Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus biorxiv.org 2026-06-08 The cellular diversity in the human brain is underpinned by neural progenitor cells(NPCs).
Homophily-informed generative models of brain maps biorxiv.org 2026-06-08 The structural and functional organization of the brain can be studied across multiple scales, yielding richly detailed topographic brain maps of biol
Distinct associations between thalamo-amygdala pathways and state anxiety biorxiv.org 2026-06-08 Neurobiological models of emotion have proposed the existence of multiple direct subcortical pathways in humans, often referred to as "low roads", lin
Sound-evoked orofacial motion only affects a fraction of visually responsive V1 neurons in a multisensory detection task with delayed reward delivery biorxiv.org 2026-06-08 Auditory stimuli have been known to elicit neural responses in visual cortical areas, but such responses are partly associated with sound-evoked orofa
Genome degradation in the c-di-GMP signaling pathways and serovar-specific YhjH-YciG interactions rewired motility regulation in Salmonella Paratyphi A biorxiv.org 2026-06-08 Salmonella enterica serovars Typhimurium (STM) and Paratyphi A (SPA) cause clinically distinct diseases, yet the molecular bases for their different l
The huntingtin-HAP40 complex is a bidirectional cellular rheostat biorxiv.org 2026-06-08 Huntingtin-associated protein 40 (HAP40) is an obligate structural subunit of huntingtin (HTT) and is rapidly degraded when unbound, yet has been cons
Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed biorxiv.org 2026-06-08 Species distribution forecasts commonly overlook intraspecific genetic variation, missing a potentially important mechanism of ecosystem change: clima
Cross Potential Selection for Multiple Traits Considering the Progeny Distribution of Future Inbred Lines in Plant Breeding Programs biorxiv.org 2026-06-08 In plant breeding, it is often necessary to improve a target trait while maintaining other essential traits within desirable ranges.
Genomic Inbreeding and Selection Signatures analyses in the Doberman Pinscher breed biorxiv.org 2026-06-08 The Doberman Pinscher population has undergone strong artificial selection for morphology and behavior, which can reduce genomic diversity and increas
scFAIR Consortium: a decentralized hub for single-cell RNA-Seq data standardization and unification biorxiv.org 2026-06-08 The rapid accumulation of single-cell RNA-Seq (scRNA-seq) data across multiple repositories presents major challenges for data accessibility, integrat
Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin biorxiv.org 2026-06-08 Prestin (SLC26A5), a membrane protein in cochlear outer hair cells, drives electromechanical transduction essential for mammalian hearing.
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer biorxiv.org 2026-06-08 Drug resistance to the androgen receptor (AR) antagonist is a critical obstacle in the clinic for advanced prostate cancers.
Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses biorxiv.org 2026-06-08 Multiple myeloma (MM) evolves from asymptomatic precursor conditions through progressive genetic and epigenetic remodeling, yet the regulatory mechani
A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interface biorxiv.org 2026-06-08 Lung metastasis drives mortality across cancer types, yet how infiltrating tumor cells remodel the lung epithelium to establish metastatic niches rema
Tumor-derived FXII engages the intrinsic coagulation cascade to support breast cancer liver metastasis. biorxiv.org 2026-06-08 Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined.
Biotic versus environmental controls on microbial degradation of permafrost organic matter biorxiv.org 2026-06-08 Permafrost thaw exposes ancient organic matter to microbial degradation, which is predicted to release globally significant quantities of greenhouse g
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma biorxiv.org 2026-06-07 Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to con
AKIP1 is an inner scaffold component required for centriole integrity biorxiv.org 2026-06-07 Centrioles are microtubule-based organelles that play crucial roles in various biological processes, including cell division, ciliogenesis and flagell
Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments biorxiv.org 2026-06-07 ADAR1 converts adenosine to inosine in endogenous double-stranded RNAs (dsRNAs) to prevent excessive MDA5-driven interferon-stimulated gene expression
Effects of ERK1/2 Signaling on Cell Cycle Regulation by the Tuberin-Cyclin B1 Complex biorxiv.org 2026-06-07 How cells balance growth (cell size) and division (cell number) requires a complex interplay between response to external signals, including growth fa
Heterochromatin organization and liquid-liquid phase separation: it is not about if but about when biorxiv.org 2026-06-07 Heterochromatin is a membraneless compartment within the cell nucleus.
Copper transport to mitochondria by SLC25A3 contributes to skeletal myoblast differentiation and is required for survival of differentiated myotubes biorxiv.org 2026-06-07 Differentiation of skeletal muscle is associated with increased mitochondrial biogenesis and reliance of oxidative phosphorylation (OXPHOS).
Cell free-mtDNA release drives pyroptosis and inflammation in cell models carrying the mitochondrial m.3243A>G pathogenic variant biorxiv.org 2026-06-07 Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) syndrome is primarily caused by the heteroplasmic m.3243A>G/MT-TL1
A transient epithelial plasticity state defines the developmental window for uterine gland specification biorxiv.org 2026-06-07 Uterine gland development and function is essential for reproduction and womens health, yet the epithelial cell states and signaling interactions that
Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy biorxiv.org 2026-06-07 Background: Successful pregnancy requires substantial maternal cardiovascular adaptation, including expansion and remodelling of the uterine arteries
The WormFood CURE: Screening for bioactive metabolites that antagonize the Caenorhabditis elegans Ras signaling pathway biorxiv.org 2026-06-07 Course-based Undergraduate Research Experiences (CUREs) provide an accessible, scalable platform for scientific discovery.
