Generation of functional vasculature from engraftable human pluripotent stem cell-derived progenitors biorxiv.org
A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles biorxiv.org The binding of transmembrane (TM) ligands to their cognate TM receptors on neighboring cells governs intercellular adhesion and direct cell-cell commu
AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD biorxiv.org
The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast biorxiv.org
CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity biorxiv.org
Orai1 is required for Ca2+-dependent plasma membrane repair and mechanoadaptation biorxiv.org Ca2+-dependent repair of plasma membrane breaches is essential for animal cell viability.
Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1 biorxiv.org Genome-wide association studies have identified rare and common mutations associated with increased risk of pulmonary arterial hypertension (PAH), but
HOPS is required for non-canonical mTORC1 signaling by recruiting Rags and FLCN to lysosomal membranes biorxiv.org
Development and characterisation of an optimised in vitro differentiation protocol for deriving hepatocyte-like cells from mouse embryonic stem cells biorxiv.org
Bio-BLIP: A Multimodal Architecture for Transferable Reasoning in Genomic Variant Interpretation biorxiv.org
Identification of rare pseudouridylated microRNA by comprehensive small RNA bisulfite sequencing of mouse and human tissues biorxiv.org
H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas biorxiv.org
A novel matrix multiplication framework for modeling genotype-by-environment interaction in genomic prediction biorxiv.org
Chemical inactivation of a bacterial immune system de-domesticates a temperate phage and promotes its spread biorxiv.org
Obligate multicellularity circumvents population genetic barriers to collective-level adaptation biorxiv.org
Developmental delay in attaining adult levels of motor excitability in children and adolescents with Tourette syndrome: a mega-analysis study biorxiv.org
A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type biorxiv.org
Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity biorxiv.org
Spatiotemporal analysis of autism gene enrichment implicates cortex, thalamus, and hypothalamus biorxiv.org
A chromatin accessibility map of pea aphid brain and embryo identifies tissue-specific regulatory elements biorxiv.org
Active repression of muscle fate preserves neural lineage identity during cerebellum development biorxiv.org
A spectral partial information decomposition framework for quantifying information about cognitive variables in oscillatory brain networks biorxiv.org
Statistical Learning in a Stressful Environment: Autonomic Nervous System Reactivity Shapes Learning Probabilistic Patterns from Speech Streams biorxiv.org
Complementary δ2-protocadherin expression delineates parallel basal ganglia circuits in primates biorxiv.org
Associations between brain structure and both language proficiency and language balance in early bilinguals biorxiv.org
Cerebellar perturbation impairs human working memory and degrades spatial tuning throughout cortex biorxiv.org
Neurotransmitter circuits of the human language network and their disruption in post-stroke aphasia biorxiv.org
Oncolytic measles virus reprograms the tumor microenvironment in a vascularized mesothelioma-on-chip model biorxiv.org
Sustained multigenerational fitness benefits of natural immigration biorxiv.org The fitness of immigrants and their descendants determines the effectiveness of gene flow.
Linking land-use change, water quality, and host-parasite dynamics with droplet digital PCR and Bayesian path analyses biorxiv.org
The phenotypic landscape of the model firmicute Bacillus subtilis biorxiv.org Firmicutes are gram-positive bacteria with important roles in human health, disease, and industry.
Context-Dependent Modulation of Duration Encoding in the Supplementary Motor Area biorxiv.org Temporal perception adapts to the statistical structure of recent experience: the brain extracts distributional statistics from encountered durations
Integrating trajectory inference and gene regulatory network analysis to resolve transcriptional programs of T cell state transitions in the tumor microenvironment biorxiv.org Reconstructing dynamic immune cell state transitions from single-cell transcriptomic data requires coordinated analytical strategies that capture both
A novel method to select Reference Proteomes in UniProt biorxiv.org Motivation: The ongoing revolution in genome sequencing is delivering an unprecedented number of genome assemblies to global repositories, resulting i
A weak-interaction model defines the cell-autonomous function of DNA methylation in gastrulation biorxiv.org DNA methylation is essential for mammalian embryonic development, yet its functional implications remain debated.
New chromosome-level haplotyped genome assemblies and annotation for the Japanese Quail (Coturnix Japonica) biorxiv.org The Japanese quail (Coturnix japonica) is a widely used model organism in developmental biology, genetics, and agriculture.
A historical specimen of False Lingzhi (Ganoderma lucidum) resolves a 245-year-old confusion within an important medicinal mushroom group biorxiv.org Plants and fungi are major sources of natural products beneficial to society, making the study of distinct species essential for discovering new drugs
Segmentation and profile-based classification of movement strategies from animal tracking data biorxiv.org
Comparative analysis of cloacal microbiota in Henophidia (non-venomous) and Caenophidia (venomous) snakes biorxiv.org The evolutionary divergence between Henophidia (non-venomous) and Caenophidia (venomous) snakes has produced distinct cranial morphologies, digestive
Pollinator Plant Network Interactions of Bees (Hymenoptera: Anthophila) in an Urban Garden biorxiv.org
The biogeography of hydrothermal vent giant viruses across the global ocean biorxiv.org Viruses are the most abundant known biological entities in the ocean and play central role in microbial ecology.
Fecal untargeted metabolomic and short-chain fatty acid analyses in cats with chronic kidney disease biorxiv.org