Evaluating Protein Language Model Embeddingsfor Structural Similarity in the Protein-Sequence Twilight Zone biorxiv.org 2026-07-31 Evaluating protein sequence similarity remains challenging in the protein-sequence twilightzone (20-35% sequence identity), where traditional methods
Fast remote nucleotide sequence alignment with Riboseek biorxiv.org 2026-07-31 Structure prediction has reached RNA, where generating deep alignments is now the bottleneck.
Dengue virus 2 lacking N153 glycosylation displayed enhanced recognition by neutralizing antibodies biorxiv.org 2026-07-31 Deglycosylated (N153Q) dengue virus (DENV) mutant shows attenuated infection in a mouse model, mainly due to its increased antibody susceptibility.
Competing Molecular Interactions Govern the Dynamical Arrest of G3BP1 Condensates biorxiv.org 2026-07-31 G3BP1 is a central scaffold of stress granules (SGs).
Hydrogel-enhanced bioelectrochemical nitrate reduction for ammonium recovery from dilute nitrate via Shewanella oneidensis MR-1 biorxiv.org 2026-07-31 Bioelectrochemical reduction of dilute nitrate (NO3-; sub-mM to low-mM range) to ammonium (NH4+) offers a promising route toward circular nitrogen man
Defining strain variation in the maintenance of Borrelia turicatae during hyperparasitism and transovarial transmission in Ornithodoros turicata biorxiv.org 2026-07-31 Abstract: Tick-borne relapsing fever (TBRF) spirochetes are maintained in nature through vector-associated transmission routes primarily in argasid ti
Multiomic Integration Reveals Transposable Element-Embedded Regulatory Variants Underlying Brain Aging biorxiv.org 2026-07-31 Genome-wide association studies (GWAS) have identified thousands of variants associated with brain aging, most in noncoding regions whose regulatory e
Wearable magnetoencephalography in an open environment biorxiv.org 2026-07-31 A long-standing goal of neuroscience is to observe the human brain as it functions in natural and real-world environemnts, where people interact and e
MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes biorxiv.org 2026-07-31 Summary: Ancient DNA studies are increasingly targeting samples that are beyond the limit of radiocarbon dating (>50 thousand years old) and are of
ChemoCalib: multiblock PLS calibration of genome-scale metabolic models improves flux prediction over expression-only integration biorxiv.org 2026-07-31 Constraint-based metabolic modeling (FBA) needs multi-omics integration to narrow flux solution spaces, yet existing expression-only methods (E-Flux,
Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure biorxiv.org 2026-07-31 Alcohol-induced toxicity is driven largely by the accumulation of acetaldehyde and disruption of hepatic redox homeostasis during ethanol metabolism.
mock-fastq-generator: A synthetic FASTQ generator biorxiv.org 2026-07-31 Validating bioinformatics pipelines and benchmarking sequence processing algorithms requires reliable test datasets.
CyFj11: FlowJo v11 Workspace Import and Legacy Format Export for R-Based Flow Cytometry Analysis biorxiv.org 2026-07-31 High-dimensional flow cytometry measures immune cells at single-cell resolution, enabling systematic characterization of cell populations at scale.
Gastrin releasing peptide and cholecystokinin employ different intracellular pathways to elicit similar safe Ca2+ signals biorxiv.org 2026-07-31 Repetitive cytosolic Ca2+ spikes in pancreatic acinar cells, elicited by low (physiological) concentrations of acetylcholine (ACh), cholecystokinin (C
Comparative connectomics of parasite esophagus suggests evolutionary simplification of a nervous system biorxiv.org 2026-07-31 Several prominent examples suggest that the evolution of parasitism is accompanied by nervous system simplification.
Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice biorxiv.org 2026-07-31 ADGRD1 (GPR133) is an orphan adhesion G protein-coupled receptor (aGPCR) that primarily signals through Gs to regulate intracellular cAMP levels and i
The Lifespan Architecture of Human EEG biorxiv.org 2026-07-31 Human brain maturation and aging are highly nonlinear, yet their organization at the level of large-scale electrophysiological activity remains poorly
Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation biorxiv.org 2026-07-31 Cell death, DNA damage, and inflammation are closely interconnected processes implicated in ageing, cancer, and inflammatory disorders, yet the endoge
Does diet influence physiological and behavioural responses to predation risk? biorxiv.org 2026-07-31 As one of the strongest selective forces, predation risk induces antipredator responses in prey that not only maximise survival probability but are en
Real-time electrochemical protein monitoring using molecular pendulum sensors biorxiv.org 2026-07-31 Continuous monitoring of proteins in complex biological fluids is essential for advancing personalized medicine, yet existing biosensors are often lim
A curated human lactylome and protein language model framework enable accurate prediction and reveal local determinants of lysine lactylation biorxiv.org 2026-07-31 Lysine lactylation is a dynamic post-translational modification that can alter protein function and has been implicated in diverse physiological and p
vOMIX-MEGA: An ultra-fast end-to-end pipeline for terabyte-scale viral metagenomics analysis. biorxiv.org 2026-07-31 Viral identification for terabyte-scale metagenomic data is limited by scalability and computational resources.
Membrane mimetics control internal hydration and catalytic activity of the copper ATPase LpCopA from Legionella pneumophila biorxiv.org 2026-07-31 Membrane protein function depends critically on the surrounding lipid bilayer, which supports specific lipid-protein interactions and imposes constrai
Biophysical characterization of novel biomarkers and bioaffinity reagents (NanoMIPs): on the road for a low-cost diagnostic test for intestinal schistosomiasis biorxiv.org 2026-07-31 Schistosoma mansoni is a vector-borne intestinal parasite, endemic in ~70 tropical countries.
Evolutionary Dynamics of AI, Politicization, Contestation, and Trust in Science Funding biorxiv.org 2026-07-31 Economic stability and progress in modern technological societies depend on vigorous and independent public funding of science and engineering researc
Mapping Enteric Neural Circuits by Anterograde Transsynaptic Tracing biorxiv.org 2026-07-31 The diverse functions of the enteric nervous system (ENS) arise from communication between molecularly distinct neuronal populations organized into co
Ire1 membrane stress responses support cell growth upon disruptions in inter-organelle contacts biorxiv.org 2026-07-31 Disruptions in inter-organelle contacts result in membrane lipid homeostasis defects that ultimately impair cellular function and viability.
Embryonic TGF-β signaling imposes persistent changes to HSPC clonality and inflammatory landscape biorxiv.org 2026-07-31 Embryonic hematopoiesis is essential for establishing lifelong blood and immune system function.
Neglecting movement-disease feedback biases wildlife epidemic forecasts biorxiv.org 2026-07-31 In wildlife populations, movement drives host contact networks and disease spread.
Evaluation of ivermectin effectiveness under contrasting anthelmintic resistance scenarios in beef cattle: a comparative study in Italy and Argentina biorxiv.org 2026-07-31 Beef cattle farming plays a crucial role in the livestock-related economies of both Italy and Argentina.