An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters biorxiv.org
Disease-associated mutations in TPM2 alter regulation of actin filament stability and cofilin-dependent dynamics biorxiv.org
Unbiased Long-Read Whole-Genome Sequencing Enables High-Resolution Mapping of Transgene Concatenation and Off-target Genomic Disruption in a Mouse Model biorxiv.org
A Single-Nucleus Transcriptomic Atlas Reveals Cell-Type-Specific Responses to OsHV-1 Infection in the Pacific Oyster biorxiv.org
Long-distance dispersal drives global tropical distributions in a widespread moth lineage (Lepidoptera: Limacodidae) biorxiv.org
Beyond ex vivo and in vivo CAR T: antigen-driven CAR T (adCAR-T) expansion method enables rapid, physiological CAR T cells programming. biorxiv.org
Binary partitioning of human brain organization due to divergent human cytoskeletal evolution biorxiv.org
Repurposing native non-homologous end joining for multicopy random integration in Wickerhamomyces ciferrii biorxiv.org
Automated assembly of protein complexes from cryo-EM maps with structure-informed Monte Carlo Tree Search biorxiv.org
SpatialArtifacts: a computational framework for tissue artifact detection in spatial transcriptomics data biorxiv.org
Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery biorxiv.org
Evolutionary Conservation and Divergence of CXCL17 orthologs: Functional Evidence in Reptiles and Loss in the Avian Lineage biorxiv.org
Efficient Optimization of Genotype Pairs for Intercropping using Genomic Prediction and Bayesian Optimization biorxiv.org
Environmental stochasticity can account for patterns of within-host respiratory virus evolution biorxiv.org
AlaRS-mediated lactylation shields PARP1 from ubiquitination to promote HNSCC progression biorxiv.org
Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats biorxiv.org
Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets biorxiv.org
Mantis-Delta: Mass-Action Network Theory and Steady-State Characterization for Chemical Reaction Networks biorxiv.org
Combining amino acid frequency and 1D convolutional neural network embeddings for the identification of protein-protein interactions using a random forest classifier biorxiv.org
Time Restricted Feeding Mitigates High-Fat-Diet Induced Sleep Disruption and Amplifies NREM Substates biorxiv.org
SPATIAL HABITAT DIFFERENCES DRIVE ABUNDANCE OF RED-CHEEKED CORDON-BLEU IN HUMAN-MODIFIED LANDSCAPES biorxiv.org
The MICA rs2596542 locus is not an island: component-aware haplotype decomposition reveals a composite MHC tag with distinct regulatory axes biorxiv.org
kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis biorxiv.org
Subsecond whole-brain neural dynamics identified by hidden Markov modeling reflect value-based decision making in humans biorxiv.org
Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease biorxiv.org
Dopamine Depletion Drives Whole-Brain Oscillatory Disruptions via Cortico-Subcortical Resonance: A Multiscale Model of Parkinson's Disease in Mice biorxiv.org
Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity biorxiv.org
Integrative Genomic Analyses Identify COL21A1 and ENPEP-FGF5 Regulatory Pathways for Blood Pressure Variation in East Asians biorxiv.org
Structure of the Leiomodin-2 Regulated Actin Filament Pointed End Assembly from Profilactin biorxiv.org
HESTIA: Scalable Multimodal Integration of Histology and High-Resolution Spatial Transcriptomics for Robust Spatial Domain Identification biorxiv.org
ReMind: A Retrospective Self-Report Paradigm for Studying Mind-Wandering Onset During Reading biorxiv.org
Integrated Lipidomics and Nitro-Fatty Acid Profiling Link Adipose Redox Imbalance to Alzheimer's Disease-Related Neurovascular Injury biorxiv.org
Neutrophil subsets in SLE exhibit increased glycolysis that correlates with disease activity biorxiv.org
Circulating miR-1285-3p promotes age-associated B cell differentiation through the OXPHOS-IKZF2 axis in SLE biorxiv.org
Appetite for change: How psilocybin reshapes food reward learning through striatal dopamine function biorxiv.org
Evidence that local viscosity and NOX-dependent ROS increases render the tardigrade H. exemplaris resilient to extreme physical force biorxiv.org