Longitudinal Reorganization of Cortical and Cerebellar Functional Networks in Spinocerebellar Ataxia Type 7 biorxiv.org 2026-08-02 Spinocerebellar ataxia type 7 (SCA7) is a rare neurodegenerative disorder characterized by progressive cerebellar ataxia and visual impairment.
MreB is dispensable for viability but critical for rod shape, motility and biofilm fitness in Pseudomonas aeruginosa biorxiv.org 2026-08-02 Despite growing interest in the MreBCD morphogenetic complex as a potential antimicrobial target, its function in Pseudomonas aeruginosa remains poorl
Methodological Impacts on Microbiome Structure and Indicator Status in the Human Lower Respiratory Tract biorxiv.org 2026-08-02 Rationale: Lung cancer is the leading cause of cancer-related death globally, and rising incidence among traditionally low-risk individuals intensifie
MassGAT: a graph-based collective learning approach for untargeted detection and annotation of LC-MS data biorxiv.org 2026-08-02 Motivation: The untargeted processing of Liquid Chromatography coupled to High-Resolution Mass Spectrometry (LC-HRMS) data is a major challenge for th
Energetics of stalk intermediates elucidated from hydrostatic pressure effects on membrane fusion biorxiv.org 2026-08-02 Membrane fusion is an essential process in cells that requires a balance of lipid composition to establish biophysical properties conducive to topolog
Naturally cysteine-less LOV domains from halophilic archaea exhibit magnetic field effects on their fluorescence biorxiv.org 2026-08-02 Magnetic fields can modulate the function of certain flavoproteins through the radical pair mechanism, in which they influence the spin evolution of a
Benchmarking Deep Learning Predictions of Mutation-Induced Fold Switching biorxiv.org 2026-08-02 Many proteins are known to adopt multiple distinct folded states which are often associated with key functional behavior.
Minocycline engages microglia in the midbrain periaqueductal grey to attenuate hypoxia-triggered panic-like behaviour in rats biorxiv.org 2026-08-02 Panic disorder (PD) is a chronic and highly disabling psychiatric disorder characterised by recurrent and unexpected panic attacks, with underlying ne
Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks biorxiv.org 2026-08-02 DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between h
The gut microbiome of infants with hypoplastic left heart syndrome is enriched in pathobionts and exhibits altered responses to nutritional intervention biorxiv.org 2026-08-02 Congenital heart disease (CHD) can expose infants to chronic cyanosis, altered intestinal perfusion, and prolonged hospitalization.
Systematic comparison of pathogenic variants of the RNA exosome gene EXOSC3/RRP40 in Saccharomyces cerevisiae reveals variant-specific functional consequences biorxiv.org 2026-08-02 The RNA exosome is an essential, evolutionarily conserved ribonuclease complex that processes and degrades many classes of RNA.
Genome-wide analysis reveals the importance of histone acetyltransferase Esa1 in transcriptional regulation during nitrogen starvation biorxiv.org 2026-08-02 Macroautophagy/autophagy is a process that degrades intracellular components and is strongly triggered by nitrogen starvation (-N).
Population-Scale Landscape of Mobile Element Insertions Across 82 Diverse Indian Populations biorxiv.org 2026-08-02 Mobile element insertions (MEIs) are a major source of structural variation in human DNA that can affect gene regulation and disrupt coding sequences.
Prevalence of chloroquine and antifolate drug resistance markers in Plasmodium falciparum parasites in Rwanda, 2018 biorxiv.org 2026-08-02 Background Antimalarial drug efficacy is threatened by the development of drug resistance.
PG-MLD: Physics-Guided Molecular Representation Learning via Dynamic 3D Trajectory Distillation biorxiv.org 2026-08-02 Molecular representation learning underpins molecular property prediction and drug design by capturing molecular structure-property relationships.
Dynamics of the α2-chimaerin-Rac1 interface in Duane retraction syndrome and computational design of candidate probes biorxiv.org 2026-08-02 Duane retraction syndrome (DRS) is an eye movement disorder caused by gain-of-function mutations in CHN1, which encodes 2-chimaerin.
CD133+ progenitor cells promote pulmonary hypertension through CXCR4 signaling biorxiv.org 2026-08-02 Background: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and smooth muscle cell accumulation, but the progenitor-like
Clutter does not affect the spatial tuning of * category representations in human object-selective cortex * biorxiv.org 2026-08-02 Natural vision is frequently impaired when the visual field is crowded with multiple competing objects.
SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes biorxiv.org 2026-08-02 SLAM-associated protein (SAP) is required for T follicular helper (Tfh)-B cell interactions that underlie germinal center formation, but it is unclear
The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome biorxiv.org 2026-08-02 Reproducing a physiologically relevant tumor microenvironment in vitro is essential for developing effective immunotherapeutic treatments.
Genetic background diversifies mutational paths but converges on membrane depolarization for bleomycin resistance in yeast biorxiv.org 2026-08-01 Drug resistance evolution is shaped by both selective agent and genetic background in which resistant mutations arise, but most experimental evolution
Evolution of a large and diverse phospholipase gene cluster that defines the plant pathogenic genus Ceratocystis biorxiv.org 2026-08-01 Many Ceratocystis species cause cankers and unique vascular wilt diseases, often on a broad and unpredictable range of plant hosts.
Enhancing Recombinant Vector Assembly Efficiency: A Novel Methodological Approach biorxiv.org 2026-08-01 With the rapid development of modern biotechnology, DNA vectors have become fundamental tools for inserting, transferring, and expressing specific gen
Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization biorxiv.org 2026-08-01 The dual targeting of mitochondrial proteins regulates a host of cellular processes, including metabolism, cofactor biosynthesis, mitophagy, and stres
An alphabet of allostery: a transferable transfer entropy contact patterns predicts allosteric-site character and conformational rewiring biorxiv.org 2026-08-01 Allostery is increasingly understood as the propagation of dynamic information through a protein, yet the computational descriptors of that flow are c
Reconstructing lineage-constrained gene-program dynamics with PhyloFM biorxiv.org 2026-08-01 Cell-fate dynamics are defined not only by where cells end, but by when fate programs emerge, diverge, and reshape population structure.
Equi-depth pooling for standardized and cost-effective Adaptive Immune Receptor Repertoire sequencing (AIRRseq) biorxiv.org 2026-08-01 Bulk B- and T-cell adaptive immune receptor (BCR/TCR) repertoire sequencing (AIRRseq) enables comprehensive analysis of adaptive immune diversity, but
DEAR-OWL: a fully browser-based hybrid resource for instant or precise differential gene expression analysis biorxiv.org 2026-08-01 Motivation: Differential gene expression analysis (DEA) via RNA sequencing (RNA-seq) is essential but remains challenging for wet-lab biologists due t
A hyperspherical deep Bayesian model for interpretable clustering and relationship prediction in microbiome multi-omics integration biorxiv.org 2026-08-01 The microbiome plays a significant role in the development and progression of many diseases, yet extracting interpretable insights from multi-omics da
Optimized Multiple Circular Sequence Alignment for Cyclic Peptide Motif Discovery biorxiv.org 2026-08-01 Head-to-tail (H2T) cyclized peptides are an increasingly important modality in drug discovery, combining high target affinity and selectivity with met