Gastroschisis is a congenital abdominal wall defect in which fetal intestines herniate into the amniotic cavity.
Organizing principles in the Nitrogen-Carbon Landscape of Marine Heterotrophic Bacteria biorxiv.org 2026-06-09 Marine microbes metabolize a wide range of carbon and nitrogen sources, shaping global biogeochemical cycles.
Auditory Working Memory and Sound Segregation Ability Predict Speech-in-Noise in Adult Cochlear Implant Users biorxiv.org 2026-06-09 Abstract Objectives: Outcomes following cochlear implantation vary substantially across adult recipients, and the cognitive and perceptual factors con
Chromatic topological mapping reveals organelle-specific spatial organization within microglia biorxiv.org 2026-06-09 In branched cells, including neurons and glia, intracellular organelles are distributed across complex cellular arbors where their spatial arrangement
Foveal vision in fast-flying birds hunting on the wing biorxiv.org 2026-06-09 Processing rapid motion while maintaining high spatial acuity is a fundamental evolutionary challenge for the vertebrate visual system.
Regional specificity of neuronal cell types, functional connectivity, and cell type-specific correlation to brain disorders in the human ventral tegmental area biorxiv.org 2026-06-09 The ventral tegmental area (VTA) in the midbrain is a key reward system hub associated with multiple brain disorders.
Modulation index-based phase-amplitude coupling does not encode temporal polarity biorxiv.org 2026-06-09 Background: Phase-amplitude coupling (PAC) is widely used to quantify interactions between neural oscillations across timescales and is often interpre
Preserved self-other integration during social decision making among individuals with elevated autistic traits biorxiv.org 2026-06-09 Autistic people can find social interactions difficult to navigate, traditionally attributed to difficulties in taking others' perspectives.
PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal death biorxiv.org 2026-06-09 Genetic loss of the mitochondrial control enzyme PINK1 leads to Parkinson's disease, characterized by dopaminergic neuron degeneration and neuroinflam
Adipose tissue as a site of immune activation and dysfunction in individuals with obesity and asthma biorxiv.org 2026-06-09 Obesity increases local inflammatory responses in adipose tissue.
Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction biorxiv.org 2026-06-09 Background. Heart failure with preserved ejection fraction (HFpEF) is a systemic inflammatory syndrome with few effective therapies.
Two melanic pigment patterns are associated with a sex chromosome-linked oncogene in the mountain swordtail Xiphophorus nezahualcoyotl biorxiv.org 2026-06-09 Sex-linked traits are widespread, but their genetic architecture has been challenging to characterize, due in part to the repetitive and structurally
Prefrontal cortical pathways mediating cognitive control enhancement from internal capsule stimulation biorxiv.org 2026-06-09 Background: Deep brain stimulation (DBS) targeting the ventral internal capsule/ventral striatum (VCVS) is an effective treatment for several psychiat
What can a neuron compute biorxiv.org 2026-06-09 Cortical pyramidal neurons possess elaborate dendritic trees with diverse nonlinear membrane conductances and thousands of plastic synapses, suggestin
CRISPR-mediated Stxbp1 gene activation ameliorates epileptic and aggressive phenotypes in Stxbp1-haploinsufficient mice biorxiv.org 2026-06-09 Mutations in the syntaxin-binding protein 1 (STXBP1) gene, which encodes the presynaptic protein Munc18-1, cause a spectrum of severe epileptic enceph
Low-dimensional Neural Codes Suppress Neuronal Noise and Extend the Working Memory Duration biorxiv.org 2026-06-09 Neurons are noisy computational substrates, yet large neural populations achieve reliable computation.
Connectivity Logic of Dendritic Spines in Cortex: Increased Inputs and Ensemble Formation biorxiv.org 2026-06-09 Dendritic spines, small protrusions covering the dendrites of most neurons, are fundamental elements of synaptic connectivity, yet their network-level
Stable Vesicle-Associated BDNF from Embryonic and Young Cortical Extracellular Vesicles biorxiv.org 2026-06-09 In this work we show that small extracellular vesicles (sEVs) from embryonic mouse cortex or from cultured embryonic cortical neurons contain high lev
Prenatal exposure to maternal stress drives sex-specific neurodevelopmental disruptions in the fetal hypothalamus biorxiv.org 2026-06-09 The hypothalamus plays a central role in integrating physiological stressors to maintain homeostasis, yet how fetal neurodevelopment in the hypothalam
Towards coevolution-aware ancestral sequence reconstruction biorxiv.org 2026-06-09 Ancestral sequence reconstruction (ASR) is a powerful approach for studying molecular evolution and the emergence of protein function.
Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling biorxiv.org 2026-06-09 Objective: Pain in osteoarthritis (OA) is often discordant with structural joint damage, particularly in obesity-associated OA, where adipose-derived
PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets biorxiv.org 2026-06-09 Abstract Aims/hypothesis Single-cell RNA sequencing (scRNA-seq) of pancreatic islet tissue is a powerful tool for investigating Type 1 Diabetes (T1D).
Organ on chip model of respiratory vascular interactions under COPD relevant oxidative stress biorxiv.org 2026-06-09 Oxidative stress-induced airway injury contributes to chronic obstructive pulmonary disease (COPD).
Evaluating agentic AI for biological discovery in autonomous and copilot settings biorxiv.org 2026-06-09 Advances in large language models (LLMs)-based artificial intelligence (AI) agents have improved their ability to execute structured analytical workfl
Complex-phase stochastic modeling of mitochondrial heteroplasmy biorxiv.org 2026-06-09 Mitochondrial heteroplasmy the coexistence of both wild-type and mutant copies of mitochondrial DNA ( mtDNA ) within a cell is a key factor in the pat
TaxoFormer: Hierarchical Transformer for Predicting the Full Taxonomic Lineage of Protein Sequences biorxiv.org 2026-06-09 Predicting labels in massive, hierarchically structured output spaces is a core challenge in machine learning.
Posture and support geometry, rather than body size, dictate lateral dynamic stability in walking mammalian quadrupeds biorxiv.org 2026-06-09 Body size and limb posture vary widely across mammals and are expected to shape locomotor stability, yet direct comparative evidence remains limited.
Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation biorxiv.org 2026-06-09 Background: Protein fibrillation represents a critical challenge in therapeutic insulin delivery, yet the structural determinants and immunological co
SHERLOC: An interpretable deep learning model for longitudinal circulating tumor DNA data in survival analysis biorxiv.org 2026-06-09 Longitudinal circulating tumor DNA (ctDNA) measurements offer a noninvasive means to monitor treatment response, but clinical trial data present subst
Chronic Stress Exacerbates Long-term Microvascular Network Dysfunction Following Brain Trauma biorxiv.org 2026-06-09 Background: Preexisting factors are among the strongest predictors of recovery following traumatic brain injury (TBI), with chronic stress closely ass
Lineage tracing and live-cell imaging reveal that NeuroD1 does not reprogram microglia into neurons biorxiv.org 2026-06-09 Induction of glia-to-neuron conversion is a promising regenerative strategy for treating brain injuries and neurodegenerative diseases.
Otoprotective effect of MnTBAP in cisplatin-induced hearing loss biorxiv.org 2026-06-09 Objective: Cisplatin, a life-saving chemotherapeutic drug, causes ototoxicity.
Robust learning-driven structural and functional plasticity of spines in the mature mouse cortex biorxiv.org 2026-06-09 Spines in the adult cortex are thought to be highly stable, and that their capacity for modest remodeling supports learning.
A Low-Cost, High-Throughput Design-Build-Test Pipeline for Engineering Genetic Systems: Stress Testing with Complex Structural Proteins biorxiv.org 2026-06-09 Genetic systems engineering is constrained by high DNA synthesis costs, assembly inefficiencies, and challenges in expressing complex proteins.
Structure and functional diversity of antibodies targeting the P. falciparum circumsporozoite protein C-terminal domain biorxiv.org 2026-06-08 The Plasmodium falciparum circumsporozoite protein (PfCSP) is the major surface antigen on Pf sporozoites.
Dietary fiber selectively regulates intestinal persistence of probiotic bifidobacteria biorxiv.org 2026-06-08 Bifidobacteria dominate the gut microbiota of breast-fed infants, and are strongly associated with human health, including immune regulation, coloniza
Mapping Genome-wide Transcription Factor Binding Sites in two Rhodanobacter strains Isolated from Extreme Environments biorxiv.org 2026-06-08 Identification of target genes for bacterial transcription factors (TFs) provide a deeper understanding of bacterial response to environmental conditi
A-to-I mRNA editing recodes CqsA and affects T6SS-mediated killing in Vibrio biorxiv.org 2026-06-08 Adenosine-to-inosine (A-to-I) RNA editing alters genetic information post-transcriptionally, yet its ecological and evolutionary significance in bacte
Light-dependent and predator inducible aldehyde synthesis in Prochlorococcus for specific defense against Uronema biorxiv.org 2026-06-08 Cyanobacteria as a primary producer provide energy and carbon sources for the marine food web, of which predation-interactions play central roles in r
Redox stress agents strongly enhance mutagenesis during horizontal gene transfer in bacteria and leave distinct mutational and metabolic footprints biorxiv.org 2026-06-08 Redox stress induces DNA mutations that contribute to chronic conditions affecting human health and to the emergence of antibiotic resistance.