jaxon: a differentiable, GPU-native simulator for peripheral-nerve fiber models biorxiv.org 2026-07-31 jaxon is an open-source, fully differentiable and GPU-native reimplementation of the canonical peripheral-nerve fiber models in JAX/Jaxley: the myelin
The Capillary endothelial cell-governed niche sustains angiogenesis in proliferating infantile hemangioma via multilayer stromal support biorxiv.org 2026-07-31 Infantile hemangioma (IH), the most common benign vascular tumor in infants, is characterized by the aberrant proliferation of hemangioma endothelial
A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related Schwannomatosis biorxiv.org 2026-07-31 Background: Previous exploratory studies identified recombinant human Neuregulin-1 {beta} (rhNRG{beta}1) as a promising therapeutic strategy for inhib
IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development biorxiv.org 2026-07-31 Despite considerable progress in elucidating mechanisms leading to castration-resistant prostate cancer (CRPC), insight into the early stages of prost
Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases biorxiv.org 2026-07-31 Purpose: Liver metastases confer poor outcomes and attenuate the benefit of immunotherapy across solid tumors.
Multiplex genome engineering in yeast using the TIGR-Tas system biorxiv.org 2026-07-31 Tandem Interspaced Guide RNA (TIGR)-TIGR-associated (Tas) systems are a newly discovered family of ultracompact, modular RNA-guided DNA-targeting prot
The rabies virus interferon antagonist P protein selectively modulates interferon signalling to inhibit antiviral gene expression while supporting proviral gene expression biorxiv.org 2026-07-31 Type-I IFNs mediate the principle antiviral response of cells by controlling the expression of hundreds of IFN-regulated genes (IRGs), many of which h
Apparent survival suggests the female-biased dispersal in a truly subterranean rodent, Ellobius talpinus biorxiv.org 2026-07-31 Adult sex ratios in mammals are usually female-biased, but the northern mole vole (Ellobius talpinus) (Pallas, 1770), a cooperatively breeding subterr
A comprehensive HA-tagged PRC1 toolkit enables standardized chromatin profiling and proteomic analysis in Drosophila melanogaster biorxiv.org 2026-07-31 Polycomb group (PcG) proteins are evolutionarily conserved epigenetic regulators that maintain transcriptional states during development and are frequ
Switch-TRIBE: Lineage-specific high-resolution profiling of endogenous RNA-protein interactions biorxiv.org 2026-07-30 RNA-binding proteins (RBPs) play vital roles in regulation of cell fate and function.
Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling biorxiv.org 2026-07-30 Post-translational modifications (PTMs) diversify neuropeptide function, yet how minimal modifications encode receptor specificity without direct cont
Analysis of the conformational dynamics of amylose oligomers using molecular dynamics simulations biorxiv.org 2026-07-30 Amylose contributes to starch crystallinity, but the stability of packed amylose double helices in water at elevated temperature remains insufficientl
Sequence-dependent Stability and the Apparent Two-state Thermal Transition of Extended Collagen Triple Helices biorxiv.org 2026-07-30 The thermal stability of collagen triple helices is strongly influenced by the amino acid sequence of the repeating Gly-X-Y tripeptides, yet how these
The lncRNA SOX2OT Drives Non-Small Cell Lung Cancer Progression and Metastasis by Suppressing miR-143 biorxiv.org 2026-07-30 In terms of cancer-related death, non-small cell lung cancer (NSCLC), the world's leading cause, highlights the need for continued research into the g
Consequences of Early Postnatal Blockade of Aldosterone Synthesis on Behaviour and Stress Response in Male and Female Rats biorxiv.org 2026-07-30 Aim: The aim of the present study was to determine whether pharmacological inhibition of aldosterone synthesis during the stress-hyporesponsive period
Scale-dependent spatial organisation of action observation network responses to hand actions and emotional faces biorxiv.org 2026-07-30 Human social perception relies on multiple visual signals, including object-directed actions and emotional facial expressions.
Opposing modulation of cortical and corticospinal excitability across movement-related beta stages biorxiv.org 2026-07-30 Discrete voluntary movement depends on rapid changes in neural excitability across cortical and corticospinal circuits, yet how intrinsic movement-rel
Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis biorxiv.org 2026-07-30 Objective In the first year after onset of the autoimmune disease RA (RA), 40-60% do not achieve remission on conventional synthetic disease-modifying
Larval habitat bacteria emit volatile semiochemicals that modulate oviposition site selection in the malaria vector Anopheles gambiae (Diptera: Culicidae) biorxiv.org 2026-07-30 Background: Larval habitat management is increasingly recognized as a complementary strategy for malaria vector control.
Image-based transposon screening reveals a flavin reductase that restrains intracellular Salmonella replication in macrophages biorxiv.org 2026-07-30 Intracellular bacterial pathogens can survive and replicate within host cells, yet an isogenic population follows divergent fates: some bacteria are k
Nonlinear responses to temperature and precipitation shape the distribution of Aedes sierrensis in North America biorxiv.org 2026-07-30 Understanding the ecological determinants of species ranges is a central goal of ecology.
Experimental evidence for female choice in an angiosperm biorxiv.org 2026-07-30 Female choice is a central process of sexual selection that has shaped numerous phenotypes in animals.
Evolution of endogenized densoviral elements across aphid species biorxiv.org 2026-07-30 Endogenous viral elements (EVEs) are widespread across animal genomes, yet the processes governing EVE evolution and diversification remain poorly und
SRARec: A program for detecting recombination in sequencing reads and its application to uncover recombination patterns in SARS-CoV-2 and HIV-1 biorxiv.org 2026-07-30 The detection of recombination using consensus genome sequences has key limitations including failure to consider rare genetic variants and misidentif
Skiaviridae: a large DNA virus family that persistently infects thraustochytrid protists biorxiv.org 2026-07-30 Genomic and metagenomic sequencing has transformed our understanding of the diversity of large DNA viruses infecting eukaryotic microorganisms.
