Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-relateddisorders biorxiv.org
Systematic toxicological study of PFOS/PFOA co-exposure driving prostate cancer: Core target identification, TME immune remodeling, and combination drug prediction biorxiv.org
CausalKnowledgeTrace: A Novel Computational Framework for Automated Literature-Based Causal Graph Construction and Evidence-Based Variable Selection in Biomedical Research biorxiv.org
BatchVaria: a variance-aware framework for evaluating batch correction in high-dimensional omics data biorxiv.org
A novel vaccine and drug targets for global eradication of bovine tuberculosis: Holistic frameworks for construction of a potent vaccine and identification of drug targets biorxiv.org
TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection biorxiv.org
Spatially resolved transcriptomic and proteomic profiling reveals cell interaction programs that predict Barrett's esophagus progression biorxiv.org
Interlayer Communication Integrates Genetic and Mechanical Signals for Robust Leaf Morphogenesis biorxiv.org
Additive manufacturing of PEDOT:PSS electrodes on collagen substrates for soft and bioactive electronics biorxiv.org
Transcriptomic profiling of embryo-derived cell lines from the Chagas disease insect vector Rhodnius prolixus biorxiv.org
Pericentromeric repeat copy number tunes heterochromatin dosage to control chromosome segregation and gene expression in fission yeast biorxiv.org
Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity biorxiv.org
Size-dependent nucleus-vacuole interactions in budding yeast demonstrate a role for steric packing in organelle shape and positioning biorxiv.org
C57BL/6 BAC-CAG Huntingtons disease mice show somatic CAG expansion and responses to small interfering RNAs comparable to the FVB strain biorxiv.org
Collagen targeting IL-12 combined with Doxorubicin enhances the anti-tumor effect against osteosarcoma biorxiv.org
Modeling Post-Implantation Mammalian Embryogenesis Using Advanced In Vitro Systems: From Mice to Humans pubmed.ncbi.nlm.nih.gov
Moral equivalence and the grounds of moral status in stem cell-derived embryo models: a response to de Graeff and De Proost pubmed.ncbi.nlm.nih.gov
Beyond integration: towards benchmarks for developmental potential in human stem cell-derived embryo models pubmed.ncbi.nlm.nih.gov
Stem Cell-Derived Embryo Models: Potential Platforms for Investigating Early Development and Embryotoxicity pubmed.ncbi.nlm.nih.gov
Protocol for lattice light-sheet time-lapse imaging of early post-implantation mouse embryos pubmed.ncbi.nlm.nih.gov
A post-implantation model of human embryo development includes a definitive hematopoietic niche pubmed.ncbi.nlm.nih.gov
On the moral (in)equivalence of human embryos and stem cell-derived embryo models pubmed.ncbi.nlm.nih.gov
AI-based approach to dissect the variability of mouse stem cell-derived embryo models pubmed.ncbi.nlm.nih.gov
Using Embryo Models to Understand the Development and Progression of Embryonic Lineages: A Focus on Primordial Germ Cell Development pubmed.ncbi.nlm.nih.gov
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development pubmed.ncbi.nlm.nih.gov
Assembly of complete mouse embryo models from embryonic and induced stem cell types in vitro pubmed.ncbi.nlm.nih.gov
Synthetic Embryos Can Complete Gastrulation and Initiate Organogenesis Ex Utero pubmed.ncbi.nlm.nih.gov
Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy pubmed.ncbi.nlm.nih.gov
Stereomicroscopic and histological examination of bovine embryos following extended in vitro culture pubmed.ncbi.nlm.nih.gov
Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus, improves sperm motility and fertilization in different mammalian species pubmed.ncbi.nlm.nih.gov
Blastocysts derived from adult fibroblasts of a rhesus monkey ( Macaca mulatta) using interspecies somatic cell nuclear transfer pubmed.ncbi.nlm.nih.gov
The immunogenicity and efficacy of intranasally or parenterally administered replication-deficient vaccinia-parainfluenza virus type 3 recombinants in rhesus monkeys pubmed.ncbi.nlm.nih.gov