Surface-stabilized sub-micron condensates for compartmentalizing synthetic cells and enhanced enzyme kinetics biorxiv.org 2026-07-27 Living cells harbor numerous membraneless organelles (MOs), which are dynamic protein/nucleic acid assemblies responding to specific physicochemical t
Cryoaerosolization Enables Scalable Vitrification-Based Cell Cryopreservation biorxiv.org 2026-07-27 Cell therapies hold transformative potential for treating cancer, neurologic disorders, organ failure, diabetes, and other conditions, but their wides
Total Synthesis of Self-Assembling Semi-Synthetic Proteins Utilizing a Dendritic Solubility Tag biorxiv.org 2026-07-27 The chemical synthesis of well-defined, self-assembling semi-synthetic proteins (SSPs) has attracted growing interest in recent years.
Predictive Feature Engineering for Stress Detection using Physiological Signals, A Comparative Study biorxiv.org 2026-07-27 This paper presents a two-stage pipeline for implicit feature engineering in time series-based physiological stress detection using electrodermal acti
Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial Cancer biorxiv.org 2026-07-27 Endometrial cancer (EC), the most common gynecologic malignancy in the USA, has seen limited improvement in patient outcomes over recent decades, unde
Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment biorxiv.org 2026-07-27 Clear cell renal cell carcinoma (ccRCC) is driven by persistent HIF-2[alpha]; transcription program initiated by VHL loss, yet molecular mediators sus
Functional diversification of UBP6 in plant immunity through N-degron pathway regulation biorxiv.org 2026-07-27 Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modificat
PWO1 and TRB proteins coordinate chromatin regulation to prevent premature differentiation and ectopic lignin deposition in Arabidopsis biorxiv.org 2026-07-27 The Arabidopsis PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 (PWO1) and Telomere Repeat-Binding Proteins 1-3 (TRB1-3, TRBs) associate with distinct and shared
Functional Deorphanization and Subtype-Selective Pharmacology of Three Tyramine Receptors in the Disease Vector, Aedes aegypti biorxiv.org 2026-07-27 Biogenic amines such as tyramine (TA) and octopamine (OA) are central regulators of insect physiology and behaviour, acting through G protein-coupled
From whole-slide histology to ADC maps: Fast diffusion MRI simulation with neural operators biorxiv.org 2026-07-27 Background and Objective: Simulation of diffusion MRI signals from tissue microstructure is a fundamental problem in quantitative imaging, as it enabl
Humans Modulate Walking Speed in Response to the Perceived Energy-Time Costs of Others biorxiv.org 2026-07-27 Humans tend to walk at speeds that minimize energy expenditure and time duration.
The Live Concert of Brains: Performer-Audience Neural Coupling Links Ensemble Coordination to Shared Audience Integration biorxiv.org 2026-07-27 Collective social events often require coordinated action by one group to become shared experience in another, yet how this transformation is organize
Capturing the developing brain in motion: A practical tutorial for recording mobile EEG in naturally moving children biorxiv.org 2026-07-27 This tutorial seeks to facilitate the use of mobile electroencephalography (EEG) in young chil-dren.
Chronic stress does not induce behavioural signs of tinnitus or cochlear synaptopathy in Mongolian gerbils biorxiv.org 2026-07-27 Tinnitus is commonly associated with psychosocial stress.
Preprocessing Decisions Affect the Precision of P50 Estimates in the Paired-Click Paradigm biorxiv.org 2026-07-27 Sensory gating is commonly indexed by suppression of the auditory P50 component in the paired-click paradigm.
Dynamism in paintings and photographs: how the power of diagonals in art overcomes the oblique effect in visual perception biorxiv.org 2026-07-27 Artists and photographers use diagonals to convey dynamism, tension and instability in naturalistic and abstract images.
Role of leg campaniform sensilla sensory feedback in Drosophila melanogaster adaptive walking biorxiv.org 2026-07-27 With the newly uncovered access to a genetic line labeling all campaniform sensilla in Drosophila melanogaster and the many insights gathered from lar
A Portable Fluorescence Platform for Decentralized One-Health mcr-1 Monitoring biorxiv.org 2026-07-27 Antimicrobial resistance (AMR) represents a major global health threat, with plasmid-borne mcr genes driving colistin resistance and exposing critical
Rapid motility arrest of the Lyme disease spirochete, Borrelia burgdorferi, by vaccine-induced OspA antibodies biorxiv.org 2026-07-26 Outer surface protein A (OspA)-based Lyme disease vaccines elicit antibodies that inhibit transmission of infectious Borrelia burgdorferi spirochetes
A GSK3-dependent phosphorylation switch licenses BNIP3-mediated mitophagy biorxiv.org 2026-07-26 The turnover of mitochondria through mitophagy is essential for maintaining mitochondrial function and matching mitochondrial content to cellular dema
IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 Immunity biorxiv.org 2026-07-26 Tuft cells initiate intestinal type 2 immunity, yet the mechanisms that restrain excessive tuft cell activation remain poorly understood.
Sialyl-Tn-positive tumour-derived extracellular vesicles impair dendritic cell function via horizontal transfer of glycans biorxiv.org 2026-07-26 The sialyl-Tn (STn) glycan antigen is aberrantly expressed in a subset of triple-negative breast cancer (TNBC) and is associated with poor prognosis a
H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodies biorxiv.org 2026-07-26 Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses are currently responsible for a multi-species outbreak affecting wild birds, poultry, nu
Anti-Z-NA antibodies can distinguish accessible Z-form states across DNA, RNA, and DNA-RNA substrates biorxiv.org 2026-07-25 Left-handed (Z-form) double-stranded nucleic acid conformers (Z-DNA and Z-RNA, collectively called Z-NA) are molecular patterns recognized by ADAR1 an
Modeling Parkinsonian Freezing and Deep Brain Stimulation Effects in a Basal Ganglia Network biorxiv.org 2026-07-25 he precise mechanism through which Deep Brain Stimulation (DBS) mitigates freezing episodes in Parkinson's disease remains unknown.
A Germinal Center-Independent Innate-Like Memory B Cell Compartment of B1 Origin biorxiv.org 2026-07-25 Memory B cells (MBCs) are a critical cellular reservoir for long-term humoral immunity.
Deletion of Ferritin Heavy Chain Limits Tumor Growth and Promotes Iron-Dependent Stress in Medulloblastoma biorxiv.org 2026-07-25 Iron is essential for tumor proliferation and metabolic adaptation but becomes cytotoxic when unbuffered, creating a potential metabolic vulnerability
Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors biorxiv.org 2026-07-25 Mucosal-associated invariant T (MAIT) cells sense riboflavin metabolites through the monomorphic antigen-presenting molecule MR1, providing a unique o
Generative replay across hippocampal-neocortical circuits biorxiv.org 2026-07-25 To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together.
Concept-Level Semantic Representations Remain Decodable in Chronic Post-Stroke Aphasia biorxiv.org 2026-07-25 Aphasia is characterized by impaired word retrieval, yet most cognitive models of word production assume that underlying conceptual-semantic represent