The Spectraplakin Short Stop (Shot) Organizes an Acentrosomal Microtubule Network in Early Oogenesis, Essential for Nuclear Positioning. biorxiv.org
Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cells biorxiv.org
Extracellular citrate modulates glutamine metabolism in human macrophages during infection biorxiv.org
The Uvrag-containing PI3K complex promotes Hsc70-4 dependent endosomal clathrin removal and lysosomal maturation in Drosophila nephrocytes biorxiv.org
Expression levels and dimer abundance of lamin A/C direct nuclear shape integrity in malignant cancer cells biorxiv.org
Histone quality control by prokaryotic ClpP/ClpR regulates the eukaryotic mitotic cell cycle in malaria parasites biorxiv.org
A compact Druantia defense clears phage infections via single-stranded DNA recognition and directional duplex unwinding biorxiv.org
Smartphone-Coupled Phase Contrast Microscopy Combined with Deep Transfer Learning for Candida Species Identification: A Proof-of-Concept Study biorxiv.org Species-level Candida identification can inform antifungal management, but reliable identification platforms remain inaccessible in many clinical micr
Microbiome-mediated lauric acid turnover contributes to colonization resistance against Ralstonia in the tomato rhizosphere biorxiv.org
Iterative structural homology search identifies new substrates of the protein O-fucosyltransferases POFUT3 and POFUT4 biorxiv.org
Morphological fingerprints enable machine learning based inference of neuroblastoma cell states without transcriptomics biorxiv.org
Comparative analyses of prolonged stress responses of breast carcinoma cells after hypofractionated irradiation in vitro and in vivo biorxiv.org
Optimizing Primary Human Salivary Stem/Progenitor Cells for Tissue Engineering Applications biorxiv.org
Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation biorxiv.org
An Epstein-Barr virus-encoded snoRNA directs 2'-O-methylation of human rRNAs to control translation and the viral lytic switch biorxiv.org Epstein-Barr virus (EBV) establishes life-long latency in human B-cells yet the molecular strategies that balance its persistence with lytic replicati
Consensus substrate recognition of conserved bacterial virulence peptide-bond recombinase biorxiv.org Shigella OspB, a conserved type 3 effector, is a cysteine protease and peptide recombinase.
Soil microbiome structure and function reflect environmental variation rather than reindeer presence in a northern peatland biorxiv.org Northern peatlands store large carbon stocks but are sensitive to disturbance.
Distinct genomic adaptations of the methanogenic archaeal genus Methanocorpusculum to symbiosis with animals and protists biorxiv.org Most of our understanding of endosymbiosis originates from the bacterial endosymbionts of multicellular, terrestrial hosts, which represent habitats w
Processing of forked DNA activates a helicase-nuclease immune system biorxiv.org Innate immune systems detect molecular signatures of infection to initiate antiviral defence (1-3), yet the identity of pathogen-associated signals th
Molecular basis of the Druantia anti-phage defense system biorxiv.org Eukaryotes and prokaryotes have evolved diverse antiviral immune systems, many containing helicase modules central to defense.
Mutations in bacterial regulatory genes are linked with chronic ash tree infections biorxiv.org Long term chronic infections of plants by bacterial pathogens are largely unknown.
Engineering orthogonal quorum sensing circuits using LuxR-type systems in yeast consortia biorxiv.org Engineered microbial communities hold significant biotechnological potential because their collective metabolism can produce functions beyond those ac
Meta-analysis reveals a distinct and uniform gut microbial signature associated with endocrine-disrupting chemicals-induced diabetes biorxiv.org
A network perspective on the role of c-di-GMP-associated protein complexes in biofilm formation. biorxiv.org
Unlocking the <Alphitobius diaperinus> (Coleoptera: Tenebrionidae)-Combatting Capabilities of <Bacillus thuringiensis> INTA Mo4-4 through genomic and phenotypic characterization biorxiv.org
Assessing soluble and insoluble calcium sources for growth, biofilm formation, and biomineralization in Bacillus subtilis. biorxiv.org
BIOTIA-DX RESISTANCE Achieved the Best Antimicrobial Resistance Phenotype Prediction Accuracy at CAMDA 2026 biorxiv.org
Conformational Expansion Underlies the Evolutionary Emergence of Redox Sensitivity in Vertebrate Glucokinases biorxiv.org
Rational Design of Resistance-Suppressing Phage-Antibiotic Cocktails via Receptor Tradeoffs biorxiv.org
Antiphage defence systems Druantia III and Zorya II synergise via shared DNA intermediates in a phage-specific manner biorxiv.org
Machine learning-based prediction of memory requirements for metagenomic assembly in high-performance computing environments biorxiv.org
Reduced antibiotic effect of ciprofloxacin on bacteria in the presence of montmorillonite biorxiv.org
Microbial GAIN domains undergo autoproteolysis and enable release of diverse cell surface associated proteins biorxiv.org
Wastewater and colloidal extracts of wastewater-irrigated soils select for resistant Acinetobacter baylyi beyond what measured antibiotic concentrations predict biorxiv.org Numerous studies have shown that the abundance of antibiotic-resistant bacteria (ARBs) or antibiotic-resistance genes (ARGs) in soil increases after i
Orthohantavirus-related Proteases as Therapeutic Targets: Opportunities for Antiviral Drug Development biorxiv.org
Variable fluid mechanics explain why static efficacy tests overestimate sanitizer performance against Listeria biorxiv.org
Activation-dependent lentiviruses enable antigen-specific T cell expansion and transduction biorxiv.org
MechAInistic: An LLM-guided Multi-Agent System for Reasoning over Genome-Scale Constraint-Based Metabolic Models biorxiv.org
Comparative metabolism of the Alternaria toxins altenuene and tentoxin in rat and human primary hepatocytes biorxiv.org
A Comprehensive Benchmarking of Spatial Deconvolution andDomain Detection Methods across Diverse Tissues and SpatialTranscriptomic Technologies biorxiv.org