A Thermodynamically Consistent Reaction--Diffusion Model of Spatial Proofreading in One and Two Dimensions biorxiv.org 2026-07-30 Spatial proofreading is a mechanism that can enhance molecular discrimination by exploiting nonequilibrium diffusive transport between spatially separ
Tunable kinetic destabilization governs RNA polymerase passage through a DNA-bound transcription factor biorxiv.org 2026-07-30 Eukaryotic transcription factors recognize short motifs, creating abundant binding sites within gene bodies and potential collisions with elongating R
Genomic alterations enable BRCA1 methylation loss and promoter bypass to drive resistance in high-grade serous ovarian cancer biorxiv.org 2026-07-30 BRCA1 promoter methylation predicts sensitivity to PARP inhibitors in high-grade serous ovarian cancer, yet therapeutic resistance is common and mecha
Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma biorxiv.org 2026-07-30 Immune checkpoint blockade (ICB) therapies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become
Steady state ratios in bipartite population models emerge through obligate cross-feeding biorxiv.org 2026-07-30 Cross-feeding, the phenomenon where one organism consumes metabolites secreted by another, is a ubiquitious phenomenon in microbial communities.
Hypothalamic oligodendrocytes regulate systemic energy balance through Notch-dependent state transitions biorxiv.org 2026-07-31 The central mechanisms through which glial cells regulate whole body metabolism remain poorly understood.
A Neurotensin Brake on Exploratory Drive under Persistent Threat biorxiv.org 2026-07-31 Avoidance behavior is an adaptive response that delays exploration to promote survival.
Impaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndrome biorxiv.org 2026-07-31 Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene and characterized by profo
Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence biorxiv.org 2026-07-31 Youth adversity has been associated with alterations in hippocampal structure; however, it remains unclear whether different forms of adversity relate
Synaptic engram underlies memory biorxiv.org 2026-07-31 Memory encoding cells, or engram cells, are sparsely distributed across the brain.
Ephaptic coupling improves the neural population code biorxiv.org 2026-07-31 Neurons share an extracellular medium, so every spike's current sets up a local field that feeds back onto the membrane potential of nearby cells, an
Loss of neurofibromin alters adult metabolism via effects during a developmental critical period biorxiv.org 2026-07-31 Metabolic alterations commonly accompany neurodevelopmental disorders and may contribute to their pathophysiology.
Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling biorxiv.org 2026-07-31 The mammalian brain's long-term memory circuits integrate information from prior and new experiences.
White matter conduction in the human brain is mostly slow, with rare high velocity connections biorxiv.org 2026-07-31 White matter bundles play a crucial role in cognitive functions by rapidly transmitting information between brain regions.
A Bayesian Study to Optimally Unveil LDH Kinetic Mechanisms In Vivo biorxiv.org 2026-07-30 Many life-threatening diseases present characteristic changes in metabolic profiles throughout their progression.
Transcript-Specific Site-Directed RNA Editing Reveals Principles for Splice-aware guide RNA Design biorxiv.org 2026-07-30 Site-directed RNA editing (SDRE) utilizing the adenosine deaminase acting on RNA (ADAR) enzymes is commonly facilitated by guide RNAs (gRNAs) optimize
Structural determination of human nucleosomes reconstituted by the ExACT platform biorxiv.org 2026-07-30 The structure and function of eukaryotic chromatin have been extensively studied using conventional salt dialysis-based nucleosome assembly, which has
Exploring the molecular function of metabolites identified in Elite Controllers and their role in epithelial integrity and immune regulation biorxiv.org 2026-07-30 Despite advances in treatment, HIV-1 infection continues to remain a major global health challenge, prompting ongoing efforts to understand the mechan
Gata.a, Tbx21, and Klf6/7 function cooperatively for zygotic genome activation in ascidian embryos biorxiv.org 2026-07-30 In ascidian embryos, gene expression from the zygotic genome begins between the 8- and 16-cell stages.
Complexity-multistability relationships: How does species diversity shape the number of alternative stable states? biorxiv.org 2026-07-30 Ecologists have long investigated how community complexity affects ecological stability, yet how community complexity influences multistability, defin
From introduction to eradication: reconstructing population size and removal history of an invasive species biorxiv.org 2026-07-30 1. Understanding the processes underlying successful eradication of invasive species is essential for achieving global island conservation goals.
Major microbiota transitions across liver disease progression are mediated by key taxa linking host environments and microbial communities biorxiv.org 2026-07-30 The gut microbiome plays a critical role in chronic liver disease, yet quantitative methods that integrate microbial community structure with clinical
Structural and functional insights into the role of Cysteine-Rich Receptor-Like Kinase 18 (CRK18) in Arabidopsis biorxiv.org 2026-07-30 Plants perceive and integrate diverse environmental signals through receptor kinase (RK) networks at the plasma membrane.
Culture enhanced MSCs to boost haematopoietic engraftment in a model of the post-leukaemic bone marrow niche. biorxiv.org 2026-07-30 Relapse remains a leading cause of treatment failure in acute myeloid leukaemia (AML), making haematopoietic stem cell transplantation (HSCT) the only
Demonstration of an Integrated Process for Manure-Based Nitrogen Recovery Using the Biopolymer Cyanophycin biorxiv.org 2026-07-30 The trend towards concentrated animal feeding operations (CAFOs) has served to concentrate not only livestock animals but the waste they produce to co