Decadal warming is linked to thermal tolerance and transcriptome reprogramming in a seagrass biorxiv.org 2026-07-27 Ocean warming and marine heatwaves threaten seagrasses, which are considered highly vulnerable to rising temperatures.
The free amino acid-rich biostimulant, Leafamine, promotes cell division in tomato roots and alleviates heat stress effects biorxiv.org 2026-07-27 Several tomato (Solanum lycopersicum) varieties are sensitive to heat stress, which compromises plant growth, development, and ultimately yield.
Landscape-mediated spread dynamics and anticipatory surveillance of African swine fever in wild boar: insights from the 2025-2026 Catalonia utbreak in Spain biorxiv.org 2026-07-27 African swine fever (ASF) in wild boar poses major surveillance and control challenges, particularly in peri-urban and human-modified landscapes where
Synthetic Combinatorial Minimisation of Cell Cycle Control in Yeast biorxiv.org 2026-07-27 The eukaryotic cell cycle, with its inherent regulatory redundancy, provides an ideal target for exploring genome modularisation and minimisation thro
Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae) biorxiv.org 2026-07-27 Species-level delimitation within the genus Trichomycterus remains one of the main systematic challenges within the Trichomycterinae, particularly in
Internal perturbation reveals the flexible and adaptive nature of the coordination between decisions and movements biorxiv.org 2026-07-27 Although growing evidence indicates that decision-making and movement control are tightly coordinated, the functional significance of this coordinatio
Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber's Hereditary Optic Neuropathy biorxiv.org 2026-07-27 Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited mitochondrial disorder characterised by painless, progressive, and sequential vis
Long-term Connectivity between Spinal Cord Tissue Transplants and the Injured Phrenic Motor Network biorxiv.org 2026-07-27 Restoring vital motor functions after spinal cord injury (SCI) remains a central challenge in neuroscience and regenerative medicine.
Task-Dependent and Cell-Type-Specific Modulation of the Mouse Dorsal Cortex of the Inferior Colliculus biorxiv.org 2026-07-27 Sensory responses in the auditory system are modulated by behavioral context, and this modulation extends as early as the inferior colliculus (IC).
BRCA2 and RAD54B FxPP motifs Bind DMC1 Filaments through Persistent and Transient Interfaces biorxiv.org 2026-07-27 During meiosis, double-strand DNA breaks are programmed to initiate homologous recombination.
SyntenyPair Explorer: an installation-free, browser-based tool for interactive pairwise genome synteny visualization biorxiv.org 2026-07-27 Comparisons of genome structure between related organisms are central to understanding genome evolution, gene family dynamics, and the genomic basis o
Correlating Structure and Rheology in Ionically Crosslinked Alginate Biopolymer Hydrogels - A Case for Why "Less" can be "More" biorxiv.org 2026-07-26 We probe the structural and rheological properties of ionically crosslinked alginate, a model biopolymer hydrogel, using microscopy, rheology and visc
Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream biorxiv.org 2026-07-27 Circulating tumor cells (CTCs) are the potential seeds of distant metastases; however, little is known about how they survive in the bloodstream.
Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes biorxiv.org 2026-07-27 The kidney is a highly energetic organ, requiring substantial ATP production through mitochondrial oxidative phosphorylation to support tubular reabso
A missing PEPC1 exaptation restricts C₄ evolution in palms (Arecaceae) biorxiv.org 2026-07-27 C4 and CAM photosynthesis evolved repeatedly across angiosperms, yet the four palm species examined here - representing three of five Arecaceae subfam
Paralog diversification masks conserved diel regulatory programs during cold acclimation in Brassica rapa biorxiv.org 2026-07-27 Plant stress responses occur within daily cycles of physiology, metabolism, and growth, making timing a critical dimension of acclimation.
Comparative epigenomics across the barley pangenome links structural variation to regulatory genome function biorxiv.org 2026-07-27 Structural variants (SVs) are abundant in plant genomes and influence agronomic traits, yet their regulatory interpretation remains challenging.
