Selectivity of Lateral Epidural Spinal Cord Stimulation with Varying Electrode Diameters and Stimulation Configurations biorxiv.org 2026-06-17 Objective.
MetaHarmonizer: robust biomedical metadata harmonization and a contamination control for inflated LLM performance on public benchmarks biorxiv.org 2026-06-17 Public biomedical repositories hold substantial reuse potential, but inconsistent metadata routinely blocks integration across studies.
Mechanosensitive Piezo Channels Contribute to Airway Changes in Chronic Obstructive Pulmonary Disease biorxiv.org 2026-06-17 As an intrinsically mechanosensitive organ, the lung experiences a range of mechanical forces.
Passive acoustic monitoring of Ensiferan calling diversity in a sub-tropical forest of Northeast India. biorxiv.org 2026-06-17 Ensiferans are nocturnal insects (Order Orthoptera) that produce mating advertisement calls using stridulatory organs on modified forewings.
A Structural Principle for Macroscopic Neural Dynamics Correlations biorxiv.org 2026-06-17 A central question in neuroscience is how the brain's structural connectivity gives rise to its emergent, correlated dynamics.
Uncovering Sex Differences in the Drosophila Ventral Nerve Cord Through Connectome Alignment biorxiv.org 2026-06-17 There are now multiple Drosophila connectomes available, comprising both its brain and spinal cord - comparing these connectomes requires first classi
Mass mortality of southern elephant seals during multi-species outbreak of HPAI H5N1 on sub-Antarctic Heard Island biorxiv.org 2026-06-17 High pathogenicity avian influenza (HPAI) has spread across the sub-Antarctic, causing significant wildlife impacts.
FALCON: Closed-Loop Multi-Objective Optimization of Lipid Nanoparticles for Cell-Selective mRNA Delivery biorxiv.org 2026-06-17 Efficient, cell type-selective delivery of genetic payloads remains a central challenge in the development of gene and cell therapies.
Advanced microfluidic strategy for In-Bead MSC spheroid formation and co-encapsulation of necrosis inhibitor-loaded nanoparticles biorxiv.org 2026-06-17 Mesenchymal stem/stromal cells (MSCs) are key players in regenerative medicine due to their immunomodulatory properties and ability to promote tissue
Parallel processing of orthogonal manifolds enables zero-shot composition in recurrent networks biorxiv.org 2026-06-17 Animals flexibly combine learned behaviors into novel actions without practicing their combinations, yet the computational mechanisms that enable inde
Azacytidine restores T cell function in AML by modulating DNA methylation biorxiv.org 2026-06-17 AML is an aggressive blood cancer associated with poor clinical outcomes.
SPACA9 Acts as a Molecular Staple Modulating Microtubule Dynamic Instability biorxiv.org 2026-06-17 Motile cilia rely on highly stable axonemal microtubules reinforced by microtubule inner proteins (MIPs) that form a network within their lumen, yet t
Annotation-Based Gene-Peak Links Improve Regulatory Network Prediction of Gene Expression in Human Kidney Multi-Omics biorxiv.org 2026-06-17 Abstract Background Linking distal regulatory elements to their target genes is a central problem for interpreting chromatin accessibility and other n
Effects of long-term fasting: longitudinal epigenetic responses in humans biorxiv.org 2026-06-17 Prolonged fasting induces marked metabolic adaptations, but whether such time-limited yet intensive interventions engage molecular processes related t
Towards Passive Dietary Monitoring: Dilated CNN-Based Meal Detection Using Ambulatory High-Resolution Electrogastrography biorxiv.org 2026-06-17 Background: Objective tools for longitudinal dietary monitoring, despite its importance in the health triad of diet, sleep, and exercise, remain limit
Experiment-free learning of exoskeleton assistance is not an unsolved problem biorxiv.org 2026-06-17 We present three quantitative methods: 1) estimation of exoskeleton mechanical power and energy ratio from published data, 2) a systematic review of t
Nanomechanics of Mandible Wear in Insects biorxiv.org 2026-06-17 Many animals rely on specialised mouthparts to process food.
