Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models biorxiv.org 2026-06-03 Mapping human brain function at high spatiotemporal resolution is constrained by the physical limitations of non-invasive imaging and the sparse sampl
ViTAMIn-O: Democratizing computer vision-based machine learning for stem cell research biorxiv.org 2026-06-03 Deep Learning (DL) holds exciting potential in automating the prediction of organoid differentiation results.
ROTS 2.0: A reproducibility-driven framework for robust statistical modeling across diverse high-throughput omics study designs biorxiv.org 2026-06-03 Reproducibility is fundamental to reliable scientific discoveries.
Kindlin-1 loss disrupts vascular and extracellular matrix organisation to sustain hypoxia in cutaneous squamous cell carcinoma biorxiv.org 2026-06-03 Kindlin-1, encoded by FERMT1, is an essential integrin co-activator that regulates cell extracellular matrix (ECM) adhesion, tissue architecture, and
Tracing Sticky Trails: The Historical Biogeography of Australia's Glandular Goose-foots (Dysphania, Chenopodioideae, Amaranthaceae) biorxiv.org 2026-06-03 Abstract Aim The overarching aim of this study is to reconstruct the spatiotemporal evolutionary history of Australian Dysphania, including testing th
Distance Mapping and Variable-Specific Geometry of Goal-Relevant Frames in the Retrosplenial Cortex biorxiv.org 2026-06-03 Goal-directed navigation requires animals to continuously update their position relative to an unmarked goal.
High-order brain interactions distinguish wakefulness, anaesthesia, and recovery induced by deep brain stimulation biorxiv.org 2026-06-03 Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation.
Phosphorylation-dependent regulation of Hsp70 chaperones stimulates client recruitment biorxiv.org 2026-06-03 Molecular chaperones of the Hsp70 family play essential roles in maintaining proteostasis, particularly under conditions of cellular stress.
Hyaluronic Acid Plays Differential Molecular Weight and Concentration Dependent Pathway Centric Changes to Human Lung Derived Microvascular Endothelial Cells in Culture biorxiv.org 2026-06-03 Background Hyaluronan (HA) is a major extracellular matrix glycosaminoglycan that regulates vascular integrity and immune signaling in the lung.
Loss of tissue specificity and recurrent pan-cancer activation define a conserved oncogenic microRNA class biorxiv.org 2026-06-03 MicroRNAs (miRNAs) act as crucial post-transcriptional regulators of large gene networks, and their aberrant expression drives key oncogenic processes
Reachability-Preserving Minimum Edge Cut Problem and Applications in Biology biorxiv.org 2026-06-03 Biological pathway analysis often requires identifying interventions that block reachability to an undesirable state, such as a disease-associated mod
Optimized MALDI-TOF mass spectrometry enables reliable identification of freshwater snails from schistosomiasis-endemic areas in Mauritania biorxiv.org 2026-06-03 Freshwater snails act as intermediate hosts for parasites affecting both humans and livestock, including schistosomes.
Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia biorxiv.org 2026-06-03 Schizophrenia (SCZ) is a severe and debilitating neurodevelopmental disorder with lifelong impact on everyday life.
Cell-specific regulatory circuits connect genetic variation to disease susceptibility biorxiv.org 2026-06-03 Genome-wide association studies have identified thousands of variants associated with immune-related diseases, yet most lie in non-coding regions, com
Multiome Profiling Reveals Astrocyte and Neuroendocrine Targets of Prenatal Acoustic Programming in Zebra Finch Embryos biorxiv.org 2026-06-03 Climate change is driving more frequent and severe heat events, yet the developmental mechanisms by which organisms anticipate and adapt to thermal st
Eco-evolutionary dynamics are shaped by competition in experimental range expansions biorxiv.org 2026-06-03 Most theory and empirical research on range expansion assumes populations spread into empty landscapes with abundant resources, however expanding popu
A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson Disease biorxiv.org 2026-06-03 Adverse outcome pathways (AOPs) describe stressor non-specific sequences of events between a first molecular trigger (molecular initiating event, MIE)
A tonoplast cytokinin riboside transporter gates intracellular hormone availability at the plant-microbe interface biorxiv.org 2026-06-03 Cytokinin ribosides are major mobile and precursor forms of cytokinins, but the mechanisms that control their intracellular availability remain poorly
Opposing intrinsic and synaptic plasticity mechanisms stabilize altered cortical networks during sleep deprivation biorxiv.org 2026-06-03 Sleep deprivation alters brain activity and impairs performance, yet many aspects of behaviour are preserved in this state.
