Spatially resolved transcriptomic identification of thousands of neurons recorded in vivo. biorxiv.org
Benchmarking Short-Read ITS2 and Full-Length ITS Sequencing Reveals Pipeline-Dependent Biases in Indoor Fungal Community Profiling biorxiv.org
Stepwise assembly of virulence-associated traits in the intracellular pathogen Coxiella burnetii biorxiv.org Coxiella burnetii is the only member of the order Legionellales known to primarily infect vertebrates.
Metagenome-guided substrate selection enriches Terriglobus, reveals co-occurring taxa, and enables isolation of a novel species biorxiv.org Microbes that remain uncultivated occupy nearly every ecosystem on the planet; this is particularly true in soils, where despite their prevalence, the
Influence of non-content instructor talk on students' motivation-related outcomes in laboratory courses biorxiv.org Course-based undergraduate research experiences (CUREs) can expand undergraduates' access to research and motivate students to stay in science.
Deciphering conformational preferences of RNA in protein-RNA recognition biorxiv.org Conformational plasticity of RNAs plays important roles in recognizing RNA-binding proteins, and is often modulated by their binding partners.
An Exponential Scale Mixture Model for Metatranscriptomics Data with Application to Inflammatory Bowel Disease biorxiv.org
Environmental microbial communities and host selection shape larval microbiomes biorxiv.org Ocean warming is altering abiotic environments and biotic interactions experienced by marine organisms, where sensitive early developmental windows oc
Differential collagen crosslinking and network organization creates distinct tissue remodeling patterns in fibrosis and COPD biorxiv.org Collagens are key components of the extracellular matrix (ECM) that play a crucial role in maintaining structure, strength, and function of the lungs.
Lipid Hydrogen Stable Isotope Probing Reveals Decadal-Scale Generation Times for Archaea in Hot Spring Sediments biorxiv.org Quantifying the lipid biosynthesis rate of archaea in hot spring sediments is necessary to interpret the abundance, isotopic patterns, and environment
SroA links SigS-dependent stress signaling to metabolic remodeling in Staphylococcus aureus biorxiv.org Staphylococcus aureus encounters diverse environmental conditions during colonization and infection, including fluctuations in nutrient availability,
Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans biorxiv.org WD40 domains are major protein–protein interaction (PPI) scaffolds, yet their contributions to fungal pathogenicity remain poorly defined.
Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology biorxiv.org Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools.
Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal Transporter biorxiv.org
De novo design of transmembrane accessory subunits for fold stabilization and expansion biorxiv.org Transmembrane (TM) proteins play essential roles in biology as transporters, ion channels, chaperones, enzymes, and mediators of signal transduction.
CN-RNN: a Deep Learning Framework for Copy Number Variation Detection with Exome Sequencing Data biorxiv.org
Codon degeneracy contributes to divergent fitness effects of rare tRNAs with A-starting anticodons biorxiv.org
In vitro dormancy models improve ability to predict treatment response in severe marmoset tuberculosis lesions biorxiv.org
Ticks and tickborne diseases in the upper Midwestern United States: role for citizen science in assessing exposure risk biorxiv.org
A Panel of Human Monoclonal Antibodies for Tracking the Antigenic Evolution of Influenza H5N1 Clade 2.3.4.4b biorxiv.org
Mutations in MreB suppress β-lactam sensitivity upon c-di-AMP accumulation in Listeria monocytogenes biorxiv.org
Listianol, a Carotenoid Biosynthesis Inhibitor from a Methylotrophic Bacterium, Alters the Composition of a Phyllosphere Microbial Community biorxiv.org
A protease-sensing circuit links neutrophil inflammation to virulence regulation in Streptococcus pyogenes biorxiv.org
Susceptibility of Klebsiella pneumoniae Clinical Isolates in Biofilms to Antibiotics and Assessment of Secondary Drug Effects biorxiv.org
Manipulation of rhizosphere microbiome by Microbacterium sp. GB16_1_BI to promote plant growth. biorxiv.org
Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue biorxiv.org
Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels biorxiv.org
BioMARathons as a seasonal engagement model for marine citizen science: adapting BioBlitzes to challenging coastal environments biorxiv.org
A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation biorxiv.org
A modular Bayesian framework for inferring transmission networks from polyclonal infections, with application to Plasmodium falciparum biorxiv.org
The human gut virome is a non-redundant and clinically informative component of the microbiome biorxiv.org
Structures of the Pseudomonas aeruginosa MlaC-MlaD complexes reveal a conformational switch mediated by the C-terminal helix of MlaC biorxiv.org Gram-negative bacteria maintain an asymmetric outer membrane that protects cells from environmental stresses and antibiotics.
Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase biorxiv.org Malaria remains one of the major threats to human health.
Single-cell RNA sequencing reveals that host Glutamine Metabolism Inhibition Enhances Macrophage Phagocytosis of Mycobacterium tuberculosis biorxiv.org
Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses biorxiv.org
Decades of Parkinson's disease neuropathology yield a sparse and underpowered map of neuronal vulnerability: a systematic review and meta-analysis biorxiv.org Parkinson's disease is defined clinically by motor dysfunction, but its pathology is not confined to nigral dopaminergic neurons.
An N, S-acetylated L-cysteine-cysteamine conjugate hinders pyocyanin redox cycling to weaken Pseudomonas aeruginosa biofilm and dampens LPS-driven acute pulmonary inflammation biorxiv.org
LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells biorxiv.org
Pan-Viral Conformational Landscapes of Frameshifting Elements Reveal Length-Dependent Plasticity and Antisense-Driven Structural Reprogramming biorxiv.org Programmed ribosomal frameshifting (PRF) is an essential strategy used by many RNA viruses to expand their coding capacity within compact genomes.