Drought Dominates Engineered Lipid Sink Effects on Sorghum Physiology and Carbon Allocation biorxiv.org 2026-05-30 Determining the environmental limits that govern how engineered metabolic traits control whole-plant carbon (C) allocation is essential for developing
Soundscape reflects breeding phenology in colonial seabirds biorxiv.org 2026-05-30 Migratory seabirds are valuable indicators of marine ecosystem change but can be difficult to monitor during the breeding season due to dense colonies
Structure can emerge from disorder under neutral evolution biorxiv.org 2026-05-30 Mutations are often thought to destabilize protein structures.
Allele-specific expression reveals complex cis- and trans-regulatory divergence underlying fruit phenotypic differences between cultivated and wild tomato species biorxiv.org 2026-05-30 Tomato (Solanum lycopersicum) is one of the most important agricultural crops and serves as a model system for fleshy fruit biology.
Local Temperature and Humidity are Associated with Proportion of Antimicrobial-Resistant Escherichia coli isolates in Farm Environments: Considerations for On-Farm Surveillance biorxiv.org 2026-05-30 Evidence suggests that increased local temperatures are associated with higher prevalence of antimicrobial resistance (AMR) in environmental bacteria.
Supplemental deinoxanthin ameliorates bone marrow microenvironmental impairments and recovers functional damage of bone marrow-retained cells in total body irradiation-exposed mice biorxiv.org 2026-05-30 Total body irradiation (TBI) can impair the bone marrow (BM) microenvironment and dysregulate the fates of BM-residing cells by overproducing reactive
Vorinostat (SAHA) alters the skeletal muscle differentiation program biorxiv.org 2026-05-30 Epigenetic regulation, particularly histone acetylation, plays a critical role in skeletal muscle differentiation by modulating gene expression progra
Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis biorxiv.org 2026-05-30 Background: Ionizing radiation (IR) accelerates atherosclerosis through induction of cellular senescence, DNA damage, defective efferocytosis, and dys
Glucocorticoid Programming of Erythrocyte Hypoxic Memory Enables Rapid High-Altitude Acclimatization biorxiv.org 2026-05-30 Background: Rapid ascent to high altitude causes acute mountain sickness (AMS) and life-threatening pulmonary/cerebral edema, yet no prophylaxis enabl
PCP-dependent polarity propagation across neuronal columns in the Drosophila medulla biorxiv.org 2026-05-30 Planar cell polarity (PCP) signaling establishes coordinated tissue polarity through asymmetric localization of core PCP factors and propagation of po
Bartonella and hemotropic Mycoplasma species in synanthropic bats in Kenya biorxiv.org 2026-05-30 Identifying and characterizing zoonotic pathogens in wildlife is essential for understanding disease risk to humans.
Vegetation and fires under climate change: a Mediterranean modelled case study from central Italy biorxiv.org 2026-05-30 Wildfire regimes in Mediterranean landscapes are undergoing significant changes due to the combined effects of land-use transitions and climate change
Fiat lux: A hotspot of Luciola fireflies on Western Mediterranean islands biorxiv.org 2026-05-30 Islands are priority areas for the study and conservation of biodiversity, as they frequently harbour distinct lineages.
Top-down and bottom-up landscape processes influence the formation of microbial partnerships in herbivorous insects biorxiv.org 2026-05-30 Many insects form intimate associations with microbial partners, spanning a continuum from obligate mutualisms to transient associations.
Unifying coexistence theory for ecological communities and pathogen strain competition biorxiv.org 2026-05-30 Predicting the outcome of species or pathogen strain competition is a fundamental aim in both community ecology and infectious disease dynamics.
Advancing Great Lakes Coastal Wetland Food Web Models Using an Integrative Tracer Approach biorxiv.org 2026-05-30 Coastal wetlands of the Laurentian Great Lakes support abundant populations of fish, invertebrates, and vegetation, though the trophic linkages connec
Bayesian optimal designs for common single-driver experiments in ecology biorxiv.org 2026-05-30 When measuring the impact of continuous independent variables, regressions are the appropriate tool.
Agroforestry transition increases insect diversity and reorganizes soil function in a Mediterranean orchard biorxiv.org 2026-05-30 Agricultural intensification has reduced biodiversity and weakened ecosystem functions essential for sustainable crop production.
Dormancy stabilizes structured food webs biorxiv.org 2026-05-30 Theory predicts that strong species interactions drive ecological instability, but strong interactions are common in ecosystems while strong instabili
Spatiotemporal variation in honeybee (Apis mellifera L.) virome composition across landscape types and seasons biorxiv.org 2026-05-30 Honeybees face increasing threats from biotic stress of viral pathogens that can severely impact colony health and contribute to global colony decline
Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Compared to Macrophage Foam Cells in Human Atherosclerosis biorxiv.org 2026-05-30 BACKGROUND: Smooth muscle cells (SMCs) comprise the majority of cells in human atherosclerotic lesions and are thought to be a major source of cholest
Beyond copy number: The regulatory architecture of mitochondrial DNA gene expression biorxiv.org 2026-05-30 Mitochondrial DNA (mtDNA) copy number is widely used as a biomarker for mitochondrial function and disease risk, yet its relationship to mtDNA gene ex
Enhanced Irrigation during Extreme Heat Events Preserves Anthocyanins in Cabernet Sauvignon biorxiv.org 2026-05-30 Globally, heat waves (HWs) have become more frequent, intense, and prolonged, with extreme temperatures that reduce quality or result in crop loss in
Improving viral protein clustering using both diversified protein profiles and structural information biorxiv.org 2026-05-30 Viruses are abundant, ancestral and potentially fast-evolving biological entities.