Gap junctions in the alimentary tract regulate reproductive span in C. elegans biorxiv.org 2026-06-07 Aging does not occur uniformly throughout an organism but is instead differentially regulated across distinct physiological systems.
Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles biorxiv.org 2026-06-07 Epigenetic state modulates gene regulation in a manner not always predictable from DNA sequence alone, yet current genomic deep learning models do not
FBH1 Reverses Stalled Replication Forks via Sequential Unwinding of Nascent Strands biorxiv.org 2026-06-07 Replication fork reversal is a DNA damage tolerance mechanism important for genome stability that entails annealing of parental DNA to push the fork b
Development of a Staining-based Electrophoretic Mobility Shift Assay for Analyzing Pbx1, DNA and HoxA9 Interactions biorxiv.org 2026-06-07 Transcription factors (TFs) are master regulators of gene expression and control a wide range of cellular functions including embryonic development, s
TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70 biorxiv.org 2026-06-07 HOP is a cochaperone that facilitates client transfer between two major chaperones, Hsp90 and Hsp70.
Small but Mighty: The Surprising Metabolic Range of a Bacterial Microcompartment biorxiv.org 2026-06-07 Bacterial microcompartments (BMCs) are protein-based metabolic modules increasingly investigated as potential intracellular nanoreactors.
Glycolipid MPIase is essential for the TAT (Twin-Arginine Translocation) pathway biorxiv.org 2026-06-07 TAT (Twin-Arginine Translocation) is a preprotein translocation system dedicated to membrane translocation of prefolded proteins in plants and bacteri
Overestimating zero-shot fitness prediction: Broad benchmarks mask local failures and practical limitations biorxiv.org 2026-06-07 Deep learning models have emerged as promising tools for navigating mutational landscapes in protein engineering.
A Passive-Oxygenation Silicone Platform for Biomass Production: Maximizing Labor Productivity and Process Efficiency in Cellular Agriculture Development biorxiv.org 2026-06-07 The commercial production of cell-based food is currently hindered by existing bioreactor technologies, which require substantial capital investment,
Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex biorxiv.org 2026-06-07 The Nucleosome Remodeling and Deacetylase complex (NuRD) plays a key role in regulating hemoglobin expression in adult erythroid cells.
Chaperonin recognition of protein dynamics drives drug resistance biorxiv.org 2026-06-07 The emergence of drug resistance is typically driven by mutations that alter drug-target affinity, yet the role of host cellular machinery regulating
Recipient cell identity governs intracellular transport and membrane interactions of extracellular vesicles across species biorxiv.org 2026-06-07 Extracellular vesicles (EVs) function as a natural communication system, enabling transfer of biomolecules between cells.
Molecular dynamics insights into biomineralisation mediated by acidic intrinsically disordered proteins: a case study of molluscan Aspein from the pearl oyster Pinctada fucata biorxiv.org 2026-06-07 Biomineralisation is a ubiquitous phenomenon that still fascinates the scientific community.
Autoantibodies Drive Fc Gamma Receptor-Dependent Colon Inflammation During Immune Checkpoint Blockade biorxiv.org 2026-06-07 Immune-related adverse events (irAEs), particularly colitis, are major limitations of immune checkpoint inhibitor (ICI) therapy, but their mechanisms
High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesions biorxiv.org 2026-06-07 Immunotherapy with Nocardia rubra cell wall skeleton (Nr-CWS) can clear human papillomavirus (HPV) and induce regression of cervical precancerous lesi
Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo biorxiv.org 2026-06-07 The neonatal cochlear epithelium harbors regenerative capacity, attributable to the transient greater epithelial ridge (GER).
Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis biorxiv.org 2026-06-07 Tertiary lymphoid structures (TLSs) are sites of immune organization in peripheral tissues that arise from chronic inflammation.
G quadruplex DNA facilitates a pervasive path to homologous recombination biorxiv.org 2026-06-07 Homologous recombination (HR) requires efficient homology search and strand invasion, yet how homologous templates are identified within the nucleus r
Correlative SHG-AFM imaging workflow for label-free quantitative analysis of collagen structure-function relationships biorxiv.org 2026-06-07 We present a user-friendly correlative second harmonic generation (SHG) and atomic force microscopy (AFM) imaging workflow for quantifying the nanomec
Why diabetes matters in dementia studies. Excluding diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimers disease biorxiv.org 2026-06-08 Diabetes is a major risk factor for Alzheimers disease (AD), and both diseases involve mitochondrial dysfunction.
Associations Between Plasma Lipoprotein(a) Levels and Circulating Monocyte Subsets Differ across Populations biorxiv.org 2026-06-07 Objective: Lipoprotein(a) [Lp(a)] is a causal cardiovascular disease (CVD) risk factor, with plasma concentrations generally higher in Black than Whit
Validation-free estimation of chronological age via close-kin biorxiv.org 2026-06-07 Age is a fundamental life-history parameter in animal ecology and wildlife management.
Exploring the diversity and spatial distribution of Anopheles mosquitoes and their associated Plasmodium species in Tanzania using the ANOSPP amplicon panel biorxiv.org 2026-06-07 Species-level identification of malaria vectors and parasites is essential for targeted vector control, surveillance, and clinical case management.
An Automated Wireless Seesaw System Enabling Spatial Separation of Action and Reward in Group-Housed Marmosets biorxiv.org 2026-06-07 Cooperation in social species is shaped by ongoing social relationships, partner choice, and group interactions, demanding experimental systems that p