Locus coeruleus activation transforms cortical taste representations biorxiv.org 2026-06-05 Norepinephrine neurons in the locus coeruleus (LC) shape sensory responses across the brain, yet how LC activity reorganizes population representation
Distinguishing Photoacoustic and Photothermal Neuron Stimulation Through Quantitative Mapping Spatiotemporal Field Evolution biorxiv.org 2026-06-05 Neuromodulation is a rapidly advancing strategy for modulating brain function and treating neurological disorders, yet the mechanisms of optical neura
Stimulus-Specific and Generalized Taste Aversion Behaviors and Their Relationship to Cortical Dynamics biorxiv.org 2026-06-05 Aversive taste behaviors, such as gaping, are commonly viewed as fixed, hard-wired responses important for ejecting potentially toxic tastes from the
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA biorxiv.org 2026-06-05 Enteroendocrine cells (EECs) are specialized sensors of the gastrointestinal (GI) epithelium that regulate gut function and systemic metabolism throug
Auditable recovery of single-cell RNA-seq zeros with SPARE biorxiv.org 2026-06-05 In Single-cell RNA-seq, observed zeroes are the mix between biological absence and technical limitations.
Balancing of immune activation and suppression during phage infection biorxiv.org 2026-06-05 Signaling-based anti-bacteriophage systems such as CBASS and Thoeris synthesize infection-triggered nucleotide signals that activate anti-phage effect
Immobilization in nanocellulose matrix reallocates cyanobacterial proteome resources from growth to bioproduction biorxiv.org 2026-06-05 Solid-state photosynthetic cell factories transform dissolved and atmospheric carbon into chemicals and biomass, offering a platform for the sustainab
A digital droplet microarray for measuring tolerance to antibiotics biorxiv.org 2026-06-05 Antibiotic tolerance enables populations of microbes to survive normally lethal antibiotic concentrations, increasing the likelihood of reinfection an
Extreme envelope plasticity drives temperature-dependent morphogenesis in the LPS-free bacterium Sphingobium yanoikuyae biorxiv.org 2026-06-05 Bacterial growth patterns are generally considered to be constrained and species-specific.
Structural Dynamics of RNA Polymerase II During Nucleotide Addition Cycle biorxiv.org 2026-06-05 RNA polymerase II (RNAPII) drives gene expression through iterative nucleotide addition cycles (NACs) comprising translocation, substrate binding, and
Analgesic preference and injury behaviour in Blaptica dubia biorxiv.org 2026-06-05 Insects are increasingly recognised as behaviourally complex animals, yet whether they experience pain as an affective state beyond nociception remain
Flexible route planning and rapid structure learning by mice in complex environments biorxiv.org 2026-06-05 Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circui
Deep learning-guided design of hydrolases for crystalline PET depolymerization biorxiv.org 2026-06-05 Poly(ethylene terephthalate) (PET), a ubiquitous polyester used in packaging and textiles, persists in the environment due to its high crystallinity a
Development of the Mitochondrial Base Editor Analysis Package (MitoBEAP). biorxiv.org 2026-06-05 For many years, the genetic manipulation of mitochondrial DNA was largely hampered by inefficient delivery of nucleic acids to mitochondria.
A Reproducible and Extensible Benchmark of Supervised Cell Type Annotation Tools for Cytometry Data biorxiv.org 2026-06-05 High-dimensional cytometry technologies such as flow cytometry (FCM) and mass cytometry (CyTOF) are central to immunophenotyping in research and clini
Mycol: A user-friendly app for automating analysis of microscopy images biorxiv.org 2026-06-05 Microscopy image analysis is central to modern biology, yet many available platforms remain inaccessible to non-specialist users because they require
The molecular asynchrony of single cells biorxiv.org 2026-06-05 Integrating single-cell transcriptomic and epigenomic data provides a robust framework for investigating gene regulation mechanisms.