Machine learning-guided olivetolic acid cyclase engineering enables tailored cannabinoid biosynthesis in yeast biorxiv.org 2026-06-17 Cannabinoids comprise a diverse class of bioactive natural products with important therapeutic potential, but efficient microbial production remains l
Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy biorxiv.org 2026-06-17 Label-free optical redox imaging utilizes endogenous NAD(P)H and FAD autofluorescence to evaluate metabolism in living specimens.
Intra-nanoparticle Drug-protein Interactions Mediate Sequential Therapeutic Release biorxiv.org 2026-06-17 Controlled drug delivery systems have important implications in many therapeutic applications to improve patient health, but it remains challenging to
In silico characterization of lysis and host-recognition modules in Staphylococcus aureus bacteriophage genomes biorxiv.org 2026-06-17 Background/aim: Antimicrobial resistance in methicillin-resistant Staphylococcus aureus (MRSA) requires precision non-antibiotic therapeutics, yet pha
An Integrated Framework for Transcriptomic Characterization and Lorentzian Hyperbolic Visualization of a High-Risk Topological Branch in Alzheimer's Disease biorxiv.org 2026-06-17 Alzheimer's disease (AD) is a highly heterogeneous brain disorder in which molecular alterations vary across brain regions, disease stages, and patien
Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults biorxiv.org 2026-06-17 Transporters localized to the small intestinal epithelium govern the absorption of many orally administered drugs and nutrients, and thorough characte
AZD5069 Inhibits Angiogenesis Without Cytotoxicity In Human Endothelial Cell Culture biorxiv.org 2026-06-17 Background: The CXCR2 receptor pathway plays a major role in inflammatory and invasive angiogenesis in human disease.
Emotions and bodily sensations evoked by cardiac adenosine stress biorxiv.org 2026-06-17 Peripheral physiological processes contribute to emotions; however, the extent of the influence of internal signals to subjective emotional experience
Whos been sleeping in my bedroom? Sleep and cardiorespiratory physiology when co-sleeping with a dog, cat, or child biorxiv.org 2026-06-17 Co-sleeping with pets or children is common, yet its effects on sleep, cardiorespiratory physiology, and behavioral outcomes are understudied.
Black women undergraduates' perspectives on how mentors and role models shape their beliefs about the attainability of science research careers biorxiv.org 2026-06-17 Undergraduate research experiences offer important paths into scientific research careers, yet students do not experience them uniformly.
Single-cell, single-shot stimulation reveals heterogeneous network recruitment not explained by standard functional properties. biorxiv.org 2026-06-17 Understanding how minimal perturbations influence cortical network dynamics remains a central challenge in neural engineering.
Incorporation of single-neuron projectome-based connectivity motifs enhances the cortex-specific performance of artificial neural networks biorxiv.org 2026-06-17 The organizational principles of natural neural networks could inspire the new architecture design of artificial neural networks (ANNs).
Pupil responses reveal temporally distinct signatures of value updating and decision strategy biorxiv.org 2026-06-17 Adaptive decision making depends on dopaminergic and noradrenergic systems supporting value learning and exploratory decision strategies, respectively
Characterizing the Effects of Chronic Cannabis Vapour Exposure and Withdrawal on Cannabinoid Triad, Somatic Signs and Behavioural Network Reorganization Adult Male Rats biorxiv.org 2026-06-17 Rationale: Cannabis withdrawal contributes to relapse in individuals with cannabis use disorder, yet preclinical studies have largely focused on withd
An age-dependent reversal of the baseline-inflammation to vaccine-antibody-response relationship: a meta-analytic replication in ImmuneSignatures2 with independent influenza cohorts biorxiv.org 2026-06-17 Background.
