Functional T cells trapped behind a stromal wall: a Brake-with-Wall phenotype redefines pancreatic adenocarcinoma immunotherapy resistance biorxiv.org Background Pancreatic ductal adenocarcinoma (PDAC) is the paradigmatic immunotherapy-refractory cancer, with a 5-year survival of approximately 12% an
Individual variation in sound localization accuracy is correlated with the properties of eye movement-related eardrum oscillations (EMREOs) biorxiv.org
Growth under constraints: root tip development controls trade-offs between speed and mechanical efficiency biorxiv.org
The miR-221-5p/RAD18/RAD51 axis regulates DNA damage tolerance and homologous recombination to drive platinum resistance in ovarian cancer. biorxiv.org
The CNS-penetrant MAP4K inhibitor famlasertib restrains medulloblastoma dissemination without developmental toxicity biorxiv.org
Ablation of glypican-3 enhances radiosensitivity in liver cancer by prolonging G2/M arrest and activating the ATM/CHK2 pathway biorxiv.org
PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1 biorxiv.org
Substrate mediated mechanical forces enable optimal kinetic proofreading by T-cell receptors biorxiv.org
GlyComboCLI enables command line-based FAIR workflows for glycan composition assignment in mass spectrometry data biorxiv.org
Biophysical and enzymatic comparison of Bacillus safensis and Bacillus subtilis malate dehydrogenase (MDH) enzymes biorxiv.org
Mutational and bioinformatic analysis of the binding site for the ribonucleotide reductase-specific transcriptional repressor NrdR biorxiv.org
Context-dependent tonic signaling shapes the performance and manufacturability of a 4-1BB- based HER2 CAR-T cell therapy biorxiv.org
Spatial proteomics reveals CD8+ T cell signatures and cellular niches associated with active HIV-1 replication in lymph nodes biorxiv.org
foxQ2 marks fast-acting brain interneurons including a subset of dopaminergic neurons innervating mushroom bodies and central complex in the beetle Tribolium castaneum biorxiv.org
Molecular and Structural Characterization Reveals Divergent Extracellular Vesicle Profiles Between Wild Type and Alzheimer's Disease Cerebrocortical Organoids biorxiv.org Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of patients globally.
Global quantification of mammalian gene expression noise biorxiv.org Even cells of the same type growing in the same environment show cell-to-cell differences in protein abundance, a phenomenon known as gene expression
LOCOPOTS: a low-cost high-throughput screening platform for in vitro potato phenotyping under abiotic stress biorxiv.org
A workflow for the identification of oligomeric structures on tilted sample planes in Cryo-SMLM biorxiv.org
Integrative host transcriptomic and mucosal microbiome profiling reveals region-specific host-microbiome associations across the human intestine biorxiv.org
Temporal Transcriptomics Identifies Isoform-specific Trans-regulation by Multiple lncRNAs in Human iPSCs biorxiv.org
A TSST 1 structural motif disrupts endothelial programs required for vascular regeneration. biorxiv.org
Nitazoxanide activates BMP9-ALK1-SMAD signaling cascade and improves HHT vascular pathology biorxiv.org
Motor Neuron Dysfunction in SORD Deficiency: Implications for Therapeutic Development in Peripheral Neuropathies biorxiv.org
The Cappuccino interactome reveals an intracellular role for Semaphorin-2a in Drosophila oogenesis biorxiv.org
Caregiver-infant interactions selectively shape emerging functional connectivity in the neonatal brain biorxiv.org
Neural Substrates of Duration Serial Dependence: Opposing Modulation in Basal Ganglia and Posterior Medial Cortex biorxiv.org
Distinct yet neighboring neural populations encode past, future, and surrounding speech context in the human temporal lobe biorxiv.org
Transcriptional plasticity of melanin-concentrating hormone neurons in the medial preoptic area of lactating mouse dams biorxiv.org
Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits biorxiv.org
Cellular Mechanisms of Transcranial Magnetic Stimulation in Climbing Fibers and Purkinje Neurons in the Cerebellum biorxiv.org
Stage-aware transcriptomics reveals selective haplotype persistence in short-term ex vivo cultured Plasmodium vivax biorxiv.org
Glutamylated vimentin proteoform identified by a synthetic binder links to epithelial-mesenchymal plasticity biorxiv.org
A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasis biorxiv.org
Unmasking Glycoforms: Lectin-Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in CHO Cells biorxiv.org