Programmable acoustic single cell manipulation with model-free machine learning biorxiv.org 2026-07-03 Precise, non-invasive manipulation of individual living cells remains a central challenge in biomedical science, with far-reaching implications for si
SAS_MoCa: a software for small-angle scattering data analysis of large unilamellar vesicles biorxiv.org 2026-07-02 Small-angle X-ray or neutron scattering (SAXS/SANS) analysis of large unilamellar vesicles (LUVs) is often limited by high-dimensional bilayer models
No Evidence for a Wakeful Rest Benefit on Associative Memory: A Within-Participant EEG Study biorxiv.org 2026-07-03 Wakeful rest after learning has been proposed to facilitate memory consolidation compared to engaging in a distraction task, with prior EEG studies li
The effects of estrogen exposure on survival, growth, and fecundity of Daphnia magna biorxiv.org 2026-07-02 High concentrations of steroidal hormone compounds are a growing source of concern for environmental pollution in aquatic ecosystems.
Deletion of GPR39 Prevents Pulmonary Arterial Hypertension by Attenuating Hypoxia-Induced Aberrant Signaling biorxiv.org 2026-07-02 Pulmonary arterial hypertension (PAH) is a devastating disease with poor outcome affecting relatively young subjects.
Cognitive Color Coding: Chromatic Tuning Underlying Numerosity Adaptation - Experimental and Factor-Analytic Evidence from Individual Differences biorxiv.org 2026-07-02 Numerosity adaptation (the underestimation of number after exposure to a numerous adaptor) is reduced when adaptor and test differ in color, suggestin
Uncovering internal states with a robust shared-state multi-neuron GLM-HMM framework biorxiv.org 2026-07-02 Neural systems exhibit multiple firing states that reflect an organism's internal state and modulate the relationship between external environmental s
Spinal cord population activity lacks rotational dynamics during an alternating isometric task in macaque biorxiv.org 2026-07-02 Recent studies report rotational population dynamics in spinal cord neuronal activity during rhythmic movements, suggesting computational principles s
Age-related changes in noise correlations in a decision-making task biorxiv.org 2026-07-02 Age-related declines in sensory and cognitive performance may arise from changes in neural variability, including how variability is shared across neu
Kv2.1/Kv8.2 Channels Regulate Fluid Homeostasis in the Outer Retina biorxiv.org 2026-07-02 Purpose: Photoreceptor Kv2.1/Kv8.2 voltage-gated potassium channels carry an outward potassium current, helping to set the resting membrane potential
Activity-dependent synthesis of translational machinery through dynamic remodeling of ribonucleoprotein granules biorxiv.org 2026-07-02 Neuronal stimulation drives gene-expression programs supporting long-lasting changes, yet how depolarization reshapes post-transcriptional regulation
Large phenological advances and delays over 124 years of climate change alter co-flowering among North American Viola biorxiv.org 2026-07-02 Shifts in flowering phenology are one of the most well studied plant responses to global climate change.
Socioecological differentiation and the evolution of brain size and synaptic architecture in predatory ants, Neoponera biorxiv.org 2026-07-02 Brain size and structure are hypothesized to be adaptively designed to satisfy the behavioral requirements of securing food and living socially.
Drivers of immune-related genetic variation across human populations biorxiv.org 2026-07-02 Pathogen-mediated disease burden imposes some of the strongest selective pressures on human populations, shaping genetic variation in immune-related g
Knowledge-guided Bayesian optimization using pre-trained LLMs speeds up the identification of superior genotypes from germplasm collection biorxiv.org 2026-07-02 Background: Germplasm collections contain wide genetic diversity that is valuable for plant breeding, but conducting phenotypic evaluation for all gen
Bridging Gene Expression and Morphology: A Cell Size Score and Its Applications Across Multiple Diseases and Physiological Contexts biorxiv.org 2026-07-02 Cell size is a critical morphological parameter determining cellular functional homeostasis, yet existing large-scale transcriptomic databases lack di
Fentanyl-Induced Diaphragmatic Discoordination during Overdose biorxiv.org 2026-07-02 Synthetic opioids like fentanyl are a leading cause of overdose mortality.
