miR-378a Controls Cardiomyocyte Metabolism and Angiogenic Signaling biorxiv.org 2026-07-08 AimsWhile the muscle-enriched microRNA-378a (miR-378a) has been implicated in cardiac hypertrophy and stress responses, its role in maintaining cardio
Suspension-Based Human Esophagoids Recapitulate WNT2B-Dependent Regulation of Esophageal Basal Progenitors biorxiv.org 2026-07-08 Background & AimsThe human esophagus undergoes a tightly regulated developmental program, transitioning from a simple columnar epithelium in early
Defining biologically directed therapy target signatures in urothelial carcinoma: A transcriptomic framework for precision therapy biorxiv.org 2026-07-08 IntroductionNectin-4 targeting antibody-drug conjugate (ADC) enfortumab vedotin (EV), in combination with pembrolizumab, is the first-line treatment f
A genetic toolkit to reduce wheat immunogenicity and incidence of celiac disease biorxiv.org 2026-07-08 Celiac disease (CeD) is an immune-mediated condition triggered by wheat gluten in genetically predisposed individuals.
Complete elucidation and heterologous reconstruction of the biosynthetic pathway of camptothecin biorxiv.org 2026-07-08 Camptothecin derivatives are first-line anticancer drugs used worldwide for the treatment of diverse malignant tumors.
Decoding Spatial Programs in Human Glioblastoma Through Surprisal Information-Theoretical Analysis biorxiv.org 2026-07-08 Glioblastoma (GBM) is a highly heterogeneous and invasive brain tumor in which complex interactions among tumor cells, immune cells, and neurons shape
Comparative characterization of Cas12a2 orthologs identifies high-activity nucleases for programmable cell elimination biorxiv.org 2026-07-08 Cas12a2 CRISPR nucleases, including SuCas12a2, have been shown to have extensive collateral activity towards RNA, ssDNA, and dsDNA.
Ionic Exposure History Shapes Inner Nuclear Membrane Voltage and Chromatin Texture Responses biorxiv.org 2026-07-08 While bioelectricity is increasingly recognized as an important regulator of cell function and morphogenesis, the field has almost exclusively focused
Relapse-founding cancer persister cells in follicular lymphoma biorxiv.org 2026-07-08 Follicular lymphoma (FL) is an incurable, prototypical relapse-remitting cancer, implying the existence of therapy-persistent cells that survive front
LUstiGE, Light responsive Ustilago maydis Gene Expression: Optogenetic control of morphogenesis and pathogenesis in the corn fungal pathogen Ustilago maydis biorxiv.org 2026-07-09 The basidiomycete Ustilago maydis is a well-characterized model organism for studying pathogen-host interactions and of great interest for a broad spe
The Boolean Breast-Cancer Network (BBCN): structural controllability of cell-fate signalling and a bistable resistance-apoptosis switch biorxiv.org 2026-07-09 We model a breast tumour as a Boolean network of signalling pathways and pose therapy as a control problem: find minimal, druggable interventions that
Overinflation and overconcentration: why Cauchy perturbation kernels are the right choice for ABC-SMC biorxiv.org 2026-07-09 Approximate Bayesian computation sequential Monte Carlo (ABC-SMC) propagates its particles with a perturbation kernel, and with the standard Normal ke
Overnight Th1 immune activation predicts the cortisol awakening response biorxiv.org 2026-07-09 The cortisol awakening response (CAR) marks the transition from rest to wake phase by a sharp increase in cortisol levels upon awakening in the mornin
Spatial transcriptomic programs relate to spectrolaminar rhythms across macaque cortex biorxiv.org 2026-07-09 The laminar organization of cortical dynamics is thought to reflect underlying cell-type architecture, but this relationship has not been resolved acr
Primate Astrocyte Evolution Controls the Tempo of Neuronal Development biorxiv.org 2026-07-08 Prolonged neuronal maturation, also referred to as neoteny, constitutes a hallmark of human brain evolution.
Disrupted myelin homeostasis in grey matter of Alzheimer's disease biorxiv.org 2026-07-08 Alzheimer's disease (AD) is characterized not only by amyloid-beta; plaques, tau neurofibrillary tangles and associated neuronal loss, but also by alt
Regulation of protein abundance in neurons by selective translation of 3'UTR isoforms biorxiv.org 2026-07-09 The precise regulation of protein synthesis is essential for cellular function and survival.
