Asynchronous structural rearrangements govern constriction of the human nuclear pore complex biorxiv.org 2026-08-01 The nuclear pore complex (NPC) is responsible for transport between the cytoplasm and nucleus.
How a single sperm protein recognizes highly divergent egg coat components biorxiv.org 2026-08-01 For successful fertilization, sperm must recognize and penetrate the egg coat, called vitelline envelope (VE) or, in mammals, zona pellucida (ZP).
Maintenance of phenotypic divergence in two sympatric monkeyflowers with weak reproductive isolation biorxiv.org 2026-08-01 Sympatric species often exhibit permeable reproductive barriers, yet many of them coexist as phenotypically distinct entities.
Integrative genomics of the siphonophore Physalia utriculus reveals the regulatory logic of colonial division of labour and the molecular basis of venom activity biorxiv.org 2026-08-01 How a single genome gives rise to specialised multicellular individuals that function as an integrated organism remains a fundamental question in the
Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging biorxiv.org 2026-08-01 Aging is a primary risk factor for osteoarthritis (OA), yet the mechanisms that preserve extracellular matrix integrity in long-lived connective tissu
An Open-Source, Excitation-Resolved UV-NIR Imaging Platform for Bioluminescence, Luminescence-Decay, and Chemical Discrimination Measurements biorxiv.org 2026-08-01 Multispectral imaging is a cornerstone of chemical imaging, with bioluminescence, fluorescence, and phosphorescence imaging underpin much of preclinic
Stable and robust differentiation programs are predominantly irreversible biorxiv.org 2026-08-01 Multicellular differentiation programs are almost always irreversible, with cells rarely revisiting states observed during earlier developmental stage
FITdb, an Integrated Functional Immunogenomics and Transcriptomics Database biorxiv.org 2026-08-01 Genetic screens in immune cells enable the systematic interrogation of gene function at scale, uncovering key regulators of cell functions such as tum
Carbohydrate degradation machineries in lichen fungal symbionts reveal distinct symbiotic footprints across Ascomycota biorxiv.org 2026-08-01 Lichens--the archetypal symbiosis--have long been known for their nutritional relationship, in which the photoautotrophic partners subsidize the carbo
Sound-shape correspondences in macaques reveal evolutionary roots of sound symbolism biorxiv.org 2026-08-01 Humans reliably associate certain speech-like sounds with visual shapes, most notably in the Bouba-Kiki Effect, where rounded and spiky shapes are mat
Pangenome Graph Node-Phenotype Association shows GWAS-like quality results with only few individuals biorxiv.org 2026-08-01 Purpose: We introduce GraNPA, standing for Graph Node-Phenotype Associa- tion, a method performing a GWAS-like analysis on a pangenome variation graph
Millisecond-scale, single-neuron credit assignment in a songbird biorxiv.org 2026-08-01 Learning an adaptive behavior requires identifying which actions, in which contexts, lead to particular outcomes.
Disrupted Developmental Trajectory of Ultrasonic Vocalizations in a Rat Model of Fragile X Syndrome biorxiv.org 2026-08-01 Communication deficits are a defining feature of autism spectrum disorder (ASD) and among the earliest detectable markers of atypical neurodevelopment
Distinct transcriptomic and hierarchical organization associated with brain hyperconnectivity and hypoconnectivity in autism spectrum disorder biorxiv.org 2026-08-01 Functional hyperconnectivity and hypoconnectivity in autism spectrum disorder (ASD) are typically treated as opposing expressions of a single circuit-
Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk biorxiv.org 2026-08-01 Primates are distinguished by large brains relative to body size, with humans showing the greatest expansion.
Common schizophrenia heritability concentrates in an evolutionarily young, brain-regulatory subset of fine-mapped credible-set variants biorxiv.org 2026-08-01 Common variation explains a substantial fraction of schizophrenia heritability, yet why these risk alleles persist remains unresolved.
A TmaT-AftD interaction is required for the CmpL4 mycomembrane biogenesis pathway in Corynebacterium glutamicum. biorxiv.org 2026-07-31 Bacteria in the Mycobacteriales order like mycobacteria and corynebacteria surround themselves with a multilayered cell envelope.