Dynamic structural changes and inhibition of insect delta and epsilon glutathione S-transferases by ethacrynic acid and permethrin biorxiv.org 2026-07-27 Insect glutathione S-transferases (GSTs) play critical roles in xenobiotic detoxification and insecticide resistance, making them promising targets fo
The FKBP42, TWISTED DWARF1, prioritizes auxin over brassinosteroidtransport by peptidyl-prolyl cis-trans isomerization of ABCB1 biorxiv.org 2026-07-27 The ATP-binding cassette (ABC) transporter ABCB1 transports both auxins and the brassinosteroid brassinolide (BL).
MeFluHyA: a novel fluorescent screening tool for high-throughput identification of HDAC6-selective inhibitors biorxiv.org 2026-07-27 The cytosolic histone deacetylase 6 (HDAC6) plays a key role not only in cancer but also in neurodegenerative diseases, including amyotrophic lateral
Cerclage Wire as an Affordable Alternative for Internal Fixation in Murine Critical Sized Defect Models biorxiv.org 2026-07-27 Critical sized defects (CSDs) are a serious challenge in orthopedics that require the development of more robust and effective treatments to improve q
Surface-stabilized sub-micron condensates for compartmentalizing synthetic cells and enhanced enzyme kinetics biorxiv.org 2026-07-27 Living cells harbor numerous membraneless organelles (MOs), which are dynamic protein/nucleic acid assemblies responding to specific physicochemical t
Cryoaerosolization Enables Scalable Vitrification-Based Cell Cryopreservation biorxiv.org 2026-07-27 Cell therapies hold transformative potential for treating cancer, neurologic disorders, organ failure, diabetes, and other conditions, but their wides
Total Synthesis of Self-Assembling Semi-Synthetic Proteins Utilizing a Dendritic Solubility Tag biorxiv.org 2026-07-27 The chemical synthesis of well-defined, self-assembling semi-synthetic proteins (SSPs) has attracted growing interest in recent years.
Predictive Feature Engineering for Stress Detection using Physiological Signals, A Comparative Study biorxiv.org 2026-07-27 This paper presents a two-stage pipeline for implicit feature engineering in time series-based physiological stress detection using electrodermal acti
Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial Cancer biorxiv.org 2026-07-27 Endometrial cancer (EC), the most common gynecologic malignancy in the USA, has seen limited improvement in patient outcomes over recent decades, unde
Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment biorxiv.org 2026-07-27 Clear cell renal cell carcinoma (ccRCC) is driven by persistent HIF-2[alpha]; transcription program initiated by VHL loss, yet molecular mediators sus
Functional diversification of UBP6 in plant immunity through N-degron pathway regulation biorxiv.org 2026-07-27 Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modificat
PWO1 and TRB proteins coordinate chromatin regulation to prevent premature differentiation and ectopic lignin deposition in Arabidopsis biorxiv.org 2026-07-27 The Arabidopsis PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 (PWO1) and Telomere Repeat-Binding Proteins 1-3 (TRB1-3, TRBs) associate with distinct and shared
Functional Deorphanization and Subtype-Selective Pharmacology of Three Tyramine Receptors in the Disease Vector, Aedes aegypti biorxiv.org 2026-07-27 Biogenic amines such as tyramine (TA) and octopamine (OA) are central regulators of insect physiology and behaviour, acting through G protein-coupled
From whole-slide histology to ADC maps: Fast diffusion MRI simulation with neural operators biorxiv.org 2026-07-27 Background and Objective: Simulation of diffusion MRI signals from tissue microstructure is a fundamental problem in quantitative imaging, as it enabl
Humans Modulate Walking Speed in Response to the Perceived Energy-Time Costs of Others biorxiv.org 2026-07-27 Humans tend to walk at speeds that minimize energy expenditure and time duration.
