The Capillary endothelial cell-governed niche sustains angiogenesis in proliferating infantile hemangioma via multilayer stromal support biorxiv.org 2026-07-31 Infantile hemangioma (IH), the most common benign vascular tumor in infants, is characterized by the aberrant proliferation of hemangioma endothelial
A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related Schwannomatosis biorxiv.org 2026-07-31 Background: Previous exploratory studies identified recombinant human Neuregulin-1 {beta} (rhNRG{beta}1) as a promising therapeutic strategy for inhib
IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development biorxiv.org 2026-07-31 Despite considerable progress in elucidating mechanisms leading to castration-resistant prostate cancer (CRPC), insight into the early stages of prost
Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases biorxiv.org 2026-07-31 Purpose: Liver metastases confer poor outcomes and attenuate the benefit of immunotherapy across solid tumors.
Multiplex genome engineering in yeast using the TIGR-Tas system biorxiv.org 2026-07-31 Tandem Interspaced Guide RNA (TIGR)-TIGR-associated (Tas) systems are a newly discovered family of ultracompact, modular RNA-guided DNA-targeting prot
The rabies virus interferon antagonist P protein selectively modulates interferon signalling to inhibit antiviral gene expression while supporting proviral gene expression biorxiv.org 2026-07-31 Type-I IFNs mediate the principle antiviral response of cells by controlling the expression of hundreds of IFN-regulated genes (IRGs), many of which h
Apparent survival suggests the female-biased dispersal in a truly subterranean rodent, Ellobius talpinus biorxiv.org 2026-07-31 Adult sex ratios in mammals are usually female-biased, but the northern mole vole (Ellobius talpinus) (Pallas, 1770), a cooperatively breeding subterr
A comprehensive HA-tagged PRC1 toolkit enables standardized chromatin profiling and proteomic analysis in Drosophila melanogaster biorxiv.org 2026-07-31 Polycomb group (PcG) proteins are evolutionarily conserved epigenetic regulators that maintain transcriptional states during development and are frequ
Switch-TRIBE: Lineage-specific high-resolution profiling of endogenous RNA-protein interactions biorxiv.org 2026-07-30 RNA-binding proteins (RBPs) play vital roles in regulation of cell fate and function.
Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling biorxiv.org 2026-07-30 Post-translational modifications (PTMs) diversify neuropeptide function, yet how minimal modifications encode receptor specificity without direct cont
Analysis of the conformational dynamics of amylose oligomers using molecular dynamics simulations biorxiv.org 2026-07-30 Amylose contributes to starch crystallinity, but the stability of packed amylose double helices in water at elevated temperature remains insufficientl
Sequence-dependent Stability and the Apparent Two-state Thermal Transition of Extended Collagen Triple Helices biorxiv.org 2026-07-30 The thermal stability of collagen triple helices is strongly influenced by the amino acid sequence of the repeating Gly-X-Y tripeptides, yet how these
The lncRNA SOX2OT Drives Non-Small Cell Lung Cancer Progression and Metastasis by Suppressing miR-143 biorxiv.org 2026-07-30 In terms of cancer-related death, non-small cell lung cancer (NSCLC), the world's leading cause, highlights the need for continued research into the g
Consequences of Early Postnatal Blockade of Aldosterone Synthesis on Behaviour and Stress Response in Male and Female Rats biorxiv.org 2026-07-30 Aim: The aim of the present study was to determine whether pharmacological inhibition of aldosterone synthesis during the stress-hyporesponsive period
Scale-dependent spatial organisation of action observation network responses to hand actions and emotional faces biorxiv.org 2026-07-30 Human social perception relies on multiple visual signals, including object-directed actions and emotional facial expressions.
Opposing modulation of cortical and corticospinal excitability across movement-related beta stages biorxiv.org 2026-07-30 Discrete voluntary movement depends on rapid changes in neural excitability across cortical and corticospinal circuits, yet how intrinsic movement-rel
Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis biorxiv.org 2026-07-30 Objective In the first year after onset of the autoimmune disease RA (RA), 40-60% do not achieve remission on conventional synthetic disease-modifying
Larval habitat bacteria emit volatile semiochemicals that modulate oviposition site selection in the malaria vector Anopheles gambiae (Diptera: Culicidae) biorxiv.org 2026-07-30 Background: Larval habitat management is increasingly recognized as a complementary strategy for malaria vector control.
Image-based transposon screening reveals a flavin reductase that restrains intracellular Salmonella replication in macrophages biorxiv.org 2026-07-30 Intracellular bacterial pathogens can survive and replicate within host cells, yet an isogenic population follows divergent fates: some bacteria are k
Nonlinear responses to temperature and precipitation shape the distribution of Aedes sierrensis in North America biorxiv.org 2026-07-30 Understanding the ecological determinants of species ranges is a central goal of ecology.
Experimental evidence for female choice in an angiosperm biorxiv.org 2026-07-30 Female choice is a central process of sexual selection that has shaped numerous phenotypes in animals.
Evolution of endogenized densoviral elements across aphid species biorxiv.org 2026-07-30 Endogenous viral elements (EVEs) are widespread across animal genomes, yet the processes governing EVE evolution and diversification remain poorly und
SRARec: A program for detecting recombination in sequencing reads and its application to uncover recombination patterns in SARS-CoV-2 and HIV-1 biorxiv.org 2026-07-30 The detection of recombination using consensus genome sequences has key limitations including failure to consider rare genetic variants and misidentif
Skiaviridae: a large DNA virus family that persistently infects thraustochytrid protists biorxiv.org 2026-07-30 Genomic and metagenomic sequencing has transformed our understanding of the diversity of large DNA viruses infecting eukaryotic microorganisms.
A Thermodynamically Consistent Reaction--Diffusion Model of Spatial Proofreading in One and Two Dimensions biorxiv.org 2026-07-30 Spatial proofreading is a mechanism that can enhance molecular discrimination by exploiting nonequilibrium diffusive transport between spatially separ
Tunable kinetic destabilization governs RNA polymerase passage through a DNA-bound transcription factor biorxiv.org 2026-07-30 Eukaryotic transcription factors recognize short motifs, creating abundant binding sites within gene bodies and potential collisions with elongating R
Genomic alterations enable BRCA1 methylation loss and promoter bypass to drive resistance in high-grade serous ovarian cancer biorxiv.org 2026-07-30 BRCA1 promoter methylation predicts sensitivity to PARP inhibitors in high-grade serous ovarian cancer, yet therapeutic resistance is common and mecha
Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma biorxiv.org 2026-07-30 Immune checkpoint blockade (ICB) therapies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become
Steady state ratios in bipartite population models emerge through obligate cross-feeding biorxiv.org 2026-07-30 Cross-feeding, the phenomenon where one organism consumes metabolites secreted by another, is a ubiquitious phenomenon in microbial communities.
Hypothalamic oligodendrocytes regulate systemic energy balance through Notch-dependent state transitions biorxiv.org 2026-07-31 The central mechanisms through which glial cells regulate whole body metabolism remain poorly understood.