Embryo models as experiments in self-organization: The logic of productive failure pubmed.ncbi.nlm.nih.gov
The endothelial scavenger receptor stab2 is required for proper hematopoietic stem and progenitor cell development in the fetal blood stem cell niche biorxiv.org 2026-07-08 Hematopoietic stem and progenitor cell (HSPC) niches support lifelong production of blood and immune cells.
Inter-population connectivity of southern elephant seals and the likely intra-species transmission pathways of high pathogenicity avian influenza biorxiv.org 2026-07-08 High Pathogenicity Avian Influenza (HPAI) H5N1 clade 2.3.4.4b has spread beyond birds to affect seals across the Southern Ocean and sub-Antarctic regi
Nemo2.4: fast and accurate quantitative genetics forward-time simulations biorxiv.org 2026-07-08 We present Nemo 2.4, an advanced forward-time individual-based simulation framework designed to model the complex eco-evolutionary dynamics and geneti
Flavin cycling under prebiotic conditions: bidirectional electron transfer and versatility in nickel and iron containing environments biorxiv.org 2026-07-08 Flavins are organic redox cofactors central to metabolism and uniquely capable of acting as extracellular electron shuttles.
Hydrodynamic shear enables enrichment of functional tumor antigen-reactive T cells biorxiv.org 2026-07-08 Adoptive T-cell therapies rely on the identification and expansion of rare tumor-reactive T cells, yet current enrichment strategies are limited by th
Bifidobacterium pseudocatenulatum extracellular vesicles promote Ly6G+ granulocyte infiltration to inhibit melanoma tumour progression biorxiv.org 2026-07-08 Harnessing the immunomodulatory capacity of commensal bacteria is an emerging avenue in cancer therapy.
S100A9-Dependent CXCR2hi Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC biorxiv.org 2026-07-08 Most high-dimensional studies of tumor-immune interactions focus on metastatic models, limiting insight into how immune remodeling in primary tumors s
A spatiotemporal single-cell atlas reveals coordinated immune, metabolic, and nutrient exchange programs and a coumarin-centered metabolic switch during soybean arbusular mycorrhizal symbiosis biorxiv.org 2026-07-08 Arbuscular mycorrhizal fungi (AMF) establish intimate symbiosis with plant roots, yet the cell-type-specific regulatory and metabolic programs governi
UstiGate: Next generation toolkit for advanced genetic engineering of the basidiomycete chassis Ustilago maydis biorxiv.org 2026-07-08 BackgroundThe corn smut fungus Ustilago maydis is an important microbial model organism representing a genetically amenable and readily cultivable bas
Dissociating representations of object shape, real-world size, and mobility in human visual cortex biorxiv.org 2026-07-08 Object representations in the human ventral occipitotemporal cortex (VOTC) are organized along multiple dimensions, including shape (rectilinear vs.
A DNA mass conservation mechanism underpins cellular mtDNA number regulation biorxiv.org 2026-07-08 The nucleoid, which houses mtDNA within the mitochondrial matrix, is a phase-separation-driven biomolecular condensate capable of carrying out a broad
MYC2 mediated regulation of xylan substitution patterns biorxiv.org 2026-07-08 O-Acetylation is the most abundant xylan decoration in eudicot plants and plays a critical role in determining xylan conformation and its interactions
Pathogenic DRP1 variants reveal a role for biomolecular condensation in mitochondrial fission biorxiv.org 2026-07-08 Fission is essential for proper mitochondrial function and for cellular homeostasis.
