First Evidence of Dicistroviruses Infecting Protists biorxiv.org 2026-07-27 Molecular surveys suggest that RNA viruses are abundant and diverse in the ocean, but the hosts for most of these viruses are unknown because so few h
Genome-wide screen for genes required for smooth lipopolysaccharide production in Escherichia coli K-12 biorxiv.org 2026-07-27 Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria, contributing to membrane integrity and environmental in
Metabolic cost as a determinant of light quality acclimation: a full-PAR characterization of the CA3 cyanobacterium Nostoc sp. CCAP 1453/38 biorxiv.org 2026-07-27 Light quality acclimation is one of the key drivers of cyanobacterial physiology, ecology, and productivity.
Cortical organoids from congenital DM1 PSCs reveal MBNL-dependent corticogenesis defects and enable preclinical testing of therapeutic compounds biorxiv.org 2026-07-27 Myotonic dystrophy type 1 (DM1) is caused by an expansion of a CTG repeat in the 3' untranslated region of the DMPK gene, leading to accumulation of t
Desialylated platelets promote hepatocyte proliferation via the ERK1/2 signaling pathway biorxiv.org 2026-07-27 Platelets are increasingly recognized as active regulators of tissue repair and liver regeneration beyond their classical roles in hemostasis and thro
Transcriptomic Illuminations: How light intensity reshapes the Chlamydomonas reinhardtii cell cycle biorxiv.org 2026-07-27 The unicellular algae cell cycle can be divided into several phases, including the commitment point (CP), a point-of-no-return where the cell decides
Achiral Odd Mechanics in Cell Monolayers biorxiv.org 2026-07-27 Cell monolayers are active, orientationally ordered materials whose mechanics can depart from near-equilibrium behavior.
SCAMP - an open-source tool for the quantification of calcification in fish larvae biorxiv.org 2026-07-27 Quantifying skeletal mineralization phenotypes in larval fish is complicated by the natural curvature of the notochord and by sample-to-sample variabi
A minimal model of stable autocatalytic RNA-replication through integration of replication, molecular regulation, and energy conversion biorxiv.org 2026-07-27 Catalysis and allostery are complementary principles of biological function: catalysis accelerates biochemical reactions, whereas allosteric regulatio
Container-less Acoustic Levitation Expands Plasma Extracellular Vesicle Proteome Coverage by Mitigating Size-Dependent Peptide Loss biorxiv.org 2026-07-27 Proteomic profiling of plasma-derived extracellular vesicles (EVs) is limited in part by adsorptive loss of peptides and proteins to container walls d
A membrane-bound aromatic O-prenyltransferase catalyzes the last reaction step in citrus auraptene biosynthesis biorxiv.org 2026-07-27 Plants produce a variety of O-prenylated aromatics that exhibit biological activities beneficial to human health, and the presence of the O-prenyl moi
Robust Regularization Enables Automated, Real-Time Square-Wave Voltammetry Signal Quantification biorxiv.org 2026-07-27 Square-wave voltammetry (SWV) is widely used for electrochemical biosensing because it enables sensitive, temporally resolved measurement of redox rep
Targeted measurement of blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy biorxiv.org 2026-07-27 Significance : Diffuse Correlation Spectroscopy (DCS) is an established technique for non-invasive monitoring of Cerebral Blood Flow (CBF), but existi
The Mechanical and Biological Evolution of Pressure Ulcer Formation and Healing in Mice biorxiv.org 2026-07-27 Pressure ulcers arise from sustained mechanical loading that impairs perfusion and damages skin tissues, yet the coupled mechanical and biological mec
Detecting the Information Flow in Proteins by Hodge Decomposition biorxiv.org 2026-07-27 Allosteric communication in proteins is commonly quantified as a directed or undirected coupling between residues, but such descriptors mix distinct m
B-SMART-Former: An Explainable Transformer-Based Deep Learning Model for Predicting Drug-Drug Interactions Between Biotech and Small-Molecule Drugs biorxiv.org 2026-07-27 Drug-drug interactions between biotech and small-molecule drugs play a critical role in medication safety and therapeutic efficacy.
Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition biorxiv.org 2026-07-27 The clinical benefit of MAPK-targeted therapies depends on greater pathway inhibition in tumors than normal tissues.
Differential modulation of crassulacean acid metabolism according to macronutrient deficiencies in C4 Portulaca oleracea biorxiv.org 2026-07-27 C4 photosynthesis and the crassulacean acid metabolism (CAM) rarely co-evolved in a single lineage, but Portulaca can switch from C4 to CAM under drou
The Sulfated PSY Peptide Negatively Regulates Receptor Kinase Activity to Promote Growth biorxiv.org 2026-07-27 Complex signaling pathways organize cell expansion and proliferation across cells to pattern tissues and organs in plants.
APICE-Py: An Open-Source MNE-Python Pipeline for Scalable EEG Preprocessing biorxiv.org 2026-07-27 Electroencephalography (EEG) is fundamental to cognitive neuroscience as it provides a direct measure of human neural activities with millisecond prec
Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis biorxiv.org 2026-07-27 Skeletal and mesenchymal cells have limited bone-forming potential due to their rarity, tendency for senescence and/or unstable osteogenic lineage com
Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol biorxiv.org 2026-07-27 Tendons are commonly injured, not only in athletes, but also during normal everyday activities, particularly in older age.
ZHP-2/HEI10 generates CO precursors and triggers procrossover factor coarsening and CO formation through Polo kinase recruitment biorxiv.org 2026-07-27 During meiosis, programmed DNA double-strand breaks (DSBs) are repaired with the homolog to form crossovers (COs) essential for chromosome segregation
The SoxC transcription factors regulate multiple early retinal lineages and function in parallel with Atoh7 to promote retinal ganglion cell genesis biorxiv.org 2026-07-27 Retinal development is orchestrated by a network of transcription factors that guide multipotent retinal progenitor cells (RPCs) to fate-committed lin
Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC) biorxiv.org 2026-07-27 Hurthle cell carcinoma (HCC) is an aggressive form of thyroid cancer.
A Neuroendocrine Circuit That Suppresses Excretion and Pelvic Pain During Activity biorxiv.org 2026-07-27 Mate-seeking during peak sexual receptivity is tightly coupled with exploratory movement, a process made more efficient by transient suppression of ex
Phenylalanine Treatment Suppresses Necrotrophic and Biotrophic Pathogens in Mono- and Dicotyledonous Plants biorxiv.org 2026-07-27 L-phenylalanine (Phe) is converted via the phenylpropanoid pathway into phenolic compounds, and elevated phenolic/flavonoid levels are generally assoc
The micro-plant remains preserved on lithics and in the associated sediment of the Hoabinhian Laang Spean cave site, Battambang province, Cambodia. biorxiv.org 2026-07-27 This study seeks to advance understanding of how ancient Hoabinhian communities engaged with the diversity of their environments, focusing on plant re
TAS2R10 Suppresses ABCG2 Transporter-Associated Chemoresistance and Enhances Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma biorxiv.org 2026-07-27 Cisplatin resistance remains a major barrier in head and neck squamous cell carcinoma (HNSCC) treatment.
Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing biorxiv.org 2026-07-27 The extracellular matrix (ECM) stiffness influences many physiological and pathological processes.
Actively cycling cells in uninjured connective tissue are not a prerequisite for appendage regeneration biorxiv.org 2026-07-27 Multiple hypotheses have been formulated to explain differences in tissue repair ability across vertebrates.
Microbiome plasticity, not gut morphology, is linked to amphibian larval performance under elevated temperatures and low food quality biorxiv.org 2026-07-27 In many ecosystems, anthropogenic warming is reshaping thermal regimes, leading to resource quality declines and imposing a dual constraint for ectoth
Temperature variation as a driver of Wolbachia release efficacy: implications for dengue control in warming climates biorxiv.org 2026-07-27 Background Wolbachia-based control methods reduce dengue transmission by suppressing Aedes aegypti populations or blocking viral replication, yet thei
Rubber mapping reveals opportunities and current limitations of deforestation due-diligence biorxiv.org 2026-07-27 Commodity maps and the ability to monitor commodity-driven deforestation are essential for sustainability risk assessment and due diligence.
