Dynamics of ML-based Morphological Features Indicate a Shear Stress-Dependent Bifurcation of hiPSC-Derived Endothelial Cell States biorxiv.org 2026-07-11 Cell states are increasingly conceptualized as attractors of high-dimensional dynamical systems, yet quantitative approaches for integrating phenotypi
ERK overstimulation leads to cell hyperproliferation in hereditary hemorrhagic telangiectasia landscape biorxiv.org 2026-07-11 Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disorder caused by pathogenic variants in members of the BMP9/ALK1 signaling hub.
Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup) biorxiv.org 2026-07-11 Evidence of negative health and environmental effects of glyphosate-based herbicides (GBHs) has led to marketing of glyphosate-free formulations.
Comparing Harmonization Approaches for Protocol-Related Variability in Multisite Diffusion MRI Data biorxiv.org 2026-07-11 Diffusion MRI (dMRI) enables assessment of white matter microstructural abnormalities in Alzheimer's disease (AD), and multisite datasets enable more
Primate visual cortex spontaneously computes the beauty of objects biorxiv.org 2026-07-11 During everyday vision, beauty is a spontaneous experience.
Encoding and Retrieval in Parallel: ERP Correlates of Continuous Recognition Memory for Natural Scenes biorxiv.org 2026-07-11 Human long-term memory for visual scenes is remarkably robust, yet the neural mechanisms supporting memory encoding and retrieval remain poorly unders
Structure-guided computational design and mechanistic understanding of the p95HER2-targeting NAZ-mAb antibody and its variants biorxiv.org 2026-07-11 Human epidermal growth factor receptor 2 (HER2) is an oncogenic receptor tyrosine kinase in breast cancer and other malignancies.
Scalable 3D cell-interaction analysis via supercell graphs for prostate cancer risk stratification biorxiv.org 2026-07-11 Cellular interactions underlie fundamental biological processes but are not fully represented in conventional 2D histology images.
First report on Chicken Pediculosis in Modern Battery-Cage Layer Farms in Bangladesh: Behavioral, Pathological and Production Performance Impacts biorxiv.org 2026-07-11 The recent shift in Bangladesh from tradition backyard rearing system to modern commercial layer farming has made the birds immune to infectious disea
Griphus Software for Multi Panel Figure Composition and Experimentation with Emphasis on Taxonomy biorxiv.org 2026-07-11 The preparation of multi panel figures remains a labor intensive step in scientific publication.
APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice biorxiv.org 2026-07-11 Old age and the apolipoprotein E4 (APOE4) genotype are two of the greatest risk factors for late-onset Alzheimer's disease (LOAD).
Cortical Activity During Sustained Isometric Ankle Contractions Following Chronic Sleep Restriction: A High-Density EEG Study biorxiv.org 2026-07-11 Background: Chronic sleep restriction (CSR) impairs cognitive function, but its effects on the cortical dynamics underlying active motor performance r
Spatial confinement shapes organelle architecture and remodeling in axons biorxiv.org 2026-07-11 Axons are extended cellular compartments that mediate neuronal connectivity over extraordinary distances, placing unique demands on local organelle or
Age-Associated Behavioral Alterations in Laboratory-Housed Octodon degus biorxiv.org 2026-07-11 Octodon degus are long-lived, diurnal, and highly social rodents increasingly used in studies of aging and neurodegeneration.
Secure LSL: A Unified Encryption Architecture for the Lab Streaming Layer biorxiv.org 2026-07-11 Objective: The Lab Streaming Layer (LSL) protocol, widely adopted for synchronized multimodal biosignal recording in neuroscience research, transmits
Structural presentation of amyloid β by HLA biorxiv.org 2026-07-11 HLA-DR-restricted T-cell reactivity to amyloid {beta} (A{beta}) has been associated with Alzheimer's disease (AD), but structural evidence for HLA pre
Robustness tuning: mechanisms of acclimation-driven plasticity in a central pattern generator biorxiv.org 2026-07-11 Temperature influences neuronal and circuit output and extreme temperatures can disrupt neuronal performance.
