Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects biorxiv.org 2026-07-22 The need for improved treatments for chronic pain has driven increased interest in cannabis-based therapeutics.
GEM-GPT Enables Personalized Cell Type-Resolved Therapeutic Design for Systems Pharmacology biorxiv.org 2026-07-22 Generative artificial intelligence (AI) has emerged as a powerful framework for drug discovery, yet most current approaches follow one-drug-one-gene t
Social and neuroendocrine phenotypes reprogrammed by endocrine-disrupting chemicals can be mitigated by Limosilactobacillus reuteri modulation of the gut microbiome-thyroid-oxytocin axis biorxiv.org 2026-07-22 Introduction: Environmental factors are increasingly implicated in the etiology of autism spectrum disorder (ASD).
A novel, complex-spike burst-dependent form of BCM-like metaplasticity regulates the induction of behavioral timescale synaptic plasticity biorxiv.org 2026-07-22 The induction of Hebbian LTP can produce a persistent, heterosynaptic suppression of LTP induction at other synapses.
Biologically Plausible Dopamine-Modulated STDP Model of Pavlovian Learning in Spiking Neural Networks biorxiv.org 2026-07-22 Spike-timing-dependent plasticity (STDP) and dopamine (DA) are fundamental to reward-based learning and memory formation.
Motor Learning and Transfer Are Symmetric Across Hands biorxiv.org 2026-07-22 Functional asymmetry between the cerebral hemispheres is a defining feature of the sensorimotor system, with the dominant hemisphere playing a central
In vitro evolution of uropathogenic Escherichia coli to fosfomycin resistance in a 3D cultured human bladder microtissue model biorxiv.org 2026-07-22 In vitro studies of antimicrobial resistance (AMR) using laboratory growth media produce important, fundamental information.
Multi-Omic Dissection of Autism Reveals Dominant Effects of Family, Sex, and Host-Microbe Metabolic Interactions biorxiv.org 2026-07-22 Autism spectrum disorder (ASD) has been associated with gut microbiome and metabolic alterations, but reported biomarkers are inconsistent and often i
Lipid Headgroup Hydration Regulates Distinct Remodeling of the Membrane Interface by Polyethylene Glycol and Dextran biorxiv.org 2026-07-22 Water-soluble polymers commonly interact with cell membranes, but their interactions are poorly understood.
Animal model of leprous neuritis using transfer of sensitized lymphocytes into M. leprae-inoculated nude mice biorxiv.org 2026-07-22 Background Leprosy is curable with multidrug therapy, but preventing peripheral neuropathy remains challenging.
A canonical four-state macro-architecture governs multimodal fear-goal arbitration across learning and relapse biorxiv.org 2026-07-22 Fear, safety, and goal pursuit are often studied with separate behavioral readouts, leaving open whether multimodal behavior is organized by continuou
A Chairside Multimodal Platform for Temporomandibular Joint Biomechanical Assessment: Technical Evaluation and Illustrative Application biorxiv.org 2026-07-22 Background: Temporomandibular joint (TMJ) biomechanics can be characterized by mandibular motion, masticatory muscle activity, and bite force generati
TrioNsight: Building a meta-predictor to evaluate the clinical impact of TrioN-like Dbl-homology domain variants biorxiv.org 2026-07-22 TRIO is a member of the Rho family of guanine nucleotide exchange factors (Rho GEFs), which promote the exchange of GDP for GTP to activate Rho GTPase
IOBRpy enables agentic multi-omics decoding of anti-tumor immunity biorxiv.org 2026-07-22 Decoding the tumor immunity is pivotal for cancer immunotherapy, yet transcriptomic pipelines remain bottlenecked by fragmented tools and biased inter
Distinct nigral and brainstem pathology markers map onto separable subthalamic electrophysiological signatures in Parkinson's disease biorxiv.org 2026-07-22 Subthalamic local field potentials (LFPs) are increasingly used as physiomarkers of the symptomatic state in Parkinson's disease, but their relationsh
Nausea reshapes visual exploration and pupillary responses to affective images biorxiv.org 2026-07-22 Perception is not a passive recording of external events.
