Dynamic anatomy of the replisome under stress biorxiv.org 2026-06-04 When exposed to replication stress, the factors involved in DNA replication display differing responses that in many cases remain unexplained.
Big data analysis of animal movements in aquatic ecosystems with acoustic telemetry biorxiv.org 2026-06-04 Underwater receiver networks (passive acoustic telemetry systems) are deployed to track animals in aquatic habitats all over the world, but remarkably
Fluorescently-labeled split-QF hemidrivers: simplifying and enhancing methods enabling intersectional targeting of discrete cell types biorxiv.org 2026-06-04 Single cell transcriptomics data predict greater cell type diversity than previously appreciated, defined by combinatorial gene expression "codes".
Single-molecule nucleosome spacing coordinates chromatin fiber interactions biorxiv.org 2026-06-04 Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains content
Genomic, Transcriptomic, and Regulomic Analyses Do Not Support Profound Autism as a Distinct Biological Category biorxiv.org 2026-06-04 The Lancet Commission on the Future of Care and Clinical Research in Autism proposed the construct of "profound autism" as a recognizable subtype of a
Ploidy shapes gemcitabine response through altered potency and delayed cell death biorxiv.org 2026-06-04 Tumor ploidy is increasingly recognized as a determinant of therapeutic response, but the mechanisms by which ploidy shapes sensitivity to specific cy
Depression Severity Modulates the Cognitive Process of Facial Affect Representation: Evidence from a Genetic-Algorithm Face Synthesis Task biorxiv.org 2026-06-04 Depression is associated with biased facial emotion processing, yet existing paradigms measure only the recognition of pre-selected stimuli, conflatin
Longitudinal versus Cross-sectional effects of Age on MEG Power Spectra Parameters: Implications for Normative Models and Brain Ageing biorxiv.org 2026-06-04 Ageing produces changes in brain function.
One Circuit, Many Flow Fields: Mechanistic Models of Single-Trial Neural Dynamics biorxiv.org 2026-06-04 A single neural circuit can exhibit qualitatively different dynamics across trials: one circuit, many flow fields.
Rat hepatitis E virus infection has multiphasic viral replication kinetics in vivo biorxiv.org 2026-06-04 Background and Aims: Hepatitis E virus (HEV) infections are a growing threat to global public health.
ATG16L2 creates a VAIL-dedicated heterodimer with ATG16L1 biorxiv.org 2026-06-04 The ATG8 conjugation machinery supports both canonical autophagy, in which ATG8 proteins are lipidated on forming autophagosomes, and CASM, in which A
Invasion history reconstruction and potential distribution of the ambrosia beetles Euwallacea fornicatus and E. perbrevis (Coleoptera: Scolytinae), two global emerging pests biorxiv.org 2026-06-04 The global spread of invasive insects poses serious ecological and economic threats to forest ecosystems. Euwallacea fornicatus and E.
Genetic and epigenetic diversity of Salmonella enterica isolates from Kazakhstan from clinical and veterinary sources biorxiv.org 2026-06-04 Background: Salmonella enterica is a major cause of foodborne and invasive infections worldwide.
Nature-inspired Nanoparticle Adiposomes Enable Targeted Delivery of Hydrophobic Drug for Anti-Cancer Treatment biorxiv.org 2026-06-04 The predominance of lipophilic molecules in drug pipelines poses a fundamental delivery challenge in the aqueous physiological environment.
Stereotaxic targeting of the Dorsal Vagal Complex biorxiv.org 2026-06-04 The Dorsal Vagal Complex (DVC) is a critical brainstem relay for visceral sensory information, sympathetic regulation, and gut-brain communication.
Where the tree of life is empirically resolved, and where it is not: an open atlas of species-level phylogenies and their archival uncertainty biorxiv.org 2026-06-04 Comparative and macroevolutionary biology depends on knowing two things at once: where the species-level tree of life is empirically resolved, and whe
Proteomics-constrained deconvolution reveals spatial cell-type programs in tumours biorxiv.org 2026-06-04 Accurately resolving cell-type mixtures in spatial transcriptomics remains challenging, particularly in heterogeneous tumours where cell populations a
Hierarchical classification of immune cell transcriptomes at population-scale biorxiv.org 2026-06-04 Accurate immune cell classification is essential for interpreting single-cell RNA sequencing (scRNA-seq) data.
Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells biorxiv.org 2026-06-04 Tumours reshape their surrounding extracellular matrix (ECM), creating a microenvironment with altered chemical and mechanical properties.
Lifespan Analysis of the Lung Epithelium Reveals Inflammatory Reprogramming and Regenerative Decline biorxiv.org 2026-06-04 Aging is a major risk factor for chronic lung diseases, associated with chronic low-grade inflammation (inflammaging) and impaired epithelial regenera
On the Distribution of Free-Energy in Metabolism biorxiv.org 2026-06-04 Chemical potential is coupled to cellular processes by the flow of metabolites through catalytic networks known collectively as metabolism.
Supraphysiological Estradiol During Ovarian Stimulation Reveals Microbiome Resilience and Prevotella Opportunism biorxiv.org 2026-06-04 How the oral ecosystem responds to acute, high-amplitude hormonal perturbations remains poorly defined.
Probiotic wheat sprouts: A novel functional food developed through Lacticaseibacillus casei inoculation with improved bioactivity and probiotic survival biorxiv.org 2026-06-04 In this research we inoculated Lacticaseibacillus casei (L. casei) into wheat sprouts and studied the viability of the bacteria in the sprout. L.
