Ascending inputs to inferior colliculus subdivisions reveal pathway-specific hybrid organization in the external cortex biorxiv.org
Computer experimentation on E. coli ammonium transport and assimilation reveals mechanisms for energy coupling, balanced futile cycling, and robust growth biorxiv.org
Efficient Bayesian inference for ordinary differential equation models from experimental data with uncertain measurement times biorxiv.org
Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon biorxiv.org The human airway epithelium (HAE) is composed of diverse cell types that coordinate essential functions and host defenses.
Chorismate and isochorismate turnover reveal hidden dynamics of aromatic metabolism in Arabidopsis biorxiv.org
HAIRpred2: Human Host-Specific Prediction of Antibody-Interacting Residues Using Hybrid Physicochemical and Structural Features biorxiv.org
A transgenic zebrafish for direct optogenetic activation of FGF/ERK signaling biorxiv.org Dynamic FGF/ERK signaling plays key roles in development, regeneration, and disease.
Shared roles and team membership are reflected in functional connectome similarity: Neural evidence from real-world volleyball teams biorxiv.org In task-oriented teams, long-term coordination among specialized roles may contribute to shared patterns of cognition and behavior, yet little is know
Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome biorxiv.org
Benthic diatoms navigate shear flows via hydrodynamic rolling and active gliding biorxiv.org Navigating fluid flow is a fundamental challenge for microbial life across diverse aquatic environments.
Dual curvature sensing governs cell orientation and curvotaxis biorxiv.org Cells lying in a curved environment can respond to the surface curvature by reorienting their shape.
Frequency-Dependent Modulation of Adult Hippocampal Neurogenesis, Memory, and BDNF Signaling by Low-Intensity Focused Ultrasound biorxiv.org Adult hippocampal neurogenesis plays a central role in learning, memory formation, and adaptive neural plasticity, making it an attractive target for
Ultrasound-led stratification of carpal tunnel syndrome reveals structure-function mismatch biorxiv.org The severity stratification of carpal tunnel syndrome (CTS) relies on ultrasound morphological markers and electromyography.
Sequence-Defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery biorxiv.org Oligonucleotide therapeutics hold transformative potential, yet their clinical translation is hindered by delivery barriers, including rapid renal/hep
A Multi-Omics Atlas of Naturally Occurring Myelomeningocele in a Large-Animal Model Reveals Heritable Architecture. biorxiv.org Neural tube closure relies on tightly coordinated morphogenetic programs integrating convergent extension, apical constriction of the neuroepithelium,
Coevolution and synchronized evolutionary rates in aphid dual endosymbiosis biorxiv.org Many insects depend on obligate endosymbionts for their nutrition.
Whole body elongation drives coordinated vertebral shape evolution in Lake Malawi cichlid fishes biorxiv.org
Phenotypic integration and morph-specific strategies in a colour-polymorphic lizard, Ctenophorus pictus. biorxiv.org
Remote underwater photographs reveal environmental correlations and patterns in reef manta ray habitat use in Laamu Atoll, Maldives biorxiv.org
Naked antisense oligonucleotides remain endolysosomally sequestered despite induced membrane damage biorxiv.org
Exosome-like biogenesis from the Golgi releases extracellular vesicles lacking conventional tetraspanins that mediate immune evasion in cancer biorxiv.org
RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed bymultiplexed optogenetics and biosensor imaging biorxiv.org
GRK-dependent ACKR3 endocytosis and chemokine scavenging is independent of receptor phosphorylation and beta-arrestin biorxiv.org
Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport biorxiv.org
Endogenous network modeling reveals mechanisms of repair Schwann cell decline and potential recovery targets biorxiv.org
AAV tools enable functional modulation and readout of central and peripheral nervous systems in spiny mice biorxiv.org
Single-cell quantification of the iron-neuromelanin balance in dopaminergic neurons across the lifespan biorxiv.org
Metagenomics-enabled proteomics reveals how AMF and PSB co-inoculation reshapes tomato rhizosphere dynamics across growth stages biorxiv.org
Engineering a 3D Lung Co-culture Platform to Model Epithelial-Fibroblast Interactions in Pulmonary Fibrosis biorxiv.org
Divergent signaling profiles in mTOR gain-of-function Smith-Kingsmore syndrome (SKS) and TSC2 deficiency biorxiv.org
Preserved Type 2 Immune Cell Plasticity in Human Obesity and Differential Immune Reconstitution After Bariatric Surgery biorxiv.org Background Obesity disrupts type 2 immune cell populations in white adipose tissue, replacing the homeostatic network of group 2 innate lymphoid cells
DynoSys 2.0: Graph-Based Modeling of Dynamic Risk States and System Transitions in Human Behaviours Development biorxiv.org Human behavioral and mental health outcomes arise from interactions among genetic, environmental, and neurobiological systems.
Cave-dwelling Planariidae in Croatia exhibit differing levels of cave trait evolution biorxiv.org The Dinaric karst of Croatia encompasses a network of over 10,000 caves and represents one of the world’s most important subterranean biodiversity hot
upSPLAT: Early-Barcoded Library Preparation for Cost-Effective Population-Scale Genomics biorxiv.org Advances in high-throughput sequencing have substantially reduced sequencing costs, yet library preparation remains a major financial and logistical b
First Lithic Age Caribbean genomes document pre-Ceramic genetic continuity and affinities to Central America and northern South America biorxiv.org The population history of the Caribbean’s first inhabitants has been challenging to reconstruct because few human remains are known from the region’s
Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice. biorxiv.org KLF14 acts as a master regulator of gene expression in adipose tissue and variants at the human KLF14 gene show strong and reproducible association wi
δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20 biorxiv.org Coordinated maturation of diverse neural cell types drives mammalian cortical circuit development.
Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies biorxiv.org Alternative lengthening of telomeres (ALT)-associated PML bodies (APBs) concentrate single-stranded (ss) telomeric DNA and RNA species that are critic
SUMO paralogues differentially affect phase separation and aggregation of intrinsically disordered proteins biorxiv.org SUMO, the small ubiquitin-like modifier, modulates interactions of folded proteins, but also affects the dynamics of biomolecular condensates.
Neural tracking of biological motion rhythms in early infancy: links to caregiver touch-related behaviours and attitudes biorxiv.org Infant environments are rich in rhythms, many of which are social in nature.
Motor Sequence Learning in Children and Adults: Age Differences in the Time Course of Brain Activation and Representational Stability biorxiv.org