Evolutionary Trajectories of Ciprofloxacin Resistance in P. aeruginosa Lung Biofilms: Mutation Dynamics, Metabolomic Shifts, and Collateral Sensitivity biorxiv.org
Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus biorxiv.org
Fixation-locked hippocampal activity reflects semantic content and temporal order of visual exploration during scene encoding biorxiv.org
Verb-Specific Linking Properties Modulate the N400 Effect: Evidence from Thematic Reversal Anomalies in Malayalam biorxiv.org
Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer's Disease pathology biorxiv.org
Trajectories of brain organisation transition from predicting externalising to internalising symptoms across adolescence biorxiv.org
Astrocytes transform the transcriptomic and epigenetic landscape of developing cortical neurons to promote activity via intrinsic excitability control biorxiv.org
Reduced MOV10 reveals novel functional cortical connections in an increased fear response biorxiv.org
Reduced cortical VPS26B levels are associated with altered glutamate receptor expression and synaptic protein loss in the primary motor cortex of a Parkinsonian mouse model biorxiv.org
Anhedonia buffers the effects of early-life unpredictability on threat-reward decision-making. biorxiv.org
Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of SCN2A-Related Disorders biorxiv.org
Behavioral Relevance Coding in Human Area 46 Precedes Selective Motor Activation to Action Targets biorxiv.org
Neural correlates of successful relational memory in younger and older adults: An activation likelihood estimation meta-analysis biorxiv.org
Longitudinal tracking reveals developmental transitions in zebrafish clock gene expression biorxiv.org
A bidirectional nanAKE locus enables sialic acid catabolism in gut microbiome member Hungatella hathewayi biorxiv.org
FlexENN: A Graph Neural Network for Binding Energy Prediction of Globular and Intrinsically Disordered Proteins biorxiv.org
Solid state NMR characterization of wild-type and mutant GFAP intermediate filament assemblies biorxiv.org
Species-rich and genomically diverse: comparative genomics reveals how fusions, fissions, and sex chromosomes have shaped beetle evolution biorxiv.org
Rare plants can make an important contribution to sustain local biodiversity through biological interactions biorxiv.org
Human cytomegalovirus virion delivered UL14 is a viral tropism factor for epithelial cells biorxiv.org
Genome-wide computational prediction of miRNAs encoded by influenza A virus (H3N2) predicts target genes involved in pulmonary and antiviral innate immunity biorxiv.org
Environmental impacts on gene expression noise and its relationship with fitness biorxiv.org Genetically identical cells grown in the same environment show variation in gene expression known as expression noise.
Molecular epidemiology of the globally spreading genetic lineage IV of peste des petits ruminants virus biorxiv.org Peste des petits ruminants (PPR) is a highly contagious viral disease of small ruminants caused by the peste des petits ruminants virus (PPRV), which
Functional genomic map of local adaptation in sorghum to guide allele mining biorxiv.org Genomic data from genebanks could be exploited to find alleles adapted to target environments for resilience breeding, but it can be difficult to prio
Navigating a dynamic winterscape: habitat composition and individual variability shape daily movement in wintering common cranes in western India biorxiv.org Background: Wintering migratory birds must balance energetic requirements, resource availability, and disturbance in increasingly human-modified lands
Direct and Indirect Entomological Efficacy of Targeted Indoor Residual Spraying against Aedes aegypti in Iquitos, Peru biorxiv.org Background: Control of Aedes aegypti, the primary vector of dengue and other Aedes-borne viruses, is challenged by insecticide resistance, limited eff
Noise and determinism in Trinidadian guppy population dynamics biorxiv.org Natural populations are often nonlinear and exhibit substantial variability.
Trans-Kingdom dsRNA Sensing: Aspergillus fumigatus Mycovirus Activates MDA5/MAVS Immunity and Limits Allergic Bronchopulmonary Aspergillosis biorxiv.org
Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy biorxiv.org
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead biorxiv.org
Cooperative antibiotic response in coupled biofilm and planktonic E. faecalis communities biorxiv.org
Mechanistic Insights into TMPyP4 Recognition of the HIV-1 LTR-III G-Quadruplex in Dilute and Protein Condensate Environments Reveal Hidden Dual Binding Modes biorxiv.org
ALS mutations in the TIA1 RNA granule protein have differing effect on low complexity domain fibril formation biorxiv.org
An extracellular vesicle biogenesis-inspired engineering platform for efficient protein delivery and therapeutic base editing biorxiv.org