A field method to optimize dried blood spot sampling for mercury biomonitoring biorxiv.org 2026-06-01 Abstract 1. Heavy metals are pervasive environmental contaminants that can impair the health of organisms globally.
Functional characterization and classification of mechanosensitive bladder afferents biorxiv.org 2026-06-01 Normal urinary bladder function relies on afferent fibers that detect and integrate mechanical and chemical cues related to bladder distension.
Globin digest and its constituent peptides promote skeletal muscle hypertrophy and enhance physical performance biorxiv.org 2026-06-01 Globin digest (GD), an acidic protease hydrolysate of hemoglobin, has been recognized for its anti-obesity and glucose-modulating effects; however, it
C4 photosynthetic pathway fluxes in transgenic rice plants biorxiv.org 2026-06-01 Most land plants photosynthesize using the ancestral C3 pathway, in which ribulose bisphosphate carboxylase/oxygenase (Rubisco) fixes CO2 into 3-carbo
Osmotic-stress-inducible nuclear condensates restrict gene inducibility biorxiv.org 2026-06-01 Plants, as sessile organisms, have developed various mechanisms to respond to environmental stress conditions.
Structure determination and dual targeting of a plant TACO1 identifies its ancient role as an organelle translation regulator biorxiv.org 2026-06-01 Ribosome stalling caused by polyproline (PPs) motifs is common.
Anterior default mode brain state dynamics predict depressive symptom severity before and during TMS treatment biorxiv.org 2026-06-01 Transcranial magnetic stimulation (TMS) targeting the left dorsolateral prefrontal cortex is known to progressively reduce symptoms of depression.
Grooming as a window into the post-stress recuperative process biorxiv.org 2026-06-01 Alterations in rodent self-grooming have been used to model various facets of neuropsychiatric illness.
Hindmarsh-Rose neuronal network with spike-timing-dependent plasticity demonstrates coordinated reset neuromodulation biorxiv.org 2026-06-01 Computational models of brain structures impacted by Parkinson's disease are useful for exploring potential therapies.
A model of schema learning based on biological dimensionality reduction during sleep biorxiv.org 2026-06-01 Reorganizing learned knowledge into generalized representations and transferring it to future learning are essential aspects of cognition, often descr
Behavioural plasticity in Caenorhabditis elegans navigating dynamic granular environments biorxiv.org 2026-06-01 The mechanisms that steer behavioural plasticity in complex environments remain poorly understood.
Monkey hear, monkey do what? An application of Automated Behavioural Response systems for hypothesis testing in the worlds smallest monkey biorxiv.org 2026-06-01 Observer effects are a frequent problem in animal behaviour studies, particularly when assessing responses to human disturbance.
Ultra-efficient High Resolution 3D Reconstruction of Spatial Omics Data with Neural Transcriptomic Field biorxiv.org 2026-06-01 Biological tissues are inherently three-dimensional (3D) ecosystems where spatial architecture dictates cellular function.
Local mechanical gradients underlie coordinated cascades of epithelial cell-cycle advance biorxiv.org 2026-06-01 Cell division mechanically perturbs the local environment in epithelial tissues, yet whether and how these perturbations propagate to coordinate cell-
Label-free 3D virtual histology of human formalin-fixed paraffin-embedded (FFPE) prostate needle biopsies with propagation-based phase-contrast micro-CT (PBCT) biorxiv.org 2026-06-01 For over a century, the goal of estimating clinical outcome from tumor biopsies has been based on histomorphology of 2D tissue slices that represent a
An Integrative Taste Receptor Links pH and Amino Acids to Sugar Sensing in Bemisia tabaci biorxiv.org 2026-06-01 Phloem-feeding insects execute complex behavioral decisions to secure essential nutrients from a diet characterized by nitrogen scarcity and severe os
Multiscale intraspecific variation and coordination of hydraulic traits in silver fir biorxiv.org 2026-06-01 - Intraspecific variability in hydraulic and morphological traits may alter projections of forest vulnerability to climate change.
The Drosophila IR20a Integrates L-arginine and Salt Signals via Distinct Subunit Assemblies biorxiv.org 2026-06-01 Amino acids and salts are essential nutrients that frequently occur together in natural food sources.
Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina biorxiv.org 2026-06-01 Comprehensive wiring diagrams from electron microscopy (EM) are a powerful tool to understand the inner workings of the brain.
Decoding Graded Grip-Force Intensity from fMRI Data Reveals a Transformation from Abstract to Effector- and Movement-Specific Codes prior to Execution biorxiv.org 2026-06-01 Motor planning entails a progressive transformation of neural representations - from abstract motor goals, which represent intended action-outcomes in
Characterizing variability in resting-state functional magnetic resonance imaging (rsfMRI) metrics: a normative modeling framework biorxiv.org 2026-06-01 Clinical adoption of new biomedical techniques depends on establishing reference values against which individual patients can be compared.
Opposing roles of GSDMD and NINJ1 shape early IL-1β dependent host defense during Toxoplasma gondii infection biorxiv.org 2026-06-01 Inflammasome activation is a central component of host defense against Toxoplasma gondii, yet how downstream pyroptotic effectors shape infection outc
Altered PI3K-PTEN balance promotes preferential killing of human IgE+ plasma cells by BCR crosslinking biorxiv.org 2026-06-01 Immunoglobulin E (IgE) drives allergic disease, yet what restrains the persistence of IgE production remains poorly understood.
