Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer biorxiv.org 2026-07-30 Small cell lung cancer (SCLC) remains a highly lethal disease with limited targetable surface antigens beyond delta-like ligand 3 (DLL3).
Custom Probe-Based Spatial Transcriptomics Enables Microbiome Detection in FFPE Colorectal Cancer Tissue biorxiv.org 2026-07-30 Intratumoral bacteria have emerged as functionally relevant components of the tumor microenvironment, yet the spatial relationship between these bacte
Global integrators of light signalling and nutrient homeostasis safeguard symbiosis under light stress biorxiv.org 2026-07-30 Their large, protein-rich seeds render many legume plants like beans, peas or soy attractive food or fodder crops.
Evolutionary Origins and Synthetic Reconstruction of Gingerols biorxiv.org 2026-07-30 How new enzymatic activities become integrated with existing metabolic networks to generate lineage-restricted plant chemistry remains a central quest
A genetic switch involving EGR1 and EZH2 links aging and development across human tissues biorxiv.org 2026-07-30 Aging is often regarded as the last chapter of development. There is growing evidence that aging and development are mechanistically linked.
Modulation of noisy gene expression by general sequestration mechanisms biorxiv.org 2026-07-30 Sequestration of gene products through diverse mechanisms forms a fundamental layer of regulation in intracellular biochemical processes, including po
Dynamics of a Hes1-Dll1 regulatory network in coupled muscle stem cells: stability, bifurcations, and coexistence of oscillatory states biorxiv.org 2026-07-30 Muscle regeneration relies on the coordinated activation of muscle stem cells, whose fate decisions are regulated by intracellular gene expression dyn
Combination of indomethacin and temperature produces reliable strobilation in Cassiopea xamachana but batch effects create high variability in ephyra outcomes biorxiv.org 2026-07-30 Indomethacin and temperature shocks are both widely used to induce ephyra production in Cassiopea polyps, yet the combined effect of these stimuli on
Aerobic GenX Defluorination by a Wastewater Cladosporium halotolerans Strain with a Genomically Expanded Haloacid Dehalogenase Repertoire biorxiv.org 2026-07-29 Per- and polyfluoroalkyl substances (PFAS) such as GenX (HFPO-DA) are aerobically recalcitrant contaminants for which biological treatment options rem
Taxonomic vs. Functional Diversity for the Impact Assessment of Offshore Oil & Gas Activities: An Exploratory Study on Benthic Prokaryotes biorxiv.org 2026-07-29 Improving environmental management in the offshore Oil & Gas sector requires approaches that capture the ecosystem services (ES) provided by marin
Microbial Biogeography Across the Bovine Body: A Meta-analysis of 27 Anatomical Niches biorxiv.org 2026-07-29 Cattle harbor diverse bacterial communities across the gastrointestinal, respiratory, reproductive, mammary and other anatomical systems, but body-wid
A Single Lipid Nanoparticle Formulation Enables Delivery of Diverse RNA Therapeutics to Human Muscle Models of Duchenne Muscular Dystrophy biorxiv.org 2026-07-29 Duchenne muscular dystrophy is a lethal neuromuscular disorder caused by the absence of dystrophin, for which no curative treatment is available.
Early Partitioning of Structural Paralog Diversity Shapes Immune Evolution Across Habitat Transitions in Gobiiform Fishes biorxiv.org 2026-07-29 Habitat transitions expose species lineages to novel pathogen regimes and are often hypothesized to drive adaptive diversification of immune gene fami
A single-nucleus atlas of the adult laying hen liver reveals metabolic specialization and improved cellular resolution through enhanced genome annotation biorxiv.org 2026-07-29 The liver of laying hens plays a central role in metabolism and reproduction, supporting the synthesis of egg yolk precursors under strong hormonal re
Parallel and scalable balanced minimum evolution algorithm for large-scale phylogenetic inference biorxiv.org 2026-07-29 The rapid growth of biological data demands scalable yet robust phylogenetic methods.
How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate biorxiv.org 2026-07-29 Electrostatic interactions often play a role in determining the thermodynamic and kinetic properties of protein-protein interactions.
A minimal kinase-phosphatase system and its lipid substrates self-organize into dynamic patterns biorxiv.org 2026-07-29 Competing lipid kinases and phosphatases are critical for organizing cellular membranes, but whether a minimal system can autonomously organize protei
Cellular origin and therapeutic potential of SERPINA3N in ischemic stroke biorxiv.org 2026-07-29 Murine serine protease inhibitor clade A member 3N (SERPINA3N) and its human homolog SERPINA3 are injury-associated molecules induced in virtually all
Microbial diversity and insights into feeding behavior of the two-spot cotton leaf hopper (Amrasca biguttula) biorxiv.org 2026-07-29 The recent invasion of the two-spot cotton leaf hopper (TSCL) (Amrasca biguttula) into the U.S.
Capsular polysaccharide can sensitize bacteria to non-antibiotic drugs biorxiv.org 2026-07-29 Medications administered over long durations, such as phenothiazine antipsychotics, accumulate in the gut at concentrations that affect microbial grow
Saprotrophic soil fungus dissolves lithium lepidolite through inositol rescue metabolism biorxiv.org 2026-07-29 Microbial weathering of minerals represents a key biogeochemical process through which microorganisms access essential nutrients locked within rock an
The orphan histidine kinase TodK controls Myxococcus xanthus biofilm development by inactivating the CRP/Fnr homolog, MrpC biorxiv.org 2026-07-29 Environmental bacteria have abundant signaling systems wired into complex gene regulatory networks to adapt to fluctuating conditions.
Molecular basis for chikungunya virus recognition of a mosquito-specific receptor biorxiv.org 2026-07-29 Alphaviruses are arthropod-borne viruses that recognize cellular receptors in both vertebrate hosts and mosquito vectors to complete their transmissio
Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity biorxiv.org 2026-07-29 Biophysical pleiotropy, the phenomenon in which a mutation affects multiple protein properties, underlies many genetic diseases and shapes protein evo
Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity biorxiv.org 2026-07-29 The Atlantic surfclam, Spisula solidissima solidissima supports multimillion dollar harvests in the western North Atlantic, including Georges Bank and
Histone methyltransferase MET-2 differentially regulates autosome and X-chromosome structure and transcription during meiosis in C. elegans biorxiv.org 2026-07-29 During meiosis, accurate chromosome segregation requires significant condensation and compaction.
PlasChain: an algorithm for improving long plasmid reconstruction from metagenome assemblies biorxiv.org 2026-07-29 Background: Plasmids play a critical role in horizontal gene transfer and the spread of antibiotic resistance.
SketchDNA: A GUI-Enabled Toolkit for Multiscale Modeling of Topological DNA Structures biorxiv.org 2026-07-29 Computational modeling tools have enabled detailed exploration of the structural dynamics of nucleic acids at the nanoscale.
Stator pool size shapes the mechanosensitivity of the bacterial flagellar motor biorxiv.org 2026-07-29 The bacterial flagellar motor adapts to mechanical load by adding or removing stator units, which can either be inactive in the inner membrane (the st
Parallel construction of object motion from retina to cortex biorxiv.org 2026-07-29 Detecting a moving object against a moving background is fundamental to survival.