Language Modeling Materializes a World Model of Protein Biology biorxiv.org 2026-06-04 Proteins are fundamental to life.
A horizontally transferred fungal deubiquitinase facilitates insecticides resistance in whitefly biorxiv.org 2026-06-04 Horizontal gene transfer (HGT) has enabled insects to acquire novel genetic material that can fuel adaptation to environmental change.
Integrated valorization of glycerol and PET into lipids and PHAs using an engineered Yarrowia lipolytica strain and a Pseudomonas-Comamonas consortium biorxiv.org 2026-06-03 The accumulation of plastic waste necessitates innovative strategies that convert polymer carbon into value-added products.
Vertical stratification drives additive prokaryotic diversity in beech forest floors, while site conditions shape boundary layers biorxiv.org 2026-06-03 The forest floor is a key interface regulating carbon and nutrient processing and transfer to the mineral soil, yet it is threatened by climate-change
The hypercubic Mk model in reduced state space for the coupled, reversible coevolution of multiple binary characters biorxiv.org 2026-06-03 Many scientific questions involve the coevolution of coupled, binary features over time -- from phenotypes in evolutionary biology to mutations in can
Genetic Information Processing Complexity as a Determinant of Virus Diversity biorxiv.org 2026-06-03 Viruses exhibit diverse genome architectures and replication strategies that shape their evolutionary trajectories and taxonomic diversification.
Convergent genome- and gene-level constraints shape repeated environmental adaptation in grasses biorxiv.org 2026-06-03 Grasses (Poaceae) dominate terrestrial ecosystems and sustain global food security, yet the genomic principles enabling their repeated adaptation to e
Horizontally acquired mitochondrial alternative oxidase contributes to springtail bioenergetics and life belowground biorxiv.org 2026-06-03 Springtails are tiny hexapods that occupy habitats ranging from above the soil surface to hypoxia-prone belowground environments, yet the physiologica
Divergent evolution of the PRPS enzymes across the tree of life biorxiv.org 2026-06-03 The phosphoribosyl pyrophosphate synthetase (PRPS) enzyme plays a central role in core biochemical pathways across all life, reflecting its deep evolu
Breeding pig transport drives the dispersal of swine influenza A virus across Europe biorxiv.org 2026-06-03 Pigs serve as reservoirs of former human influenza A virus (IAV) H1N1 and H3N2 lineages and act as mixing vessels for diverse strains, facilitating th
Deciphering and Improving Human Homogentisate 1,2-Dioxygenase Function Through Knowledge Gaining Directed Evolution: Implications for Alkaptonuria biorxiv.org 2026-06-03 Human homogentisate 1,2-dioxygenase (HGD) catalyses the oxidative cleavage of homogentisic acid (HGA) to maleylacetoacetate (MAA), a key step in tyros
More isn't always better: Too much exoskeleton torque can disrupt balance biorxiv.org 2026-06-03 Wearable exoskeletons are a promising tool for augmenting balance and reducing fall risk.
Auditory Profiles in Tinnitus are Age-Dependent: Electrophysiological and Behavioral Evidence biorxiv.org 2026-06-03 Tinnitus is commonly associated with hearing loss, yet it can also occur in individuals with clinically normal audiometric thresholds.
Novel recombinant bovine papular stomatitis virus expressing foot and mouth disease virus-like particles elicits protective levels of neutralizing antibodies in cattle biorxiv.org 2026-06-03 Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity
A novel tumor-targeted interferon-α/-β receptor 1 antagonist increases replication of oncolytic vesicular stomatitis virus in a mouse mesothelioma model biorxiv.org 2026-06-03 Type I Interferons (IFN-I) are cytokines with pleiotropic activities involved in antiviral and antitumor immune responses.
Population Resilience Under Environmental Deterioration in Socially Monogamous Systems with Mutual Mate Choice biorxiv.org 2026-06-03 Rapid environmental change and biodiversity loss make it increasingly important to identify factors influencing population extinction risk.