Cycles of contamination and recovery: Combined sewer overflows drive acute but transient antimicrobial resistance exposure in an urban stream biorxiv.org 2026-07-10 Combined sewer overflows (CSOs) are a major pathway for untreated wastewater into urban streams, yet their role in shaping antimicrobial resistance (A
Diet-Induced Obesity Exacerbates Helicobacter pylori-Associated Precancerous Phenotypes biorxiv.org 2026-07-10 Stomach infection with the bacterium Helicobacter pylori (Hp) can cause chronic gastric inflammation, metaplasia (transdifferentiation of mature cell
Biphasic bacterial community assembly predicted from generalized first principles of monoculture growth and inferred species interactions biorxiv.org 2026-07-10 Microbial communities occur in all habitats, yet how individual growth on available nutrients scales to community assembly remains poorly understood.
Climate isolation and percolation as drivers of terrestrial vertebrate richness biorxiv.org 2026-07-10 Climate is a strong predictor of global species richness, but the effects of climatic conditions are difficult to separate from the geography of the c
Sequential predictive e-diagnostics for hidden Markov models of animal movement biorxiv.org 2026-07-10 Hidden Markov models are standard for inferring behavioural states from animal movement data, but checking whether a fitted latent-state model predict
InsectDCT: A generalized pipeline for detection, taxonomic classification, and tracking of insects in camera-trap recordings biorxiv.org 2026-07-10 Automated monitoring of insect pollinators in natural environments with insect camera traps and trained deep learning algorithms provides novel data f
move2utils: a utility toolkit for the move2 ecosystem biorxiv.org 2026-07-10 1. Studying animal movement at the population scale requires a stable, modern software substrate.
New genes play a prominent role in evolution of new sperm classes of Drosophila biorxiv.org 2026-07-10 The widespread and regulated production of infertile parasperm assisting fertilization of eusperm provides a compelling model for elucidating the mech
Chromosome-level genome assembly of Calotes wangi with dynamic colour variation biorxiv.org 2026-07-10 The Wang's garden lizard, Calotes wangi, is a widely distributed agamid species in Southern China and Northern Vietnam and exhibits pronounced colour
Evolutionary trade-offs between antimicrobial resistance and virulence in Pseudomonas aeruginosa biorxiv.org 2026-07-10 Antibiotics impose strong selection on bacteria, resulting in the emergence and spread of antimicrobial resistance.
Inbreeding depression is greater in benign than in stressful environments biorxiv.org 2026-07-10 The potential for environmental change to compound the detrimental effects of inbreeding depression in small and isolated populations is a significant
The gonad as a mediator of life history tradeoffs: Antagonistic hormonal pleiotropy facilitates evolutionary divergence in reproductive strategies biorxiv.org 2026-07-10 High investment in current reproduction can limit future reproductive opportunities, but how selection shapes these hormone-mediated traits remains po
Protein fitness landscapes are simpler under evolutionary distributions biorxiv.org 2026-07-10 Understanding how mutations combine to shape protein fitness remains a central challenge in biology, driven in part by the prevalence of high-order ep
Sedimentary ancient DNA reveals Late Pleistocene faunal connectivity between Ireland and Eurasia biorxiv.org 2026-07-10 Late Pleistocene sea-level fluctuations and glacial corridors intermittently connected the island of Ireland to Britain and continental Eurasia, shapi
One Health genomic surveillance reveals structured urban rabies transmission and major surveillance gaps biorxiv.org 2026-07-10 Persistent local foci remain a barrier to eliminating dog-mediated rabies.
