SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia biorxiv.org 2026-07-29 T-cell acute lymphoblastic leukemia is a heterogeneous hematologic malignancy in which LMO2 gamma/delta-like T cell acute lymphoblastic leukemia (T-AL
Dysregulated neutrophil extracellular trap formation is a novel driver of clonogenicity and therapeutic vulnerability in CMML biorxiv.org 2026-07-29 Chronic myelomonocytic leukemia (CMML) is an aggressive hematologic malignancy characterized by excess inflammatory signaling and clonal myeloprolifer
Single-cell profiling reveals MMP7-associated epithelial transition and immune-stromal remodeling in esophageal carcinogenesis biorxiv.org 2026-07-29 The progression from reflux esophagitis (RE) to Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) is a major route of inflammation-associat
Spatially Resolved Epithelial States Delineate Immunosuppressive Niches of Impaired Myeloid Antigen Presentation in PDAC biorxiv.org 2026-07-29 Bulk transcriptomic classifiers stratify pancreatic ductal adenocarcinoma (PDAC) into classical and basal-like subtypes with prognostic and therapeuti
CRISPR/Cas9 gene editing in the heterotrophic protist Acanthamoeba castellanii biorxiv.org 2026-07-29 Members of the amoebozoan genus Acanthamoeba are unicellular heterotrophic protists that inhabit a wide range of terrestrial and aquatic environments.
Patterns and drivers of cranial evolution in rhinos (Rhinocerotoidea; Perissodactyla): allometry, phylogeny and tempo of evolution biorxiv.org 2026-07-28 Despite their currently scarce taxonomic diversity, rhinocerotoids were among the most evolutionarily successful clades of large herbivorous mammals t
Hologenomics of xylotrophic bivalves reveals a minimalist, remote-acting evolutionary strategy of wood digestion biorxiv.org 2026-07-28 Wood constitutes the largest reservoir of biogenic carbon on Earth, yet remarkably few animals can exploit it.
Pangenome Analysis Reveals Gene Content Variation and Evolutionary Dynamics Across the Culex pipiens Species Complex biorxiv.org 2026-07-28 The Culex pipiens species complex contains the principal northern-hemisphere vectors of West Nile virus, lymphatic filariasis and several arboviruses;
Transcriptomic datasets of melittin- and un-treated murine cervical carcinoma U14 cells biorxiv.org 2026-07-28 Melittin, a potent amphipathic cationic peptide derived from bee venom, exhibits broad-spectrum antineoplastic efficacy, notably against cervical carc
Sequence determinants of pathogenicity in glucose-6-phosphatase linked to glycogen storage disease type 1a biorxiv.org 2026-07-28 Glycogen storage disease type 1a (GSD1a) is an autosomal recessive Mendelian disorder that can be caused by missense variants in glucose-6-phosphatase
Transplanting enzyme active site geometry into antibody CDRs for catalytic antibody design biorxiv.org 2026-07-28 Antibodies provide programmable molecular recognition, whereas enzymes enable repeated chemical transformation.
A dCas9 Proximity Reporter for Investigating DNA Linear and Rotational Dynamics biorxiv.org 2026-07-28 The dCas9 system has rapidly been developed into many tools to explore different aspects of the human genome; the high binding specificity, coupled wi
ImpuT2T: Pangenome-Based Patching for Human Genome Assemblies biorxiv.org 2026-07-28 With improvements in sequencing and assembly have come many high-quality telomere-to-telomere assemblies and reference pangenomes.
Electron counting enables cryo-electron ptychography for near-atomic-resolution cryo-electron microscopy biorxiv.org 2026-07-28 Cryo-electron ptychography is an emerging technique for studying radiation-sensitive biological specimens, developed from four-dimensional transmissio
Intersubject variations in national identity ideology map onto variations in neural dynamics during geopolitical video viewing biorxiv.org 2026-07-28 When people watch the same political narrative, they often form different interpretations.
Stressor-specific dynamic patterns of noradrenaline release in the paraventricular nucleus of the hypothalamus in freely moving mice biorxiv.org 2026-07-28 An organism is constantly challenged with various stressors.
Characterizing Functional Clusters of V4 Neurons in Digital Twins biorxiv.org 2026-07-28 Neurons in primate visual cortical area V4 display tuning for multiple visual features, including color, shape, texture, and depth.
Atherosclerosis destabilizes regulatory T cells (Tregs) resulting in multiple families of exTregs biorxiv.org 2026-07-28 How regulatory T cells (Tregs) lose lineage identity during chronic inflammation remains poorly understood.
Safety profiling of CAR-T cells using an organotypic human tissue platform biorxiv.org 2026-07-28 CAR-T-cell-associated on-target off-tumor (OTOT) toxicity represents a major safety concern, as recognition of target antigens on healthy tissues can
Voluntary exercise during weight loss attenuates adipose CD8+ T cell exhaustion that persists after weight regain biorxiv.org 2026-07-28 Background: Weight gain and loss induce adipose CD8+ T cell exhaustion, which persists and may worsen glucose tolerance following weight regain.
Microbial communities in tropical soils are highly resilient to fluctuating redox conditions biorxiv.org 2026-07-28 Many wet tropical soils alternate frequently between fully oxygenated and anaerobic conditions, constraining the terminal electron acceptors available
Native virion structure reveals stochastic genome assortment underlying dose-dependent Orsay virus infection biorxiv.org 2026-07-28 Orsay virus (OrV), infecting Caenorhabditis elegans, is a valuable model for studying host-virus interactions, yet its bipartite RNA genome packaging
Hippurate hydrolases encoded by Klebsiella pneumoniae and Klebsiella oxytoca are functional biorxiv.org 2026-07-28 Human urine is non-sterile, harbouring its own microbiota (urobiota).
Screening of Isolation and Culture Conditions of Lactic Acid Bacteria in Mongolian Horse Feces biorxiv.org 2026-07-28 ABSTRACT Objective: This study aimed to establish an efficient isolation, culture, and preservation system for lactic acid bacteria from Mongolian hor
Dissecting the phenotypic and genetic determinants of maize-bean interactions in intercropping biorxiv.org 2026-07-28 Cereal-legume intercropping is a cornerstone of agroecological systems because interactions between species can enhance agroecosystem resilience.
Proteomic consequences of male mate preference learning and female phenotype in the butterfly Bicyclus anynana biorxiv.org 2026-07-28 Mate preference learning, where individuals use past social experience to choose mates, is prevalent in many species.
Methane-producing microorganisms are widespread in surface waters and floating algal mats of inshore Baltic Sea habitats biorxiv.org 2026-07-28 Inshore coastal waters are almost invariably supersaturated with respect to methane and are thereby sources of methane to the atmosphere.
Biomechanical response of the human brain to low-intensity blast: a finite element study of single and repeated exposures biorxiv.org 2026-07-28 Repetitive low-intensity blast (LIB) exposure has been identified as a probable cause of mild blast-induced traumatic brain injury (mbTBI) and a chron
Ontology-Guided Pathway Activity Identifies a Cell-Intrinsic Defense Response Program Associated with MEK Inhibitor Sensitivity biorxiv.org 2026-07-28 Predicting cancer drug response from gene expression requires models that expose which biological pathways drive cell-line-specific sensitivity.
Passive copper release from ornamental rain chains is harmful to mosquito larvae and deters egg-laying biorxiv.org 2026-07-28 Urban mosquitoes use accumulated rainwater in private gardens and public green spaces for reproduction.