Genome-wide multi-layered epigenomic profiling across human aging biorxiv.org 2026-07-27 Aging is characterized by highly reproducible alterations across multiple layers of the epigenetic landscape, including DNA methylation, chromatin acc
Conformation of the Catalytic Lysine is a Key Determinant of 2-Deoxyribose-5-phosphate Aldolase (DERA) Stereoselectivity biorxiv.org 2026-07-27 2-Deoxyribose-5-Phosphate Aldolase (DERA) is a key enzyme in the pentose phosphate pathway.
Compact red-shifted near-infrared fluorescent proteins enable deep-tissue SWIR imaging with in vivo optical clearing. biorxiv.org 2026-07-27 Compact near-infrared (NIR) fluorescent proteins (FPs) with red-shifted emission are needed for deep-tissue short-wavelength infrared (SWIR) imaging.
Aptaswitch/aptakiss adenosine sensor design based on the selection of new DNA/DNA kissing complexes biorxiv.org 2026-07-27 Kissing complexes involve interactions between complementary loops of two RNA hairpins.
A generalizable speech neuroprosthesis biorxiv.org 2026-07-27 Intracortical brain-computer interfaces (BCIs) can restore communication to people with vocal tract paralysis by decoding cortical activity during att
Computationally guided design of a metastasis-on-a-chip platform for quantitative evaluation of chemotactic cues in developmental cancers biorxiv.org 2026-07-27 Metastatic dissemination is initiated by tumor cells interpreting spatially organized biochemical and biophysical cues that remain difficult to reprod
An integrated single-cell atlas of human lung across the lifespan biorxiv.org 2026-07-27 The healthy adult lung is largely quiescent but can respond to injury and replace damaged or lost cells.
Discrete Inverse Rendering: Biological Data Analysis with Integer Programming biorxiv.org 2026-07-27 Biological image analysis is full of discrete decisions: whether an object is present, which of several overlapping detections is real, whether two de
Estimation of biological age using HRV data: comparison of the Klemera-Dubal method with the multiple linear regression method biorxiv.org 2026-07-27 The aim of this study was to compare three methods for estimating biological age (BA) based on heart rate variability (HRV) indices recorded in the su
Explainable Artificial Intelligence for Cross-Dataset Generalizable Biomarker Discovery in Cardiovascular diseases (CVDs) biorxiv.org 2026-07-27 CVDs are heterogeneous, multifactorial disorders that remain the leading cause of global mor- tality from infancy to old age.
LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma biorxiv.org 2026-07-27 Retinoblastoma (RB), the most common pediatric intraocular malignancy, is initiated by biallelic inactivation of the RB1 tumor suppressor gene.
Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer biorxiv.org 2026-07-27 CD47 is a ubiquitously expressed transmembrane protein that functions as a negative immune checkpoint, marking host cells as "self" by delivering an i
Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed Immunotherapy biorxiv.org 2026-07-27 Cancer immunotherapy targeting B-cell specific CD19 antigen meant a major breakthrough in the treatment of B-cell malignancies.
A data-driven approach to integrative taxonomy biorxiv.org 2026-07-27 Central to understanding biodiversity is the systematic classification of biological taxa where concepts on integrating 'omics data have not yet been
Effects of different shading levels on growth, physiology and leaf surface micromorphology of Sorbus sibirica "Dong Hong" seedlings biorxiv.org 2026-07-27 Background: Sorbus sibirica "Dong Hong" is a promising ornamental cultivar, but its optimal light conditions remain unclear.
SWI3b restricts AGO5 expression to promote the initiation of megagametogenesis in Arabidopsis biorxiv.org 2026-07-27 Female germline development is fundamental to plant reproduction.