The Fas-FADD-caspase-8 axis is a cancer cell-intrinsic determinant of cytotoxic lymphocyte-mediated killing biorxiv.org 2026-06-17 Cytotoxic lymphocytes induce cancer cell death through death receptor-ligand interactions and the perforin-granzyme pathway.
NKG2C+CD27- Defines Human CD8+ Regulatory T Cells biorxiv.org 2026-06-17 Here we identify NKG2C+CD27- as a novel surface marker unifying multiple previously reported CD8+ regulatory T cell (Treg) populations.
Species-level variation in primate social behavior is correlated with climate extremes and variability biorxiv.org 2026-06-17 Cooperatively breeding species are disproportionately found in extreme and unpredictable climates globally, suggesting that cooperation is beneficial
Beyond straight lines: migration costs considering geography enhance tracing human genetic ancestry biorxiv.org 2026-06-17 Reconstructing the spatio-temporal history of human genetic lineages is fundamental to understanding human evolution and population distribution.
Multi-layered characterization of ~700,000 conserved noncoding elements within the human genome biorxiv.org 2026-06-17 Conserved noncoding elements (CNEs) have been extensively studied for their roles as regulatory elements, particularly enhancers.
Single-nucleus multiomic analysis reveals modulation of the gene regulatory circuit landscape in pituitary cell types during mouse estrous cycle. biorxiv.org 2026-06-17 The estrous cycle transcriptional and chromatin dynamics in pituitary cell types have not been investigated.
Sequential- vs. density gradient- centrifugation for the isolation of mitochondria-containing extracellular vesicles biorxiv.org 2026-06-17 A subset of extracellular vehicles (EVs) with particle diameters >200 nm, large vesicles (lEVs) contain mitochondria that increase recipient cell b
Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression biorxiv.org 2026-06-17 Background & Aims: Systemic metabolic dysfunction promotes degenerative diseases in many organs, including liver and kidney.
Exposure to perfluorooctanoic acid accelerates Drosophila melanogaster juvenile development and disrupts mitochondrial metabolism biorxiv.org 2026-06-17 Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with poorly understood sublethal effects on insects.
Sleep forms flexible context representations in toddlers biorxiv.org 2026-06-17 Sleep consolidates episodic memory through a hippocampus-dependent process in adults.
Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation biorxiv.org 2026-06-17 Many neural circuits undergo competitive input selection, a process in which supernumerary connections compete for innervation territory on target cel
Cell-type-specific cortical feedback coordinates hierarchical credit assignment biorxiv.org 2026-06-17 Learning is thought to arise from synaptic modifications embedded in brain-wide circuits, yet how such circuits coordinate plasticity to support compl
Mitochondrial Complex I Modulator Restores Network Resilience in Advanced Alzheimer's Disease Through Metabolic Reprogramming biorxiv.org 2026-06-17 Mitochondrial dysfunction and lipid dysregulation are among the earliest abnormalities in Alzheimer's disease (AD), yet their mechanistic interplay an
Maintenance of immune tolerance during aging requires competitive expansion of memory phenotype regulatory T cells biorxiv.org 2026-06-17 Memory phenotype (MP) CD4 T cells accumulate with age; however, the immunological significance of this population shift and the mechanisms that preser
SOLiD-MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA biorxiv.org 2026-06-17 RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and e
RNA virus-mediated metabolic reprogramming in a bloom-forming, marine diatom biorxiv.org 2026-06-17 Diatoms are a widespread group of phytoplankton that disproportionately influence the global carbon cycle through substantial contributions to primary
Transposable elements underlie chromosomal fusions and fissions in a highly species-rich group of butterflies biorxiv.org 2026-06-17 Chromosomal fusions and fissions reshape karyotypes, recombination landscapes and patterns of speciation, yet the molecular mechanisms underlying thei
Holocentromere diversity in Cyperaceae: contrasting repeat organisation in Mapanioideae and Cyperoideae biorxiv.org 2026-06-17 Centromeres ensure accurate chromosome segregation and are typically confined to a single, localised region in monocentric chromosomes.