Optimizing Signal Acquisition and Chemometric Pipelines for Micro NIR Plant Identification: Evaluating Spectral Backgrounds and Data Processing in Herbarium Specimens biorxiv.org 2026-07-07 Premise: Rapid and accurate plant species identification is a critical challenge exacerbated by the taxonomic impediment.
Robust analysis of comparative subcellular omics with complex designs biorxiv.org 2026-07-07 Subcellular omics technologies now allow us to obtain insights into steady-state localisation and re-localisation of biomolecules in high-throughput.
Critical reassessment of lipophilic dye labeling reveals negligible incorporation into small extracellular vesicles derived form serum-free cultured cells biorxiv.org 2026-07-08 Lipophilic dyes are widely used to track extracellular vesicles (EVs), yet their labeling efficiency toward bona fide small EVs (sEVs) remains poorly
Azacitidine Response in Myelodysplastic Syndromes is Marked by NK-like CD8 T-Cell Expansion and CXCL12+ Reticular Cell Remodeling biorxiv.org 2026-07-08 Myelodysplastic syndromes (MDS) are driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs), leading to clonal expansion and in
Reprogramming a Protein Ligase for Genetic Code Expansion biorxiv.org 2026-07-08 The ribosome's DNA-encoded production of defined polymer sequences is naturally limited to 22 amino acids.
Five Decades of Rariphotic Research: A Systematic Reviewof Trends, Biases, and Future Directions biorxiv.org 2026-07-08 The rariphotic zone, typically spanning depths of approximately 130 to 300 meters, represents a key transition between light-dependent coral reef ecos
Joint tissue explant model using psoriatic arthritis synovial fluid as a tool to capture patient-specific responses to treatments biorxiv.org 2026-07-08 Objective We developed a patient- and joint-specific explant co-culture system to model active psoriatic arthritis (PsA) and capture donor-specific ti
SELECT-seq allows Pre-Sequencing Enrichment of SNP Edits in One-Pot Single-Cell Whole-Transcriptome Sequencing biorxiv.org 2026-07-08 Advances in high-throughput sequencing have associated millions of putative genetic variants with disease.
Judging the reasons for fixations: A direct experimental method to assess the contribution of saliency and semantic factors to gaze control biorxiv.org 2026-07-07 Current debates regarding the relative contribution of saliency versus semantics to gaze control often rely on comparing the predictive power of salie
SupeRJump: Determining normal and leukemic differentiation fate through semi-supervised jump diffusion modeling biorxiv.org 2026-07-07 Single cell RNA-seq (scRNA) has provided unprecedented resolution into cellular and clonal heterogeneity.
ORBIT: Annotation-Aware Empirical Enrichment and Semantic Reranking for Interpretable Functional-Class Recovery biorxiv.org 2026-07-07 Gene-set interpretation workflows are widely used to summarize transcriptomic and proteomic experiments, yet standard enrichment tools often return lo
Modeling human echolocation using a Kalman filter biorxiv.org 2026-07-07 Some blind individuals use echolocation, a skill that allows them to better navigate their environment using echoes from self-generated mouth clicks r
YAP/TAZ Signaling in Endothelial Cells Mediates the Pathogenesis of Abdominal Aortic Aneurysm Formation biorxiv.org 2026-07-07 Background: Abdominal aortic aneurysms (AAA) are characterized by dilation of the aorta that can lead to aortic rupture and death.
Genomic compartmentalization of pervasive sex-biased gene expression in the vine mealybug Planococcus ficus biorxiv.org 2026-07-07 The vine mealybug, Planococcus ficus, is a globally invasive pest of grapevine and a vector of leafroll viruses.
Immobilization-free chemotaxis analysis reveals the novel behavioral mode of leaving in Caenorhabditis elegans biorxiv.org 2026-07-07 Animals balance staying in a favorable environment with exploring new ones. In C.