Hepatic Cholesteryl Ester Transfer Protein Regulates Sex-specific Liver Metabolic Adaptation and Metabolic-Associated Steatotic Liver Disease Risk in Diet-induced Obesity biorxiv.org 2026-07-02 Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) and associated dyslipidemia is a growing health issue that gives rise to cardiovascul
Independent Online Visuomotor Control to Cursor and Target Motion biorxiv.org 2026-07-02 Skilled control of visually-guided reaching is fundamental for many daily activities.
EEG biomarkers of reinforcement learning and motivation: A multi-task battery biorxiv.org 2026-07-02 Serotonin and dopamine make dissociable contributions to reinforcement learning (RL) sub-components, yet we lack neural biomarkers capable of detectin
Repetition Dissociates Pointer and Content-based Representations in Visual Working Memory: Contrasting the CDA with Multivariate Shape Decoding biorxiv.org 2026-07-02 Memorizing a new phone number or address is hard at first, but becomes easier with repetition, as information shifts from working memory to long-term
Matrix remodeling plays an etiological role in driving laminin-α2 deficient pathology biorxiv.org 2026-07-02 Laminin-2 (gene: LAMA2) is a key protein in the basement membrane of muscle and Schwann cells.
Cryo-EM structure of the Arabidopsis thaliana V-type ATPase biorxiv.org 2026-07-02 Vacuolar-type ATPases (V-ATPases) are evolutionarily conserved rotary proton pumps that play essential roles in the eukaryotic cell.
Neural Tracking of Speech Envelope as an Index of Spatial Release from Masking biorxiv.org 2026-07-02 Understanding speech in noisy environments relies strongly on binaural cues such as interaural time differences (ITDs) and interaural level difference
The human language processing system straightens natural speech biorxiv.org 2026-07-02 Large language models trained on next-word prediction have impressive linguistic capabilities.
Network and hierarchical organization of intrinsic timescales in the human brain biorxiv.org 2026-07-02 Intrinsic neural timescales represent the characteristic duration over which information is maintained in neuronal circuits.
Modulating Neural Tracking of Speech in Infants biorxiv.org 2026-07-02 Neural oscillations synchronize to the rhythmic structure of speech, a process known as cortical tracking that is thought to support speech perception
A Dual-Ensemble Model of Infralimbic Cortex Function in Behavioural Flexibility biorxiv.org 2026-07-02 The infralimbic cortex (IL) has been described as both facilitator and terminator of reward-seeking, yet both functions appear mutually exclusive.
Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer's disease biorxiv.org 2026-07-02 Alzheimer's disease (AD) is defined and staged by the stereotyped, progressive accumulation of amyloid-beta (A{beta}) plaques and hyperphosphorylated
A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses biorxiv.org 2026-07-02 An appropriate stress response is essential for properly responding to, coping with, and subsequently recovering from disturbing environmental stimuli
Dual thalamic drive defines the intra-amygdala wiring complexity biorxiv.org 2026-07-02 The amygdala plays a key role in affective behaviors by integrating incoming signals and conveying them towards subcortical output regions.
Subthalamic Nucleus Optogenetic Inhibition Bidirectionally Regulates Social Motivation According to Familiarity and Social Hierarchy biorxiv.org 2026-07-02 Background: Social behavior is a core component of mental health, and its disruption characterizes many neuropsychiatric disorders such as autism.
