eIF5A is an indispensable protein for eukaryotic cells biorxiv.org 2026-07-23 eIF5A is an evolutionarily conserved protein found in all eukaryotes, and in Archaea and bacteria.
Circadian transcriptome in cultured cells depends on synchronisation method and differs from in vivo condition biorxiv.org 2026-07-23 In vitro synchronisation is widely used to study circadian clocks in cells, but whether cultured cells recapitulate tissue-level rhythmic outputs rema
Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification biorxiv.org 2026-07-23 RNA modification analysis by LC-MS/MS is central to epitranscriptomics, yet quantitative comparison across laboratories and instrument platforms remai
Self-powered electronics-free Wearable Disposable Electrotherapy (WDE) platform for accelerated wound healing biorxiv.org 2026-07-23 Electrical stimulation accelerates wound repair by modulating endogenous bioelectric signals that regulate inflammation, angiogenesis, extracellular m
Macrophage-instructed GSDME couples glioblastoma cell-state plasticity with inflammatory cell death biorxiv.org 2026-07-23 Glioblastoma (GBM) cell states reflect spatial microenvironmental interactions.
Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice. biorxiv.org 2026-07-23 Background: Protease-activated receptor 4 (PAR4) is the only functional thrombin receptor on mouse platelets.
Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer biorxiv.org 2026-07-23 Morphological changes in prostate glands, assessed by Gleason grading, remain the gold standard for diagnosing prostate cancer, yet molecular biomarke
Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-beta clearance in Alzheimer's disease models biorxiv.org 2026-07-23 Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, yet the environmental drivers that accelerate its progression remain p
Complement protein concentrations and activity in human cervical mucus biorxiv.org 2026-07-22 Abstract Problem: Complement, a system of over 30 interacting proteins, functions as a critical immune mediator at mucosal surfaces including the inte
Non-retroviral Endogenous Viral Element Acts as a Stable Antiviral Regulator Across Mosquito Life Stages and Generations biorxiv.org 2026-07-22 Endogenous viral elements (EVEs) from non-retroviral RNA viruses are widespread in host genomes, yet their functional significance in vivo remains poo
Promoter architecture decodes response regulator phosphorylation into distinct transcriptional logics in Pseudomonas aeruginosa biorxiv.org 2026-07-22 Two-component systems convert environmental signals into transcriptional responses, but how one response-regulator phosphorylation state produces diff
Detection of bifidobacterial lipoproteins with anti-viral potential in donor human milk biorxiv.org 2026-07-22 Background: Group B coxsackieviruses (CVBs) are involved in triggering type 1 diabetes.
Proteomic mapping of the dengue virus NS1 microenvironment in infected cells identifies novel host dependency factors including TM9SF3 biorxiv.org 2026-07-22 Dengue virus (DENV) is endemic in over 100 countries and causes approximately 100 million symptomatic infections annually, with symptoms ranging from
A boundary-referenced framework for quantifying shoreline-associated movement in white sharks biorxiv.org 2026-07-22 Persistent habitat edges can structure animal movement, yet many analyses treat boundary geometry only implicitly.
Parallel and Divergent Evolution in Pseudomonas aeruginosa Under Constant and Fluctuating Predator-Mediated Selection biorxiv.org 2026-07-22 Environmental predation is a major driver of bacterial evolution and may indirectly influence virulence through coincidental selection.
Contamination of widely used databases compromises rRNA based taxonomic assignment of metagenomes and metatranscriptomes biorxiv.org 2026-07-22 axonomic annotation of metagenomic and metatranscriptomic datasets frequently relies on aligning small subunit (SSU) rRNA reads to annotated reference
A Disease-Agnostic Nasal Microbiome Wellness Index for Standardized Assessment of Upper-Airway Respiratory Health biorxiv.org 2026-07-22 Background: Upper-airway and respiratory conditions impose a large and growing global burden, yet there is no standardized way to assess whether a nas
Interaction of involuntary and executive attention during development biorxiv.org 2026-07-22 Attentional control requires the fine-tuned interaction of attentional networks supporting alertness, orienting and higher-level executive control.
A roadmap for enriching rare cell populations from human post-mortem brain, demonstrated by 100% microglial purity. biorxiv.org 2026-07-22 Understanding brain disease requires studying the specific cell types that drive each condition: microglia in Alzheimer's, dopaminergic neurons in Par
Endogenous attention is invariant to sequential effects in performance around the visual field biorxiv.org 2026-07-22 Covert spatial attention selects and prioritizes relevant sensory information. Endogenous attention is voluntary, goal-driven, and flexible.
Branch-resolved IFN/STING-linked lesion-state architecture in psoriasis: multi-cohort derivation, held-out bulk replication and single-cell context analysis biorxiv.org 2026-07-22 Objective and design: We tested whether a frozen branch-resolved IFN/STING-linked lesion-state architecture derived from paired psoriasis transcriptom
A Synthetic Microbial Therapy Rewires Antitumor Immunity Across Multiple Cancer Types biorxiv.org 2026-07-22 Microbial immunotherapies show promise against cancer, yet broad efficacy and mechanistic insight remain elusive.
Unconventional presentation of an immunodominant HLA-DR15-restricted nephritogenic proteinase 3 epitope implicated in vasculitis biorxiv.org 2026-07-22 Proteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is associated with HLA-DR15, implicating HLA-DR15-restricted CD4
A sensitive bioassay for detecting Plasmodiophora brassicae in canola field soils biorxiv.org 2026-07-22 We describe a biodegradable-cup bioassay for detecting viable Plasmodiophora brassicae in soil samples.
Widespread introgression and a potential role for a neo-sex chromosome in booby diversification and speciation biorxiv.org 2026-07-22 Speciation in marine taxa is dynamic and complex, often occurring in the absence of absolute geographic barriers to gene flow.
Development of Audiovisual Integration in Beginning Readers: A Longitudinal fMRI Study biorxiv.org 2026-07-22 Acquiring reading proficiency, unlike spoken language, requires the brain to engage several specialized neural systems to map visual symbols (letters)
Sensory experience and mTORC1 interplay orchestrates the maturation of cortical interneuron connectivity and tactile sensitivity biorxiv.org 2026-07-23 Sensory abnormalities are core features of neurodevelopmental disorders, including autism.
Hierarchical neural integration of musical structure during expert performance biorxiv.org 2026-07-23 Music, which is organized hierarchically (notes, phrases, sections), provides an ideal model for studying fine-grained motor sequence production.
Constraints for spatially and temporally precise learning in a neural circuit model of reinforcement learning biorxiv.org 2026-07-22 Reinforcement learning is a key means by which animals learn appropriate actions in a given context.
Enhanced neural encoding of individual exemplars in the Super-Recogniser brain is specific to faces biorxiv.org 2026-07-22 Super-Recognisers are known for their exceptional ability to encode and remember faces.