ConvergeCELL: An end-to-end platform from patient transcriptomics to therapeutic hypotheses biorxiv.org
Cephalo-pelvic covariation and sexual dimorphism are disrupted in hybrid mice: implications for the human obstetrical dilemma biorxiv.org
Alzheimer's Disease Risk Allele APOE4 Interacts with Arsenic Exposure to Drive Microglial Dysfunction biorxiv.org
The distinct role of actin isoforms on mechanosensing-based maturation of hiPSC-derived neurons unveiled by isoform-specific mutations biorxiv.org
An fMRI dataset of verbalized spontaneous thought with annotated transcripts and self-report trait measures biorxiv.org
Role of GABA and NMDA receptors in shaping cortical timescales and large-scale network dynamics biorxiv.org
Nucleolus transformation and Pol1 activity pattern dual transcriptomes of neuronal subtype identity biorxiv.org
Single-cell Transcriptomics Analyses Reveal Specialized Microglial Subsets with Oligodendrocyte-like Signatures biorxiv.org
Reversible in vivo regulation of drug metabolizing enzyme CYP1A2 activity through a dTAG knock-in strategy biorxiv.org
CardioSafe: Multi-task prediction of cardiac ion channel activity with reverse-leak audited benchmarking biorxiv.org
Enhanced processing of cartoons in infant visual cortex biorxiv.org Developing sensory systems may have heightened sensitivity to exaggerated features that emphasize diagnostic information, as shown by the benefits of
Semantic category and presentation frequency-based expectations are associated with distinct neural prediction effects. biorxiv.org
From flexible to anticipatory processing: alpha and beta oscillatory signatures of feedback-guided strategy adaptation and memory updating biorxiv.org
Developmental Bioenergetic Reprogramming and Glycolytic Shift in Schizophrenia Vulnerability biorxiv.org
Mapping Individualized Developmental Imbalance in Youth and Its Association with Psychopathology biorxiv.org
Evolutionary insights into bilin biosynthesis: Functional characterization of pre-PcyA enzymes biorxiv.org
Autistic Traits are Associated with Suboptimal Decision Bias Strategies in Subsecond Timing biorxiv.org Time perception difficulties are frequently reported in Autism Spectrum Disorder, yet empirical findings remain inconsistent.
A nucleotide-triggered molecular switch orchestrating septin polymerization biorxiv.org Septins are conserved cytoskeletal GTP-binding proteins that form higher-order structures critical for cytokinesis and polarized growth across opistho
Quinone reductase 2 dimerization is dynamically driven by ligand binding biorxiv.org Human quinone reductase 2 (QR2, NQ02) is a cytosolic flavoprotein involved in cell physiology and metabolism, and implicated in several diseases.
A bare host cell membrane with minimal glycocalyx is an optimal surface for targeting by virulence-primed Salmonella Typhimurium biorxiv.org Gut pathogens such as Salmonella enterica serovar Typhimurium target intestinal epithelial cells for adhesion and type-3-secretion-system-dependent in
Shared early impairments of medial entorhinal cortex function across distinct Alzheimer's disease etiologies biorxiv.org The medial entorhinal cortex (MEC) harbors diverse spatially and object-tuned cell types essential for spatial coding and episodic memory, and is amon
Hippocampus single-nucleus transcriptomics reveals coordinated regulation of social and spatial representation development by perinatal SERT expression in CA3 pyramidal neurons biorxiv.org The hippocampal formation (HPF) provides neural substrates integrating disparate sensory cues into episodic memories and coherent action.
Modulating supplementary motor area excitability enhances groove-related pleasure during music listening biorxiv.org Pleasurable urge to move to music is often referred to as groove.
SLD5/GINS4 controls dynein-dependent centrosome maturation and exposes a candidate mitotic vulnerability in cancer. biorxiv.org
Hero11 Unlocks TDP-43 Condensate Fluidity via Targeting Inter-Helical Interactions biorxiv.org Biomolecular condensates formed by intrinsically disordered proteins (IDPs) rely on a balance of sequenceencoded interactions and secondary-structure
A novel mouse model of rare neurodevelopmental disorder, TBCK Syndrome biorxiv.org TBCK Syndrome is a rare Mendelian disorder caused by variants in the TBCK gene.
Integrated Metagenomics and Metabolomics Studies Reveal Core Bacterial Guild Regulating Carbohydrate Metabolism in Pediatric MASLD biorxiv.org
Anchored for action: a dual role for integrin β1 in mast cell perivascular positioning and vasoactivity to license leukocyte recruitment biorxiv.org
Programmable DNA Origami Caps for Site-Selective Functionalization of Microtubule Tips and Lattice Defects biorxiv.org
Molecular characterization of the effector-immunity pair Rhs2-SciX from Salmonella Typhimurium biorxiv.org
Patterns of association between mothers and offspring and their outcomes in a polygynous ungulate biorxiv.org
From diminishing returns to entrenchment: a unifying theory of epistasis along adaptive walks revealed by Fisher's geometric model biorxiv.org
A Multi-Scale Ecological Approach to Assessing Antimicrobial Resistance in a Freshwater Fish biorxiv.org
Multi-locus metabarcoding and intensive sampling reveal extraordinary diversity carried in the ballast water of a single vessel biorxiv.org
In mice, a population of male germ cells show characteristics of non-apoptotic cell death during G0 arrest biorxiv.org
Liver sinusoidal endothelial cells integrate metabolic and immune signals for MAPK-dependent BMP6 regulation and hepcidin induction biorxiv.org