Anti-Melanoma Differentiation-Associated protein 5 Auto-Antibodies Promote a Profibrotic Phenotype in a Human Lung Fibroblast Cell Line biorxiv.org 2026-06-01 Anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies identify a distinct dermatomyositis subset frequently associated with ra
Antimicrobial activity of polymyxin A, and characterisation of the cognate biosynthetic gene cluster within the genome of the producing Paenibacillus polymyxa. biorxiv.org 2026-06-01 We report the isolation and identification of a Paenibacillus polymyxa strain from the citizen science project; Swab and Send.
Impairment of bacteriophage activity in blood: a case study revealing constraints in phage isolation and translation biorxiv.org 2026-06-01 Background Phage therapy is increasingly considered a promising alternative for treating multidrug-resistant (MDR) infections.
Scouting ecological drivers of natural enemies in citrus orchards: implications for biological control in the Corsican agricultural landscape biorxiv.org 2026-06-01 1.
Replicate-anchored calibration of within-host single nucleotide variant detection in Mycobacterium tuberculosis whole genome sequencing biorxiv.org 2026-06-01 Abstract Background.
p38 dependent IL-33 responses define a conserved inflammatory programme in mast cells biorxiv.org 2026-06-01 Interleukin-33 (IL-33) is a key cytokine in mast cell mediated immunity, promoting inflammatory cytokine production without inducing degranulation.
Heme orchestrates a tissue stress response to proteolytic damage biorxiv.org 2026-06-01 Whereas cellular stress responses are well defined, tissue-level stress remains poorly understood.
Thousandfold Expansion Microscopy biorxiv.org 2026-06-01 Biological macromolecules, such as proteins, are made of concatenated building blocks.
Overexpression of Eaf1, a subunit of the NuA4 lysine acetyl transferase complex, rescues growth defects in the budding yeast H3K36M oncohistone model via histone H4 tail acetylation biorxiv.org 2026-06-01 Histone proteins are critical for regulating functions that occur at DNA, such as gene expression.
A Foundation Model for the Cancer Genome biorxiv.org 2026-06-01 Cancer is a disease of the genome, in which somatic mutations and copy-number alterations determine tumour identity, clinical behaviour, and response
Computational Design of Two New 5-HT1B Serotonin Receptor Agonists Derived from Naratriptan biorxiv.org 2026-05-31 Migraine headaches affect over one billion people internationally and can be defined as episodes of acute severe pain wrapping around the head and are
Antibiotics and copper drive compartment-specific dysbiosis and functional reprogramming in tomato microbiomes biorxiv.org 2026-05-31 Plant-associated microbiomes help sustain plant immunity and productivity, yet the degree to which agricultural antimicrobials reshape these microbial
Comprehensive characterization of skeletal muscle remodeling in hSOD1G93A mice reveals limited functional impact of systemic FOXO1 inhibition biorxiv.org 2026-05-31 Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss, muscle atrop
The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa biorxiv.org 2026-05-31 Photoreceptor degeneration drives electrophysiological remodeling in downstream retinal neurons, including hyperactive firing of retinal ganglion cell
Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients biorxiv.org 2026-05-31 Background: Bispecific T-cell Engagers (TCEs) targeting B7H3 (CD276) show promise for solid tumors but are limited by systemic toxicities and poor tum
Clinical isolates of Mycobacterium avium complex reveal an M. intracellulare-associated IL-17/neutrophilic pulmonary immune program in a murine disease model biorxiv.org 2026-05-31 Mycobacterium avium complex (MAC) is the leading cause of nontuberculous mycobacterial pulmonary disease (NTM-PD) and mainly comprises M.
Organoid-T cell co-cultures functionally stratify tumor-reactive T cells and their responses to immune checkpoint inhibitors biorxiv.org 2026-05-31 Tumor-reactive T cells (TRTs) are critical for anti-tumor immunity but are incompletely captured by current assays, which fail to reproduce tumor-spec
GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation biorxiv.org 2026-05-31 The mammalian circadian clock relies on precisely timed transcriptional and post-translational events to generate ~24-hour rhythms.
Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans biorxiv.org 2026-05-31 Background: Thoracic aortic aneurysm (TAA) is a life-threatening condition with an unpredictable lisk of rupture.
Detection of Pancreatic Cancer Using a Methylation-Specific PCR-Based Multi-Cancer Early Detection Test biorxiv.org 2026-05-31 Context: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy often diagnosed at advanced stages due to the lack of early clinical symp
The defining features of intrinsic transcription terminators biorxiv.org 2026-05-31 Transcription terminators are universal landmarks that delimit RNAs and tune downstream gene expression, yet the sequence rules that define them remai
Ultra-Slow Rhythmic Movement in the Elongating Tail of Xenopus Tadpoles biorxiv.org 2026-05-31 Since Darwin's time, ultra-slow oscillatory movements have been recognized as a characteristic feature of axis elongation in plant organs such as shoo
Identifying a cooperative catalytic network for efficient esterase catalysis biorxiv.org 2026-05-31 Active-site redesign frequently yields modest improvements because residues controlling physical steps like substrate binding and product release lie
LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery biorxiv.org 2026-05-31 Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins.
Instance-Wise Contrastive Graph Neural Network Enables the Discovery of Novel Aedes aegypti Larvicidal Compounds biorxiv.org 2026-05-31 Aedes aegypti remains a major arboviral vector, making larval control a critical strategy to reduce mosquito populations.
Analytical Choices Drive Toxicogenomic Potency Estimates: A Systematic Evaluation of Transcriptomic Points of Departure biorxiv.org 2026-05-31 Omics technologies are increasingly integrated into next-generation risk assessment, yet quantitative toxicogenomics outcomes remain highly dependent
Decoding Hierarchical Cell-Cell Communication in Spatial Multi-Omics with CellSTIC biorxiv.org 2026-05-31 Cell-cell communication helps to coordinate tissue development, homeostasis, and immune responses, but identifying signaling interactions within intac