β-Blockers for ED Presentations with Recent Cocaine Use: A Systematic Review biorxiv.org 2026-06-05 Background: Cocaine produces cardiovascular toxicity through intense sympathetic stimulation and direct myocardial injury, generating presentations ra
Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease biorxiv.org 2026-06-05 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common monogenic kidney disease worldwide.
Non-destructive Spatial Reconstruction of Plant Leaf Starch Using Reduced-Band SWIR Spectroscopy and Chemometric Modeling biorxiv.org 2026-06-05 Non-structural carbohydrates (NSCs) are central to plant carbon allocation and physiological regulation, yet their quantification typically relies on
Exercise-induced sweat suppresses depression-like behaviors in mice biorxiv.org 2026-06-05 Depression represents a major global public health challenge.
Spatially resolved mapping of tau amplification rates via differentiable simulation of prion-like propagation biorxiv.org 2026-06-05 Neurodegenerative diseases exhibit characteristic yet heterogeneous patterns of pathological spread, whose underlying determinants remain unclear.
Walking on the Moon: Hypogravity drives the emergence of a proprioception-dependent locomotor state biorxiv.org 2026-06-05 Animals must adapt locomotion to changing environments, but how the nervous system flexibly select gait remains unclear.
Cross-modal applications of a neuromorphic olfactory learning algorithm biorxiv.org 2026-06-05 We adapted an olfactory neuromorphic algorithm to image and sound recognition.
Spontaneous neurotransmitter release is regulated by Unc-5 biorxiv.org 2026-06-05 The spontaneous quantal release of single vesicles of neurotransmitter in the absence of an action potential is a universal feature of all neuronal ch
Immersive bottle effect: Influence of virtual object simulation on modulation of corticospinal excitability by motor imagery biorxiv.org 2026-06-05 Motor imagery is a cognitive process that engages the motor system and facilitates motor learning, recovery, and performance.
Hepatic Differentiation of Human Pluripotent Stem Cells into Functional In Vitro Models Recapitulating Native Liver Complexity for MASLD Modelling biorxiv.org 2026-06-05 Human in vitro hepatic models that accurately recapitulate liver function are essential for fundamental and translational research; however, currently
Chemically Engineered Carbon Nanotubes Map Class-Selective Metabolite Enrichment from Human Plasma biorxiv.org 2026-06-05 The spontaneous adsorption of biomolecules onto nanoparticle surfaces has been extensively characterized at the protein level, but the metabolite coro
Collecting Duct-Targeted Lipid Nanoparticles Deliver Pkd2 mRNA to Restore Polycystin-2 and Attenuate ADPKD biorxiv.org 2026-06-05 Autosomal dominant polycystic kidney disease (ADPKD), a leading genetic cause of kidney failure, is caused by mutations in the PKD1 or PKD2 genes, res
Optical Conductivity as a Stage-Sensitive Imaging Biomarker for Alzheimer's Disease biorxiv.org 2026-06-05 Early detection of Alzheimer's disease (AD) remains limited by the inability of current imaging biomarkers to capture dynamic tissue changes preceding
Tumor extracellular vesicle RNA profiling predicts treatment response in pediatric diffuse midline glioma biorxiv.org 2026-06-05 Detection of reliable markers of therapy response and drug resistance remains a major unmet need in brain cancer, as serial tumor biopsy is often not
Validation of an oral self-administration model of xylazine use in mice biorxiv.org 2026-06-05 Xylazine is a pervasive adulterant in clandestine opioid supplies.
Obstructive Sleep Apnea Syndrome Disrupts Glymphatic-Related Physiological Brain Pulsations biorxiv.org 2026-06-05 Background: Obstructive sleep apnea (OSA) affects over one billion people and increases neurodegenerative risk.
Physiological and Biochemical Responses of Grafted Tomato Plants to Salinity Stress: Evidence from the Syrian Coast biorxiv.org 2026-06-05 The research was carried out in Tartus (Syria), in a plastic greenhouse during the season 2024- 2025.
