Early reaction time variability predicts implicit statistical learning: a comparison of four variability indices biorxiv.org 2026-05-31 High intra-individual reaction time variability (RTV) is traditionally viewed through a deficit perspective and interpreted as a maladaptive signature
Category-selective functional connectivity during episodic encoding and retrieval in younger and older adults biorxiv.org 2026-05-31 Regions within ventral occipito-temporal cortex exhibit category-selective BOLD responses during episodic encoding and retrieval of visual information
Olfactory learning potentiates long-range cortical GABAergic inputs onto adult-born neurons. biorxiv.org 2026-05-31 Adult neurogenesis in the olfactory bulb (OB) contributes to structural and functional plasticity, influencing olfactory perception, learning, and mem
Relative Hemodynamic Timing in Human White Matter biorxiv.org 2026-05-31 Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health.
Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells biorxiv.org 2026-05-31 Chronic stress induces structural and functional changes in the brain, increasing susceptibility to major depressive disorder and other mental illness
PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners biorxiv.org 2026-05-30 Small-molecule agonists of class B1 G-protein-coupled receptors (GPCRs) remain rare because these receptors typically require large extracellular pept
HARP: Hierarchical Anatomical Refinement of Pathways for Whole-Brain Tractography biorxiv.org 2026-05-30 Diffusion MRI tractography is an ill-posed inverse problem that requires anatomical constraints to ensure the plausibility of reconstructed white-matt
Macrophages reshape cytokine responses and bacterial spatial organization in an airway epithelial cell culture model biorxiv.org 2026-05-30 The increasing prevalence of antibiotic-resistant bacterial infections highlights the need for physiologically relevant in vitro models that recapitul
Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans biorxiv.org 2026-05-30 Due to the complex biology of HIV-1 broadly neutralizing antibodies (bnAbs), HIV-1 vaccines must target unmutated germline precursor antibodies with B
Structural basis for the ATP-dependence of omegasome biogenesis by DFCP1 biorxiv.org 2026-05-30 Autophagosome formation begins at phosphatidylinositol 3-phosphate-enriched endoplasmic reticulum (ER) subdomains termed omegasomes.
Cyclic voltammetry electropolymerization of PEDOT: Polydopamine on gold electrodes biorxiv.org 2026-05-30 This work presents a facile and rapid fabrication method for high-performance bioelectrode coatings through electropolymerization of poly(3,4-ethylene
A Sandwich-Structured Silk Fibroin Mesh with ROS-Responsive and Immunoregulatory Functions for Pelvic Floor Repair biorxiv.org 2026-05-30 Current biodegradable meshes for pelvic floor repair are constrained by a limited ability to actively modulate the hostile immune microenvironment fol
Information-Theoretic Functional Connectivity Characterizes Multiscale Network Reorganization in Postoperative Cognitive Decline biorxiv.org 2026-05-30 Postoperative cognitive decline (POCD) after coronary artery bypass grafting (CABG) is increasingly conceptualized as a system-level disturbance of la
Drug Affinity and Functionalization of Gold Nanoparticles: AFMSEIRA and SERS Study biorxiv.org 2026-05-30 This study presents the first investigation of the adsorption behaviour of Afatinib on gold nanoparticle (AuNP) monolayers, employing a combination of
Design-space requirements for abundance-amplified drug-like targeting of RHSVV/PAb240-like p53 exposure in TP53-mutant cancer biorxiv.org 2026-05-30 TP53-mutant cancers often accumulate p53 protein, creating a potential abundance-amplified therapeutic target, but wild-type p53 can also rise in stre
Growth-resolved genome-scale metabolic modeling of Priestia megaterium SR7 validated by chemostat and 13-C flux analysis biorxiv.org 2026-05-30 Priestia megaterium SR7 is a promising candidate chassis for bioprocess engineering, but its development is limited by the availability of condition-g
Intestinal Dysbiosis in Necrotic Enteritis: Dissecting the Roles of Eimeria and Clostridium perfringens biorxiv.org 2026-05-30 Necrotic enteritis (NE), caused by Clostridium perfringens, is major enteric disease in poultry with substantial economic impact.