Identification of Beneficial Bacterial Strains for Tomato Growth Promotion and Biocontrol of Bacterial Canker Caused by Clavibacter michiganensis biorxiv.org 2026-06-04 Bacterial canker of tomato, caused by Clavibacter michiganensis (Cm), remains difficult to control due to lack of effective management options.
PonA2?s contributions to biofilm and colony formation independent of its catalytic domains in Mycobacterium smegmatis. biorxiv.org 2026-06-04 Biofilm and colony growth creates microenvironments that require coordinated localization and function of cell surface molecules within the membrane.
D-alanine aminotransferase (Dat) promotes Staphylococcus aureus colonization fitness on human nasal respiratory epithelium biorxiv.org 2026-06-04 Nasal colonization by Staphylococcus aureus is an established risk factor for invasive infection, yet bacterial determinants promoting fitness on huma
Learning residue-level context for modeling protein-protein interactions biorxiv.org 2026-06-04 Protein language models (PLMs) enable prediction of protein properties by learning residue-level features from sequence, yet most PLM-based approaches
Single-cell characterization of tumor immune landscapes in colorectal cancer humanized mice biorxiv.org 2026-06-04 Colorectal cancer (CRC) displays inter-patient heterogeneity in molecular tumor features and immune cell composition, which influence therapy response
G-CSF associates with poor survival in cutaneous melanoma and promotes metastasis through coordinated effects on macrophages and tumor cells biorxiv.org 2026-06-04 Macrophage-melanoma interactions critically shape the tumor microenvironment, yet the cytokine networks driving this process remain incompletely under
Multiscale modeling of the subcutaneous administration of peptides biorxiv.org 2026-06-04 With the increasing prevalence of subcutaneous administration of peptides, understanding their release and absorption is key to designing formulations
Peacock Eye Disease Management (PedMan) System: Validation and Implementation in Addressing Key Biological Questions biorxiv.org 2026-06-04 Peacock eye disease, caused by Venturia oleaginea, is a major foliar disease of olive (Olea europaea) in Mediterranean regions, resulting in defoliati
Sleep immediately after noise overexposure worsens tinnitus in mice biorxiv.org 2026-06-04 Subjective tinnitus is the most common auditory phantom perception in the absence of an acoustic stimulus yet there is no cure nor widely effective tr
Low-dimensional prefrontal representations of objects during working memory biorxiv.org 2026-06-04 There is an ongoing debate regarding the dimensionality of neural representations.
Targeting Nitric Oxide Synthase 2 Reverses Learning Deficits in an Oligodendrocyte-Focused Model of Costello Syndrome biorxiv.org 2026-06-04 Myelination of axons by oligodendrocytes (OLs) greatly improves information processing in the brain; consequently, compromised myelin negatively impac
Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors biorxiv.org 2026-06-04 Background: The dorsolateral striatum (DLS) is a key site for coordinating the alcohol-induced stimulant response, a behavioral marker predictive of f
Adaptive Bayesian localization of motor representation areas biorxiv.org 2026-06-04 Transcranial magnetic stimulation (TMS) enables non-invasive localization of cortical motor representations, with important clinical applications in p
Differences in microbial community structure and soil nutrients between healthy and diseased soils of Zingiber officinale biorxiv.org 2026-06-04 To investigate the differences in soil nutrients and microbial community structure in the rhizosphere between healthy and diseased Zingiber officinale
Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging biorxiv.org 2026-06-04 Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration.
An interpretable machine learning framework for dog breed inference and ancestry decomposition biorxiv.org 2026-06-04 The over 300 currently recognized breeds of domesticated dogs are the culmination of centuries of intense artificial selection and recurrent populatio
Theta gates and routes information in the frontal cortex biorxiv.org 2026-06-04 Theta (4-10 Hz) oscillations seem well-suited for coordinating neural activity.
Neural decoding of speech using deep neural ensembles biorxiv.org 2026-06-04 Speech brain-computer interfaces (BCIs) can restore rapid communication to people with paralysis, but decoding errors still limit performance.
The emergent mental operation of the learning brain biorxiv.org 2026-06-04 How does the learning brain give rise to emergent mental operations that enable skill internalization and generalization?
Dual-channel whole-brain imaging reveals distinct dopamine and calcium dynamics in walking Drosophila biorxiv.org 2026-06-04 Simultaneous recording of intra- and extracellular neuronal signals across the brain during behavior is crucial for unraveling brain information proce
Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence biorxiv.org 2026-06-04 Although spread of internalized Mtb from the initial infected alveolar macrophages (AMs) is a crucial determinant of infection outcomes, the role of c
Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila biorxiv.org 2026-06-04 Tetrahymena thermophila is a ciliated protist that has played pivotal roles in biological discovery.
α-Synuclein and γ-Tubulin Cooperatively Regulate Activity-Evoked Presynaptic Microtubule Nucleation to Gate Dopamine Release biorxiv.org 2026-06-04 alpha-Synuclein has long been implicated in the regulation of synaptic activity, but the molecular basis that underlies this function has been elusive
Estimating spatially adjusted temperature-dependent time-varying reproduction numbers for vector-borne diseases biorxiv.org 2026-06-04 Estimating the effective reproduction number is crucial for understanding and managing infectious disease outbreaks.
Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis biorxiv.org 2026-06-04 Extended duration of under-treated psychosis (DUP) is among the strongest predictors of poor outcome, yet diagnostic heterogeneity impedes treatment m
Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of congenital myasthenic syndrome biorxiv.org 2026-06-04 Congenital myasthenic syndromes (CMS) are rare inherited diseases of the neuromuscular junction (NMJ).
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling biorxiv.org 2026-06-04 Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature.