Recurrent inhibition, not presynaptic inhibition, contributes to the velocity-dependent control of motoneuron output during eccentric contractions biorxiv.org 2026-07-24 It is well documented that both motoneuron output and the effectiveness of activated Ia afferents to discharge soleus -motoneurons decrease during ecc
Multi-area single-cell calcium imaging dataset of the mouse cortex across wakefulness, sleep, and anesthesia biorxiv.org 2026-07-24 We present a reusable dataset of neuronal population activity from multiple cortical areas, recorded from layers 2/3 of the mouse cortex at single-cel
Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sex biorxiv.org 2026-07-24 The cornea is classically regarded as an immune-privileged tissue.
Whole mitochondrial genome sequencing identifies unique haplotype diversity and a lack of fine-scale genetic structure: a case study in the vulnerable estuarine turtle Malaclemys terrapin biorxiv.org 2026-07-24 A central goal when assessing patterns of population structure for conservation is to identify populations with unique genetic compositions.
On the characterization and interpretation of phenotypic ellipse geometry, with examples from Canis and sigmodontine rodents. biorxiv.org 2026-07-24 Data on the shape of a group of organisms can be conceptualized as forming a point cloud in the multivariate space of measurement.
Plasticity of the mutation rate and spectrum in eukaryotic marine phytoplankton biorxiv.org 2026-07-24 The ability to adapt shapes the future of any species or population.
BioGeoSyn: a graphical software for reproducible biogeographic analyses and cross-clade synthesis of biogeographic events biorxiv.org 2026-07-24 1.
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models biorxiv.org 2026-07-24 Accurate predictions of transcriptomic responses to genetic perturbations could unlock our understanding of gene functions and regulatory networks.
Intergenerational epigenetic signatures of prenatal adversity and their role in emerging child psychopathology biorxiv.org 2026-07-24 Background: Adversity during pregnancy is associated with alterations in offspring brain development.
MetaClaw: an auditable AI agent for end-to-end, multi-directional metagenomic and multi-omics analysis biorxiv.org 2026-07-24 Omics studies increasingly depend on long, multi-directional workflows, making auditability as important as individual analytical tools.
Phenotype-driven de novo molecular design from gene expression signatures biorxiv.org 2026-07-24 Target-based and structure-guided drug design remain central to modern drug discovery, but complementary strategies are needed when predefined targets
A non-invasive method of air pollutant exposure in an avian model of development biorxiv.org 2026-07-24 Air pollution is a growing public health concern.
An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics biorxiv.org 2026-07-24 Intestinal insect cells are integral to pharmacokinetic research, unfortunately they do not serve as cell models for more advanced studies comparable
Natriuretic Peptide Augmentation Attenuates Renin Cell Hyperactivation and Afferent Arteriolar Hypertrophy During Long-Term Renin-Angiotensin System Inhibition biorxiv.org 2026-07-24 BACKGROUND: Chronic renin-angiotensin system (RAS) inhibition activates renin cells and induces afferent arteriolar hypertrophy, a maladaptive vascula
Recent Adversity Shapes Autonomic and Neural Threat Learning and Retrieval Under Imminent Threat: A Prospective Longitudinal Study biorxiv.org 2026-07-24 Recent adversity (RA) increases the risk of later mental health problems, but the mechanisms underlying this association remain largely unclear.
Eye movements reveal representational geometry biorxiv.org 2026-07-24 Mental representations are the explanatory construct of the cognitive sciences, but there is no widely accepted characterization of how they cause beh
Numerosity adaptation reflects multiple levels of sensory processing biorxiv.org 2026-07-24 Psychophysical and neuroimaging studies have repeatedly suggested that perceived numerosity is susceptible to adaptation, involving high-level number
Nasal inhalations and exhalations evoke distinct prefrontal-cortex responses with constant latency biorxiv.org 2026-07-24 Neuronal activity synchronous to breathing is salient across the mammalian brain.