The Neurodynamic Core of Meditation: Dissociating Meditation from Rest and Task in a Reliability-based EEG study biorxiv.org 2026-05-30 Background: Electroencephalographic (EEG) studies attempting to characterise the neural signature of meditation typically rely on contrasts with passi
Pathogenic MYBPC3 missense variants alter protein-protein interactions within the sarcomere biorxiv.org 2026-05-30 Aims: Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that leads to left ventricular hypertrophy, heart failure, and arrhythmias.
The TCA cycle and pentose phosphate pathway are linked to lipid droplet expansion in nitrogen-starved Lipomyces starkeyi cells biorxiv.org 2026-05-30 In eukaryotic cells, lipid droplets (LDs) play critical roles in storing energy, preventing lipotoxicity, promoting membrane biogenesis, and regulatin
Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosis biorxiv.org 2026-05-30 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which the earliest cellular events driving fibrosis remain poorly de
Structure and Variation in Dam-Daughter Bonds in Captive Rhesus Macaques biorxiv.org 2026-05-30 Mother-daughter relationships are central to social organization in rhesus macaques, providing the foundation for kin familiarity, affiliative bias, a
Monitoring Sphingomyelin Biosynthesis at Nanoscale Resolution by Expansion Microscopy biorxiv.org 2026-05-30 Sphingomyelin is the most abundant sphingolipid in mammalian cells and is synthesized by two isoenzymes, sphingomyelin synthase 1 and 2, located in th
reComBat-seq: Regularized negative binomial regression for batch-effect correction in underdetermined transcriptomics datasets biorxiv.org 2026-05-30 Motivation: Batch effect correction is essential for the integration of large-scale transcriptomics datasets such as single-cell RNA-seq or multi-stud
SpatialDataAgent: Autonomous Spatial Omics Data Curation at Decade Scale biorxiv.org 2026-05-30 Fragmented metadata in spatial omics archives has rendered large volumes of multimodal molecular-histological data inaccessible as 'dark data'.
Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata biorxiv.org 2026-05-30 Kalanchoe pinnata is a perennial plant that grows wild in tropical regions and is traditionally used as a medicinal plant.
Genome editing of key domestication genes overcomes self-incompatibility and bitter taste in cultivated buckwheat biorxiv.org 2026-05-30 Buckwheat (Fagopyrum spp.) is a climate-resilient pseudocereal, yet its global adoption is constrained by the distylous self-incompatibility of common
EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin biorxiv.org 2026-05-30 Endometrial receptivity assessment currently requires invasive tissue biopsy, yet recent randomized trials have questioned the clinical utility of bio
Epidermal microstructure and tactile sensitivity in the glabrous skin of hands and feet biorxiv.org 2026-05-30 Glabrous skin on the human palms and soles is specialised for mechanical interaction and is characterised by papillary ridges, an absence of hair foll
Task-Dependent Modulation of Feedback Control in Human Steering biorxiv.org 2026-05-30 We examined whether human steering behavior conforms to optimal feedback control (OFC) principles when driving a vehicle through sequences of upcoming
Molecular Basis of Histone H3 Reading and Writing by Legionella pneumophila SET Domain Lysine Methyltransferases biorxiv.org 2026-05-30 RomA and its highly conserved strain ortholog LegAS4 are SET and ankyrin domain-containing effector proteins of the intracellular bacterial pathogen L
Structural Connectivity Between the Zinc Linchpin Motif, the cluster, and the active site orchestrates DNA repair in MUTYH biorxiv.org 2026-05-30 The DNA glycosylase MUTYH protects genomic integrity by excising adenine mispaired with 8-oxoguanine (OG), which initiates base excision repair (BER).
