Therapeutic potential of Relaxin-2 in Heart Failure with preserved Ejection Fraction (HFpEF) biorxiv.org
Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche biorxiv.org
DamageFormer: a damage-aware multimodal deep learning framework for DNA lesion identification from nanopore sequencing biorxiv.org
Dissecting the regulatory and genomic drivers of the dichogamy determining G-locus in pecan biorxiv.org
T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity biorxiv.org
Microplastics inhibit macrophage bioenergetics impairing homeostatic function and immune responsiveness biorxiv.org
Two Pellioditis biocontrol nematode species infect Ariolimax columbianus, the Pacific banana slug, and increase mortality in laboratory infectivity trials biorxiv.org
Mast Cells Enhance Myeloma Engraftment and Promote Bone Destruction in the NSG-hIL6 Patient Derived Xenograft Model biorxiv.org
Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes biorxiv.org
Frequency-Dependent Bioimpedance Signatures of Ocular Tissues in Intact Ex Vivo Eyes Under Simulated Surgical Conditions biorxiv.org
Mechanical cues from muscle contraction regulate TGFβ signaling and epitenon formation during embryonic tendon development. biorxiv.org
PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance biorxiv.org
Restoration of E-cadherin Expression Alters Metastatic Organotropism in Invasive Lobular Breast Carcinoma Models biorxiv.org
Microbiota-gut-brain axis modulation drives glioblastoma progression and therapy resistance biorxiv.org
A Spatial Proteomic Atlas of Tertiary Lymphoid Structures in Non-Small Cell Lung Cancer Identifies a Novel Predictive Class of Lymphoid Aggregates biorxiv.org
Discriminative learning of substitution matrices and gap penalties for pairwise alignment of biological sequences biorxiv.org
SLE Monocyte Subsets Are Pro-Inflammatory and Display Dysregulated Metabolism in Response to Bacterial Stimuli biorxiv.org Systemic lupus erythematosus (SLE) is associated with infection susceptibility and altered innate immune function.
BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4⁺ T cell differentiation biorxiv.org Although the endolysosome system is central to intracellular recycling, signal transduction, and intercellular communication via exocytosis, its role
β-Hydroxybutyrate elicits divergent metabolic responses between MCF-7 and T47D ER+ breast cancer cells under glucose restriction biorxiv.org Background: The ketogenic diet is being explored as an adjuvant intervention in breast cancer because it lowers circulating glucose and elevates keton
High-Throughput Characterization of Trends in Transmembrane Helix Partitioning into Membrane Domains biorxiv.org The plasma membrane is a laterally heterogeneous environment in which lipid organization plays a central role in regulating protein function.
Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism biorxiv.org The restoration of chromatin in the wake of a DNA or RNA polymerase is essential to maintain the integrity of eukaryotic genomes.
Characterization of spe-40/Fam187 identifies a deeply conserved sperm protein at the C. elegans fertilization synapse biorxiv.org
MYC overexpression drives poor prognosis and differential sensitivity to treatments according to TP53 status in chronic lymphocytic leukemia biorxiv.org
Metabarcode and transcriptome datasets of Pinus sylvestris to assess fungal phyllosphere and disease dynamics. biorxiv.org
Nutritional-Metabolic Lipid Profiling with LipidOne for plasma lipidomics interpretation in metabolic health biorxiv.org
The Paipu framework enables creation of a large-scale mammalian cancer transcriptomics atlas biorxiv.org
From Spectra to Digital Phenotypes: Wearable Multispectral Sensing for Precision Light and Green Space Exposure biorxiv.org
A Comprehensive Computational Model of the Human head for Designing and Optimizing Visual Brain-Machine Interfaces biorxiv.org
Large disruptions to mammalian spermatogenesis downstream of genetic perturbations in meiotic double-strand break repair biorxiv.org
SOX9 and SEMA7A regulate cell plasticity in the postpartum mammary gland with implications for breast cancer biorxiv.org
Type III Druantia two-component antiphage defense depends on the DruH-DruE interaction for halting phage DNA cyclization and replication biorxiv.org
Genomic Characterization of the RyC collection: 50 Multidrug Resistant Clinical Isolates of Escherichia coli and Klebsiella spp. biorxiv.org
Effective macrophage clearance of Klebsiella pneumoniae requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidase biorxiv.org