Goal-directed action selection relies on conjunctive representations that bind goals, actions and expected sensory outcomes biorxiv.org 2026-07-28 Goal directed actions are performed to obtain specific sensory outcomes.
Combinatorial Control of Corticospinal Axon Growth by Retinoic Acid Receptors biorxiv.org 2026-07-28 Regeneration of central nervous system (CNS) axons depends on Transcription Factors (TFs) that reactivate developmental growth programs, yet most such
Carbonyl stress primes the metastable aging brain for Alzheimer's disease biorxiv.org 2026-07-28 Alzheimer's disease (AD) is defined by amyloid-{beta} (A{beta}) plaques and tau tangles, yet the inflammation that comes with it is only partly locali
Blade-dependent molecular identity and neurogenic potential in the adult dentate gyrus biorxiv.org 2026-07-28 The dentate gyrus (DG) is a key hippocampal gateway for cognition and emotion and a major site of adult neurogenesis, yet its organization along the t
Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer's disease biorxiv.org 2026-07-28 INTRODUCTION: Alzheimer's disease (AD) progresses over decades, yet plasma biomarkers that resolve disease stage rather than simply detect disease rem
Invasiveness Screening Kit (ISK) v3: an integrated multilingual decision-support platform for non-native species risk identification biorxiv.org 2026-07-28 Risk identification of non-native species is widely used to support prioritization, early warning, horizon scanning and management decisions.
The epigenomic landscape of deep lineage divergence: The case of the European sea bass biorxiv.org 2026-07-28 Understanding the role of non-coding genomic variation in speciation remains a major challenge in evolutionary biology.
A Preparation-Free Mixture-of-Experts Framework for Protein-Ligand Affinity Prediction biorxiv.org 2026-07-28 Protein-ligand affinity (PLA) prediction is central to AI-driven drug discovery, but precise interaction-based methods require costly conformation pre
PG-LLM: Benchmarking General-Purpose Language Models for Protein Variant Ranking biorxiv.org 2026-07-28 General-purpose language models are being increasingly utilized in protein-design workflows, yet their ability to evaluate variant effects remains unc
Droplet microfluidics reports digital and tuneable single-platelet ADP secretion describing primed, active and hyper-active states biorxiv.org 2026-07-28 New platelet function assays that provide an accurate assessment of platelet reactivity as a surrogate for thrombosis risk could change the paradigm f
Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales biorxiv.org 2026-07-28 White matter hyperintensities (WMH) are a highly prevalent finding on FLAIR MRI scans and a prominent feature of white matter pathology across cerebro
Laser-integrated nanophotonic neural probes with on-chip sensors for addressable photostimulation biorxiv.org 2026-07-28 Studying the role of individual neurons in behavior and disease requires tools for controlling neural activity with high spatiotemporal resolution.
Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models biorxiv.org 2026-07-28 Psychedelic drugs offer a potentially promising avenue for novel therapeutics for the treatment of psychiatric conditions, including for mood and anxi
Characterization of nucleus accumbens dopamine dynamics during positive and negative operant reinforcement in rats biorxiv.org 2026-07-28 We previously reported, using in-vivo fiber photometry, that operant responding reinforced by access to a peer (social self-administration) is associa
Autonomic Decoupling in Listening Effort: Why Single-Channel Biomarkers Fail biorxiv.org 2026-07-28 Objective: Current theoretical frameworks operationalize listening effort as a monolithic, unified sympathetic response, driving the search for a sing
Rapid direct neuronal reprogramming of human dental pulp stem cells biorxiv.org 2026-07-28 Direct neuronal reprogramming offers an alternative to induced pluripotent stem cell-based differentiation by converting somatic cells directly into n
Circadian phase reconfigures information transmission in the mouse visual thalamus biorxiv.org 2026-07-28 Circadian clocks are a ubiquitous feature of the mammalian brain, yet whether they regulate how neural circuits encode and transmit information remain
Concurrent TMS and Spinal Cord fMRI Reveal Intensity-Dependent Modulation of Spinal Circuits biorxiv.org 2026-07-28 The spinal cord serves as a crucial relay for motor commands, yet the role of its local circuitry in sensorimotor integration remains poorly understoo
Multiple morphological pathways underlie climatic adaptation in North American mustelids biorxiv.org 2026-07-28 Ecogeographic rules predict that endotherms inhabiting colder environments exhibit larger body sizes and shorter appendages to reduce heat loss.
Cross-session generalization in automated behavioral tracking of Galleria mellonella larvae: comparison of classical computer vision, deep learning and generative domain adaptation biorxiv.org 2026-07-28 Background: Automated behavioral tracking is increasingly used in biological and biomedical research; however, robustness across heterogeneous imaging
Baseline regulatory programs in larval and adult neural progenitors converge towards an injury-induced state after spinal cord injury biorxiv.org 2026-07-28 Regeneration after spinal cord injury requires progenitor cells to convert injury-associated signals into coordinated remodeling of gene regulatory pr
Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism biorxiv.org 2026-07-28 Circadian rhythms are conserved biological timekeeping mechanisms crucial for the temporal compartmentalization of metabolic processes.
Nyx: a flexible framework for sleep scoring across species, lifespan and modalities biorxiv.org 2026-07-28 Sleep is a key factor in almost every physiological process, yet scoring tools lag behind innovations in basic to clinical research.
Serotonin Receptor Signaling Promotes Amoeboid Migration of Melanoma Cells Through cAMP/PKA Activation biorxiv.org 2026-07-28 Melanoma cells frequently utilize bleb-driven amoeboid migration to navigate confined microenvironments during metastasis.
STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53-mutated AML biorxiv.org 2026-07-28 TP53-mutated acute myeloid leukemia (AML) has dismal outcomes with current treatments and represents a critical unmet need.
Targeting CBP/p300 Overcomes Acquired Vincristine Resistance in Medulloblastoma biorxiv.org 2026-07-28 Background: Medulloblastoma is the most common malignant pediatric brain tumor.
Solanum americanum Bs2 and ZAR1 homologs recognize Xanthomonas euvesicatoria effectors essential for infection. biorxiv.org 2026-07-28 Multiple recognition events of pathogen-secreted effectors by immune receptors confer robust disease resistance in plants.
Engineering antigen-driven co-stimulation and T helper cell activity into TCR-T cells with CD8-41BB fusion receptors enhances anti-tumor activity biorxiv.org 2026-07-28 Adoptive cell therapy using tumor antigen-targeting T cell receptors (TCRs) offers a compelling approach to treat both hematological cancers and solid
A targeted plasma-proteomic axis separates autoimmune thyroid disease from growth-hormone deficiency biorxiv.org 2026-07-28 Targeted mass spectrometry (multiple-reaction monitoring, MRM) enables reproducible, multiplexed quantification of plasma proteins, but whether a fixe
Deep-learning based 3D segmentation of heterogeneous lizard claw tissue from CT data biorxiv.org 2026-07-28 The accurate segmentation of lizard claws is important as they are materially heterogeneous, comprising both bone and keratinous tissue.