The Live Concert of Brains: Performer-Audience Neural Coupling Links Ensemble Coordination to Shared Audience Integration biorxiv.org 2026-07-27 Collective social events often require coordinated action by one group to become shared experience in another, yet how this transformation is organize
Capturing the developing brain in motion: A practical tutorial for recording mobile EEG in naturally moving children biorxiv.org 2026-07-27 This tutorial seeks to facilitate the use of mobile electroencephalography (EEG) in young chil-dren.
Chronic stress does not induce behavioural signs of tinnitus or cochlear synaptopathy in Mongolian gerbils biorxiv.org 2026-07-27 Tinnitus is commonly associated with psychosocial stress.
Preprocessing Decisions Affect the Precision of P50 Estimates in the Paired-Click Paradigm biorxiv.org 2026-07-27 Sensory gating is commonly indexed by suppression of the auditory P50 component in the paired-click paradigm.
Dynamism in paintings and photographs: how the power of diagonals in art overcomes the oblique effect in visual perception biorxiv.org 2026-07-27 Artists and photographers use diagonals to convey dynamism, tension and instability in naturalistic and abstract images.
Role of leg campaniform sensilla sensory feedback in Drosophila melanogaster adaptive walking biorxiv.org 2026-07-27 With the newly uncovered access to a genetic line labeling all campaniform sensilla in Drosophila melanogaster and the many insights gathered from lar
A Portable Fluorescence Platform for Decentralized One-Health mcr-1 Monitoring biorxiv.org 2026-07-27 Antimicrobial resistance (AMR) represents a major global health threat, with plasmid-borne mcr genes driving colistin resistance and exposing critical
Rapid motility arrest of the Lyme disease spirochete, Borrelia burgdorferi, by vaccine-induced OspA antibodies biorxiv.org 2026-07-26 Outer surface protein A (OspA)-based Lyme disease vaccines elicit antibodies that inhibit transmission of infectious Borrelia burgdorferi spirochetes
A GSK3-dependent phosphorylation switch licenses BNIP3-mediated mitophagy biorxiv.org 2026-07-26 The turnover of mitochondria through mitophagy is essential for maintaining mitochondrial function and matching mitochondrial content to cellular dema
IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity biorxiv.org 2026-07-26 Tuft cells initiate intestinal type 2 immunity, yet the mechanisms that restrain excessive tuft cell activation remain poorly understood.
Sialyl-Tn-positive tumour-derived extracellular vesicles impair dendritic cell function via horizontal transfer of glycans biorxiv.org 2026-07-26 The sialyl-Tn (STn) glycan antigen is aberrantly expressed in a subset of triple-negative breast cancer (TNBC) and is associated with poor prognosis a
H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodies biorxiv.org 2026-07-26 Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses are currently responsible for a multi-species outbreak affecting wild birds, poultry, nu
Anti-Z-NA antibodies can distinguish accessible Z-form states across DNA, RNA, and DNA-RNA substrates biorxiv.org 2026-07-25 Left-handed (Z-form) double-stranded nucleic acid conformers (Z-DNA and Z-RNA, collectively called Z-NA) are molecular patterns recognized by ADAR1 an
Modeling Parkinsonian Freezing and Deep Brain Stimulation Effects in a Basal Ganglia Network biorxiv.org 2026-07-25 he precise mechanism through which Deep Brain Stimulation (DBS) mitigates freezing episodes in Parkinson's disease remains unknown.
A Germinal Center-Independent Innate-Like Memory B Cell Compartment of B1 Origin biorxiv.org 2026-07-25 Memory B cells (MBCs) are a critical cellular reservoir for long-term humoral immunity.
Deletion of Ferritin Heavy Chain Limits Tumor Growth and Promotes Iron-Dependent Stress in Medulloblastoma biorxiv.org 2026-07-25 Iron is essential for tumor proliferation and metabolic adaptation but becomes cytotoxic when unbuffered, creating a potential metabolic vulnerability
Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors biorxiv.org 2026-07-25 Mucosal-associated invariant T (MAIT) cells sense riboflavin metabolites through the monomorphic antigen-presenting molecule MR1, providing a unique o
Generative replay across hippocampal-neocortical circuits biorxiv.org 2026-07-25 To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together.