Super-resolution complexome of human mitochondria elucidates translocase, morphology and OXPHOS networks biorxiv.org 2026-05-30 Mitochondria function as cellular powerhouses and central hubs in metabolism, redox and stress reactions, signaling and apoptosis.
BasalCell: A project scaffold generator for bioinformatics analysis biorxiv.org 2026-05-30 In the current bioinformatics landscape, where R-centric and Python-centric ecosystems coexist and overlap, there is an increasing demand for the orga
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer biorxiv.org 2026-05-30 Background Transcriptional regulation is shaped by both genomic variants and the environment.
Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes biorxiv.org 2026-05-30 Cancer genome analysis relies on standard human reference genomes but detecting somatic alterations in highly repetitive or individual-specific region
Deformation Gradient Tensor Model of Roll-Spiral Transformation for Protein Assembly Refractile Body biorxiv.org 2026-05-30 Spiral geometries commonly occur in natural and engineered systems and are fundamentally described by curvature and torsion.
Bayesian optimisation and graph-based rheology enable sequence-dependent modelling of DNA materials biorxiv.org 2026-05-30 Bridging molecular and emergent properties is essential for designing soft matter.
Amplicon/Protein Bead Display enables quantitative in vitro biochemistry at scale biorxiv.org 2026-05-30 Scalable methods for producing and characterizing protein libraries are essential for generating standardized datasets needed to train models linking
Disentangling RNA evolution and thermodynamics in genomic language models biorxiv.org 2026-05-30 Genomic language models (gLMs) trained only on large-scale nucleic acid sequence data seem to capture signals of RNA structure, yet the specifics of h
Age and Gender-Dependent Group-Average Brain Biomechanics Models for Traumatic Brain Injury biorxiv.org 2026-05-30 Experimental studies involving mechanical loading of the human head and brain in vivo are necessarily limited, making computational modeling essential
Quantum transport in mitochondrial complex I is governed by a conserved structural bottleneck biorxiv.org 2026-05-30 Electron transport in mitochondrial complex I is mediated by a chain of redox centers, yet how electrons traverse this network beyond the canonical pa
TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma biorxiv.org 2026-05-30 Tyrosine kinase inhibitors (TKIs) are the first-line therapy for chronic myeloid leukemia (CML), yet fail to eliminate quiescent CML cells residing in
Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis biorxiv.org 2026-05-30 Idiopathic pulmonary fibrosis (IPF) is characterized by failed alveolar epithelial repair and progressive fibrotic remodeling.
Tetramerization and RNA-guided filament assembly control Schlafen-Argonaute antiphage defense biorxiv.org 2026-05-30 Two deeply conserved protein families, Argonaute (Ago) and Schlafen (SLFN), play defense roles in diverse prokaryotes and eukaryotes, including humans
TgmRHel drives unified RNA processing of coxI mRNA generated from a complex mitochondrial genomic context biorxiv.org 2026-05-30 The mitochondrial genome of Toxoplasma gondii is highly fragmented and recombination-prone, creating a structurally dynamic genetic landscape.
Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation biorxiv.org 2026-05-30 Insulinomas are rare and benign human pancreatic adenomas that overproduce insulin and display increased beta cell mass.
Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture biorxiv.org 2026-05-30 The pioneer factor hypothesis posits that specialized transcription factors access nucleosomal DNA to enable binding of secondary factors, implying a
Ultra-low biomass sequencing workflow (LBV-Seq) enables de novo metagenomic reconstruction of DNA and RNA viral genomes biorxiv.org 2026-05-30 Genome-resolved virome analysis remains inaccessible for many samples, including those with clinical relevance, because viral nucleic acid recovered a
Fragmentation Patterns of Human Telomeric Chromatin in Plasma cfDNA biorxiv.org 2026-05-30 The unique chromatin structure at telomeres protects the linear ends of chromosomes from DNA surveillance machineries.