Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model biorxiv.org 2026-07-23 Repeated low dose psilocybin is being developed as a scalable outpatient treatment for mood and anxiety disorders, but chronic exposure raises concern
Dronedarone hydrochloride reverses obesity-related metabolic syndrome while preserving skeletal muscle mass biorxiv.org 2026-07-23 Obesity-driven metabolic syndrome poses a critical global threat, yet standard therapies like GLP-1 receptor agonists trigger substantial lean mass wa
Persistent microbial material contributes to Alzheimer disease and is targetable by vaccination biorxiv.org 2026-07-23 Chronic neuroinflammation is increasingly recognized as a contributor to Alzheimer disease, yet the upstream stimuli that sustain it remain poorly def
A predictive theory of experimental design for inferring neural population geometry in large-scale recordings biorxiv.org 2026-07-23 Ongoing technological advances will lead to recordings with progressively increasing numbers of neurons, while trial counts may only increase modestly
Individual limb measures of split-belt adaptation are correlated with shifts in lower limb position sense biorxiv.org 2026-07-23 Stable gait in humans relies on both precise estimates of lower limb position and the ability to robustly adapt walking movements across different env
Decoding Individual Musical Pitches in Perception and Imagery using Evoked Theta and Beta Power in EEG biorxiv.org 2026-07-23 Imagery evokes perceptual-like experiences and recruits similar neural activity to perception.
Uni-TINT: Unifying T and Innate Lymphoid Cell Taxonomy with a high resolution, pan-disease and pan-tissue single-cell transcriptomic atlas biorxiv.org 2026-07-23 T cells and innate lymphoid cells (ILCs) exhibit extensive phenotypic diversity across tissues and diseases, yet inconsistent annotation limits cross-
Evolutionary dynamics of the Timopheevii wheat lineage biorxiv.org 2026-07-23 Wheat, the most widely cultivated crop globally, includes multiple species with varying ploidy levels.
Can urban fence lizards identify cats? biorxiv.org 2026-07-23 Urban habitats can serve as wildlife refuges, or as ecological traps.
Flower engineering by yeasts: reversal of nectar sugar concentration gradient within Darwin's syndrome inflorescences biorxiv.org 2026-07-23 Yeasts thriving in floral nectar have a proven ecological engineering capacity, as they modify the internal environment and the rewards of individual
Host traits, phylogeny, and symbiont identity explain variation in colony-level symbiont switching across reef-building corals biorxiv.org 2026-07-23 Flexibility in the coral-algal symbiosis has been proposed as a mechanism by which coral colonies may acclimatize to shifting environmental conditions
Species traits shape the intercontinental introduction patterns of bark and ambrosia beetles biorxiv.org 2026-07-23 1.
Local trait responses and aquatic microclimates increase projected habitat suitability for field-collected Anopheles stephensi in southern Ethiopia biorxiv.org 2026-07-23 Background Trait-based models of mosquito environmental suitability commonly use global thermal performance curves compiled from laboratory studies.
Warming amplifies short-term responses to disturbance in lake food webs biorxiv.org 2026-07-23 Ecological communities can exhibit transient amplification after disturbance even if asymptotically stable, yet how environmental change reshapes thes
High resolution structure of plant Light-Harvesting Complex II (LHCII) provides insight into lutein conformations and energy quenching biorxiv.org 2026-07-23 Plant Light Harvesting Complex II (LHCII) is found in the thylakoid membranes of chloroplasts and balances two roles: energy collection for photosynth
A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells biorxiv.org 2026-07-23 Photocatalytic proximity labeling proteomics (photo-PLP) has emerged as a powerful technology for rapid capture of protein interactomes in situ.
Extracellular vesicles derived from cells overexpressing HGSNAT rescue defects in Mucopolysaccharidosis IIIC neurons biorxiv.org 2026-07-23 Mucopolysaccharidosis III type C (MPS IIIC) is a rare neurological lysosomal storage disorder caused by genetic deficiency of the lysosomal membrane e
iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations biorxiv.org 2026-07-23 Glucose-6-phosphate (G6P) is a key intermediate in multiple energetic and anabolic pathways, and quantifying its dynamics is essential for understandi
Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope biorxiv.org 2026-07-23 The size of the nucleus scales with cell size, suggesting a universal scaling rule.
An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases. biorxiv.org 2026-07-23 Treatment-emergent neuroendocrine prostate cancer (NEPC) is an aggressive, therapy-resistant disease arising in up to 20% of castration resistant pros
An immune-stimulating antibody conjugate spatiotemporally targeting CD47 and TLR9 elicits macrophage-dependent tumor clearance and durable anti-cancer adaptive immunity biorxiv.org 2026-07-23 Cluster of differentiation 47 (CD47) blockade promotes tumor cell phagocytosis; however, transitioning this initial innate immune event into durable a
Vitamin K2 Limits Ferroptosis-Associated Lipid Peroxidation and Attenuates Aortic Valve Stenosis biorxiv.org 2026-07-23 Background: Calcific aortic valve stenosis (AS) is the most common valvular heart disease in the aging population and lacks effective pharmacological
Elevated CO2 enhances tomato tolerance to Botrytis cinerea through transcriptional and metabolic defence reprogramming biorxiv.org 2026-07-23 Atmospheric CO2; concentration is projected to rise substantially over the coming decades, yet its impact on the molecular mechanisms governing plant
Schwann Cell-Specific TDP-43 Rescue Improves Peripheral Nerve Myelin Pathology Without Altering Motor Behaviour in a Mouse Model of ALS biorxiv.org 2026-07-23 Amyotrophic lateral sclerosis (ALS) is a terminal disease caused by motor neuron loss.
IFNγ at the crossroads of systemic protection and brain vulnerability to coronavirus infection biorxiv.org 2026-07-23 The COVID-19 pandemic, together with previous outbreaks caused by highly pathogenic coronaviruses, highlighted the importance of understanding the hos
TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism biorxiv.org 2026-07-23 TMEM135 has been implicated in lipid metabolism, but its role in regulating hepatic lipid homeostasis remains unclear.
Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity biorxiv.org 2026-07-23 The endosomal sorting complex required for transport (ESCRT) is a hetero-multimeric membrane-remodeling machinery essential for endosomal sorting, int
p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells biorxiv.org 2026-07-23 Age is a principal risk factor for chronic respiratory diseases.
Structural modeling supports an interaction between the Drosophila Estrogen-Related Receptor and Sima/HIF-1α biorxiv.org 2026-07-23 The Drosophila Estrogen Related Receptor (dERR) is an orphan nuclear receptor that regulates developmental metabolism, yet the protein cofactors that
Maps of historical forests in France and their temporal continuity since the first half of the 19th century biorxiv.org 2026-07-23 Integrating environmental history is essential for understanding present-day ecosystem dynamics and guiding modern conservation strategies, particular