Resolving the oak tree of life: comparing RADseq and whole genome resequencing methods for oak phylogenetics biorxiv.org
Structural Basis of Ligand-Specific Orthosteric-Allosteric Coupling and Sensory Tuning in the Human Bitter Taste Receptor TAS2R14 biorxiv.org
Mycobacteriophage TM4 requires XylR for successful infection in Mycobacterium smegmatis mc2155 biorxiv.org
Antimicrobial resistant bacteria in wastewater-irrigated Mexican soils and transfer of resistant bacteria from irrigated soils to cilantro plants biorxiv.org
Quaternary ammonium compounds (QACs), QAC resistance genes, and QAC tolerant bacteria in livestock and human waste streams biorxiv.org
Mutation E300 recommended by protein language models gives ChrimsonR amplified photocurrent response biorxiv.org
Proximity labeling reveals unique and shared interactomes of unmodified and pyroglutamate amyloid beta in human hippocampus in Alzheimers disease biorxiv.org
MyD88 deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates disease biorxiv.org
Enzymatic and Biophysical Analysis of two Highly Related Cytochrome P450 Reductases from Artemisia annua Reveals Differences in Their Ligand Interactions and Domain Motions biorxiv.org
Validation and testing of an in vitro model to study medical treatments for anterior urethral stricture disease: assessing the potential efficacy of phosphodiesterase-4 (PDE4) inhibition and testosterone biorxiv.org
Direct Counting of mRNA Copies Inside Individual Lipid Nanoparticles Using In Situ Lysis and Labeling biorxiv.org
INTEGRATOR: Structural Elucidation of the INO80 Chromatin Remodeler via Experimentally Guided Molecular Simulations biorxiv.org
Drug design using unique conformations to preferentially target a specific site on collagen-bound MMP1 biorxiv.org
IntegrateRigor: annotation-free integration optimization for cell identity recovery reveals cancer-immune interface niches biorxiv.org
Combined Cartilage Thickness and Mechanical Property Mismatch Drives Local Strain Amplification at the Patellar Osteochondral Allograft Interface biorxiv.org
Loss of the Central Region Reshapes the Dynamic Landscape of the Cellular Prion Protein and Its Plasma Membrane Interaction biorxiv.org
Nearest Neighbor Parameters for Estimating the Folding Stability of RNA Including Pseudouridine biorxiv.org
Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation biorxiv.org
Paired Tumor Biopsies Reveal Spatiotemporal Myeloid Remodeling After Local Chemotherapy in Glioblastoma biorxiv.org
Tumor-derived mitochondria enhance CD8+ T cell cytotoxicity through SPHK2-dependent S1P signaling biorxiv.org
VPS41 loss triggers iron overload, oxidative stress, and mitochondrial fragmentation linked to ferroptosis biorxiv.org
Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells biorxiv.org
Melanin regulates mitochondrial dynamics, metabolism and inflammatory signaling to protect the retina biorxiv.org
1,3-1,6 β-glucans reduce aging hallmarks in multiple organs and rapidly induce mitochondrial biogenesis and autophagy via direct effect on the killifish brain and human neurons biorxiv.org
Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction-Associated Steatohepatitis in Mice biorxiv.org
Fibronectin and laminin differentially affect the inflammatory environment in microphysiological systems biorxiv.org
Comparison of Osteoblast Calcification in Bio-Oss, Cerasorb, Pro Osteon, and Bio-Tiss Cerabone biorxiv.org
Dynamic Reprogramming of Fungal Cell Walls Underlies Germination and Immune Exposure in Zygomycetous Fungal Pathogens biorxiv.org
Cell-Type Clusters in the MICrONS Connectome Reveal Hidden Organizational Principles of the Mouse Visual Cortex and Possible Candidate Substrates for Elementary Perceptual States biorxiv.org
Maternal iron deficiency remodels cardiac mitochondria and alters stress responses in hypertensive pregnancy biorxiv.org
Overweight status drives early tumor microenvironment reprogramming in pancreatic ductal adenocarcinoma: a cell-type-resolved Bayesian hierarchical modeling and interactome analysis biorxiv.org
Reprogramming tumour-associated macrophages from immune suppressive to inflammatory state by Checkpoint kinase 1 inhibitor combination treatment biorxiv.org
Evo 2 Predicts Cardiomyopathy-Associated Variants and Elucidates Their Underlying Mechanisms biorxiv.org
Targeting therapy-induced senescence across multiple breast cancer subtypes in a metastatic bone-like microenvironment biorxiv.org
HPV co-infection burden, vaginal microbiota restructuring, and host context are associated with Cervical precancer risk in a racially restricted observational cohort biorxiv.org