Genetic Architecture of Reproduction and Longevity in Historical Dutch Cohorts biorxiv.org 2026-06-03 Life-history theory predicts a trade-off between reproduction and survival, often invoked to explain human ageing through antagonistic pleiotropy, yet
Evolution of supernumerary chromosomes in wheat blast fungal pathogens biorxiv.org 2026-06-03 A genome of Pyricularia oryzae (synonym Magnaporthe oryzae), the fungus that causes blast disease on diverse grass species, has seven core chromosomes
Independent evolutionary trajectories of genomic repeats and non-repeat genome features in Actinomycetota biorxiv.org 2026-06-03 Genomic repeats, particularly simple sequence repeats, influence genome stability and gene regulation.
De novo mutation of an RNA virus is increased in the presence of engineered synonymous mutations that disrupt RNA structural elements biorxiv.org 2026-06-03 Using a combination of methods including selective 2?-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq), a complete RNA structure
Segmentation gene expression and function in Vanessa cardui, an emerging model for Lepidoptera biorxiv.org 2026-06-03 Although all insects are segmented, the genes that control this process vary across species.
Complex adaptive architectures constrain the pace of adaptations sweeping across human gut microbiomes biorxiv.org 2026-06-03 Recent work has shown that commensal gut bacteria can evolve rapidly within hosts on short timescales of days to months, fueled by the enormous mutati
Sea-level and climate changes drive lineage diversification in the imperiled Venus flytrap (Dionaea muscipula J. Ellis, Droseraceae) biorxiv.org 2026-06-03 Venus flytrap (Dionaea muscipula) is an insectivorous plant in the monotypic genus Dionaea, endemic to the Southeastern United States, and found in a
Constraining pesticide resistance using evolution-informed selection regimes biorxiv.org 2026-06-03 The rapid evolution of pesticide resistance in sexually reproducing pests threatens global food security, yet the evolutionary principles needed to de
Explaining the rapid evolution of mammalian meiotic recombination proteins biorxiv.org 2026-06-03 Meiotic recombination, the exchange of genetic material between parental chromosomes during gamete production, is critical for fertility, genome stabi
Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning biorxiv.org 2026-06-04 Adolescent psychopathology is partly rooted in measurable disruptions across key neural networks, yet the field still lacks an integrated, multimodal
Emergence of social recognition in auditory and integrative circuits during pair bonding biorxiv.org 2026-06-04 Social relationships profoundly shape the perception of communication signals.
Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease biorxiv.org 2026-06-04 CLN3 disease, the most common form of the Neuronal Ceroid Lipofuscinoses (NCLs), causes progressive cognitive decline and language impairment in human
Measurement Equivalence of On-Scalp OPM-MEG and Cryogenic MEG for Auditory and Somatosensory Cortical Mapping Across Development biorxiv.org 2026-06-04 Wearable optically pumped magnetometer magnetoencephalography (OPM-MEG) reduces sensor-to-cortex distance compared with conventional cryogenic SQUID-M
Sensorimotor encoding of epistemic value during goal-directed causal learning biorxiv.org 2026-06-04 Understanding the neural and computational mechanisms underlying goal-directed causal learning is a central challenge in both cognitive neuroscience a
Multiplexed dopamine neurons predominate in the ventral midbrain of young macaques biorxiv.org 2026-06-04 Dopamine (DA) is important in many fundamental behaviors, including positive and negative reinforcement, incentive salience, and decision-making.
Theta phase and theta-gamma coupling organise the spoken language network biorxiv.org 2026-06-04 Speech production requires rapid coordination of conceptual and lexical processes across distributed cortical networks, yet the neurophysiological mec
Visibly Transparent, Near-Infrared Absorbing Nanofluids Enable High-Efficiency and Safe Laser Lithotripsy biorxiv.org 2026-06-03 Laser lithotripsy (LL) is the gold standard for urinary stone management yet maximizing ablation efficiency while maintaining procedural safety remain
Convergent Evolution in Tumor Genomes Targets Functional Domains biorxiv.org 2026-06-03 Tumor evolution is shaped by selective pressures that repeatedly favor similar functional outcomes across genetically distinct cancers.