Cpf1(Cas12a)-based genome editing in the filamentous cyanobacterium Nostoc punctiforme biorxiv.org 2026-07-31 The filamentous cyanobacterium Nostoc punctiforme is a key model organism used to study several aspects of cyanobacterial biology, including developme
Colistin resistance-mediated lipopolysaccharide modification in Klebsiella pneumoniae modulates host inflammatory response biorxiv.org 2026-07-31 Resistance to the polymyxin antimicrobial colistin in Gram-negative bacteria is associated with a modification of the immunogenic lipid A moiety of th
Direct targeting of the WAVE-regulatory complex and the actin cytoskeleton by the Anaplasma phagocytophilum effector, AnkA biorxiv.org 2026-07-31 The obligate intracellular tick-borne pathogen Anaplasma phagocytophilum is unusual in its tropism for neutrophils, within which it survives and repli
Effects of culture conditions on morphology and growth of Linderina macrospora (Kickxellomycotina, Kickxellales) biorxiv.org 2026-07-31 The obscure life histories of many kickxellalean genera remain a bottleneck for comprehensive taxon sampling and phylogenetic reconstruction of the or
Human cytomegalovirus UL2 is not required for lytic replication or viral latency and reactivation biorxiv.org 2026-07-31 Human cytomegalovirus (HCMV) remains a significant cause of morbidity and mortality in transplant patients and is a major cause of congenital disease.
Impact of Neurons on Group B Streptococcus Interactions at the Blood Brain Barrier biorxiv.org 2026-07-31 Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive opportunistic pathogen and the leading cause of neonatal bacterial meningitis
Two Amazon freshwater sponges, Drulia brownii and Tubella paulula, share a resilient microbiome strongly shaped by seasonality and urbanization biorxiv.org 2026-07-31 Sponges are among the earliest-diverging metazoans, and their evolutionary success has been strongly linked to their symbiosis with microorganisms.
A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut-Brain, and Gut-Liver Signaling biorxiv.org 2026-07-31 Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communica
Trypanosoma congolense Variant Surface Glycoprotein gene expression occurs in the absence of monoallelic transcription control biorxiv.org 2026-07-31 Antigenic variation is a very widespread process for pathogen evasion of mammalian adaptive immunity, involving the continuous change of exposed antig
Microbial colonization establishes stratified radial niches that coordinate host epithelial and immune maturation in the colon biorxiv.org 2026-07-31 Microbial colonization is essential for intestinal maturation, yet how spatial organization of the microbiome shapes host tissue function remains unre
A panel of biologically contained orthoebolaviruses for the screening of broad-spectrum antivirals biorxiv.org 2026-07-31 Filoviruses, particularly those of the Orthoebolavirus genus, pose ongoing public health threats due to their increasing frequency and geographic spre
Antibiotic Resistomes And Microbial Communities In The 18th-Century Urban Settlement And Slaughterhouse Environment biorxiv.org 2026-07-31 Antimicrobial resistance (AMR) is an ancient and natural phenomenon, yet it now poses a critical threat to global health.
Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections biorxiv.org 2026-07-31 Trypanosoma brucei exploits an extreme form of antigenic variation to escape the mammalian immune response.
Genomics and biogeography of novel Trichodesmium isolates from the Sargasso Sea biorxiv.org 2026-07-31 The cyanobacterium Trichodesmium is important in ocean nitrogen (N) and carbon (C) biogeochemistry through fixation of N2 gas and CO2 into NH3, amino
A c-di-AMP-controlled glutamine synthesis pathway promotes persistence of Staphylococcus aureus thymidine-dependent small colony variants in the lung biorxiv.org 2026-07-31 Children with cystic fibrosis (CF) commonly harbor Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs), which are associated wit
A Comparative Chemical-Genetic Screen Reveals Divergent Roles for Host ALK2 Signaling Across Intracellular Bacterial Niches biorxiv.org 2026-07-31 Diverse vacuolar architectures present unique signaling challenges for intracellular bacteria, yet whether distinct niches share host requirements rem
Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomics biorxiv.org 2026-07-31 Most of our knowledge about bacterial functional roles in microbiomes comes from bulk measurements.