Calorie Restriction-Induced Daily Hibernation in Mice Drives Cyclic DNA Damage and Repair biorxiv.org 2026-06-05 Hibernation consists of bouts of torpor, characterized by profound decreases in metabolism and body temperature (Tb), alternated with periods of euthe
Integrating longitudinal hyperspectral phenotyping with AI and GWAS to dissect barley waterlogging responses biorxiv.org 2026-06-05 Waterlogging is a major constraint on barley productivity, yet its dynamic, multi-phase nature makes it challenging to dissect using traditional pheno
NeuroCaptain v2 - Interactive Three-Dimensional fNIRS Optode and Probe Montage Design Platform Based on Blender biorxiv.org 2026-06-05 Significance: Accurate and reproducible optode placement is crucial for obtaining high-quality fNIRS data in both individual and group-level neuroimag
Brain dynamics supporting high cognitive performance reorganize after midlife biorxiv.org 2026-06-05 Quantifying functional brain aging trajectories at scale remains a fundamental challenge due to the scanner-bound limitations of traditional neuroimag
Global nonequilibrium cortical dynamics tie mid-level pupil-linked arousal to optimal task performance in humans biorxiv.org 2026-06-05 Ongoing fluctuations in brain state, largely driven by neuromodulators of arousal, shape how sensory inputs are processed and decisions are made.
Intrinsic Population Dynamics are a Neuronal Substrate for Visual Attention biorxiv.org 2026-06-05 Perception results from a dynamic interplay between the feedforward processing of sensory stimuli and intrinsic neural activity, which is often dismis
Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation biorxiv.org 2026-06-05 Efficient identification of new targets to treat human disease requires a scalable way to link genotype to phenotype directly in the target organ.
An enhancer-centric approach applied to human immune system epigenomes revealed the association of macrophage enhancers with cardiovascular disease biorxiv.org 2026-06-05 Complex diseases are influenced by both genetic and environmental factors.
SOD1 Catalyses Thiol Oxidation to Thiosulfinates biorxiv.org 2026-06-05 Cu/Zn superoxide dismutase (SOD1) is canonically regarded as a superoxide scavenging antioxidant yet is paradoxically associated with multiple disease
RISOP, a Reference-Assisted Approach for Enhanced Identification of Oxidized Phospholipids biorxiv.org 2026-06-05 Oxidized phospholipids (OxPLs) play critical roles in inflammation, ferroptosis, and other oxidative stress-associated processes, yet their systematic
inGSEA: An Improved Method for Gene Set Enrichment Analysis Using a Weighted Integral Statistic biorxiv.org 2026-06-05 Gene Set Enrichment Analysis (GSEA) is one of the most popular methods for transcriptomic analysis, yet its statistical power is limited when the biol
Insight across contexts: Phenomenological differences and the role of meaning in belief change biorxiv.org 2026-06-05 Insight is commonly studied in laboratory paradigms as a sudden shift in understanding accompanied by characteristic "Aha!" experiences.
Tracking multi-site somatic voltage dynamics via high-speed fiber photometry biorxiv.org 2026-06-05 Investigating neural circuit dynamics across distributed brain regions in awake, behaving animals is crucial for understanding complex behavior.
Hippocampal consummatory reward ensembles dynamically engage theta-SWR states during spatial working memory biorxiv.org 2026-06-04 Reward consumption consists of temporally structured sensory and behavioral episodes critical for memory-guided behavior.
Dysregulated flow responses drive pathogenesis in a cellular model of Sturge-Weber syndrome biorxiv.org 2026-06-04 Vascular diseases comprise a broad spectrum of conditions associated with organ dysfunction, yet how endothelial responses to mechanical forces drive
Passive acoustic monitoring of the rare orange-bellied parrot: automated detection using BirdNET-based transfer learning biorxiv.org 2026-06-04 Efficiently finding rare species is a perennial challenge in conservation science.