Discrete Inverse Rendering: Biological Data Analysis with Integer Programming biorxiv.org 2026-07-27 Biological image analysis is full of discrete decisions: whether an object is present, which of several overlapping detections is real, whether two de
Estimation of biological age using HRV data: comparison of the Klemera-Dubal method with the multiple linear regression method biorxiv.org 2026-07-27 The aim of this study was to compare three methods for estimating biological age (BA) based on heart rate variability (HRV) indices recorded in the su
Explainable Artificial Intelligence for Cross-Dataset Generalizable Biomarker Discovery in Cardiovascular diseases (CVDs) biorxiv.org 2026-07-27 CVDs are heterogeneous, multifactorial disorders that remain the leading cause of global mor- tality from infancy to old age.
LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma biorxiv.org 2026-07-27 Retinoblastoma (RB), the most common pediatric intraocular malignancy, is initiated by biallelic inactivation of the RB1 tumor suppressor gene.
Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer biorxiv.org 2026-07-27 CD47 is a ubiquitously expressed transmembrane protein that functions as a negative immune checkpoint, marking host cells as "self" by delivering an i
Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed Immunotherapy biorxiv.org 2026-07-27 Cancer immunotherapy targeting B-cell specific CD19 antigen meant a major breakthrough in the treatment of B-cell malignancies.
A data-driven approach to integrative taxonomy biorxiv.org 2026-07-27 Central to understanding biodiversity is the systematic classification of biological taxa where concepts on integrating 'omics data have not yet been
Effects of different shading levels on growth, physiology and leaf surface micromorphology of Sorbus sibirica "Dong Hong" seedlings biorxiv.org 2026-07-27 Background: Sorbus sibirica "Dong Hong" is a promising ornamental cultivar, but its optimal light conditions remain unclear.
SWI3b restricts AGO5 expression to promote the initiation of megagametogenesis in Arabidopsis biorxiv.org 2026-07-27 Female germline development is fundamental to plant reproduction.
Decadal warming is linked to thermal tolerance and transcriptome reprogramming in a seagrass biorxiv.org 2026-07-27 Ocean warming and marine heatwaves threaten seagrasses, which are considered highly vulnerable to rising temperatures.
The free amino acid-rich biostimulant, Leafamine, promotes cell division in tomato roots and alleviates heat stress effects biorxiv.org 2026-07-27 Several tomato (Solanum lycopersicum) varieties are sensitive to heat stress, which compromises plant growth, development, and ultimately yield.
Landscape-mediated spread dynamics and anticipatory surveillance of African swine fever in wild boar: insights from the 2025-2026 Catalonia utbreak in Spain biorxiv.org 2026-07-27 African swine fever (ASF) in wild boar poses major surveillance and control challenges, particularly in peri-urban and human-modified landscapes where
Synthetic Combinatorial Minimisation of Cell Cycle Control in Yeast biorxiv.org 2026-07-27 The eukaryotic cell cycle, with its inherent regulatory redundancy, provides an ideal target for exploring genome modularisation and minimisation thro
Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae) biorxiv.org 2026-07-27 Species-level delimitation within the genus Trichomycterus remains one of the main systematic challenges within the Trichomycterinae, particularly in
Internal perturbation reveals the flexible and adaptive nature of the coordination between decisions and movements biorxiv.org 2026-07-27 Although growing evidence indicates that decision-making and movement control are tightly coordinated, the functional significance of this coordinatio
Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber's Hereditary Optic Neuropathy biorxiv.org 2026-07-27 Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited mitochondrial disorder characterised by painless, progressive, and sequential vis
Long-term Connectivity between Spinal Cord Tissue Transplants and the Injured Phrenic Motor Network biorxiv.org 2026-07-27 Restoring vital motor functions after spinal cord injury (SCI) remains a central challenge in neuroscience and regenerative medicine.
Task-Dependent and Cell-Type-Specific Modulation of the Mouse Dorsal Cortex of the Inferior Colliculus biorxiv.org 2026-07-27 Sensory responses in the auditory system are modulated by behavioral context, and this modulation extends as early as the inferior colliculus (IC).
BRCA2 and RAD54B FxPP motifs Bind DMC1 Filaments through Persistent and Transient Interfaces biorxiv.org 2026-07-27 During meiosis, double-strand DNA breaks are programmed to initiate homologous recombination.
SyntenyPair Explorer: an installation-free, browser-based tool for interactive pairwise genome synteny visualization biorxiv.org 2026-07-27 Comparisons of genome structure between related organisms are central to understanding genome evolution, gene family dynamics, and the genomic basis o
Correlating Structure and Rheology in Ionically Crosslinked Alginate Biopolymer Hydrogels - A Case for Why "Less" can be "More" biorxiv.org 2026-07-26 We probe the structural and rheological properties of ionically crosslinked alginate, a model biopolymer hydrogel, using microscopy, rheology and visc
Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream biorxiv.org 2026-07-27 Circulating tumor cells (CTCs) are the potential seeds of distant metastases; however, little is known about how they survive in the bloodstream.
Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes biorxiv.org 2026-07-27 The kidney is a highly energetic organ, requiring substantial ATP production through mitochondrial oxidative phosphorylation to support tubular reabso
A missing PEPC1 exaptation restricts C₄ evolution in palms (Arecaceae) biorxiv.org 2026-07-27 C4 and CAM photosynthesis evolved repeatedly across angiosperms, yet the four palm species examined here - representing three of five Arecaceae subfam
Paralog diversification masks conserved diel regulatory programs during cold acclimation in Brassica rapa biorxiv.org 2026-07-27 Plant stress responses occur within daily cycles of physiology, metabolism, and growth, making timing a critical dimension of acclimation.
Comparative epigenomics across the barley pangenome links structural variation to regulatory genome function biorxiv.org 2026-07-27 Structural variants (SVs) are abundant in plant genomes and influence agronomic traits, yet their regulatory interpretation remains challenging.
Dynamic structural changes and inhibition of insect delta and epsilon glutathione S-transferases by ethacrynic acid and permethrin biorxiv.org 2026-07-27 Insect glutathione S-transferases (GSTs) play critical roles in xenobiotic detoxification and insecticide resistance, making them promising targets fo
The FKBP42, TWISTED DWARF1, prioritizes auxin over brassinosteroidtransport by peptidyl-prolyl cis-trans isomerization of ABCB1 biorxiv.org 2026-07-27 The ATP-binding cassette (ABC) transporter ABCB1 transports both auxins and the brassinosteroid brassinolide (BL).
MeFluHyA: a novel fluorescent screening tool for high-throughput identification of HDAC6-selective inhibitors biorxiv.org 2026-07-27 The cytosolic histone deacetylase 6 (HDAC6) plays a key role not only in cancer but also in neurodegenerative diseases, including amyotrophic lateral
Cerclage Wire as an Affordable Alternative for Internal Fixation in Murine Critical Sized Defect Models biorxiv.org 2026-07-27 Critical sized defects (CSDs) are a serious challenge in orthopedics that require the development of more robust and effective treatments to improve q