Intrinsic flexibility of Type VII secretion central pore is required for substrate translocation biorxiv.org 2026-07-31 Mycobacteria have up to five distinct type VII secretion pathways that play diverse roles in the cell ranging from iron uptake to virulence.
Compositional Heterogeneity Structures Microbial Microhabitats across Distinct Mineral Substrates biorxiv.org 2026-07-31 Microbial communities living on and in rocks operate at the microscale, where interactions with minerals fundamentally shape community structure and f
ALDH3A2 acts as a metabolic safeguard that regulates sphingolipid metabolism to suppress DNA damage and cell death biorxiv.org 2026-07-31 Highly reactive aldehydes are generated during metabolic processes in the body, and their detoxification is essential for maintaining cellular homeost
Environmental monitoring for pathogen detection in zebrafish housing systems using molecular techniques: A 3Rs principles-based approach biorxiv.org 2026-07-31 Health monitoring is essential to ensure laboratory animal welfare and the reliability of experimental data in zebrafish research facilities.
A modular platform for scalable recombinant production of highly toxic bacterial proteins biorxiv.org 2026-07-31 Bacterial protein toxins constitute a vast and largely untapped reservoir of antimicrobial activities with substantial therapeutic and biotechnologica
A Structural Antibody Benchmark of AlphaFold3 reveals Hallucinated Epitopes and a Bias for Orderness biorxiv.org 2026-07-31 AlphaFold3 has shown promise as a tool for predicting antibody-antigen binding, yet its performance across large datasets has not been fully character
Evaluating Protein Language Model Embeddingsfor Structural Similarity in the Protein-Sequence Twilight Zone biorxiv.org 2026-07-31 Evaluating protein sequence similarity remains challenging in the protein-sequence twilightzone (20-35% sequence identity), where traditional methods
Fast remote nucleotide sequence alignment with Riboseek biorxiv.org 2026-07-31 Structure prediction has reached RNA, where generating deep alignments is now the bottleneck.
Dengue virus 2 lacking N153 glycosylation displayed enhanced recognition by neutralizing antibodies biorxiv.org 2026-07-31 Deglycosylated (N153Q) dengue virus (DENV) mutant shows attenuated infection in a mouse model, mainly due to its increased antibody susceptibility.
Competing Molecular Interactions Govern the Dynamical Arrest of G3BP1 Condensates biorxiv.org 2026-07-31 G3BP1 is a central scaffold of stress granules (SGs).
Hydrogel-enhanced bioelectrochemical nitrate reduction for ammonium recovery from dilute nitrate via Shewanella oneidensis MR-1 biorxiv.org 2026-07-31 Bioelectrochemical reduction of dilute nitrate (NO3-; sub-mM to low-mM range) to ammonium (NH4+) offers a promising route toward circular nitrogen man
Defining strain variation in the maintenance of Borrelia turicatae during hyperparasitism and transovarial transmission in Ornithodoros turicata biorxiv.org 2026-07-31 Abstract: Tick-borne relapsing fever (TBRF) spirochetes are maintained in nature through vector-associated transmission routes primarily in argasid ti
Multiomic Integration Reveals Transposable Element-Embedded Regulatory Variants Underlying Brain Aging biorxiv.org 2026-07-31 Genome-wide association studies (GWAS) have identified thousands of variants associated with brain aging, most in noncoding regions whose regulatory e
Wearable magnetoencephalography in an open environment biorxiv.org 2026-07-31 A long-standing goal of neuroscience is to observe the human brain as it functions in natural and real-world environemnts, where people interact and e
MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes biorxiv.org 2026-07-31 Summary: Ancient DNA studies are increasingly targeting samples that are beyond the limit of radiocarbon dating (>50 thousand years old) and are of
ChemoCalib: multiblock PLS calibration of genome-scale metabolic models improves flux prediction over expression-only integration biorxiv.org 2026-07-31 Constraint-based metabolic modeling (FBA) needs multi-omics integration to narrow flux solution spaces, yet existing expression-only methods (E-Flux,