Grip Force Complexity Under Constraint: Evidence from Fractal and Entropy Analyses biorxiv.org 2026-06-03 The present study investigates how grip force (GF) and load force (LF) dynamics reorganize under varying task constraints, focusing on the fractal and
Visual gamma stimulation causes prolonged enhancement of low-frequency blood flow oscillations across cortical regions in mice biorxiv.org 2026-06-03 Introduction Gamma entrainment using sensory stimuli (GENUS) uses 40Hz-pulsed sensory stimuli to entrain neural activity in the gamma band (30-150Hz).
Homeostatic Plasticity Enables Stable, Flexible, and Tunable Assemblies biorxiv.org 2026-06-03 Strongly interconnected neuronal populations, called assemblies, dynamically form through synaptic plasticity mechanisms and are thought to be a subst
Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology biorxiv.org 2026-06-03 Purpose: To investigate the short-T1 fraction as a potential biomarker of white matter myelin integrity, using myelin histology as ground truth.
Hypothalamic MCH neurons links tau pathology to sleep disruption biorxiv.org 2026-06-03 Sleep disruption is an early and pervasive feature of Alzheimer's disease (AD), yet the circuit mechanisms linking tau pathology to sleep-wake dysfunc
OLT1177 (Dapansutrile) inhibits Gasdermin D-dependent IL-1β Release and Pyroptotic Cell Death in Bone Marrow-derived Macrophages biorxiv.org 2026-06-03 Gasdermins are a family of pore-forming proteins that regulate the release of pro-inflammatory cytokine, interleukin-1beta (IL-1beta) from infected or
Horizontal gene transfer by plasmids relaxes the evolutionary constraints of its own tradeoff biorxiv.org 2026-06-03 Horizontal gene transfer (HGT) is a defining feature of plasmid biology, enabling plasmids to spread between bacterial cells and driving the global di
Recombination and incomplete lineage sorting resolve the enigma of lysozyme evolution biorxiv.org 2026-06-03 Lysozyme has long been a model for understanding enzyme structure, function, and evolution.
Achiasmatic meiosis underlies propagation of clonal genome and B chromosomes in hexaploid Carassius gibelio females but not males biorxiv.org 2026-06-03 Sexual reproduction in eukaryotes relies on meiosis, recombination, and fertilization, yet hybridization can lead to transitions to asexuality.
Revisiting resonance-excitation collision-induced dissociation for data-independent acquisition biorxiv.org 2026-06-03 Data-independent acquisition (DIA) proteomics relies almost exclusively on beam-type collision-induced dissociation (HCD) because its short activation
A Cone-Plate Bioreactor for Applying Physiologically Derived Shear Stress Waveforms to Study Endothelial Mechanotransduction and Cardiac Cell Signaling biorxiv.org 2026-06-03 Fluid shear stress is a critical regulator of endothelial cell function and cardiovascular development, yet in vitro platforms often lack the ability
Shape, Shrink, Spheroid: A DIY High-throughput Spheroid Generation Device biorxiv.org 2026-06-03 3D spheroids, which closely replicate three-dimensional cell-cell and cell-extracellular matrix interactions, offer superior predictive capabilities c
ORIGAMI: Orientation-Aware Graph Neural Network for Assessing Multimeric Interfaces of Protein Complex Structures biorxiv.org 2026-06-03 Deep learning-based protein structure prediction methods have led to a paradigm-shift in computational structural biology, yet reliably assessing the
sstar2: A Python Package for S*-based Archaic Introgression Detection with Machine Learning biorxiv.org 2026-06-03 Detecting introgressed genomic fragments from unsampled or extinct source populations remains challenging.
CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research biorxiv.org 2026-06-03 DNA methylation research has vastly expanded over the past decade, producing a wealth of epigenome-wide association studies, biomarker algorithms such
Mapping the structural coverage of Arabidopsis thaliana plant developmental proteins: Insights from Experimental and AlphaFold Approaches biorxiv.org 2026-06-03 Background: Plant development is a multifaceted process governed by intricate protein regulatory networks.
Genotype-Resolved Interaction Landscape of the Dengue Envelope Glycoprotein with Host Cellular Proteins: Structural Dynamics, Thermodynamic Cooperativity, and Binding Specificity biorxiv.org 2026-06-03 Dengue virus (DENV) is a mosquito-borne flavivirus responsible for approximately 390 million infections annually, representing one of the most signifi
Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas biorxiv.org 2026-06-03 Background While hypoxia is a well-established driver of glioblastoma progression, its role in IDH-mutant gliomas, characterized by localized hypoxic
Deficiency of CD239 increases susceptibility to chronic kidney disease biorxiv.org 2026-06-03 CD239, also known as Lutheran blood group glycoprotein (Lu) or basal cell adhesion molecule (B-CAM), is a transmembrane protein belonging to the immun
CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling biorxiv.org 2026-06-03 Gibberellin (GA) promotes plant growth primarily by triggering degradation of DELLA transcription regulators, yet how DELLA activity is fine-tuned dyn
The demonstration of a single origin for nodule evolution, with nodule engineering in a non-nodulating species biorxiv.org 2026-06-03 The nitrogen-fixing root-nodule symbiosis provides a sustainable source of nitrogen for plants within the Nitrogen (N)-fixing clade (NFC).
TabularQual: A spreadsheet-based format for annotating and curating logical models in SBML-qual biorxiv.org 2026-06-03 Logical models are widely used to study regulatory and signaling systems, yet their reuse, annotation, and exchange across tools remain challenging.
Bracket Coding: The Optimal Balance Between Temporal Integration and Segregation in Early Visual Processing biorxiv.org 2026-06-03 Despite over a century of research into the neural code, the fundamental principles by which the brain encodes sensory information remain debated.
Amino Acid Stress Induces Non-AUG Initiation of c-myc Translation biorxiv.org 2026-06-03 Initiation of translation at non-AUG start codons can generate novel isoforms of important cellular regulators, with activities or localization distin
CellClick: an interactive platform for adjustable and accurate cell type annotation in single-cell and spatial omics data biorxiv.org 2026-06-03 Single-cell omics and spatial omics technologies are nowadays widely used in biological and medical research.
ATG7 function promotes pancreatic cancer progression independently of autophagy biorxiv.org 2026-06-03 Autophagy is a cellular degradation process that recycles dysfunctional components to maintain cellular homeostasis.
Expanded implementation of Fast & Fair paid peer review reduces time to first decision without reducing review quality in a biology journal biorxiv.org 2026-06-03 Traditional peer review is often slowed by delays in identifying willing reviewers and waiting for completed review reports.
Primary cilia promote cardiac fibrosis and limit heart function after myocardial infarction biorxiv.org 2026-06-03 Cardiomyocytes die and do not regenerate after an injury such as a myocardial infarction (MI), a leading cause of mortality worldwide.
Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell Lines biorxiv.org 2026-06-03 Genome-scale metabolic models (M-models) provide mechanistic insight into intracellular metabolism by simulating fluxes subject to nutrient and energy
Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa biorxiv.org 2026-06-03 Tau aggregation at synapses is a key process driving Alzheimer's disease but the mechanism(s) that cause this have not been established.
Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains. biorxiv.org 2026-06-03 Apolipoprotein E (APOE) associates with amyloid plaques A{beta} in Alzheimer disease (AD).