Proliferative and Motile Cell Interplay in Glioma Invasion: Go-or-Grow Switching Caps the Invasion Speed biorxiv.org 2026-07-07 Diffuse gliomas are deadly because the individual tumor cells invade - they travel far from the imageable mass, so it is impossible to remove the tumo
High-Intensity Interval Training Remodels Adipose Tissue Inflammatory Signaling and Enhances Immunometabolic Health via microRNA Regulation biorxiv.org 2026-07-07 Sedentary behavior promotes chronic low-grade inflammation in adipose tissue, contributing to metabolic dysfunction and insulin resistance.
Neural correlates of glioma progression using implanted neural interfaces biorxiv.org 2026-07-07 High-grade glioma is an incurable brain cancer with a median survival of approximately 14 months.
Opposing GIPR brainstem circuits differentially control feeding behaviour biorxiv.org 2026-07-07 Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet ho
IFN and IFN mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation biorxiv.org 2026-07-07 Type I interferons (IFN-I) and IFN{gamma} exert divergent effects during tuberculosis, but the mechanisms that determine whether macrophage activation
UVfinder: a tool to extract bryophyte sex-linked gene copies from the GoFlag408 probe set biorxiv.org 2026-07-07 Target enrichment sequencing using probe sets like GoFlag 408 has revolutionized phylogenetics, yet recent genomic data indicate that some probes may
Investigating nanostructure and -mechanics of contracting actin stress fibers by scanning ion conductance microscopy biorxiv.org 2026-07-07 Scanning ion conductance microscopy (SICM) provides gentle, non-contact cell surface imaging, but it has not been used to investigate intracellular st
Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience biorxiv.org 2026-07-07 Endothelial cells (ECs) express organ-specific gene programs supporting tissue homeostasis and resilience.
Cross-architecture ensembling of DNA foundation models improves the precision and stability of chimera detection in long-read metagenomic bins biorxiv.org 2026-07-07 Motivation: Chimeric metagenome-assembled genomes (MAGs) that pool DNA from multiple organisms contaminate downstream analyses.
BRAID: RT-PCR-calibrated conformal intervals for splicing ΔPSI biorxiv.org 2026-07-07 Differential splicing workflows usually report a {Delta}PSI point estimate and a statistical score, but these outputs do not directly state whether th
Distinct roles for DNA- and RNA-sensing immune pathways in control of genital HSV-2 infection and restriction of neuroinvasion biorxiv.org 2026-07-07 Early control of viral infection is thought to rely on pattern-recognition receptors (PRRs) that induce interferons (IFNs) and leukocyte recruitment,
CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical models biorxiv.org 2026-07-07 CD47 delivers a dominant "Dont Eat Me" signal that inhibits macrophage-mediated clearance of tumour cells.
Structural Determinants of Catalytic Directionality in an AMP-Forming Acetyl-CoA Synthetase from Syntrophus aciditrophicus biorxiv.org 2026-07-07 Acetyl-coenzyme A (CoA) is a central metabolic intermediate that links carbon and energy metabolism across all domains of life.
Structure-function studies of HRIKD-{triangleup}KI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase biorxiv.org 2026-07-07 EIF2alpha kinase heme-regulated inhibitor (HRI) is a novel target for haematological malignancies with modulators reported to trigger cell death via t
Breaking the Synthesis Barrier for AI-Designed DNA Libraries biorxiv.org 2026-07-07 Designing DNA libraries is a key challenge from drug design to protein engineering and synthetic biology.