Endothelium-Dependent Vasodilation is Impaired in Chronic Spinal Cord Injury and is Associated with Oxidative Stress biorxiv.org 2026-05-30 Background: Individuals with spinal cord injury (SCI) experience accelerated atherosclerotic cardiovascular disease that is not fully explained by tra
Arteriolar GMP signaling revealed by FRET-based real-time measurement in vivo biorxiv.org 2026-05-30 cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO.
Environmental heterogeneity facilitates competitive suppression of drug resistance biorxiv.org 2026-05-30 Antimicrobial resistance is an emergent property of ecological interactions within complex microbial communities.
The genetics of transcriptional responses to stress in yeast biorxiv.org 2026-05-30 Alteration of gene expression levels is a key cellular strategy for responding to internal and external challenges.
Genomic-Adjusted Radiation Dose from Bulk RNA Sequencing for Personalized Radiotherapy biorxiv.org 2026-05-30 Radiotherapy is delivered to more than half of all patients with cancer yet is prescribed using uniform physical doses despite well-established interp
A functional genomics screen identifies novel drivers of FR900359 resistance in uveal melanoma cells biorxiv.org 2026-05-30 Uveal melanoma (UM) is the most common form of intraocular cancer in adults and has a median survival rate of ~1 year after metastasis occurs.
Genome replication and cell division control by the methylation-sensitive GcrA regulator in Agrobacterium tumefaciens biorxiv.org 2026-05-29 Bacteria with complex genomes including secondary chromosomes and/or megaplasmids face unique challenges when controlling their cell cycle: they not o
Non-triazole agricultural fungicides indirectly select for triazole resistance in the human pathogen Aspergillus fumigatus biorxiv.org 2026-05-29 The intensification of agriculture relies on chemical fungicides to manage crop disease1,2, leading to the evolution of resistance in plant pathogens.
RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation biorxiv.org 2026-05-29 Replication stress, a major source of DNA damage and vulnerability in cancer, activates innate immunity through both the cGAS-STING and RIG-I-like rec
Governance scale and network structure shape pollinator recovery under pesticide reduction biorxiv.org 2026-05-29 Reducing pesticide risks while maintaining food production remains a central challenge for sustainable agriculture.
Choice-driven remapping of action- and stimulus-anchored value in human single neurons biorxiv.org 2026-05-29 Whether stimulus- and action-based choices rely on a shared neural architecture remains intensely debated.
Single-cell proteomic maps of human induced pluripotent stem cells and their differentiation into motor neurons biorxiv.org 2026-05-29 The majority of single cell-studies use RNA to identify the cell state.
Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane trafficking. biorxiv.org 2026-05-29 Missense mutations in the Grik2 gene that encodes the kainate receptor subunit GluK2 are associated with neurodevelopmental disorders, but how individ
Comparison of a Novel Real-World Speech in Noise Auditory Attention Task to Standard Clinical Audiological Metrics biorxiv.org 2026-05-29 Pure tone audiometry (PTA) remains the clinical standard for evaluating hearing ability, yet individuals with similar audiometric profiles often exhib
Physiological Markers of Auditory Situational Awareness in Complex Spatialised Scenes biorxiv.org 2026-05-29 Detecting changes in acoustic environments is essential for situational awareness.
Physical activity promotes longitudinal white matter brain adaptations that support fluid intelligence with age biorxiv.org 2026-05-29 The aging population continues to grow, and along with it the need to better understand the unique characteristics of the aging brain.
Satellite DNA dynamics across phylogenetic scales in ground beetles and other insects biorxiv.org 2026-05-29 Satellite DNAs (satDNAs) are tandemly repeated sequences that can comprise large fractions of eukaryotic genomes.
GRAFT: phylogenetic signal in patent applications across the tree of life biorxiv.org 2026-05-29 Whether closely related species are repurposed for similar biotechnologies, a phylogenetic signal in human technological interest, has lacked a tracta
Pleiotropy constrains the evolution of immune system plasticity while promoting domain modularity biorxiv.org 2026-05-29 Pleiotropic genes control multiple traits.
Circular RNA-associated QTLs show stronger association with splicing-QTLs than with expression-QTLs biorxiv.org 2026-05-29 Introduction: Circular RNA quantitative trait loci (circQTLs) have emerged as a class of regulatory variants, but their mechanistic basis remains poor
Identification of Genomic Loci Associated with Cellular Rhythms in Diversity Outbred Mice biorxiv.org 2026-05-29 Inter-individual variation in human molecular and behavioral circadian rhythms motivates genetic dissection in model systems with human-like diversity
Chromosome-level genome assembly of the swallowtail butterfly Parides eurimedes mylotes is a valuable resource for studying wing coloration biorxiv.org 2026-05-29 High-quality chromosome-scale assemblies are scarce in Papilionidae. This limits comparative genomics to model species, Lepidoptera, Bombyx mori.
Neuronal ramping and theta power during freely-moving and head-fixed mouse interval timing. biorxiv.org 2026-05-29 An important paradigm to study executive function is interval timing, which requires participants to estimate a temporal interval, often with a motor
Gaze information enhances remote skill transfer of piano performance biorxiv.org 2026-05-29 Remote instruction is increasingly used to teach complex sensorimotor skills, yet conventional audio-video communication poorly conveys the fine-grain
Temporal structure of task engagement organizes infra-slow BOLD dynamics biorxiv.org 2026-05-29 Task-based fMRI has traditionally characterized cognitive engagement through spatial patterns of BOLD activation, leaving less understood whether task
Soma-seq links intracellular protein states to transcriptional programs in the human brain biorxiv.org 2026-05-29 Neurodegenerative disease is largely driven by pathological protein states, which cannot be fully inferred from transcript levels.