A non-invasive method of air pollutant exposure in an avian model of development biorxiv.org 2026-07-24 Air pollution is a growing public health concern.
An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics biorxiv.org 2026-07-24 Intestinal insect cells are integral to pharmacokinetic research, unfortunately they do not serve as cell models for more advanced studies comparable
Natriuretic Peptide Augmentation Attenuates Renin Cell Hyperactivation and Afferent Arteriolar Hypertrophy During Long-Term Renin-Angiotensin System Inhibition biorxiv.org 2026-07-24 BACKGROUND: Chronic renin-angiotensin system (RAS) inhibition activates renin cells and induces afferent arteriolar hypertrophy, a maladaptive vascula
Recent Adversity Shapes Autonomic and Neural Threat Learning and Retrieval Under Imminent Threat: A Prospective Longitudinal Study biorxiv.org 2026-07-24 Recent adversity (RA) increases the risk of later mental health problems, but the mechanisms underlying this association remain largely unclear.
Eye movements reveal representational geometry biorxiv.org 2026-07-24 Mental representations are the explanatory construct of the cognitive sciences, but there is no widely accepted characterization of how they cause beh
Numerosity adaptation reflects multiple levels of sensory processing biorxiv.org 2026-07-24 Psychophysical and neuroimaging studies have repeatedly suggested that perceived numerosity is susceptible to adaptation, involving high-level number
Nasal inhalations and exhalations evoke distinct prefrontal-cortex responses with constant latency biorxiv.org 2026-07-24 Neuronal activity synchronous to breathing is salient across the mammalian brain.
Sub-endothelial platelet activation amplifies neutrophil transmigration within venular walls biorxiv.org 2026-07-24 Neutrophil recruitment into inflamed tissues requires coordinated transmigration across the multilayered venular wall, yet how this process is regulat
Targeting neutrophil signaling networks in immune complex-mediated autoimmune disease biorxiv.org 2026-07-24 Fragment crystallizable gamma receptor (Fc{gamma}R)-induced signaling is a crucial process that determines the cellular response to immune complexes (
PopZ is dispensable for cell fitness but required for polar localization of ParB in Zymomonas mobilis. biorxiv.org 2026-07-24 Chromosome segregation is an essential process in monoploid bacteria, in which faithful inheritance of the genetic material is required for viability
FXR-mediated recruitment of PPP1CB suppresses SMAD2/3 phosphorylation to mitigate pulmonary fibrosis biorxiv.org 2026-07-24 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited treatment options and poorly understood molecula
Peroxiredoxin 6 limits mitochondrial peroxidation to prevent mitochondrial ER contact site assembly and inflammatory signalling following adaptive stress biorxiv.org 2026-07-24 Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme with peroxidase, calcium independent phospholipase A2 (aiPLA2) and lysophospatidylcholine acyltran
Identification of lipid specificity in membrane organizing protein complexes biorxiv.org 2026-07-24 Organelle membrane identity is encoded by protein and lipid composition. Human cells produce thousands of distinct lipid species for this purpose.
CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation biorxiv.org 2026-07-24 The non-receptor protein-tyrosine phosphatases Shp1 (PTPN6) and Shp2 (PTPN11) play critical roles in hematopoietic signaling networks, yet their speci
Sex Differences in Physiological Hair Cycling and Adhesive Material-Induced Hair Regeneration in Mice biorxiv.org 2026-07-24 Sex differences in hair growth are clinically evident, but sex-dependent regulation of physiological hair cycling and injury-induced hair regeneration
Climate and urbanization structure West Nile virus vector communities: Tools for surveillance under environmental change biorxiv.org 2026-07-24 West Nile virus (WNv) in eastern North America is transmitted primarily by Culex pipiens and Culex restuans, two cryptic vector species whose relative
T50 as a proxy of PS II heat tolerance: time dependence, differences in calculation methods and implications for its suitability to assess the heat tolerance of tree species biorxiv.org 2026-07-24 The heat tolerance of tree species has recently received increased attention, as it is critical for the response of forest ecosystems to climate chang
Land-use influence on benthic algal assemblage structure and biomass in Afrotropical headwater streams biorxiv.org 2026-07-24 Benthic algae integrate catchment- and reach-scale pressures in streams.
Kin discrimination in plants: competitive ability over kinship response biorxiv.org 2026-07-24 Numerous studies on plant-plant interactions aim to distinguish positive from negative effects, especially among related individuals.
Deciphering complete archaic introgression sequences in modern human genomes biorxiv.org 2026-07-24 Genetic introgression from archaic hominins has profoundly reshaped the genetic diversity and adaptive potential of modern humans, yet the full catalo
A rapid HPLC-based method to determine NAD(P)(H) and NMN redox cofactor concentrations and ratios in microbes biorxiv.org 2026-07-24 Redox cofactors are a key part of cellular physiology as they are involved in most metabolic pathways, and their ratios are linked to cellular robustn
Bioengineering of a Chimeric Metarhizium anisopliae cPr1A Protease with Enhanced Binding and Enzyme Activity Through C-terminal Fusion of Bombyx mori Chitin-Binding Domain biorxiv.org 2026-07-24 Abstract Metarhizium anisopliae is an important entomopathogenic fungi used in biological control of agricultural pests, but its commercial applicatio
A transcriptional signature of LKB1 functional loss defines a large, therapeutically addressable patient population across human cancers biorxiv.org 2026-07-24 Loss of the tumor suppressor LKB1 (STK11) drives metabolic reprogramming and immune evasion, but its clinical footprint is defined almost entirely by
The receptor kinase NILR1 confers nematode resistance through developmental rather than canonical immune signaling biorxiv.org 2026-07-24 NILR1 contributes to quantitative resistance against Heterodera schachtii and signals through a brassinosteroid-type kinase cascade, but whether its c
Repeated intermittent clenbuterol administration induces exposure history-dependent proteomic remodeling in mouse skeletal muscle biorxiv.org 2026-07-24 Clenbuterol (CB), a {beta}2-adrenergic receptor agonist, is known to increase skeletal muscle mass.
Inflammatory suppression and cancer-associated bypass of the b0,+selenium-utilization program in the human intestine biorxiv.org 2026-07-24 The b0,+ transporter (SLC3A1/SLC7A9) imports cystine and selenocystine at the enterocyte apical membrane and defines a selenium-utilization program in
DNA barcoding-based paired daughter cell analysis reveals division preferences of hematopoietic stem cells biorxiv.org 2026-07-24 Hematopoietic stem cells(HSCs) maintain their pools by stem-stem division and produce mature blood cells through stem-progenitor or progenitor-progeni
COP9 complex maintains neuroblast growth and proliferation by regulating Akt/mTor pathway biorxiv.org 2026-07-24 The nervous system consists of the brain and associated structures that are replete with highly specialised neurons and glia.
Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork biorxiv.org 2026-07-24 Purpose: Aqueous humor outflow through the trabecular meshwork (TM) is segmental, demonstrating high flow (HF) and low flow (LF) regions.
Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function biorxiv.org 2026-07-24 {gamma}{delta} T-cells, which are predominantly enriched in epithelial tissues, have been used in cancer therapy because of their capacity for rapid c