Joint analysis of multiply perturbed cells improves statistical power and cost efficiency in Perturb-seq biorxiv.org 2026-07-11 Perturb-seq measures transcriptomic responses to genetic perturbations at scale, but conventional designs that enrich for one guide RNA per cell remai
A Genetic Atlas of Direct and Inverse Neuropsychiatric-Cancer Comorbidity biorxiv.org 2026-07-11 Direct and inverse comorbidities between neuropsychiatric disorders and cancer are increasingly recognised as important features of the nervous system
Spatial mitochondrial lineage tracing uncovers a premetastatic niche and microenvironment programmed fate switching in osteosarcoma biorxiv.org 2026-07-11 Osteosarcoma progression involves complex spatiotemporal dynamics, yet the lineage relationships underlying tumor cell fate decisions remain poorly un
Glycine molecule radical: Predicted properties and dipeptide formation biorxiv.org 2026-07-10 Numerous advances in quantum and computational chemistry over the last decades, as well as the development of computer science, allowed utilisation of
MARiO: predicting cancer variant pathogenicity by integrating in silico evaluation and patient-level mutational contexts biorxiv.org 2026-07-10 Comprehensive genomic profiling (CGP) supports precision medicine in cancer care, but accurate assessment of missense variant pathogenicity, especiall
Benchmarking AI-Driven PTIm-mAb Across Eleven FDA-Approved Bispecific Antibodies: A Cross-Tool Validation Study biorxiv.org 2026-07-10 Background.
Safeguarding open-weight genomic foundation models through weight locking biorxiv.org 2026-07-10 Background.
Interaction-finder: automated literature-based discovery of biological entity associations with quote-level provenance biorxiv.org 2026-07-10 Identifying interactions between biological entities is a cornerstone of molecular research, but assembling such lists from the literature is slow and
MAERM: Predicting Enzyme-Reaction Matching Relationships with a Mixed-Attention Model biorxiv.org 2026-07-10 Harnessing enzyme specificity requires a thorough understanding of enzyme promiscuity, which determines enzymes' catalytic scope; however, measuring t
Comparative Modelling of Actin-Tropomyosin Interfaces biorxiv.org 2026-07-10 Tropomyosins are coiled-coil dimers that polymerize head-to-tail along actin filaments.
Evaluating the cross-species transferability and scaling of sequence-to-function predictions in AlphaGenome biorxiv.org 2026-07-10 Deep learning models that predict molecular phenotypes directly from DNA sequence offer a powerful framework for interpreting genomic variation.
Improved 3D Radial Phyllotaxis Trajectories for Uniform Density Distribution of Readout Directions and Sequential Binning biorxiv.org 2026-07-10 Purpose: To develop 3D radial spiral phyllotaxis trajectories that provide a uniform density distribution of readout directions and support retrospec-
AtlasLens: Metadata-centric exploration and analysis of single-cell atlases biorxiv.org 2026-07-10 Motivation: The rapid expansion of single-cell RNA sequencing (scRNAseq) atlases has generated datasets comprising millions of cells annotated with in
Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems biorxiv.org 2026-07-11 Abstract Background: Calcineurin inhibitors (CNIs) are indispensable for transplantation immunosuppression, yet cyclosporine A (CsA) produces renal to
Fetal sex shapes placental inflammatory responses to extracellular mitochondrial DNA biorxiv.org 2026-07-11 Aberrant changes in circulating cell-free mitochondrial DNA (ccf-mtDNA) across gestation are associated with adverse pregnancy outcomes.
Hepatitis C Virus Remodels Lipid Droplets to Promote Mitochondrial Fatty Acid Accumulation and Metabolic Activation biorxiv.org 2026-07-10 Here, we investigated the temporal remodeling of LD-associated metabolic pathways during HCV JFH-1 infection of human hepatoma Huh7 cells.
AI-Driven Discovery and BSL-4 Validation of Cross-Filovirus Ebola-Marburg Inhibitors and their Synergistic Combinations biorxiv.org 2026-07-10 Filovirus outbreaks caused by Ebola virus (EBOV) and Marburg virus (MARV), pose severe global health threats characterized by high rates of fatal hemo
Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestration biorxiv.org 2026-07-10 Objective: Systemic inflammation triggered by microbial insults can disrupt endothelial homeostasis, impair blood-brain and blood-retinal barriers, le