VESTA: Machine Learning-Enabled Estimation of ViscoElastic Ratios from On-Axis Spatio-Temporal ARFI Features biorxiv.org 2026-07-07 Viscoelastic characterization of tissue has significant diagnostic value in oncology, as tumor progression alters both elasticity and viscosity in way
ThermoFusion: A Multimodal Deep Learning Framework for Generalizable Prediction of Enzyme Thermostability biorxiv.org 2026-07-07 Protein thermostability is a critical property for both industrial and biomedical enzyme applications, yet experimental evaluation of mutation-induced
First estimates of the population growth rate of the parasitic honey bee mite Tropilaelaps mercedesae in Apis mellifera colonies biorxiv.org 2026-07-07 A parasitic mite of honey bee brood (Tropilaelaps mercedesae), is spreading through populations of Apis mellifera honey bees in new regions and poses
Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers biorxiv.org 2026-07-07 Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into th
A PLK1-Directed Mitotic Genome Maintenance Network Promotes DNA Synthesis in Mitosis biorxiv.org 2026-07-07 Polo-like kinase 1 (PLK1) is a master regulator of mitosis and is known to dictate DNA repair pathway choice at this stage of the cell cycle.
The genome organizer SMC1A mediates the gene expression response in inflammation by dissociating from nuclear-speckles and redistributing to the nuclear periphery biorxiv.org 2026-07-07 Nuclear architectural proteins are increasingly recognized as multifunctional regulators whose roles extend well beyond static genome organization.
Characterisation of the RNA-Binding Properties of the MRSA β-lactam resistance enzyme PBP2a biorxiv.org 2026-07-07 Analysis of RNA-binding proteome data from different bacterial species revealed many cell wall metabolic enzymes cross-linking to RNA in vivo, hinting
PACMOS: an R package for Projection And Classification of Multi-Omic Samples biorxiv.org 2026-07-07 Motivation: Integrated multi-omic analyses have transformed our understanding of cancer biology, giving rise to data-driven molecular classifications
Ocimum gratissimum essential oil nanoemulsions as a safe topical nanoplatform for antibacterial and wound-healing activities biorxiv.org 2026-07-07 Background: Natural essential oils exhibit antimicrobial and wound-healing properties, but their therapeutic application is limited by poor water solu
Stimulus dependent modulation of perceptual filling-in is predicted by the properties of early visual cortex biorxiv.org 2026-07-07 Filling-in occurs during the perceptual disappearance of a blank figure presented on a textured background.
Topological data analysis captures complex behavioral dynamics during naturalistic social interaction between domestic ferrets biorxiv.org 2026-07-07 Capturing naturalistic behavioral dynamics is essential for understanding social interaction in ecologically valid settings.
Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation biorxiv.org 2026-07-07 X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials.
TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries biorxiv.org 2026-07-07 Polygenic scores summarise genetic predisposition to a trait, but a population-level accuracy figure cannot tell a clinician whether a given predictio
Determinants of Blood Group Antigen Expression and Prediction of Phenotypes by Machine Learning biorxiv.org 2026-07-07 Blood group antigens, defined by epitopes on the erythrocyte surface, are central to transfusion safety and maternal-fetal compatibility.
A Requirement for K+ Ion Dehydration Governs Gating of the Shaker K+ Channel: Quantum Calculations Show Complex Interactions of Ions, Water, Protons, and Protein Side Chains biorxiv.org 2026-07-07 There is a vast literature on the voltage gating of ion channels, with a fairly large fraction concerned with potassium channels, especially of the KV
ScaleSurfer: multi-scale anatomical segmentation and parcellation of the human brain biorxiv.org 2026-07-07 Human brain magnetic resonance imaging (MRI) revolutionized our ability to non-invasively probe individual differences in neuroanatomy.
Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs biorxiv.org 2026-07-07 Sensory neurons encode information about external stimuli in the form of stimulus-specific patterns of activity across their population.
Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation biorxiv.org 2026-07-07 Exogenous opioids that activate mu-opioid receptors (MORs) in nociceptive circuits mediate transient pain relief lasting minutes to hours but have mor
Walking in circles: Linking high- and low-level parameter scaling of visually guided and spontaneous turning behaviour biorxiv.org 2026-07-07 The ability of animals to adjust their heading, i.e. to turn, is essential for all walking animals.
Spatial lung niches shape Pseudomonas aeruginosa persistence biorxiv.org 2026-07-07 Chronic Pseudomonas aeruginosa lung infection is a major cause of morbidity and mortality in people with pre-existing lung disease.