Sub-endothelial platelet activation amplifies neutrophil transmigration within venular walls biorxiv.org 2026-07-24 Neutrophil recruitment into inflamed tissues requires coordinated transmigration across the multilayered venular wall, yet how this process is regulat
Targeting neutrophil signaling networks in immune complex-mediated autoimmune disease biorxiv.org 2026-07-24 Fragment crystallizable gamma receptor (Fc{gamma}R)-induced signaling is a crucial process that determines the cellular response to immune complexes (
PopZ is dispensable for cell fitness but required for polar localization of ParB in Zymomonas mobilis. biorxiv.org 2026-07-24 Chromosome segregation is an essential process in monoploid bacteria, in which faithful inheritance of the genetic material is required for viability
FXR-mediated recruitment of PPP1CB suppresses SMAD2/3 phosphorylation to mitigate pulmonary fibrosis biorxiv.org 2026-07-24 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited treatment options and poorly understood molecula
Peroxiredoxin 6 limits mitochondrial peroxidation to prevent mitochondrial ER contact site assembly and inflammatory signalling following adaptive stress biorxiv.org 2026-07-24 Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme with peroxidase, calcium independent phospholipase A2 (aiPLA2) and lysophospatidylcholine acyltran
Identification of lipid specificity in membrane organizing protein complexes biorxiv.org 2026-07-24 Organelle membrane identity is encoded by protein and lipid composition. Human cells produce thousands of distinct lipid species for this purpose.
CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation biorxiv.org 2026-07-24 The non-receptor protein-tyrosine phosphatases Shp1 (PTPN6) and Shp2 (PTPN11) play critical roles in hematopoietic signaling networks, yet their speci
Sex Differences in Physiological Hair Cycling and Adhesive Material-Induced Hair Regeneration in Mice biorxiv.org 2026-07-24 Sex differences in hair growth are clinically evident, but sex-dependent regulation of physiological hair cycling and injury-induced hair regeneration
Climate and urbanization structure West Nile virus vector communities: Tools for surveillance under environmental change biorxiv.org 2026-07-24 West Nile virus (WNv) in eastern North America is transmitted primarily by Culex pipiens and Culex restuans, two cryptic vector species whose relative
T50 as a proxy of PS II heat tolerance: time dependence, differences in calculation methods and implications for its suitability to assess the heat tolerance of tree species biorxiv.org 2026-07-24 The heat tolerance of tree species has recently received increased attention, as it is critical for the response of forest ecosystems to climate chang
Land-use influence on benthic algal assemblage structure and biomass in Afrotropical headwater streams biorxiv.org 2026-07-24 Benthic algae integrate catchment- and reach-scale pressures in streams.
Kin discrimination in plants: competitive ability over kinship response biorxiv.org 2026-07-24 Numerous studies on plant-plant interactions aim to distinguish positive from negative effects, especially among related individuals.
Deciphering complete archaic introgression sequences in modern human genomes biorxiv.org 2026-07-24 Genetic introgression from archaic hominins has profoundly reshaped the genetic diversity and adaptive potential of modern humans, yet the full catalo
A rapid HPLC-based method to determine NAD(P)(H) and NMN redox cofactor concentrations and ratios in microbes biorxiv.org 2026-07-24 Redox cofactors are a key part of cellular physiology as they are involved in most metabolic pathways, and their ratios are linked to cellular robustn
Bioengineering of a Chimeric Metarhizium anisopliae cPr1A Protease with Enhanced Binding and Enzyme Activity Through C-terminal Fusion of Bombyx mori Chitin-Binding Domain biorxiv.org 2026-07-24 Abstract Metarhizium anisopliae is an important entomopathogenic fungi used in biological control of agricultural pests, but its commercial applicatio
A transcriptional signature of LKB1 functional loss defines a large, therapeutically addressable patient population across human cancers biorxiv.org 2026-07-24 Loss of the tumor suppressor LKB1 (STK11) drives metabolic reprogramming and immune evasion, but its clinical footprint is defined almost entirely by
The receptor kinase NILR1 confers nematode resistance through developmental rather than canonical immune signaling biorxiv.org 2026-07-24 NILR1 contributes to quantitative resistance against Heterodera schachtii and signals through a brassinosteroid-type kinase cascade, but whether its c
Repeated intermittent clenbuterol administration induces exposure history-dependent proteomic remodeling in mouse skeletal muscle biorxiv.org 2026-07-24 Clenbuterol (CB), a {beta}2-adrenergic receptor agonist, is known to increase skeletal muscle mass.
