Cooperation, privatization and cheating in microbial exoenzyme synthesis: theoretical analysis in view of biotechnological applications biorxiv.org 2026-05-31 This study presents a mathematical framework for investigating the dynamics of coexistence and competition among heterotrophic microbes across differe
PFAS exposure is associated with accelerated epigenetic ageing in a wild marine mammal biorxiv.org 2026-05-31 Chronic contaminant exposure may impose hidden physiological costs long before obvious demographic or health effects become detectable in wildlife pop
Water availability has stronger effects on West Nile virus dynamics in water-limited regions biorxiv.org 2026-05-31 West Nile virus dynamics are shaped by hydrological conditions that influence mosquito habitat and pathogen transmission, but identifying causal relat
Tryptophan became part of the universal genetic code post-LUCA biorxiv.org 2026-05-31 We evaluate whether tryptophan (W), widely thought to be the last of the 20 canonical amino acids added to the genetic code, was already present in th
GPU accelerated population genetics statistics using pg_gpu biorxiv.org 2026-05-31 Population genetics summary statistics-- diversity, divergence, linkage disequilibrium, selection scans, and dimensionality reduction-- are fundamenta
Functional class 2 CCA-adding enzymes in Asgard archaea and their implications for eukaryogenesis biorxiv.org 2026-05-31 CCA-adding enzymes are essential for transfer RNA (tRNA) maturation and translation among all domains of life.
Variable jackpot individuals provide most alleles for repeated, rapid adaptation to freshwater by anadromous Threespine Stickleback biorxiv.org 2026-05-31 The Threespine Stickleback has become a key model organism to study evolutionary biology.
Population genomics reveals divergent lineages in the European peatland plant Drosera rotundifolia biorxiv.org 2026-05-31 Genomic variation within populations reflects both past and contemporary evolutionary processes.
Modes of natural selection on maternal and zygotic gene expression in Drosophila melanogaster embryos biorxiv.org 2026-05-31 Early embryonic development involves the coordination of gene expression from two distinct genomes, as mothers load eggs with gene products prior to t
Discovery of novel members of the Potyviridae family reveals expanded diversity, a broad host range, and evidence of fungal and oomycete infections biorxiv.org 2026-05-31 The family Potyviridae represents the largest and most economically important group of plant-infecting RNA viruses.
From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT biorxiv.org 2026-05-31 Pathologist-annotated tissue regions provide a fundamental reference for examining spatial omics data, yet such annotations are available for a limite
Genomic hallmarks of parasexual reproduction in three hybrid groups of the human pathogen Cryptococcus neoformans biorxiv.org 2026-05-31 Hybridization is a major driver of fungal evolution, yet knowledge of the molecular mechanisms underpinning hybridization and its genomic impact remai
DanioDecima: A DNA sequence-to-function model of zebrafish embryogenesis biorxiv.org 2026-05-31 Deep learning DNA sequence-to-function models offer the promise of gaining mechanistic insights into genome regulation, however their performance is o
Coordinated neural, metabolic and muscular transcriptomic signatures associated with mite-biting behavior in honeybees (Apis mellifera L.) biorxiv.org 2026-05-31 Biting behavior is an important natural defense mechanism in honeybees (Apis mellifera) against Varroa destructor.
Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions biorxiv.org 2026-05-31 Aberrant monocyte and macrophage activation in diabetes drives chronic inflammation and complications.
Trichome and inflorescence evolution in the paleopolyploid tree genus Greyia Hook. & Harv. biorxiv.org 2026-05-31 The southern African endemic tree genus Greyia Hook. & Harv.
Genomic connectivity and the spread of adaptive insecticide resistance alleles in Anopheles arabiensis from East Africa biorxiv.org 2026-05-31 Population connectivity and adaptive gene flow in disease vectors can shape the emergence and spread of insecticide resistance, with direct implicatio
Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblasts biorxiv.org 2026-05-31 Periodontal disease is characterized by progressive degradation of the gingival extracellular matrix and loss of the physical confinement it imposes o
Cohort-HMM marker recruitment with per-OG orthology QC for phylogenomic supermatrices biorxiv.org 2026-05-31 OrthoFinder's all-vs-all DIAMOND step systematically misses single-copy orthogroups (SC OGs) at deep taxonomic divergence: a marker recovered cleanly
Range-wide validation of reduced locomotor endurance in unisexual Ambystoma salamanders biorxiv.org 2026-05-31 Locomotor endurance is a critical physiological trait dictating terrestrial dispersal and metapopulation connectivity, especially in amphibians.
Peak performance is repeatable and captures large individual differences in ruby-throated hummingbirds biorxiv.org 2026-05-31 Locomotor performance often determines the outcome of interactions with competitors, predators, and prey.
Temporal persistence of admixed phenotypes in a damselfly hybrid zone biorxiv.org 2026-05-31 In odonates, hybridization has been documented in several species pairs, yet the long-term persistence of hybrid phenotypes remains poorly understood,
Statistical inference of the Tree of Blobs of a phylogenetic network from quartet concordance factors biorxiv.org 2026-05-31 A phylogenetic network represents evolutionary relationships involving hybridization, gene flow, or admixture.
