Cannabidiol confers neuroprotection against 6-OHDA toxicity by rescuing Nrf2 proteostasis and preserving mitochondrial integrity biorxiv.org
Targeting COL4A1-Related Small Vessel Disease: Repurposed Pharmacotherapies for Genetic Vasculopathies biorxiv.org
The +1 nucleosome functions in Pol II transcription initiation and the transition to elongation biorxiv.org
The nuclear structural protein NuMA is required for efficient DNA replication by ensuring association of core replication factors to replication forks biorxiv.org
Activity of a three-phage combination against Mycobacterium tuberculosis in disease-relevant conditions biorxiv.org
Targeting PTRAMP-CSS potently inhibits P. falciparum across blood, liver and mosquito stages biorxiv.org
Chemosensory landscape of order Vibrionales: Genome-scale phylogenomics uncovers four chemosensory architectures driven by bipartite genome organization biorxiv.org
The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages biorxiv.org
Presynaptic GABAA Receptors Mediate Ethanol-Induced Suppression at a Central Auditory Synapse biorxiv.org
Differential Roles of PFDN5 Isoforms in Head and Neck Squamous Cell Carcinoma: Insights from Proximity Interactome Mapping biorxiv.org
Human Sperm-Induced Cell-Cell Fusion Requiring JUNO (hSPICER): A paradigm shift to test sperm fertilizing potential biorxiv.org
Stoichiometry-dependent specificity in biotin enrichment: a benchmarking framework for proximity labeling proteomics biorxiv.org
Cosine Similarity Conflates Clinically Distinct Cancer Variants: A Case for Typed-Graph Retrieval in Precision Oncology Decision Support biorxiv.org
Microphysiological Flow Batteries For Dynamic EDC Screening Of mESC-derived Thyroid Organoids biorxiv.org
ParSeek: Accurate cryo-EM particle picking with a deep learning model trained on synthetic data biorxiv.org
Principles of Local and Global Grouping that Underlie Segmentation of Natural Texture Images biorxiv.org
Angiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells. biorxiv.org
Facility-Scale Workflows for Data Acquisition, Standardization, Machine Learning Analysis, and Reproducible Science biorxiv.org
The astrocyte-enriched gene Tmem44 regulates circadian protein translation in mouse astrocytes biorxiv.org
Predicting Discrete Structural Transformations in Small Molecules from Tandem Mass Spectrometry biorxiv.org
A fine-tuned genomic language model adds complementary nucleotide-context information to missense variant interpretation biorxiv.org
sxRaep: A Rapid and Accurate Enzyme Predictor for high-throughput mining of enzymatic sequences biorxiv.org
G-SPRI: A Structure-Centric Graph Model for Comprehensive Prediction of Cancer Driver Events from Missense Mutations biorxiv.org
A mechanistic framework for photon-to-carbon efficiency: coupling photosynthetic energy supply and light respiration in microalgae biorxiv.org
Hydrological balance of a subalpine forest and the effects of fog presence and forest age biorxiv.org
Energetic benefits of differential migration strategies shift under climate change for a migratory bird biorxiv.org
Low-self-reactive, circulation-biased blood regulatory T cells sense danger-associated nucleotides to restrain atherosclerosis biorxiv.org
Homeostatic feedback model of energy metabolism with adaptive enzyme levels exhibits problem solving behavior biorxiv.org 2026-05-11 Metabolic networks are typically viewed as homeostatic systems that stabilize flux, energy charge, redox balance, and metabolite availability under pe
Dynamics of feeding behaviour and meal patterning in protein-restricted mice biorxiv.org 2026-05-11 Of the three dietary macronutrients, protein plays an especially pivotal role in physiological functions.
Comparative Analysis of In-Ear and On-Head EEG for Sports Applications biorxiv.org 2026-05-11 This paper presents experimental evidence that alpha-band EEG signals can be reliably detected from an in-ear electrode during physical activity, enab
Test-retest reliable and site-robust Hidden Markov Model framework for discovering whole-brain beta activity biorxiv.org 2026-05-11 Sensorimotor beta activity (13-30 Hz) is a key neuronal signature in the human sensorimotor system, and its features can be effectively measured using
Inferotemporal Cortex Joins the Circuit Before the Code: Non-Serial Inter-Area Synergy in the Macaque Ventral Stream biorxiv.org 2026-05-11 The ventral visual stream is widely modeled as a serial feedforward hierarchy in which V1, V4, and IT population codes develop sequentially during obj
Goals as dynamical attractors: a momentum-based account of stable and flexible goal commitment biorxiv.org 2026-05-11 Human goal pursuit is often marked by persistent activity toward achieving an objective, as well as flexibility in switching objectives based on envir