Generative Drug Design in a Loop with dtSFM biorxiv.org 2026-07-08 Directed evolution consisting of iterative rounds of diversification, selection, and counter-selection, underlies modern protein and antibody engineer
Multilayered specificity of transcription factor binding at cytokine promoters biorxiv.org 2026-07-08 Transcription factors (TFs) regulate gene expression through sequence-specific DNA binding, and their genomic occupancy is further influenced by TF ex
Mechanistically informed adaptive dosing for cancer immunotherapy using AI-guided decision making biorxiv.org 2026-07-08 Optimizing dose and schedule remains a central challenge in oncology drug development, particularly for immunotherapies where fixed dosing regimens of
Loss of m6A unmasks a senescence-associated inflammatory program in human microglia biorxiv.org 2026-07-08 Chronic microglial inflammation and cellular senescence are hallmarks of the aging brain, yet the molecular events that lock microglia into durable in
NinjaSeq: programmable restriction enzyme-based sequencing library preparation with random access for DNA data storage biorxiv.org 2026-07-08 DNA data storage allows sequences to be defined without biological constraints, yet readout workflows still depend on generic end-repair/dA-tailing ch
A Comparative Study of Plasma Biomarkers of Neurodegeneration in Rhesus Monkeys (Macaca mulatta) and Baboons (Papio anubis) biorxiv.org 2026-07-08 Many nonhuman primate species recapitulate the neuropathological features of sporadic Alzheimer's disease (AD) to varying degrees.
HERO: A hierarchy-aware analysis pipeline for reducing and refining whole-brain atlas-mapped cellular datasets biorxiv.org 2026-07-08 Advances in high-throughput mesoscale microscopy and machine learning-based image analysis pipelines have made unbiased whole-brain imaging widely acc
Basal forebrain projections to the lateral habenula sex-dependently regulate ethanol and sucrose consumption biorxiv.org 2026-07-08 Background: Compulsive alcohol use despite negative outcomes is a defining characteristic of alcohol use disorder.
Coupled Transcriptomic and ECM-Mechanical Remodeling Reveal Mechanotransductive Pathways in Spinal Cord Injury biorxiv.org 2026-07-08 Spinal cord injury (SCI) leads to the formation of a chronic scar composed of glial and fibrotic components that severely restrict neural regeneration
Interpretable and scalable spatial gene set activity analysis with GESSO uncovers functional tissue architecture biorxiv.org 2026-07-08 Recent advances in spatially resolved transcriptomics (SRT) enabled measurement of sets of pathway genes activity within tissues.
Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs biorxiv.org 2026-07-08 The incidence of early-onset colorectal cancer (CRC) has risen sharply in recent decades1, yet the biological basis underlying the distinct behavior o
DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required biorxiv.org 2026-07-08 Extrahepatic delivery of lipid nanoparticles (LNPs) to non-phagocytic cells is a major challenge, with the leading strategy involving surface function
Kidney medulla macrophages maintain a free flow of urine by sensing force biorxiv.org 2026-07-08 Blockade by sedimentary particles, such as mineral crystals, is a continuous risk the kidney tubule faces.
The SEA-AD DREAM Challenge: Community benchmarking human and AI agent solutions for Alzheimer's disease neuropathology prediction from single-nucleus transcriptomics biorxiv.org 2026-07-08 Single-nucleus transcriptomic atlases offer an unprecedented opportunity to connect cellular molecular states with Alzheimer's disease (AD) neuropatho
Mating imperatives drive plasticity of the daily temporal niche via dopamine signaling. biorxiv.org 2026-07-08 Temporal niche partitioning is a strategy for reducing interspecies competition and strengthening reproductive isolation.
Potential Role of Nociceptin/Orphanin FQ in the Progression of Multiple Sclerosis biorxiv.org 2026-07-08 We showed before that the endogenous peptide Nociceptin blocks the premature differentiation of oligodendrocytes (OLGs), preventing untimely precociou
The Attentional Thief: How Self-Paced Visual Exploration Compresses Subjective Time biorxiv.org 2026-07-08 Social media users often feel that time vanishes while scrolling, but real feeds confound novelty, rewards, social signals, and self-paced control, le
Lamin A/C regulates the compartment-specific contributions of immune and stromal cells to intestinal inflammation and colitis-associated colon cancer biorxiv.org 2026-07-08 Inflammatory bowel disease (IBD) arises from dysregulated crosstalk between innate immune, adaptive immune, and stromal compartments, yet the compartm
A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60 biorxiv.org 2026-07-08 HSP90/R2TP is an essential quaternary chaperone composed of RPAP3, PIH1D1 and the RUVBL1/RUVBL2 AAA+ ATPases.