Deep learning models for chemical perturbation prediction do not yet utilise drug molecular features biorxiv.org
Modeling Meibomian Gland Development and Dysfunction: A Mouse-Derived Organoid System Reveals Hippo-YAP as a Critical Regulator biorxiv.org
Mapping mouse hippocampal output circuits using direction-selective anterograde transsynaptic transduction biorxiv.org
Meaning for reading pseudowords: errors reveal semantic influences on pseudoword reading after stroke biorxiv.org
Simulated Microgravity Induces Cultivar-Specific Changes Affecting Salmonella enterica Ingression Independent of Stomatal Physiology biorxiv.org
Engineering carotenoid and steroidal glycoalkaloid depleted tomato fruit for heterologous production of high value terpenes biorxiv.org
Degradation of cytokinesis-specific Qa-SNARE KNOLLE is regulated by context-dependent ubiquitination biorxiv.org
Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent manner. biorxiv.org
Comprehensive Analysis Reveals Adaptive DNA Repair and Replication Stress Networks in Genomically Unstable Breast Cancer biorxiv.org
Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer biorxiv.org
Characterization of tumor interactions with the immune system in an autochthonous mouse model of glioblastoma biorxiv.org
Metabolic Self-Organization: Emergence of Autonomous Agency in a Metabolically Constrained LLMs biorxiv.org
Design of DNA Aptamers for Lyme disease Diagnosis Combining experimental and numerical approaches biorxiv.org
Mapping of Stripe Rust and Leaf Rust Resistance Genes in the Hard Red Winter Wheat Population Green Hammer/Lonerider biorxiv.org
An aromatic substrate prenyltransferase involved in the chemical diversification of flavonoids in Glycyrrhiza glabra biorxiv.org
Elucidating the dysbiotic features of gut microbiome, interaction with the human genome, and utility as a biomarker for treatment of Parkinson disease. biorxiv.org
Rac2 Hyperactivity Drives Neutrophil Degranulation, Myeloperoxidase Deficiency, and Lymphopenia biorxiv.org
Comparison of Machine Learning Surrogate Models for Prediction of Single-Fiber Activation in Deep Brain Stimulation biorxiv.org
High-Precision Event Synchronization for Chronic Deep Brain Stimulation Local Field Potential Recordings biorxiv.org
Genome-scale community metabolic modeling of maize root-associated microbiota shows that root exudates stimulate diverse metabolic interactions biorxiv.org
Vertical Sleeve Gastrectomy inhibits 11βHSD1 and subsequently reduces IL6 secretion in Mice and Humans: A Shared Anti-Inflammatory Mechanism biorxiv.org
Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of the class B1 GPCRs, calcitonin gene-related peptide and parathyroid hormone 1 receptors, in native-like nanodiscs biorxiv.org
Effects of NMDA antagonists on social behaviour: a systematic review and meta-analysis of preclinical studies biorxiv.org
TwinSAR: An Adaptive Kernel-based Algorithm with logit-transformed Z-score Filtering for Chemical Twin Detection in Large-scale Virtual Screening biorxiv.org
Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by Sex biorxiv.org
Digital Atlases to Unlock the Potential of Brain Biorepository Tissues for Interdisciplinary Research biorxiv.org
Length-dependent hypercontractility decoupled from cellular adaptations is the initial phenotype in MYBPC3-haploinsufficient iPSC-derived engineered cardiac tissues biorxiv.org
Tsallis-Gated Autoencoder: A Nonextensive Physics-Informed Approach for Unsupervised Anomaly Detection in Glioblastoma Multiforme RNA-seq Data biorxiv.org
Physics-Informed Neural Networks for Parameter Recovery in the Repressilator Oscillatory Model biorxiv.org
Patient-specific "Physical Twin" artery-on-chip platform reveals complex flow-dependent VWF mechanobiology and guides personalized antithrombotic therapy biorxiv.org
Multi-resolution Spatial Graphical Regression Models for Hierarchical Spatial Transcriptomics Data biorxiv.org
De novo steroidogenesis maintains female-specific Th2 identity and constrains effector function biorxiv.org
Emergent representations of graphical structure in mechanistic neural models of causal judgment biorxiv.org
Co-expression network analysis reveals repression of Igf2bp2 by REV-ERBβ in skeletal muscle biorxiv.org
A single PLAT domain protein couples reproductive arrest and carotenoid pigmentation during diapause in the two-spotted spider mite, Tetranychus urticae Koch biorxiv.org