Consistent consensus-based annotation of spatial adaptive immune receptor repertoires from long-read sequencing using LongAIRR biorxiv.org 2026-06-26 The combination of spatial transcriptomics with long-read sequencing enables spatial characterization of full-length transcripts within solid tissue s
Robust neural face identity codes in the Super-Recogniser brain biorxiv.org 2026-06-26 Super-Recognisers show exceptional ability in face recognition, providing a natural model of how perceptual systems optimise for individuating visuall
Integrating genomic and tagging data reveals spatio-temporal population structure in Northeast Atlantic European sea bass biorxiv.org 2026-06-26 Understanding spatial and temporal connectivity among individuals with different migration strategies is essential for migratory ecology and effective
Molecular Basis of Mycoparasitic Performance: Genomic and Transcriptomic Comparison of Contrasting Trichoderma atroviride Strains biorxiv.org 2026-06-26 Trichoderma species are widely used as biological control agents due to their ability to parasitize plant pathogens.
Gene model for the ortholog of DENR in Drosophila eugracilis biorxiv.org 2026-06-26 Gene model for the ortholog of Density regulated protein (DENR) in the Apr.
Computational reconstruction of hierarchical cis-regulatory networks reveals synergistic transcription control and disease-associated rewiring biorxiv.org 2026-06-26 Gene regulation emerges from coordinated interactions among dispersed cis-regulatory elements, yet how these elements integrate into functional regula
A Generalised Epigenetic Clock Reveals Therapeutic Vulnerabilities Linked to Ageing in Cancer Cells biorxiv.org 2026-06-26 Epigenetic clocks estimate biological age from DNA methylation patterns but perform poorly in cancer due to extensive epigenetic reprogramming, limiti
Exogenous thymosin β4 enhances liver regeneration biorxiv.org 2026-06-26 Thymosin {beta}4 (T{beta}4) is a conserved acidic polypeptide with 43-amino acids participating in multiple pathophysiological processes.
Multi-Omics Clustering Differentiates the Total and Intact HIV Reservoirs and Related Host Immune Mechanisms biorxiv.org 2026-06-26 HIV reservoirs are heterogeneous across individuals, yet host determinants of this variability remain unclear.
Predatory bacteria impact C. elegans life-history traits by modulating microbiota community dynamics and thereby vitamin B12 availability biorxiv.org 2026-06-26 Predatory bacteria such as Bdellovibrio are emerging as ecological modulators in microbial communities by restructuring community composition, yet the
Vegetation change and functional composition shifts in southwestern China during late MIS 3 to LGM biorxiv.org 2026-06-26 The climatic transition from Marine Isotope Stage 3 (MIS3) to the Last Glacial Maximum (LGM) had caused widespread vegetation change.
Redefining accessible food resources for paleodietary reconstruction in Britain: baseline recommendations based on isotopic data synthesis biorxiv.org 2026-06-26 Paleodietary reconstruction requires isotopic data from both humans and their accessible food resources.
Pygopods are an exceptional radiation of snake-like geckos biorxiv.org 2026-06-26 Limb loss in vertebrate animals is surprisingly common despite imposing strong functional constraints.
Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction biorxiv.org 2026-06-26 Scrub typhus is a potentially fatal infectious disease caused by the obligate intracellular bacterium Orientia tsutsugamushi.
Hot Pursuit: Bioinformatic and Biochemical Characterization of a Hyperthermophilic Family B DNA Polymerase from Pyrolobus fumarii A1 biorxiv.org 2026-06-26 Thermostable DNA polymerases are indispensable tools in molecular biology, yet enzymes from the most extreme hyperthermophiles remain largely uncharac
BIRD-Seq: B2 Protein Integrated End-to-End Pipeline for dsRNA Detection and Nanopore Sequencing for Virus Monitoring biorxiv.org 2026-06-26 Double-stranded RNA (dsRNA) is a near-universal hallmark of active viral infection.
Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains biorxiv.org 2026-06-26 The development of digital twins in medicine, i.e., virtual replicas of human organs, offers a promising path toward precision medicine by enabling in
Cell-free DNA Fragmentation Profiling at Transcription Start Sites Improves upon Cancer-Type-Specific Region Selection for Cancer Detection biorxiv.org 2026-06-26 Accurate discrimination between healthy individuals and patients with cancer using minimally invasive liquid biopsies could improve cancer diagnosis a
Patient cerebral organoids capture Alzheimers disease proteomic biomarkers and drug targets biorxiv.org 2026-06-26 Patient iPSC-derived cerebral organoids are a leading human model of Alzheimers disease, yet their proteome has never been benchmarked against human d
Longitudinal proteomic module configurations differ across human monocyte-derived differentiation and polarization conditions biorxiv.org 2026-06-26 Monocytes are key innate immune cells capable of differentiating into macrophages and dendritic cells, or adopting distinct polarization states in res
Species-specific drivers of genetic diversity are decoupled from plant community diversity biorxiv.org 2026-06-26 Understanding how habitat connectivity shapes biodiversity remains a major ecological challenge.
Extinction risk in terrestrial vertebrates is associated with niche limits that reflect climatic vulnerability biorxiv.org 2026-06-26 Anthropogenic climate and land-use change are driving an emerging extinction crisis that is expected to intensify in the future.
Antiglycation effects of imidazole dipeptides and 2-oxo-imidazole dipeptides on glyceraldehyde-induced intracellular protein glycation and neuronal cell death biorxiv.org 2026-06-26 Glyceraldehyde (GA) contributes to the development of various diseases, such as diabetes and Alzheimer's disease via protein glycation and the formati
Hydration and H/D exchange-dependent infrared signatures of the GCN4 leucine zipper biorxiv.org 2026-06-26 Attenuated total reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy of proteins in aqueous solution is often limited by water absorption a
Expanding the methionine toolkit: L-cyanohomoalanine as a multifunctional analog biorxiv.org 2026-06-26 Non-canonical amino acids (ncAAs) are valuable tools in chemical biology and biochemistry for labeling, probing, and tracking biomolecules.
Evolution of a core ribosomal innovation in octopus biorxiv.org 2026-06-26 Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma.
Expression-linked promoter selection (ELiPS) engineers short, strong ubiquitous promoters for gene therapy applications biorxiv.org 2026-06-26 Adeno-associated virus (AAV)-based gene therapy has made steady progress towards efficient delivery to numerous target cell populations, yet the virus
An in vivo platform to jointly monitor cellular and metabolic responses to chemotherapy. biorxiv.org 2026-06-26 How drug treatments reshape immune and metabolic states within intact tumors remains difficult to study with existing methods.
Modeling and validation of parallel co-flows layer widths in open-capillary trigger valve systems biorxiv.org 2026-06-26 Control of fluids is a hallmark of microfluidic systems and fundamental for the successful application of microfluidic devices.
High-Yield Recovery of Reactive Nitrogen as Cyanophycin by Engineering Acinetobacter baylyi ADP1 under Wastewater-Relevant Conditions biorxiv.org 2026-06-26 Municipal wastewater constitutes a major reservoir of unutilized reactive nitrogen, representing a significant opportunity for biological valorization
Comp2GPR: A Sequence-Driven Framework for Gene.Protein-Reaction Rule Reconstruction biorxiv.org 2026-06-26 Accurate gene-protein-reaction (GPR) associations are essential for the predictive performance of genome-scale metabolic models (GEMs),as they define
kmerRRR: A k-mer based tool for functional genomics in Repeat Rich Regions biorxiv.org 2026-06-25 Highly repetitive sequences pose problems for genome assembly and analysis.
fastder: fast, annotation-agnostic detection of expressed regions from RNA-seq coverage and splicing data biorxiv.org 2026-06-25 Features from RNA-seq experiments are usually counted using a curated annotation (GENCODE, Ensembl, etc) as reference.