Fucoidan from brown algae Laminaria japonica trigger apoptosis in colon cancer cells biorxiv.org 2026-06-03 In many cases, cancer cells develop resistance to chemotherapy and other cancer treatments.
(2R,6R)-Hydroxynorketamine elicits rapid antidepressant effects by promoting astrocytic μ-δ opioid receptor heterodimerization biorxiv.org 2026-06-03 Ketamine produces rapid antidepressant effects but is constrained by psychotomimetic properties and abuse potential.
From prediction to engagement: defining tumor-reactive T cells through biological interaction biorxiv.org 2026-06-03 Abstract Adoptive T-cell therapy (ACT), particularly tumor-infiltrating lymphocyte (TIL) therapy, demonstrates that durable regression of solid tumors
Molecular mechanisms underlying the prepupal-instar-forming metamorphosis in black soldier fly (Hermetia illucens) biorxiv.org 2026-06-03 The black soldier fly (Hermetia illucens, Diptera) undergoes an atypical metamorphic program in which a distinct non-feeding prepupal instar precedes
Modelling habitat suitability for multiple priority weed species to predict invasion hotspots for strategic management in complex landscapes biorxiv.org 2026-06-03 Established invasive alien plant species require ongoing, costly management to reduce harm to agricultural and environmental values.
Enemies, more than sex, shape butterfly post-mating odor evolution biorxiv.org 2026-06-03 Not all odors influencing mating behavior evolve as sex pheromones.
The Role of Osteocyte Estrogen Receptor β in Bone Mass Maintenance and Tibial Stiffness Following Sex Hormone Withdrawal in Male and Female Mice biorxiv.org 2026-06-03 Sex hormones are essential regulators of skeletal maintenance, but the cell-specific mechanisms by which osteocytes mediate the skeletal consequences
Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease biorxiv.org 2026-06-03 Renal fibrosis is the common final pathway of chronic kidney disease (CKD), driven in part by myofibroblast-mediated extracellular matrix deposition.
Linezolid Acts as a Selective Inhibitor of the JAK2V617F Mutation biorxiv.org 2026-06-03 The JAK2V617F (JAK2VF) driver mutation is found in 95% of patients with polycythemia vera (PV), a progressive myeloproliferative neoplasm.
Brain states recur across diverse narrative contexts during longitudinal viewing biorxiv.org 2026-06-03 What does the brain do during the continuous, varied experience of watching a story unfold?
Plant growth forms shaping biodiversity patterns can guide conservation planning on the Qinghai-Tibet Plateau biorxiv.org 2026-06-03 Plant growth forms effectively reflect profound evolutionary adaptations that underpin ecosystem functioning; however, how their biogeographic dispari
Catch me if you can: Arabidopsis thaliana lags in adaptation to contemporary climate change biorxiv.org 2026-06-03 Anthropogenic climate change fosters unprecedented temperature challenges, with each year breaking a temperature record.
Integrative genomics reveals shared and stress-specific adaptive pathways underlying acidic soil-associated metal toxicity in rice biorxiv.org 2026-06-03 Soil acidity-associated toxicities of aluminum (Al), cadmium (Cd), and manganese (Mn) severely constrain rice productivity in upland ecosystems.
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features biorxiv.org 2026-06-03 Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states.
Decoding Chromosome Radiosensitivity in G0-Phase PBMCs: Genomic Determinants, Age, Sex effects, and Implications in Radiation Dose Assessment biorxiv.org 2026-06-03 Low-dose ionizing radiation from natural and anthropogenic sources is typically not of significant concern under normal conditions.
Information Geometry of Intracellular Compartment Coupling Reveals Transcriptomic State Transitions in Single Cells biorxiv.org 2026-06-03 Single-cell transcriptomic analyses typically characterize cellular states using gene-expression variability, dimensionality reduction, and trajectory