A 3D Brain Geometry Toolkit for Multisite Neuroimaging Analysis biorxiv.org 2026-07-02 Compared to traditional gross volumetrics, surface- based models provide greater spatial precision for understanding brain alterations related to deve
Reward predictability shapes decision making states and exploitative control in marmosets biorxiv.org 2026-07-02 Animals navigating dynamic environments must transition between behavioral states dominated by exploitation of known rewards or exploration of alterna
The Premotor Language Area Encodes a Full Acoustic-to-semantic Speech Hierarchy biorxiv.org 2026-07-02 Classic neurobiological models of human speech and language have emphasized the dominant role of temporal lobe in speech perception, while premotor re
Learning Shapes the Energy Cost of Neural Tasks biorxiv.org 2026-07-02 The stark difference in energy use between AI systems and biological brains highlights both the remarkable efficiency of the brain and our limited und
Zinc Differentially Modulates Tau Aggregation, Fibril Morphology, and Prion-like Seeding in a Construct-Dependent Manner biorxiv.org 2026-07-02 The role of tau fibril structure in seeding and propagation of aggregation remains a central unresolved question in tauopathy biology.
Cryptic RNA binding sites are energetically accessible and chemically addressable biorxiv.org 2026-07-02 Cryptic binding sites generated by local conformational dynamics have become an important concept in protein-targeted ligand discovery, yet their ener
Cell Penetrating Thyclotides Facilitate Efficient Delivery of Bioactive Peptides into Cells biorxiv.org 2026-07-02 Cell penetrating thyclotides (CPTs) are synthetic molecules that promote highly efficient cellular uptake and endosomal escape of bioactive peptides.
Super-Resolution Visual ProteomEx for Hard Tissues and Clinical Samples biorxiv.org 2026-07-02 Correlating nanoscale tissue architecture with unbiased molecular composition within the same specimen remains a fundamental challenge in spatial biol
ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation biorxiv.org 2026-07-02 The RNA-binding proteins Musashi1 and Musashi2 (MSI1 and MSI2) regulate stem cell function and tissue plasticity by modulating mRNA translation.
Particle size determines mucociliary transport mechanisms in normal and cystic fibrosis airways biorxiv.org 2026-07-02 A wide spectrum of microparticles is inhaled with each breath, deposited on airway surfaces, entrapped in the mucus, and removed by mucociliary transp
BacNeMu: neutral mutation spectra reconstruction pipeline for bacteria biorxiv.org 2026-07-02 The mutational spectrum is an increasingly important molecular phenotype that quantitatively describes mutagenesis in a given gene and species, enabli
Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis biorxiv.org 2026-07-02 Joint involvement is a major driver of disability in systemic sclerosis (SSc), yet its pathophysiology remains poorly understood.
Application of Machine Learning Tools for Waterbird Colony Monitoring Provides Gains in Precision and Temporal Efficiency biorxiv.org 2026-07-02 Waterbirds serve as important indicators of both aquatic and terrestrial ecosystem health, making effective monitoring essential for tracking populati
Genomic impact of the second plague pandemic on three human populations biorxiv.org 2026-07-02 The second plague pandemic (early 14th-early 19th centuries), which was caused by Yersinia pestis, had a profound demographic, socio-economic and cult
Klf4 overexpression remodels chromatin to reprogram late retinal progenitors toward an retinal ganglion cell-like fate biorxiv.org 2026-07-02 Developing neuron-replacement therapies for retinal ganglion cells (RGCs) lost to injury or disease requires a deeper understanding of how restriction
Refinement and maintenance of receptive field size in primary visual cortex occurs without visual experience in mice biorxiv.org 2026-07-02 A critical step in visual cortical maturation is refinement of receptive field (RF) size, producing higher acuity vision.
Prenatal Cannabidiol and Δ9-Tetrahydrocannabinol exposure lead to sex-specific disruptions in risk assessment and behavioral switching via divergent rewiring of the adult mPFC biorxiv.org 2026-07-02 Background Prenatal cannabidiol (CBD) consumption is increasing, driven by a perception of safety relative to delta-9-tetrahydrocannabinol (THC).
Closed-loop optimization of a high-dimensional generative latent space for rhythmic visual response biorxiv.org 2026-07-02 Neural oscillations accompany a wide range of cognitive states and behaviors including perception, memory, and movement, and modulating them is of gro