Comparative analysis of Illumina and Ultima-Genomics sequencing for plasma cell-free small RNA profiling in pancreatic cancer biorxiv.org 2026-06-25 Plasma-derived cell-free small non-coding RNAs are promising non-invasive biomarkers for cancer detection and monitoring.
traceCB: Trans-ancestry cell-type-specific eQTLs mapping by integrating scRNA-seq and bulk data biorxiv.org 2026-06-25 Mapping cell-type-specific expression quantitative trait loci (ct-eQTLs) is essential for interpreting disease-associated variants, yet studies in und
Novel Drosophila cis-regulatory elements can be uncovered by footprinting transcription factor binding sites in ATAC-seq data biorxiv.org 2026-06-25 Developmental processes depend on carefully coordinated gene expression.
What group averages conceal: functional heterogeneity in human eyeblink habituation biorxiv.org 2026-06-25 In animal learning research, learning is often represented by plotting a behavioral measure as a function of training trials.
Bisphenol S causes deficits in social behaviour by disrupting serotonergic and BDNF-CREB1 signaling pathways biorxiv.org 2026-06-25 Bisphenol S (BPS), a widely used substitute for bisphenol A, is increasingly detected in aquatic environments; however, its neurodevelopmental effects
Value and spatial preferences guide habitual reaching and manual object selection in primates biorxiv.org 2026-06-25 Habits are automatic actions shaped by prior experience, enabling efficient and fast responses in stable environments.
Innate building blocks underly socially learned call sequences biorxiv.org 2026-06-25 Recent evidence of extensive call sequence use in non-human primates has led to the theory that syntax evolved to mitigate the constraints of their ge
Object Speed Perception during Self-Motion in Depth biorxiv.org 2026-06-25 During sideways movement of an observer, optic flow parsing - in which an objects speed in the world is extracted from all the other visual movement p
The BPI-like TULIP domain proteins of Drosophila melanogaster: a novel class of candidate odorant transporters. biorxiv.org 2026-06-25 TULIP (TUbular LIPid binding) domain proteins (TDPs) are found in all living organisms including bacteria.
Long-term memory performance optimization via Neural network-based curve fitting in Drosophila biorxiv.org 2026-06-25 Long-term memory (LTM) formation typically requires extensive training.
3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array biorxiv.org 2026-06-25 Urinary stone disease is a common urological condition with increasing incidence, particularly in developed countries.
CNSigs: An R Package for the Identification of Copy Number Mutational Signatures biorxiv.org 2026-06-25 Background: Copy number aberrations (CNAs) are gains and losses of large genomic segments present across most cancer types and are a hallmark of cance
Multi-Omics Study of Ancestry in Adults with Intracranial Cancers Glioma (MOSAIC) biorxiv.org 2026-06-25 Background: Most genomic studies of adult type diffuse gliomas have focused on predominantly European ancestry populations, limiting the generalizabil
BGC-QDR: A Quantum-Assisted Pipeline for Biosynthetic Gene Cluster Discovery and Ranking from Environmental DNA biorxiv.org 2026-06-25 Biosynthetic gene clusters (BGCs) encode enzymatic pathways for natural products with pharmaceutical potential, yet prioritizing candidates from fragm
Tissue-aware elastic net decomposition reveals shared and lineage-specific drug response biomarkers biorxiv.org 2026-06-25 Motivation: Computational models that predict cancer drug response from genomic features are central to biomarker discovery, yet a recent audit found
NanoCellAnnotator: Formalizing Expert Cell Type Annotation with Large Language Models biorxiv.org 2026-06-25 Motivation: Cell-type annotation in spatial transcriptomics is challenging due to sparse gene panels, spatial heterogeneity, and limited availability
CREPAS: a reproducible nascent chromatin sequencing analysis pipeline for epigenome replication studies biorxiv.org 2026-06-25 Chromatin-based genomics data are essential for understanding genome regulation and the mechanisms underlying epigenetic memory.