Rotating Letters in the Mind's Eye: Behavioral and electro-cortical associations with 3D Mental-Rotation Ability biorxiv.org
An anatomically distinct dopaminergic cell population of the zona incerta as evidence for the human A13 nucleus biorxiv.org
Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation biorxiv.org
PXN Unlocks the Power of Public Gene Expression Data Through Cross-Technology Integration biorxiv.org
Viral non-coding RNA structure annotation and API-based data retrieval with Rfam and R2DT biorxiv.org
Assessing Bioactivity and Biointegration of Engineered Salivary Tissue Constructs in a Preclinical Unilateral Fractionated Irradiated Rat Model biorxiv.org
Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1 biorxiv.org
The AvianMetaNetwork: biotic interactions among birds of the continental United States and Canada biorxiv.org
Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency biorxiv.org
Environmentally-determined symbiont communities highlight flexibility of Aiptasia-algal symbiosis biorxiv.org The mechanisms driving host-symbiont associations across space and time in contemporary mutualisms can give insight into the capacity for symbiotic or
ppGpp regulates transcription elongation via direct and indirect inputs to RNA polymerase pausing and nucleotide addition biorxiv.org
Embryonated chicken eggs clear systemic H3N2 influenza without RIG-I: transcriptomic evidence for innate sufficiency and brain immune privilege biorxiv.org
First record of the subfamily Eucerotinae (Hymenoptera: Ichneumonidae) from the mainland Afrotropics, with a description of a new species biorxiv.org The ichneumonid subfamily Eucerotinae has been thought to be almost absent from the tropics, with the only known Afrotropical species found in Madagas
Protein Stability, Turnover Kinetics, and Abundance Constrain the Scaling of Protein Interaction Networks biorxiv.org The propensity of proteins to form oligomers is ultimately dictated by their structural configuration(s).
Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling biorxiv.org The foodborne mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) have been associated with several adverse effects, including cytotox
Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex biorxiv.org The intestinal brush border (BB), composed of densely packed microvilli on enterocytes, is essential for nutrient absorption and host defense.
RNA synthesis and degradation regulate biomolecular condensates through non-equilibrium feedback biorxiv.org Transcriptional condensates operate far from equilibrium, where continuous RNA synthesis and degradation dynamically reshape condensate composition.
Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects biorxiv.org The rapid expansion of human genomic data has revealed a large number of naturally occurring variants, creating a major challenge for functional annot
Adaptive genomic compartments shaped by giant mobile elements underpin the ancient emergence of fungal pathogenicity biorxiv.org
CD11c+ myeloid cells are the predominant CD4+CCR5+ immune population in the foreskin and are increased in men with HIV-associated penile anaerobes biorxiv.org
Whisker-based pre-neuronal and peripheral encoding of surface stickiness biorxiv.org Texture is a multidimensional perceptual feature of touch, with coarseness, stickiness, and compliance as its major axes of variability.
Engaging working memory following skill reactivation has implications for interlimb skill generalization biorxiv.org
Intranuclear polyglycine aggregation drives neurodegeneration through epigenetic repression of chromatin accessibility and transcription biorxiv.org
Fiber dispersion in the right ventricle: A comparison of constitutive neural network predictions with experimental data biorxiv.org
Assembly-active and -inactive forms of HBV capsid protein provide distinctly different binding sites for capsid assembly modulators biorxiv.org
CYP4F2-mediated ω-hydroxylation of 1-deoxysphingolipids reveals a new hepatic detoxification pathway biorxiv.org
Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets biorxiv.org CRISPR/Cas9-induced DNA double-strand breaks (DSBs) are widely used for genome engineering, yet their capacity to provoke sister chromatid exchange (S
Distribution of prophage-encoded Pas sRNAs across pathogenic Escherichia coli biorxiv.org Numerous base pairing small RNAs (sRNAs), which are an integral part of regulatory networks in bacteria, are encoded on mobile genetic elements (MGEs)
A sea full of measures: EU conservation goals for benthic habitats will require wide-ranging spatial measures biorxiv.org The use of marine space by human activities is globally increasing, resulting in a competition with spatial management measures for marine conservatio
Demographic changes and behavioural responses shape vulnerability to infectious disease outbreaks biorxiv.org Demographic shifts are reshaping population age structures worldwide, with implications for infectious disease dynamics.
From static thresholds to dynamic waves: How biological memory destabilizes malaria transmission Potential biorxiv.org The basic reproduction number R is central to malaria epidemiology, yet it is typically treated as a static quantity derived under memoryless assumpt
Exploiting outer-membrane protein promiscuity to induce transient collateral sensitivity via efflux pump competition biorxiv.org In the fight against antimicrobial resistance, the identification of robust collateral sensitivity (CS) patterns could form the basis of successful se
Integration of immunomonitoring assays with PET/CT in TB patients identifies on-treatment biomarkers biorxiv.org Tuberculosis (TB) continues to pose a significant global public health challenge with substantial morbidity and mortality.
Determinants of persistence in sequential effort-based decision-making biorxiv.org Goal-directed behavior often requires sustained effort across a sequence of interdependent decisions, yet the determinants of persistence in such cont