New Protein Function Characterization for Human Paralog Discovery, Scraping the Bottom of the Genomics Barrel biorxiv.org 2026-05-31 IIncreasing the number of related protein paralogs is important for fully understanding protein relationships, yet it remains challenging for sequence
ERGA-BGE reference genomes of Hyalomma lusitanicum and its obligate Francisella endosymbiont as a genomic resource for One Health research biorxiv.org 2026-05-31 Hyalomma lusitanicum is a characteristic tick species of the western Mediterranean region, with a well-established distribution across the Iberian Pen
Comparison of AI protein structure ensemble prediction tools biorxiv.org 2026-05-30 Multiple AI prediction tools for protein structural ensembles have recently been released, building on the much heralded advances from AlphaFold, larg
Protonated Structure of EmrE Reveals C-terminal Tail Gating Mechanism biorxiv.org 2026-05-30 The multidrug efflux pump EmrE is one of the smallest known active transporters and has become a model system for studying multidrug recognition and t
A new skeleton of the gorgonopsian Aelurognathus tigriceps from the Daptocephalus Assemblage Zone (Karoo Basin, South Africa) with novel insights into the pelvic girdle, hind limbs, and tail biorxiv.org 2026-05-30 Gorgonopsian therapsids represent a transitional condition in the evolution of synapsid locomotion and postcranial structure.
Ontology-driven software engineering using LLMs for knowledge graphs in engineering biology biorxiv.org 2026-05-30 Large language models have transformed software engineering practices.
Rapid Isothermal Detection of Heavy Metals via Transcription-Factor-Gated DNA Strand Synthesis biorxiv.org 2026-05-30 Conventional methods for monitoring toxic heavy metals typically require sophisticated laboratory instrumentation and leave a critical gap for rapid,
Ultrasensitive response in bacterial replication initiation biorxiv.org 2026-05-30 Bacteria are able to coordinate cell growth and genome replication in different growth conditions.The DNA-binding protein DnaA is responsible for dete
Modeling of Glucosinolate Biosynthesis During Biotic Stress as a Function of mRNA biorxiv.org 2026-05-30 Glucosinolates are an important group of specialized metabolites in the Brassicaceae family, playing a role as defensive compounds against biotic atta
Functional Characterization of RSV Clades Associated with Prophylactic Breakthrough Infections in Pediatric Transmission Clusters biorxiv.org 2026-05-30 The recent development of new respiratory syncytial virus (RSV) prophylactics for the prevention of severe lower respiratory tract infections in infan
Establishing the fluorescence-activating and absorption-shifting tag as a fluorescent reporter protein in Methanothermobacter thermautotrophicus ΔH biorxiv.org 2026-05-30 The thermophilic methanogen Methanothermobacter thermautotrophicus {Delta}H is a model microbe for hydrogenotrophic methanogenesis and an emerging pla
Microbial exometabolite responses to root exudates from tallgrass prairie plants biorxiv.org 2026-05-30 Root exudates influence soil microbial community assembly and function, yet plant species-specific effects on microbially-driven metabolic transformat
A new reference-invariant consensus template generation method in ALPACA biorxiv.org 2026-05-30 1. Automated landmarking transfers anatomical landmarks from a reference specimen onto many targets, greatly increasing analytical throughput.
Development shapes molecular responses to thermal extremes in a desert bird biorxiv.org 2026-05-30 Thermal extremes are among the most immediate environmental challenges faced by animals.
Buffering of developmental noise provides a mechanism for heterosis in both polyploid and diploid hybrids biorxiv.org 2026-05-30 Using an abstract computational model of multicellular development, I show that the deleterious effects of gene expression noise on development are he
Characterizing the Molecular Determinants of Clamp Binding in B. subtilis biorxiv.org 2026-05-30 In bacteria, the ring-shaped sliding clamp, DnaN, is an essential component of the replication machinery.
Candida albicans reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesis biorxiv.org 2026-05-30 Gastric cancer (GC) is strongly associated with changes in the gastric microbiome.
Explainable machine learning reveals an RBP regulatory logic of exon skipping biorxiv.org 2026-05-30 RNA binding proteins (RBPs) regulate the life cycle of an mRNA, often through RBP-RNA interactions.
The b0+ Amino Acid Transporter Defines a Selenium-utilization Enterocyte Program in the Human Intestine biorxiv.org 2026-05-30 Selenium is an essential trace element incorporated into selenoproteins as selenocysteine, yet the intestinal cellular programs associated with seleni
PAIR-link: a ligation-free strategy that joins two RNAs into a single sequence-preserving chimeric cDNA biorxiv.org 2026-05-30 Physical proximity between RNA molecules, and between the proteins that bind them, underlies much of post-transcriptional regulation, yet the methods
A pilot assessment of avian communities and soundscapes along an Amazonian fluvial corridor biorxiv.org 2026-05-30 Quantifying biodiversity patterns in remote Amazonian ecosystems remains constrained by the limitations of traditional field surveys.
Elementary Dynamics of Neural Microcircuits biorxiv.org 2026-05-31 Interactions between distinct populations of excitatory (E) and inhibitory (I) neurons can produce complex dynamical landscapes, featuring multistabil
Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons biorxiv.org 2026-05-31 For the brain to compute, electrical signals must propagate over the membranes of individual neurons, connecting synaptic inputs to synaptic outputs.
A hierarchical Bayesian framework accommodates intraspecific and interspecific variation in multivariate traits biorxiv.org 2026-05-31 Phylogenetic comparative methods are a critical tool in biology, providing the framework to test evolutionary hypotheses of phenotypic diversification
Accounting for recurrent mutation in the frequency spectrum of rare alleles biorxiv.org 2026-05-31 As whole-genome and whole-exome datasets increase in size, they uncover alleles at lower and lower frequencies in the population.
TEX15 safeguards neuronal diversity in the mouse olfactory system biorxiv.org 2026-05-30 Animal chemosensory systems discriminate between complex mixtures of chemical compounds by leveraging large repertoires of chemoreceptor proteins.
Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch biorxiv.org 2026-05-31 The hippocampus and medial prefrontal cortex (mPFC) are required for delayed working-memory tasks, but when in the task their engagement becomes neces