Inflammatory suppression and cancer-associated bypass of the b0,+selenium-utilization program in the human intestine biorxiv.org 2026-07-24 The b0,+ transporter (SLC3A1/SLC7A9) imports cystine and selenocystine at the enterocyte apical membrane and defines a selenium-utilization program in
DNA barcoding-based paired daughter cell analysis reveals division preferences of hematopoietic stem cells biorxiv.org 2026-07-24 Hematopoietic stem cells(HSCs) maintain their pools by stem-stem division and produce mature blood cells through stem-progenitor or progenitor-progeni
COP9 complex maintains neuroblast growth and proliferation by regulating Akt/mTor pathway biorxiv.org 2026-07-24 The nervous system consists of the brain and associated structures that are replete with highly specialised neurons and glia.
Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork biorxiv.org 2026-07-24 Purpose: Aqueous humor outflow through the trabecular meshwork (TM) is segmental, demonstrating high flow (HF) and low flow (LF) regions.
Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function biorxiv.org 2026-07-24 {gamma}{delta} T-cells, which are predominantly enriched in epithelial tissues, have been used in cancer therapy because of their capacity for rapid c
Glycocalyx-Directed Enzymatic Hydrogels Unlocks Fibroblast Regeneration to Promote Diabetic Wound Healing biorxiv.org 2026-07-24 Chronic diabetic wounds remain a major clinical challenge because current therapies address infection or supplement growth factors without correcting
Routine FFPE sections support clinically compatible single-nucleus transcriptomics across six human cancer types biorxiv.org 2026-07-24 Tumor cellular composition, including malignant cell states, immune populations, and stromal populations, is increasingly recognized as a determinant
A dual-layer computational framework for prioritising therapeutic candidates targeting extracellular vesicle-mediated immune escape in pancreatic ductal adenocarcinoma biorxiv.org 2026-07-24 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterised by a highly immunosuppressive tumour microenvironment and limited th
Haplotype-based insights into the genetic architecture of net blotch resistance in barley biorxiv.org 2026-07-24 Net blotch, caused by Pyrenophora teres, is a major constraint to barley production worldwide and occurs as two epidemiologically distinct forms: net
Single-kernel near-infrared spectroscopy enables haploid kernel sorting in field and sweet corn using high-oil haploid inducers across diverse donor-inducer combinations biorxiv.org 2026-07-24 Doubled haploid (DH) technology significantly shortens the breeding cycle for developing homozygous inbred lines in maize (Zea mays).
Metabolome genome-wide association study reveals hierarchical and epistatic genetic control of flavonoid metabolism in soybean biorxiv.org 2026-07-24 Metabolic phenotypes are often governed by complex genetic architectures involving both additive and non-additive effects.
Automated design of stiffness-tunable DNA origami hollowframes for self-assembling metamaterials biorxiv.org 2026-07-24 DNA origami offers a route to engineering architected metamaterials with sub-nanometer precision by linking nanoscale building blocks into micron-scal
FMRP prevents Me31B/DDX6-associated repression of long neurodevelopmental mRNAs biorxiv.org 2026-07-24 Long, dosage-sensitive mRNAs encoding neurodevelopmental regulators are selectively dependent on fragile X messenger ribonucleoprotein (FMRP) for effi
Structural basis for emetine inhibition of ribosome translocation in Toxoplasma gondii biorxiv.org 2026-07-24 Apicomplexan parasites, including Toxoplasma gondii and Plasmodium falciparum, are major human pathogens that cause toxoplasmosis and malaria, respect