Transgene Expression Kinetics and Replication Potential of Recombinant Adenovirus Serotype 4 in a Mouse Model and its Use as a Herpes Simplex Virus Vaccine biorxiv.org
Report on pre-validation of an animal-free alternative method (NAM) for regulatory safety testing: InfiniteLungDT, an in-vitro-learned digital twin for the prediction of material-triggered chronic neutrophilic lung inflammation biorxiv.org
An Engineered Halotolerant Chimeric T7 RNA Polymerase for High-Yield, Low-Immunogenicity Synthesis of RNA via Simple Batch Transcription biorxiv.org
Beyond next-word prediction: hierarchical linguistic composition drives LLM-brain alignment in time biorxiv.org
Body size and cranial shape differentiation in urban and rural house mice (Mus musculus domesticus) biorxiv.org
Discovering conserved regulatory modules in predicted gene regulatory networks across species biorxiv.org
CRISPR/Cas12a-Mediated Knockout of the INNER NO OUTER (INO) Gene in Musa balbisiana cv. Bhimkol biorxiv.org
cfMIND: A read-level methylation framework for accurate non- invasive disease detection using cell-free DNA biorxiv.org
From Peaks to Power: Systematic Evaluation of Chromatographic Sampling Reveals Determinants of Quantification and Biological Discovery in DIA Proteomics biorxiv.org
Magnetic particle imaging reveals heterogeneous retention, leakage and redistribution of nanoparticles following intratumoral injection biorxiv.org
Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation biorxiv.org
Metagenome-scale Modeling to Assess Microbiome Metabolic Complementarity for Precision Microbiota Transplantation Therapies biorxiv.org
LONG-TERM NEURODEVELOPMENTAL AND COGNITIVE OUTCOMES FOLLOWING PRENATAL INHIBITION OF DYRK1A BY LEUCETTINE L41 IN MOUSE MODELS OF DOWN SYNDROME biorxiv.org
Bioengineered algal lipids enriched in structured medium- and long-chain triacylglycerols, linoleate, and sn-2 palmitate for human milk fat substitutes biorxiv.org
Identification of Reductases Catalyzing Benzyl Alcohol Formation during Salicylic Acid Biosynthesis in Plants biorxiv.org
AP2/ERF transcription factor RAP2.6 regulates early flowering in Arabidopsis thaliana by altering S-nitrosothiol levels and cytokinin responses biorxiv.org
The Magnaporthe oryzae Effector AvrPii Attenuates Rice Immunity by Targeting the Calcium-Associated ANK Protein AVIN8 biorxiv.org
TAMIPAMI: Software and methods for PAM/TAM identification for CRISPR and OMEGA gene editing systems biorxiv.org
Hidden State Genomics: Graph-Based Analysis of Sparse Auto-Encoder Feature Activity in Genomic Language Models biorxiv.org
OpenBase: a universal framework for high-accuracy single-molecule detection of diverse non-canonical DNA bases using nanopore sequencing biorxiv.org
Trypsin exhibits exopeptidase-like activity toward N-terminal arginine that biases proteomic analyses biorxiv.org
Mechanical tuning of replication stress tolerance and genomic stability through the checkpoint mediator Mrc1 biorxiv.org
Molecular determinants of Bcl-xL membrane insertion - Structural plasticity exploration in solution and in nanodiscs identifies IsoAsp deamidation as a loss-of function mechanism in vivo. biorxiv.org
In silico investigation of alternative splicing of microexons in human peripheral tissues biorxiv.org
Omics analysis of MRSA under antibiotic stress identifies conserved adaptive modules and candidate adjuvant targets biorxiv.org
A Far-Red FRET biosensor for AMPK enables multiplexed imaging of single-cell bioenergetic homeostasis biorxiv.org
Heterologous expression of lyngbyatoxin biosynthetic genes in Aspergillus oryzae reveals transcriptional barriers but enables LtxC-mediated biotransformation biorxiv.org
Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism biorxiv.org
Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection biorxiv.org
Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network biorxiv.org
Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity biorxiv.org
A unified benchmark of synthetic data generation for clinical transcriptomic cancer cohorts biorxiv.org