Turtle IgD2 preserves an ancestral IgXA-derived XA3-XA4 module in a duplicated and locally remodeled IgD2-IgY constant-region2 array biorxiv.org 2026-07-22 A second IgD gene, IgD2, was first described in the leopard gecko as a hybrid constant-region gene containing IgD-derived exons and terminal IgA-like
Multiscale Biomechanical and Electrophysiological Modeling of Nociceptive Activation in Musculoskeletal Joint Disorders: Insights from the Temporomandibular Joint biorxiv.org 2026-07-22 Background and objective: Musculoskeletal joint disorders often show inconsistent relationships between structural degeneration and nociceptive pain.
Evidence of residual Brugia malayi infection in TAS-III cleared areas of coastal Odisha: Findings from Molecular Xenomonitoring biorxiv.org 2026-07-22 Background: Lymphatic filariasis (LF), caused by Wuchereria (W) bancrofti, Brugia malayi and Brugia (B) timori, remains a major public health problem
338 coleopteran genomes reveal exceptional rearrangement variation compared to other insect orders biorxiv.org 2026-07-22 Chromosomal rearrangements reshape genome architecture, but rate variation across the tree of life remains poorly understood.
Relaxed selection and convergent loss erode the retained plant-cell-wall-degrading enzymes of ectomycorrhizal fungi biorxiv.org 2026-07-22 The repeated evolution of the ectomycorrhizal (ECM) symbiosis from saprotrophic ancestors is accompanied by a contraction of the plant-cell-wall-degra
Sequence-based modeling of plant epigenomes reveals cell-type-specific cis-regulatory grammar biorxiv.org 2026-07-22 How cis-regulatory sequences and their genetic variation govern chromatin accessibility, regulate gene expression, and the establishment of plant cell
BioPhasor: Decoding Cellular State Tensors from Multi-Omics Phasor Dynamics for Quantum Ready Systems Biology biorxiv.org 2026-07-22 Integrating multi-omics data - transcriptomics, proteomics, metabolomics, single-cell - remains a fundamental challenge in systems biology.
IntraTalker - Modelling Intracellular Signalling in1 Cellular Crosstalk biorxiv.org 2026-07-22 Single-cell sequencing has advanced the study of cell-cell communication, yet most methods focus on intercellular ligand-receptor interactions while n
Generation of lachrymatory factor synthase-suppressed onion (Allium cepa L.) by Agrobacterium-mediated gene transfer for CRISPR/Cas9 genome editing biorxiv.org 2026-07-22 Lachrymatory factor, an irritating volatile with tear-inducing property, is produced when onion bulbs are cut or chopped.
Continuous target-specific mutagenesis and rapid gene evolution by diversity-generating retroelements in Escherichia coli biorxiv.org 2026-07-22 Sequence-programmable directed evolution systems have great potential to accelerate bioengineering.
Division of Synthetic Cells Using a Genomically Encoded One-Protein Divisome biorxiv.org 2026-07-22 Synthetic biology is emerging as a powerful tool to understand life by building minimal synthetic cells whose functions are encoded within their genom
Defining the molecular interaction between influenza hemagglutinin and MHC-II biorxiv.org 2026-07-22 The hemagglutinin (HA) of some influenza viruses can interact with major histocompatibility complex class II (MHC-II), but how these proteins interact
Quantitative profiling of basal and stress-induced ribosome collisions biorxiv.org 2026-07-22 Ribosomes stall when they encounter problematic codons or cellular stress that perturbs translation.
Early life adversity disrupts adult social reward motivation biorxiv.org 2026-07-22 Early life adversity can produce persistent changes during development that increase vulnerability to neuropsychiatric disorders.